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MAXIMIZE SUCCESS: SYNERGY OF SEMAGLUTIDE AND BEHAVIOR SUPPORT

December 1, 2023
|
Research Spotlight
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GLP-1 receptor agonists (RA) are powerful in the fight against obesity. These
pharmaceuticals are known for their weight loss and blood sugar benefits. By
reducing body weight, GLP-1 drugs like Ozempic and Wegovy may open the door to a
more active lifestyle, especially with appropriate support. Healthy habit
support during and extending beyond the duration of medication can improve
long-term outcomes and can help patients reduce their dosages and sustain their
positive outcomes. Success can be maximized when GLP-1 RAs such as semaglutide
are combined with behavior support.


WHAT ARE THE MAJOR GLP-1 RA MEDICATIONS?

There are many GLP-1 RA medications for approved for treating obesity and type 2
diabetes. Semaglutide appears to be the most potent type of GLP-1 RA for weight
loss. You’ve likely seen their ads, with brand names for semaglutide including
Ozempic & Wegovy. Mounjaro is another popular anti-obesity / type 2 diabetes
drug that also activates the GLP receptor, but through a related molecule
(tirzepatide). Other GLP-1 RAs include liraglutide (with brand names Victoza or
Saxenda) and dulaglutide (aka Trulicity). 


HOW DO THEY WORK FOR WEIGHT LOSS?

GLP-1 receptor agonists mimick the effects of a natural hormone that stimulates
insulin release, curbs appetite, and promotes a sense of fullness. Semaglutide
medications slow the digestion process. The stomach empties much slower when
these medications are taken, reducing the total quantity of calories per day and
leading to significant weight loss for most patients. 


HOW WELL DO THEY WORK?

Semaglutide medications are effective with minimal safety issues. For instance,
in the STEP1 trial for semaglutide (2.4 mg once weekly), patients lost an
average of 15% of their body weight after a year of treatment. Healthy lifestyle
changes were suggested for both the semaglutide and placebo group. The placebo
group lost an average of 2.4% of their body weight, by comparison. 


GASTROINTESTINAL WOES FOR SOME, SURGICAL CONCERNS

Studies report that about 7% of patients on semaglutide drop out due to
vomiting, nausea and diarrhea. More serious gastrointestinal events were rare
but did occur in 1.4% of participants in the semaglutide group and 0% in the
placebo group. While the weight loss success is remarkable, this reminds us that
not all individuals can tolerate the GLP-1 RAs according to the manufacturer’s
research findings.

In the real-world, rare adverse events have also been reported. Among the rare
side effects are pancreatitis, bowel obstruction, and stomach paralysis. And
when patients undergo surgeries, they must halt their GLP-1 RA medications to
ensure their stomachs are empty before their procedure. Even after fasting for
18 hours, semaglutide-users have “substantial” amounts of food in the stomach
that can be vomited and aspirated into the lungs during surgery. Some studies
suggest the medication should be withheld for 4 weeks before surgical
procedures, while the American Society of Anesthesiologists suggest withholding
these drugs for a week prior.


HOW MANY ACHIEVE “CLINICALLY-RELEVANT” 5% WEIGHT LOSS? 

Research studies refer to 5% weight reductions because this represents a
clinical benchmark associated with improved metabolic health. In the STEP1
trial, the percentage of those who lost 5% or more of their weight was an
impressive 86% of those on semaglutide compared to 32% of those in the placebo
group. This suggests that the GLP1 RAs can more than double the amount of
individuals who see significant weight loss success. 


COMPLEMENT THE BENEFITS OF GLP-1RAS FOR WEIGHT LOSS: HEALTHY HABIT SUPPORT

While current medication addresses the physiological aspects of appetite
control, behavior change focuses on the psychological and lifestyle aspects. By
understanding our actions and developing stress management techniques,
individuals can gradually improve their eating choices and physical activity
habits through behavior support.


BETTER TOGETHER

Medication and behavior support are synergistic partners, working together to
enhance and prolong the positive effects of weight loss interventions. By
addressing the behavioral aspects of weight management, healthy guidance can
amplify the overall effectiveness of weight loss medications. Research suggests
that more than double the amount of body weight is lost when combining
behavioral training with semaglutide medications. 


SUSTAINABILITY

It’s no secret that the appetite suppression stops when the drugs are halted.
And research shows that most weight is regained once the drug is discontinued.
Patients may lose access to the drug for several reasons. They may no longer
meet prescription criteria, experience health insurance changes, or may have
adverse effects from the drug. Healthy habit support becomes indispensable in
these scenarios. By helping individuals form and sustain positive lifestyle
habits, behavior tools offer a pathway to gradual reduction in pharmaceutical
reliance. This sustainable approach aligns with the long-term goals of patients
who seek not only immediate results but lasting health improvements.


HOW TREO CAN HELP

In the journey towards effective weight management, medication and behavior
support delivers the most weight loss and overall health advantages. And by
embracing both, individuals can harness the synergistic power of physiological
interventions and behavioral change strategies. Treo’s habit support platform
can maximize the benefits of weight loss medications, but also empowers
individuals to take control of their health, fostering sustainable success for
the long term. Interested in learning more? Schedule a demo or reach out at
info@treowellness.com.


KARLIE INTLEKOFER



As Treo’s Global Wellness Researcher, Karlie uses recent research findings to
support healthier daily habits. Karlie earned her doctorate in Neuroscience and
Behavior and bachelors in Health and Exercise Science.


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