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ANAESTHESIOLOGY



Anaesthesiology


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Jan 18, 2023


NOVEL IMAGE-GUIDED FLEXIBLE-PROBE TRANSBRONCHIAL MICROWAVE ABLATION FOR STAGE 1
LUNG CANCER.

Michael A Pritchett, Janani S Reisenauer, Ryan Kern, David S Wilson

BACKGROUND
Image-guided percutaneous thermal ablation is an established treatment option
for early-stage lung cancer in medically inoperable patients but carries a high
risk of pleura-related complications, particularly pneumothorax.
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MARINA CHIARA GARASSINO, MD

1.0 CME/MOC


TARGETING HER2, HER3, TROP2, AND OTHER ALTERATIONS WITH ADCS IN NSCLC

Expert overview of the latest data and recommendations on integrating new
treatments into your practice...read more
article continues here

OBJECTIVE
This study aimed to determine if image-guided transbronchial microwave ablation
(tMWA) is a feasible approach to treat peripheral stage 1 lung cancer.
METHOD
A prospective, single-arm, multicenter study sought to enroll 40 adults who were
medically inoperable or declined surgery for peripheral stage 1 lung tumors (≤20
mm). Ablation was performed using navigational bronchoscopy and a flexible MWA
probe, guided by cone-beam CT with augmented fluoroscopy. Follow-up at 1, 6, and
12 months included CT imaging of the ablation zone and possible tumor
recurrence, adverse events (AEs), pulmonary function, and quality of life.
RESULTS
Across 2 sites, 11 tumors (10 NSCLC, 1 carcinoid) were treated in 10 enrolled
patients. Median tumor diameter was 13 × 14 mm (7-19 mm) and median minimum
ablative margin was 11 mm (5-19 mm). Technical success and technique efficacy
were achieved in all patients. No tumor recurrence was seen during 12-month
follow-up. No pneumothorax, pleural effusion, or bronchopleural fistula were
noted. Minor AEs included scant hemoptysis, pain, cough, and dyspnea. Two
serious AEs occurred ≤30 days of ablation and included a COPD exacerbation (day
9) and a death of unknown cause (day 15). The death led the sponsor to halt
enrollment. Pulmonary function and quality-of-life indices remained stable.
CONCLUSIONS
Image-guided tMWA is a technically feasible approach for peripheral early-stage
lung cancer but warrants further evaluation of safety and efficacy in larger
cohorts.
Source: Respiration; International Review Of Thoracic Diseases

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DAVID G. WARNOCK, MD

0.5 CME


PRACTICAL GUIDANCE ON DIAGNOSING AND MANAGING FABRY DISEASE

Explore current and emerging options for treatment...read more

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THE ONCOLOGIST

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BRAIN METASTASES FROM BILIARY TRACT CANCER: CASE SERIES AND CLINICOGENOMIC
ANALYSIS.

BACKGROUND Limited data from small series have suggested that brain metastases
from biliary tract cancers (BrM-BTC) affect ≤2% of patients with BTC. We sought
to review our experience with patients...read more

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NEFROLOGIA

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TOCILIZUMAB IN THE TREATMENT OF ACTIVE CHRONIC HUMORAL REJECTION RESISTANT TO
STANDARD THERAPY.

INTRODUCTION There is no consensus on the most appropriate treatment for chronic
active antibody-mediated rejection (cAMR). Recent studies suggest that treatment
with tocilizumab (TCZ) may stabilize graft function, decrease the...read more

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NEFROLOGIA

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ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE IN HLA-IDENTICAL NON-TWIN SIBLINGS.

Anti glomerular basement membrane disease (AGBM) is an autoinmune disorder
characterised by the presence of anti-glomerular basement membrane (Anti-GBM)
antibodies, alveolar hemorrhage, necrotizing glomerulonephritis, and linear
deposition of immunoglobulins through...read more

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JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION = TAIWAN YI ZHI

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IMMUNOGENICITY AND SAFETY OF THIRD-DOSE MRNA COVID-19 VACCINES IN HEALTHY ADULTS
PREVIOUSLY VACCINATED WITH TWO DOSES OF THE CHADOX1 VACCINE.

BACKGROUND/PURPOSE The efficacy and safety of coronavirus disease 2019
(COVID-19) booster vaccines remain limited. We investigated the immunogenicity
and adverse events of the third dose of mRNA vaccines in healthy...read more

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STEVEN B. DEITELZWEIG, MD, MMM, SFHM, FACP, FACC

1.25 CME/MOC/NCPD/CPE/IPCE


TREATING PATIENTS WITH VENOUS THROMBOEMBOLISM

Examine the role of DOACs in VTE management across patient populations...read
more

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RHEUMATOLOGY (OXFORD, ENGLAND)

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COVID-19 VACCINE AFFECTS NEITHER PROTHROMBOTIC ANTIBODY PROFILE NOR THROMBOSIS
IN PRIMARY ANTI-PHOSPHOLIPID SYNDROME: A PROSPECTIVE STUDY.

OBJECTIVE To explore whether inactivated coronavirus disease 2019 vaccine
influences the profile of prothrombotic autoantibodies and induces thrombotic
events in primary APS patients. METHODS We enrolled 39 primary APS
patients...read more

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