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UTILITY NAVIGATION

 * Important Safety Information
 * Prescribing Information
 * Medication Guide
 * Healthcare Professionals


FOR CAREGIVERS

LIVE SUPPORT: 1-877-744-5675REGISTER FOR A $0 CO-PAY CARDLimits, terms, and
conditions apply.

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 * Who Is SUTENT for?
   * Adjuvant Treatment After Kidney Cancer Surgery*More
     
     SUTENT treats 4 cancers. Choose which cancer you want to learn more about.
     
     
   
   * Advanced Kidney Cancer†
   * GIST, when Gleevec® didn’t work or you can’t take it‡
   * pNET that has progressed and can’t be treated with surgery§
 * About SUTENT
   * Before Taking SUTENT
   * SUTENT Dosing
 * Side Effects & Tips
 * Financial Resources
   * Financial Resources
   * Support
 * For Caregivers
   * Getting Started
   * How Caregivers Can Help
   * Staying Organized
   * Caring for Yourself

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The information provided in this website is intended only for healthcare
professionals in the United States. The products discussed herein may have
different product labeling in different countries.

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WELCOME TO SUTENT


ASK FOR SUTENT® (SUNITINIB MALATE) BY NAME




†SUTENT is used to treat advanced kidney cancer (advanced renal cell carcinoma
or RCC).

‡SUTENT is used to treat a rare cancer of the stomach, bowel, or esophagus
called gastrointestinal stromal tumor (GIST) and when you have taken the
medicine imatinib mesylate (Gleevec ®) and it did not stop the cancer from
growing or you cannot take imatinib mesylate (Gleevec ®). Gleevec is a
registered trademark of Novartis  Pharmaceuticals Corporation.

§SUTENT is used to treat a type of pancreatic cancer known as pancreatic
neuroendocrine tumors (pNET) that has progressed and cannot be treated with
surgery.

||SUTENT is used to treat adults with kidney cancer that has not spread
(localized) and who are at high risk of RCC coming back again after having
kidney surgery.

It is not known if SUTENT is safe and effective in children.

*Eligible, commercially insured patients. Patients are not eligible to use this
card if they are enrolled in a state or federally funded insurance program,
including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs
health care, a state prescription drug assistance program, or the Government
Health Insurance Plan available in Puerto Rico. Patients may receive up to
$25,000 in savings per product annually. The offer will be accepted only at
participating pharmacies. This offer is not health insurance. No membership fees
apply. Pfizer reserves the right to rescind, revoke, or amend this offer without
notice. For any questions, please call 1-877-744-5675, visit
PfizerOncologyTogether.com/terms or write: Pfizer Oncology Together Co-Pay
Savings Program, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560.

There is only one brand-name SUTENT

Prescribed by doctors for over 15 years

Ongoing commitment to product quality and safety monitoring

Eligible patients may pay as little as $0 per month for SUTENT.

Limits, terms, and conditions apply.* Patients may receive up to $25,000 in
savings per product annually.

Not actual patient.

Approved in 2006 for Advanced kidney cancer†

Approved in 2006 for Gastrointestinal stromal tumor (GIST) when imatinib
mesylate (GLEEVEC®) did not stop the cancer from growing or you cannot take
GLEEVEC‡

Approved in 2011 for Pancreatic neuroendocrine tumors (pNET) that have
progressed and cannot be treated with surgery§

Approved in 2017 for Kidney cancer in adults whose cancer has not spread and who
are at high risk of it coming back after surgery||


IF YOU CHOOSE BRAND-NAME SUTENT, MAKE SURE YOU GET THE BRAND NAME

Your prescription may have been filled with a generic version instead of
brand-name SUTENT. Follow the steps below to help ensure you receive the brand
name your doctor prescribed and, if eligible, save on your prescription.

Ask Your Doctor

Ask your doctor to prescribe brand-name SUTENT and to indicate “DAW” (Dispense
As Written)—or the language used in your state—on all of your SUTENT
prescriptions.

Get a Savings Card

Sign up for a Savings Card and, if eligible, you may pay as little as $0 per
month for SUTENT. Limits, terms, and conditions apply.* See above. Patients may
receive up to $25,000 in savings per product annually.

Check Your Pills

Check your pills to be sure they're brand-name SUTENT—not the generic. Each
SUTENT pill is stamped with Pfizer on one end. If you think your brand-name
prescription has been filled with a generic, talk to your pharmacist.


LEARN ABOUT POSSIBLE
SIDE EFFECTS AND TIPS
TO HELP MANAGE SOME
COMMON SIDE EFFECTS

LEARN MORE


LEARN ABOUT POSSIBLE
SIDE EFFECTS AND TIPS
TO HELP MANAGE SOME
COMMON SIDE EFFECTS

LEARN MORE


Important Safety Information and Indications


INDICATIONS

SUTENT is a prescription medicine used to treat:

 * a rare cancer of the stomach, bowel, or esophagus called gastrointestinal
   stromal tumor (GIST) and when:
   * you have taken the medicine imatinib mesylate (Gleevec®) and it did not
     stop the cancer from growing or
   * you cannot take imatinib mesylate (Gleevec®).
 * advanced kidney cancer (advanced renal cell carcinoma or RCC).
 * adults with kidney cancer that has not spread (localized) and who are at high
   risk of RCC coming back again after having kidney surgery.
 * a type of pancreatic cancer called pancreatic neuroendocrine tumors (pNET)
   that has progressed and cannot be treated with surgery.

It is not known if SUTENT is safe and effective in children.

SUTENT can cause severe liver problems that can lead to death. Tell your
healthcare provider right away if you develop any of the following signs and
symptoms of liver problems during treatment with SUTENT:

SUTENT can cause severe liver problems that can lead to death. Tell your
healthcare provider right away if you develop any of the following signs and
symptoms of liver problems during treatment with SUTENT:

 * itching
 * yellow eyes or skin
 * dark urine
 * pain or discomfort in the right upper stomach area

Your healthcare provider should do blood tests to check your liver function
before you start taking and during treatment with SUTENT. Your healthcare
provider may temporarily stop, reduce your dose, or permanently stop treatment
with SUTENT if you develop liver problems.

SUTENT may cause serious side effects, including:

 * Heart problems. Heart problems may include heart failure, heart attack and
   heart muscle problems (cardiomyopathy) that can lead to death. Tell your
   healthcare provider if you feel very tired, are short of breath, or have
   swollen feet and ankles.

 * Abnormal heart rhythm changes. Changes in the electrical activity of your
   heart called QT prolongation can cause irregular heartbeats that can be life
   threatening. Your healthcare provider may do electrocardiograms and blood
   tests (electrolytes) to watch for these problems during your treatment with
   SUTENT. Tell your healthcare provider right away if:
   
    * you feel faint or lightheaded, or you pass out
    * you feel dizzy
    * you feel your heart beat is irregular or fast

 * High blood pressure. High blood pressure is common with SUTENT and may
   sometimes be severe. Follow your healthcare provider’s instructions about
   having your blood pressure checked regularly. Call your healthcare provider
   if your blood pressure is high or if you have any of the following signs or
   symptoms of high blood pressure:
   
    * severe headache
    * lightheadedness
    * dizziness
    * change in vision
   
   Your healthcare provider may prescribe medicine for you to treat high blood
   pressure, if needed.

 * Bleeding problems. Bleeding is common with SUTENT, but SUTENT can also cause
   severe bleeding problems that can lead to death. Your healthcare provider
   will monitor you for bleeding and do blood tests if needed. Call your
   healthcare provider right away if you have any of these symptoms or a serious
   bleeding problem during treatment with SUTENT, including:
   
    * painful, swollen stomach (abdomen)
    * vomiting blood
    * black, sticky stools
    * bloody urine
    * headache
    * change in your mental status
    * coughing up blood

 * Serious stomach and intestinal problems that can sometimes lead to death.
   Some people have had tears in their stomach or intestine (perforation) or
   have developed an abnormal opening between the stomach and intestine
   (fistula). Get medical help right away if you get stomach-area (abdominal)
   pain that does not go away or is severe during treatment with SUTENT.
 * Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer
   cells and may lead to death. TLS can cause kidney failure and the need for
   dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your
   healthcare provider may do blood tests to check you for TLS.
 * Abnormal changes in the brain (reversible posterior leukoencephalopathy
   syndrome [RPLS]). RPLS can cause a collection of symptoms including headache,
   confusion, and vision loss. Some people who have taken SUTENT have developed
   RPLS that can lead to death.
 * Thrombotic microangiopathy (TMA) including thrombotic thrombocytopenic
   purpura (TTP) and hemolytic uremic syndrome (HUS). TMA is a condition that
   involves injury to the smallest blood vessels and blood clots can happen
   while taking SUTENT. TMA is accompanied by a decrease in red cells and cells
   that are involved with clotting. TMA may harm your body’s organs such as the
   brain and kidneys, and can sometimes lead to death.
 * Protein in your urine. Some people who have taken SUTENT have developed
   protein in their urine, and in some cases, kidney problems that can lead to
   death. Your healthcare provider will check you for this problem.

 * Serious skin and mouth reactions. Treatment with SUTENT has caused severe
   skin reactions that can lead to death, including:
   
   * severe rash with blisters or peeling of the skin.
   * painful sores or ulcers on the skin, lips, or inside the mouth.
   * tissue damage (necrotizing fasciitis).
   
   If you have any signs or symptoms of severe skin reactions, stop taking
   SUTENT and call your healthcare provider or get medical help right away.

 * Thyroid problems. Your healthcare provider may do tests to check your thyroid
   function during SUTENT treatment. Tell your healthcare provider if you have
   any of the following signs and symptoms during your treatment with SUTENT:
   
   * tiredness that gets worse and does not go away
   * loss of appetite
   * problems with heat
   * feeling nervous or agitated, tremors
   * sweating
   * nausea or vomiting
   * diarrhea
   * fast heart rate
   * weight gain or weight loss
   * feeling depressed
   * irregular menstrual periods or no menstrual periods
   * headache
   * hair loss

 * Low blood sugar (hypoglycemia). Low blood sugar can happen with SUTENT, and
   may cause you to become unconscious, or you may need to be hospitalized. Low
   blood sugar with SUTENT may be worse in people who have diabetes and take
   antidiabetic medicines. Your healthcare provider should check your blood
   sugar levels regularly during treatment with SUTENT and may need to adjust
   the dose of your antidiabetic medicines. Call your healthcare provider right
   away if you have any of the following signs or symptoms of low blood sugar
   during your treatment with SUTENT:
   
   * headache
   * drowsiness
   * weakness
   * dizziness
   * confusion
   * irritability
   * hunger
   * fast heartbeat
   * sweating
   * feeling jittery
 * Jawbone problems (osteonecrosis). Severe jawbone problems have happened in
   some people who take SUTENT. Certain risk factors such as taking a
   bisphosphonate medicine or having dental disease may increase your risk of
   getting osteonecrosis. Your healthcare provider may tell you to see your
   dentist before you start taking SUTENT. Your healthcare provider may tell you
   to avoid dental procedures, if possible, during your treatment with SUTENT,
   especially if you are receiving a bisphosphonate medicine into a vein
   (intravenous). Tell your healthcare provider if you plan to have any dental
   procedures before or during treatment with SUTENT.
   * You should stop taking SUTENT at least 3 weeks before planned dental
     procedures.
   * Your healthcare provider should tell you when you may start taking SUTENT
     again after dental procedures.
 * Wound healing problems. Wound healing problems have happened in some people
   who take SUTENT. Tell your healthcare provider if you plan to have any
   surgery before or during treatment with SUTENT.
   * You should stop taking SUTENT at least 3 weeks before planned surgery.
   * Your healthcare provider should tell you when you may start taking SUTENT
     again after surgery.
 * Fetal harm. SUTENT can harm your unborn baby. Tell your healthcare provider
   if you are pregnant or plan to become pregnant. You and your partner should
   use effective birth control (contraception) during and after treatment with
   SUTENT.
   * Females should continue to use birth control for at least 4 weeks after
     their last dose of SUTENT.
   * Males should continue to use birth control for at least 7 weeks after their
     last dose of SUTENT.

   Your healthcare provider may temporarily stop, reduce your dose, or
   permanently stop treatment with SUTENT if you develop serious side effects.
   
   Before taking SUTENT tell your healthcare provider about all of your medical
   conditions, including if you:
   
    * have any heart problems
    * have high blood pressure
    * have thyroid problems
    * have a history of low blood sugar or diabetes
    * have kidney function problems (other than cancer)
    * have liver problems
    * have any bleeding problem
    * plan to have surgery or have had recent surgery. You should stop taking
      SUTENT at least 3 weeks before planned surgery.
    * have seizures
    * have or have had pain in the mouth, teeth, or jaw, swelling or sores
      inside the mouth, numbness or a feeling of heaviness in the jaw, or
      loosening of a tooth
    * are breastfeeding or plan to breastfeed. Do not breastfeed during
      treatment with SUTENT and for at least 4 weeks (1 month) after the last
      dose.
    * are pregnant or plan to become pregnant. SUTENT can harm your unborn baby.
      
      Females who are able to become pregnant:
      
       * Your healthcare provider should do a pregnancy test before you start
         treatment with SUTENT.
       * You should use effective birth control (contraception) during treatment
         and for at least 4 weeks after your last dose of SUTENT.
       * Tell your healthcare provider right away if you become pregnant or
         think you are pregnant during treatment with SUTENT.
      
      Males with female partners who are able to become pregnant should use
      effective birth control (contraception) during treatment and for 7 weeks
      after your last dose of SUTENT.
      
      SUTENT may cause fertility problems in males and females. Tell your
      healthcare provider if this is a concern for you.

   Tell all of your healthcare providers and dentists that you are taking
   SUTENT. They should talk to the healthcare provider who prescribed SUTENT for
   you, before you have any surgery, or medical or dental procedure.
   
   Tell your healthcare provider about all the medicines you take, including
   prescription medicines and over-the-counter medicines, vitamins, and herbal
   supplements. Using SUTENT with certain other medicines can cause serious side
   effects.
   
   You may have an increased risk of severe jawbone problems (osteonecrosis) if
   you take SUTENT and a bisphosphonate medicine. Especially tell your
   healthcare provider if you are taking or have taken an osteoporosis medicine.
   
   Know the medicines you take. Keep a list of them to show your healthcare
   provider and pharmacist when you get a new medicine.
   
   Do not drink grapefruit juice or eat grapefruit. They may cause you to have
   too much SUTENT in your body.
   
   Do not take St. John’s Wort. It may cause you to have too little SUTENT in
   your body.

   Common side effects of SUTENT include:

    * tiredness
    * weakness
    * diarrhea
    * pain, swelling, or sores inside of your mouth
    * nausea
    * loss of appetite
    * indigestion
    * vomiting
    * stomach-area (abdominal) pain
    * blisters or rash on the palms of your hands and soles of your feet
    * high blood pressure
    * taste changes
    * low platelet counts

The medicine in SUTENT is yellow, and it may make your skin look yellow. Your
skin and hair may get lighter in color. SUTENT may also cause other skin
problems including: dryness, thickness, or cracking of the skin.

These are not all of the possible side effects of SUTENT.

Call your doctor for medical advice about side effects. You are encouraged to
report adverse events related to Pfizer products by calling 1-800-438-1985. If
you prefer, you may contact the US Food and Drug Administration (FDA)
directly. Visit www.fda.gov/MedWatch(link is external) or call 1-800-FDA-1088.

Visit www.fda.gov/MedWatch(link is external) or call 1-800-FDA-1088.


INDICATIONS

SUTENT is a prescription medicine used to treat:

 * a rare cancer of the stomach, bowel, or esophagus called gastrointestinal
   stromal tumor (GIST) and when:
   * you have taken the medicine imatinib mesylate (Gleevec®) and it did not
     stop the cancer from growing or
   * you cannot take imatinib mesylate (Gleevec®).
 * advanced kidney cancer (advanced renal cell carcinoma or RCC).
 * adults with kidney cancer that has not spread (localized) and who are at high
   risk of RCC coming back again after having kidney surgery.
 * a type of pancreatic cancer called pancreatic neuroendocrine tumors (pNET)
   that has progressed and cannot be treated with surgery.

It is not known if SUTENT is safe and effective in children.

Gleevec® is a registered trademark of Novartis Pharmaceuticals Corporation.

Please see patient Medication Guide and full Prescribing Information, including
BOXED WARNING regarding serious liver problems.



Important Safety Information and Indications


INDICATIONS AND IMPORTANT SAFETY INFORMATION


INDICATIONS

SUTENT is a prescription medicine used to treat:

 * a rare cancer of the stomach, bowel, or esophagus called gastrointestinal
   stromal tumor (GIST) and when:
   * you have taken the medicine imatinib mesylate (Gleevec®) and it did not
     stop the cancer from growing or
   * you cannot take imatinib mesylate (Gleevec®).
 * advanced kidney cancer (advanced renal cell carcinoma or RCC).
 * adults with kidney cancer that has not spread (localized) and who are at high
   risk of RCC coming back again after having kidney surgery.
 * a type of pancreatic cancer called pancreatic neuroendocrine tumors (pNET)
   that has progressed and cannot be treated with surgery.

It is not known if SUTENT is safe and effective in children.

SUTENT can cause severe liver problems that can lead to death. Tell your
healthcare provider right away if you develop any of the following signs and
symptoms of liver problems during treatment with SUTENT:

SUTENT can cause severe liver problems that can lead to death. Tell your
healthcare provider right away if you develop any of the following signs and
symptoms of liver problems during treatment with SUTENT:

 * itching
 * yellow eyes or skin
 * dark urine
 * pain or discomfort in the right upper stomach area

Your healthcare provider should do blood tests to check your liver function
before you start taking and during treatment with SUTENT. Your healthcare
provider may temporarily stop, reduce your dose, or permanently stop treatment
with SUTENT if you develop liver problems.

SUTENT may cause serious side effects, including:

 * Heart problems. Heart problems may include heart failure, heart attack and
   heart muscle problems (cardiomyopathy) that can lead to death. Tell your
   healthcare provider if you feel very tired, are short of breath, or have
   swollen feet and ankles.

 * Abnormal heart rhythm changes. Changes in the electrical activity of your
   heart called QT prolongation can cause irregular heartbeats that can be life
   threatening. Your healthcare provider may do electrocardiograms and blood
   tests (electrolytes) to watch for these problems during your treatment with
   SUTENT. Tell your healthcare provider right away if:
   
    * you feel faint or lightheaded, or you pass out
    * you feel dizzy
    * you feel your heart beat is irregular or fast

 * High blood pressure. High blood pressure is common with SUTENT and may
   sometimes be severe. Follow your healthcare provider’s instructions about
   having your blood pressure checked regularly. Call your healthcare provider
   if your blood pressure is high or if you have any of the following signs or
   symptoms of high blood pressure:
   
    * severe headache
    * lightheadedness
    * dizziness
    * change in vision
   
   Your healthcare provider may prescribe medicine for you to treat high blood
   pressure, if needed.

 * Bleeding problems. Bleeding is common with SUTENT, but SUTENT can also cause
   severe bleeding problems that can lead to death. Your healthcare provider
   will monitor you for bleeding and do blood tests if needed. Call your
   healthcare provider right away if you have any of these symptoms or a serious
   bleeding problem during treatment with SUTENT, including:
   
    * painful, swollen stomach (abdomen)
    * vomiting blood
    * black, sticky stools
    * bloody urine
    * headache
    * change in your mental status
    * coughing up blood

 * Serious stomach and intestinal problems that can sometimes lead to death.
   Some people have had tears in their stomach or intestine (perforation) or
   have developed an abnormal opening between the stomach and intestine
   (fistula). Get medical help right away if you get stomach-area (abdominal)
   pain that does not go away or is severe during treatment with SUTENT.
 * Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer
   cells and may lead to death. TLS can cause kidney failure and the need for
   dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your
   healthcare provider may do blood tests to check you for TLS.
 * Abnormal changes in the brain (reversible posterior leukoencephalopathy
   syndrome [RPLS]). RPLS can cause a collection of symptoms including headache,
   confusion, and vision loss. Some people who have taken SUTENT have developed
   RPLS that can lead to death.
 * Thrombotic microangiopathy (TMA) including thrombotic thrombocytopenic
   purpura (TTP) and hemolytic uremic syndrome (HUS). TMA is a condition that
   involves injury to the smallest blood vessels and blood clots can happen
   while taking SUTENT. TMA is accompanied by a decrease in red cells and cells
   that are involved with clotting. TMA may harm your body’s organs such as the
   brain and kidneys, and can sometimes lead to death.
 * Protein in your urine. Some people who have taken SUTENT have developed
   protein in their urine, and in some cases, kidney problems that can lead to
   death. Your healthcare provider will check you for this problem.

 * Serious skin and mouth reactions. Treatment with SUTENT has caused severe
   skin reactions that can lead to death, including:
   
   * severe rash with blisters or peeling of the skin.
   * painful sores or ulcers on the skin, lips, or inside the mouth.
   * tissue damage (necrotizing fasciitis).
   
   If you have any signs or symptoms of severe skin reactions, stop taking
   SUTENT and call your healthcare provider or get medical help right away.

 * Thyroid problems. Your healthcare provider may do tests to check your thyroid
   function during SUTENT treatment. Tell your healthcare provider if you have
   any of the following signs and symptoms during your treatment with SUTENT:
   
   * tiredness that gets worse and does not go away
   * loss of appetite
   * problems with heat
   * feeling nervous or agitated, tremors
   * sweating
   * nausea or vomiting
   * diarrhea
   * fast heart rate
   * weight gain or weight loss
   * feeling depressed
   * irregular menstrual periods or no menstrual periods
   * headache
   * hair loss

 * Low blood sugar (hypoglycemia). Low blood sugar can happen with SUTENT, and
   may cause you to become unconscious, or you may need to be hospitalized. Low
   blood sugar with SUTENT may be worse in people who have diabetes and take
   antidiabetic medicines. Your healthcare provider should check your blood
   sugar levels regularly during treatment with SUTENT and may need to adjust
   the dose of your antidiabetic medicines. Call your healthcare provider right
   away if you have any of the following signs or symptoms of low blood sugar
   during your treatment with SUTENT:
   
   * headache
   * drowsiness
   * weakness
   * dizziness
   * confusion
   * irritability
   * hunger
   * fast heartbeat
   * sweating
   * feeling jittery
 * Jawbone problems (osteonecrosis). Severe jawbone problems have happened in
   some people who take SUTENT. Certain risk factors such as taking a
   bisphosphonate medicine or having dental disease may increase your risk of
   getting osteonecrosis. Your healthcare provider may tell you to see your
   dentist before you start taking SUTENT. Your healthcare provider may tell you
   to avoid dental procedures, if possible, during your treatment with SUTENT,
   especially if you are receiving a bisphosphonate medicine into a vein
   (intravenous). Tell your healthcare provider if you plan to have any dental
   procedures before or during treatment with SUTENT.
   * You should stop taking SUTENT at least 3 weeks before planned dental
     procedures.
   * Your healthcare provider should tell you when you may start taking SUTENT
     again after dental procedures.
 * Wound healing problems. Wound healing problems have happened in some people
   who take SUTENT. Tell your healthcare provider if you plan to have any
   surgery before or during treatment with SUTENT.
   * You should stop taking SUTENT at least 3 weeks before planned surgery.
   * Your healthcare provider should tell you when you may start taking SUTENT
     again after surgery.
 * Fetal harm. SUTENT can harm your unborn baby. Tell your healthcare provider
   if you are pregnant or plan to become pregnant. You and your partner should
   use effective birth control (contraception) during and after treatment with
   SUTENT.
   * Females should continue to use birth control for at least 4 weeks after
     their last dose of SUTENT.
   * Males should continue to use birth control for at least 7 weeks after their
     last dose of SUTENT.

   Your healthcare provider may temporarily stop, reduce your dose, or
   permanently stop treatment with SUTENT if you develop serious side effects.
   
   Before taking SUTENT tell your healthcare provider about all of your medical
   conditions, including if you:
   
    * have any heart problems
    * have high blood pressure
    * have thyroid problems
    * have a history of low blood sugar or diabetes
    * have kidney function problems (other than cancer)
    * have liver problems
    * have any bleeding problem
    * plan to have surgery or have had recent surgery. You should stop taking
      SUTENT at least 3 weeks before planned surgery.
    * have seizures
    * have or have had pain in the mouth, teeth, or jaw, swelling or sores
      inside the mouth, numbness or a feeling of heaviness in the jaw, or
      loosening of a tooth
    * are breastfeeding or plan to breastfeed. Do not breastfeed during
      treatment with SUTENT and for at least 4 weeks (1 month) after the last
      dose.
    * are pregnant or plan to become pregnant. SUTENT can harm your unborn baby.
      
      Females who are able to become pregnant:
      
       * Your healthcare provider should do a pregnancy test before you start
         treatment with SUTENT.
       * You should use effective birth control (contraception) during treatment
         and for at least 4 weeks after your last dose of SUTENT.
       * Tell your healthcare provider right away if you become pregnant or
         think you are pregnant during treatment with SUTENT.
      
      Males with female partners who are able to become pregnant should use
      effective birth control (contraception) during treatment and for 7 weeks
      after your last dose of SUTENT.
      
      SUTENT may cause fertility problems in males and females. Tell your
      healthcare provider if this is a concern for you.

   Tell all of your healthcare providers and dentists that you are taking
   SUTENT. They should talk to the healthcare provider who prescribed SUTENT for
   you, before you have any surgery, or medical or dental procedure.
   
   Tell your healthcare provider about all the medicines you take, including
   prescription medicines and over-the-counter medicines, vitamins, and herbal
   supplements. Using SUTENT with certain other medicines can cause serious side
   effects.
   
   You may have an increased risk of severe jawbone problems (osteonecrosis) if
   you take SUTENT and a bisphosphonate medicine. Especially tell your
   healthcare provider if you are taking or have taken an osteoporosis medicine.
   
   Know the medicines you take. Keep a list of them to show your healthcare
   provider and pharmacist when you get a new medicine.
   
   Do not drink grapefruit juice or eat grapefruit. They may cause you to have
   too much SUTENT in your body.
   
   Do not take St. John’s Wort. It may cause you to have too little SUTENT in
   your body.

   Common side effects of SUTENT include:

    * tiredness
    * weakness
    * diarrhea
    * pain, swelling, or sores inside of your mouth
    * nausea
    * loss of appetite
    * indigestion
    * vomiting
    * stomach-area (abdominal) pain
    * blisters or rash on the palms of your hands and soles of your feet
    * high blood pressure
    * taste changes
    * low platelet counts

The medicine in SUTENT is yellow, and it may make your skin look yellow. Your
skin and hair may get lighter in color. SUTENT may also cause other skin
problems including: dryness, thickness, or cracking of the skin.

These are not all of the possible side effects of SUTENT.

Call your doctor for medical advice about side effects. You are encouraged to
report adverse events related to Pfizer products by calling 1-800-438-1985. If
you prefer, you may contact the US Food and Drug Administration (FDA)
directly. Visit www.fda.gov/MedWatch(link is external) or call 1-800-FDA-1088.

Visit www.fda.gov/MedWatch(link is external) or call 1-800-FDA-1088.


INDICATIONS

SUTENT is a prescription medicine used to treat:

 * a rare cancer of the stomach, bowel, or esophagus called gastrointestinal
   stromal tumor (GIST) and when:
   * you have taken the medicine imatinib mesylate (Gleevec®) and it did not
     stop the cancer from growing or
   * you cannot take imatinib mesylate (Gleevec®).
 * advanced kidney cancer (advanced renal cell carcinoma or RCC).
 * adults with kidney cancer that has not spread (localized) and who are at high
   risk of RCC coming back again after having kidney surgery.
 * a type of pancreatic cancer called pancreatic neuroendocrine tumors (pNET)
   that has progressed and cannot be treated with surgery.

It is not known if SUTENT is safe and effective in children.

Gleevec® is a registered trademark of Novartis Pharmaceuticals Corporation.

Please see patient Medication Guide and full Prescribing Information, including
BOXED WARNING regarding serious liver problems.

Pfizer Oncology Together provides personalized support and financial assistance
resources to help patients access their prescribed Pfizer Oncology medications.

CALL 1-877-744-5675(Monday–Friday 8 AM–8 PM ET)VISIT
PfizerOncologyTogether.com

Need help paying for your Pfizer medicines?

Pfizer RxPathways ® is here to help.

One program—a range of prescription assistance services.

Learn more at: PfizerRxPath.com.




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