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 * Software
   * Back
   * GastroPlus®
   * MonolixSuite™
   * ADMET Predictor®
   * DILIsym®
   * DDDPlus™
   * NAFLDsym®
   * MembranePlus™
   * PKanalix®
   * Simulx®
   * IPFsym®
   * ILDsym®
   * RENAsym®
   * MedChem Designer™
   * Custom QSP Software
 * Services
   * Back
   * Overview
   * Pharmaceutical
     * Back
     * PBPK Modeling and Simulation
     * Pharmacometric Data Assembly
     * Training and Workshops
     * Learning Services
     * Resident Clinical Pharmacology Services
     * Noncompartmental PK/TK Analysis
     * Early Drug Discovery
     * Model-Driven Development Strategies
     * PopPK & Exposure Response Modeling
     * PK/PD Support
     * Liver Safety Modeling and Analysis
     * QSP Modeling of NAFLD & NASH
     * Custom QSP Services
   * Chemical, Cosmetics, and Food Industries
     * Back
     * Early Drug Discovery
     * PBTK Modeling and Simulation
   * Global Regulatory Strategies
   * Concierge Program
   * Consult + Coach
 * Careers
   * Back
   * Career Center
   * Job Openings
 * Resource Center
 * Events
   * Back
   * Upcoming Events
   * Live Workshops
   * On Demand Workshops
   * Scientific Meetings
   * Webinars
   * Past Events
 * Investors
   * Back
   * Conference Calls & Presentations
   * Environmental, Social and Governance (ESG)
   * Corporate Profile
   * Board of Directors
   * SEC Filings
   * Press Releases
   * Shareholder Information
 * About
   * Back
   * Contact
   * Our Team
   * Simulations Plus
     * Back
     * Simulations Plus Team
     * Simulations Plus Scientific Advisory Board
   * DILIsym® Services
     * Back
     * QSP Team
     * DILI-sim Initiative
       * Back
       * DILIsym Scientific Advisory Board
       * DILIsym Development
     * RENAsym Consortium
       * Back
       * RENAsym Scientific Advisory Board
   * Cognigen® Services
     * Back
     * Cognigen Team
   * Lixoft®
     * Back
     * Lixoft Team
   * SLP University+ Program
     * Back
     * Learning Services
     * Internship+
   * Leadership
   * Partners and Collaborators
   * Privacy Notice
 * Portal Login
 * Search




SIMULATIONS PLUS

We Improve Health Through Innovative Solutions

 * Software
   * GastroPlus®
     * GastroPlus®
       PBBM/PBPK
       View Product
       
       
       PBBM / PBPK modeling & simulation software package which simulates all
       major dosing routes and drug-drug interactions (DDIs) in virtual human &
       animal population groups.
       
       Request Software Evaluation
     
     * MODULES
       
        * Drug Drug Interaction
        * PBPKPlus™
        * ADMET Predictor®
        * Additional Dosage Routes
        * Metabolism & Transporter
        * Biologics
        * Optimization
        * PDPlus™
        * PKPlus™
        * IVIVCPlus™
     
     * MORE INFO
       
        * Peer-reviewed publications citing applications of GastroPlus
        * Software Introduction
        * GastroPlus Tutorials
        * Plug n’ Play PBBM Package
        * Pulmonary Package
     
     * SHORTCUTS
       
        * Workshops
        * Simulations Plus Releases GastroPlus® Version 9.8.3
        * Download Latest GastroPlus Version
        * GastroPlus 9.8.3 Flyer
        * GastroPlus® Additional Dosage Routes Brochure
   * MonolixSuite™
     * MonolixSuite™
       PK/PD
       View Product
       
       
       Easy, fast, and powerful tool for parameter estimation in non-linear
       mixed effect models, model diagnosis and assessment, and advanced
       graphical representation.
       
       Request Software Evaluation
     
     * SUITE
       
        * Monolix®
        * PKanalix®
        * Simulx®
     
     * MORE INFO
       
        * Monolix Documentation
        * PKanalix Documentation
        * Simulx Documentation
        * Mlxtran Documentation and Language Reference
        * Data Set Documentation
     
     * SHORTCUTS
       
        * MonolixSuite™ 2023 Flyer
        * Watch MonolixSuite™ R2023 Webinar
   * ADMET Predictor®
     * ADMET Predictor®
       AIDD/ML
       View Product
       
       
       Flagship machine learning platform for ADMET modeling with extended
       capabilities for data analysis, metabolism prediction, high-throughput
       pharmacokinetic simulation (HTPK), and AI-driven drug design.
       
       Request Software Evaluation
     
     * MODULES
       
        * Overview
        * AI-Driven Drug Design (AIDD)
        * Metabolism
        * Transporters
        * Toxicity
        * Physicochemical & Biopharmaceutical
        * ADMET Modeler™
        * High-throughput Pharmacokinetic (HTPK) Simulation
        * MedChem Studio™
     
     * MORE INFO
       
        * ADMET Predictor® REST API
        * Download the AP11 Flyer
        * Peer-reviewed publications citing applications of ADMET Predictor
        * ADMET Predictor Tutorials
        * AI-Driven Drug Design (AIDD) Flyer
        * Early Drug Discovery (EDD) Flyer
     
     * SHORTCUTS
       
        * ADMET Predictor® 11 Release Webinar
        * Download ADMET Predictor 11
        * ADMET Predictor® Tutorial
   * DILIsym®
     * DILIsym®
       QST
       View Product
       
       
       Quantitative Systems Toxicology (QST) software designed to be used during
       drug development to provide deeper insight into the mechanisms
       responsible for observed drug-induced liver injury (DILI) responses.
       
       Request Software Evaluation
     
     * SUBMODELS
       
        * Overview
        * SimPops®
        * PBPK Modeling
        * Mitochondrial Function
        * Bile Acid Modeling
        * Reactive Nitrogen/Oxygen Species
        * Innate Immunity modeling
        * Hepatocyte Life Cycle
        * Clinical Readouts
     
     * MORE INFO
       
        * Applications and Regulatory Impact
        * DILIsym Inputs from Cyprotex
        * DILIsym Inputs from SOLVO
        * Corporate Licenses
        * Academic Licenses
        * FAQs
     
     * SHORTCUT
       
        * DILIsym® Product Brochure
        * Membership Login
   * DDDPlus™
     * DDDPlus™
       PBBM/PBPK
       View Product
       
       
       A mechanistic simulation engine for the in vitro dissolution experiment
       that predicts in vitro disintegration and dissolution of pharmaceutical
       dosage forms.
       
       Request Software Evaluation
     
     * MODULES
       
        * Overview
        * ADMET Predictor®
     
     * SHORTCUTS
       
        * Simulations Plus Releases DDDPlus™ Version 6
        * DDDPlus™ 6 Webinar
   * NAFLDsym®
     * NAFLDsym®
       QSP
       View Product
       
       
       Quantitative Systems Pharmacology (QSP) software for mechanistic
       mathematical modeling of nonalcoholic fatty liver disease (NAFLD.)
       
       Request Software Evaluation
     
     * MORE INFO
       
        * Overview
     
     * SHORTCUTS
       
        * NAFLDsym® Product Brochure
        * QSP/QST Capabilities Flyer
        * NAFLDsym® 2B Press Release
        * Workshops
        * NAFLDsym® Video: Prediction of Clinical Response to ACC Inhibition
        * NAFLDsym® Video: Prediction of Clinical Response to Hepatic AMPK
          Activation
        * NAFLDsym v2A Release Webinar
   * MembranePlus™
     * MembranePlus™
       PBBM/PBPK
       View Product
       
       
       A detailed modeling & simulation program for in vitro metabolism &
       transport studies.
       
       Request Software Evaluation
     
     * MODULES
       
        * Overview
        * Optimization
        * ADMET Predictor®
     
     * SHORTCUTS
       
        * Simulations Plus Releases MembranePlus™ 3.0
        * MembranePlus v3 Product Brochure
        * MembranePlus™ Version 3.0 Release Notes
   * PKanalix®
     * PKanalix®
       PK/PD
       View Product
       
       
       Graphical and interactive software for non-compartmental and
       compartmental analysis.
       
       Request Software Evaluation
     
     * MORE INFO
       
        * Overview
     
     * SHORTCUTS
       
        * Watch MonolixSuite™ R2023 Webinar
        * Documentation website
   * Simulx®
     * Simulx®
       PK/PD
       View Product
       
       
       A powerful and flexible simulator for clinical trial pharmacometrics.
       
       Request Software Evaluation
     
     * MORE INFO
       
        * Overview
     
     * SHORTCUTS
       
        * Watch MonolixSuite™ R2023 Webinar
        * Documentation website
   * IPFsym®
     * IPFsym®
       QSP
       View Product
       
       
       Quantitative Systems Pharmacology (QSP) software providing the ability to
       predict the efficacy of drugs being developed to treat idiopathic
       pulmonary fibrosis (IPF.)
       
       Request Software Evaluation
     
     * MORE INFO
       
        * Overview
        * Pulmonary Package
     
     * SHORTCUTS
       
        * Cust QSP/QST Services Flyer
        * IPFsym® version 1A Press Release
        * Workshops
        * IPFsym® Product Brochure
   * ILDsym®
     * ILDsym®
       QSP
       View Product
       
       
       Quantitative Systems Pharmacology (QSP) software for mechanistic
       mathematical modeling of interstitial lung disease (ILD) associated with
       system sclerosis (SSc.)
       
       Request More Information
     
     * MORE INFO
       
        * Overview
        * Pulmonary Package
     
     * SHORTCUTS
       
        * Custom QSP/QST Services Flyer
        * View QSP/QST Workshops
        * MIDD 2022 Replays
   * RENAsym®
     * RENAsym®
       QST
       View Product
       
       
       Quantitative Systems Toxicology (QST) software for predicting and
       understanding drug-induced kidney injury.
       
       Request Software Evaluation
     
     * MORE INFO
       
        * Overview
     
     * SHORTCUT
       
        * RENAsym® Version 1A Press Release
        * RENAsym, a QST Model to Predict Drug-Induced Kidney Injury
        * QSP/QST Capabilities Flyer
   * MedChem Designer™
     * MedChem Designer™
       ADMET/ML
       View Product
       
       
       FREE chemical sketching software tool which combines innovative molecule
       drawing features.
       
       Download MedChem Designer
     
     * MORE INFO
       
        * Overview
        * Download for Free
        * Free 30-Day Evaluation of ADMET Predictor®
     
     * SHORTCUTS
       
        * MedChem Designer Product Brochure
        * MedChem Designer 3.0 Press Release
        * ADMET Predictor Tutorial 2: MedChem Designer
   * Custom QSP Software
     * Custom QSP tools for your application
       View Product
       
       
       Custom QSP software for predicting efficacy & guiding design.
       
       Contact Us
     
     * MORE INFO
       
        * Overview
     
     * SHORTCUTS
       
        * Custom QSP/QST Service Flyer
        * RENAsym®
        * Custom QSP: IPFsym®
        * Custom QSP: NAFLDsym®
 * Services
   * Overview
   * Pharmaceutical
     * PBPK Modeling and Simulation
     * Pharmacometric Data Assembly
     * Training and Workshops
     * Learning Services
     * Resident Clinical Pharmacology Services
     * Noncompartmental PK/TK Analysis
     * Early Drug Discovery
     * Model-Driven Development Strategies
     * PopPK & Exposure Response Modeling
     * PK/PD Support
     * Liver Safety Modeling and Analysis
     * QSP Modeling of NAFLD & NASH
     * Custom QSP Services
   * Chemical, Cosmetics, and Food Industries
     * Early Drug Discovery
     * PBTK Modeling and Simulation
   * Global Regulatory Strategies
   * Concierge Program
   * Consult + Coach
 * Careers
   * Career Center
   * Job Openings
 * Resource Center
   *  * 2023 MIDD+ Replays
      * Blog
      * Contact Support
      * Datasheets
      * Flyers
      * Journal Articles
      * Video: Installing GastroPlus Software
      * Posters
   
   *  * Presentations
      * Press Releases
      * Product Brochures
      * Software Installation
      * The Simulations Plus Customer Portal
      * Videos
      * Webinars
      * White Papers
   
   * FEATURED WEBINAR REPLAY
 * Events
   * Upcoming Events
   * Live Workshops
   * On Demand Workshops
   * Scientific Meetings
   * Webinars
   * Past Events
 * Investors
   * Conference Calls & Presentations
   * Environmental, Social and Governance (ESG)
   * Corporate Profile
   * Board of Directors
   * SEC Filings
   * Press Releases
   * Shareholder Information
 * About
   * Contact
   * Our Team
   * Simulations Plus
     * Simulations Plus Team
     * Simulations Plus Scientific Advisory Board
   * DILIsym® Services
     * QSP Team
     * DILI-sim Initiative
       * DILIsym Scientific Advisory Board
       * DILIsym Development
     * RENAsym Consortium
       * RENAsym Scientific Advisory Board
   * Cognigen® Services
     * Cognigen Team
   * Lixoft®
     * Lixoft Team
   * SLP University+ Program
     * Learning Services
     * Internship+
   * Leadership
   * Partners and Collaborators
   * Privacy Notice
 * 
 * 

We Improve Health Through Innovative Solutions

We have the talent and 25+ years of experience translating science into
user-friendly software and providing expert consulting to support drug
discovery, clinical development research, and regulatory submissions.

 * View Our Software
 * View Our Solutions


0.1 About us
Worldwide
Model-Informed
Drug Development


Our reputation as thought leaders in the areas of ADMET property prediction,
physiologically-based pharmacokinetics (PBPK) modeling, pharmacometrics, and
quantitative systems pharmacology/toxicology is earned through the success our
clients have found through their relationship with us. We have the talent and
25+ years of experience translating science into user-friendly software and
providing expert consulting to support drug discovery, clinical development
research, and regulatory submissions.

25+ YEARS
Celebrating 25+ years in business and continuing the commitment to improve
public health through innovative solutions!
120+ Clients
Trusting our expert consulting supporting drug discovery, clinical development
research, and regulatory submissions.
18+ Solutions
We provide validated machine learning, QSP, QST, HTPK, PBPK, and PBBM modeling
and simulation software for novice and expert users alike.
02. Our Software
Innovative science-based software
view all software
Previous
GastroPlus®
PBBM/PBPK
ADMET Predictor®
AIDD/ML
DILIsym®
QST
MonolixSuite™
PK/PD
NAFLDsym®
QSP
DDDPlus™
PBBM/PBPK
MembranePlus™
PBBM/PBPK
ILDsym®
QSP
IPFsym®
QSP
RENAsym®
QST
MedChem Designer™
ADMET/ML
Next

GastroPlus is a mechanistically based simulation software package that simulates
intravenous, oral, oral cavity, ocular, inhalation, dermal, subcutaneous, and
intramuscular absorption, biopharmaceutics, pharmacokinetics, and
pharmacodynamics in humans and animals.

 * Learn more
 * get a demo

 * Drug Drug Interaction™
 * PBPKPlus™
 * ADMET Predictor®
 * Additional Dosage Routes
 * Metabolism & Transporter
 * Biologics
 * Optimization
 * PDPlus™
 * PKPlus™
 * IVIVCPlus™

ADMET Predictor is the flagship machine learning platform for ADMET modeling
with extended capabilities for data analysis, metabolism prediction, and
AI-driven drug design.

 * Learn more
 * get a demo

 * AI-Driven Drug Design (AIDD)
 * ADMET Modeler™
 * High-throughput pharmacokinetic (HTPK) Simulation
 * MedChem Studio™
 * Metabolism
 * Physicochemical and Biopharmaceutical (PCB)
 * Toxicity
 * Transporters

DILIsym is Quantitative Systems Toxicology (QST) software designed to be used
during drug development to provide an indication of the potential drug-induced
liver injury (DILI) hazard posed by individual molecules and/or to provide
deeper insight into the mechanisms responsible for observed DILI responses at
various stages of the development process.

 * Learn more
 * get a demo

 * PBPK
 * Mitochondrial Function
 * Bile Acids
 * Reactive Nitrogen/Oxygen Species
 * Innate Immunity
 * Hepatocyte Life Cycle
 * Clinical Readouts
 * SimPops®

Built for model-informed drug development computing, MonolixSuite is a fast,
easy-to-use, and powerful suite of applications for pharmacometrics analysis,
modeling, and simulation.

 * learn more
 * get a demo

 * Monolix®
 * PKanalix®
 * Simulx®

NAFLDsym modeling software is a mechanistic, mathematical model of nonalcoholic
fatty liver disease (NAFLD), which can be used to predict efficacy for treatment
modalities developed for NAFLD and nonalcoholic steatohepatitis (NASH).

 * learn more
 * get a demo



DDDPlus is the industry’s leading mechanistic in vitro dissolution software for
formulation and analytical scientists.

 * learn more
 * get a demo

 * ADMET Predictor®

MembranePlus is the industry’s leading mechanistic in vitro permeability &
hepatocyte modeling software for IVIVE of absorption and systemic
clearance/distribution processes.

 * learn more
 * get a demo

 * Optimization
 * ADMET Predictor®

The ILDsym QSP modeling software is a mechanistic, mathematical model of
interstitial lung disease (ILD) associated with systemic sclerosis (SSc). ILDsym
can be used to predict efficacy for treatment modalities developed for SSc-ILD
(and other interstitial lung diseases with custom modifications and additions).

 * learn more
 * get a demo



The IPFsym® QSP modeling software is a mechanistic, mathematical model of
idiopathic pulmonary fibrosis (IPF). IPFsym can be used to predict efficacy for
treatment modalities developed for IPF (and other lung diseases with custom
modifications and additions).

 * learn more
 * get a demo



RENAsym is quantitative systems toxicology (QST) software for predicting and
understand drug-induced kidney injury with the use of mechanistic, mathematical
modeling to predict whether new drug candidates will cause renal injury signals
in patients and to enhance the understanding of mechanisms that contribute to
renal safety signals already observed in the clinic.

 * learn more
 * get a demo



MedChem Designer is a tool that combines innovative molecule drawing features
with fast and accurate ADMET property predictions from our top-ranked ADMET
Predictor.

 * learn more
 * get a demo


03. our solutions
Consulting Services

QSP/QST Consulting Services

Custom software for predicting efficacy and guiding design (QSP).

PK/PD Consulting Services

Providing an expert review and second set of eyes to quality check your modeling
efforts.


04. Events
Upcoming Events
View all events
Previous
Sep
14

 * Live Workshops

PharmoGo: GastroPlus® Modeling and Simulation Workshop
 * Sept. 14th - 23rd, 2023
 * All Day
 * Hybrid: Online & Shanghai, China

Find out more
Sep
18

 * Live Workshops

GastroPlus® Advanced Workshop: DMPK and Clinical Pharmacology
 * Sept. 18th - 21st, 2023
 * 9:00 am – 2:00 pm PDT
 * Online

Find out more
Sep
18

 * Scientific Meetings

65th Congress of the Polish Chemical Society
 * Sept. 18th - 22nd, 2023
 * All Day
 * Toruń, Poland

Find out more
Sep
19

 * Webinars

QSP: The Best Kept Secret for Increasing the Technical Probability…
 * Sept. 19th, 2023
 * 8:00 - 9:00 am PDT
 * Online

Find out more
Sep
20

 * Webinars

The GastroPlus PBPK Modeling Webinar Series
 * Sept. 20th - Oct. 4th, 2023
 * 9:00-11:00 am KST
 * Online (Seoul, Korea)

Find out more
Sep
14

 * Live Workshops

PharmoGo: GastroPlus® Modeling and Simulation Workshop
 * Sept. 14th - 23rd, 2023
 * All Day
 * Hybrid: Online & Shanghai, China

Find out more
Sep
18

 * Live Workshops

GastroPlus® Advanced Workshop: DMPK and Clinical Pharmacology
 * Sept. 18th - 21st, 2023
 * 9:00 am – 2:00 pm PDT
 * Online

Find out more
Sep
18

 * Scientific Meetings

65th Congress of the Polish Chemical Society
 * Sept. 18th - 22nd, 2023
 * All Day
 * Toruń, Poland

Find out more
Sep
19

 * Webinars

QSP: The Best Kept Secret for Increasing the Technical Probability…
 * Sept. 19th, 2023
 * 8:00 - 9:00 am PDT
 * Online

Find out more
Sep
20

 * Webinars

The GastroPlus PBPK Modeling Webinar Series
 * Sept. 20th - Oct. 4th, 2023
 * 9:00-11:00 am KST
 * Online (Seoul, Korea)

Find out more
Sep
14

 * Live Workshops

PharmoGo: GastroPlus® Modeling and Simulation Workshop
 * Sept. 14th - 23rd, 2023
 * All Day
 * Hybrid: Online & Shanghai, China

Find out more
Sep
18

 * Live Workshops

GastroPlus® Advanced Workshop: DMPK and Clinical Pharmacology
 * Sept. 18th - 21st, 2023
 * 9:00 am – 2:00 pm PDT
 * Online

Find out more
Sep
18

 * Scientific Meetings

65th Congress of the Polish Chemical Society
 * Sept. 18th - 22nd, 2023
 * All Day
 * Toruń, Poland

Find out more
Sep
19

 * Webinars

QSP: The Best Kept Secret for Increasing the Technical Probability…
 * Sept. 19th, 2023
 * 8:00 - 9:00 am PDT
 * Online

Find out more
Sep
20

 * Webinars

The GastroPlus PBPK Modeling Webinar Series
 * Sept. 20th - Oct. 4th, 2023
 * 9:00-11:00 am KST
 * Online (Seoul, Korea)

Find out more
Next
05. Explore
Explore our Resources and Programs
View all resources
Journal Articles

Find out how your peers are applying our technology by reviewing various user
case studies.

Find out more
Events

Stay up-to-date with our upcoming conference attendance & presentations,
webinars & training workshops.

View Events
University+ Program

Offers one-year access to Simulations Plus software to students and educators at
accredited universities worldwide.

Find out more
We're Hiring

Explore a new career with our fast-growing team, check out some of our immediate
openings here!

See open positions
Ready to get started?

Sign-up for a free evaluation or schedule a meeting with one of our experts!

Questions? Email info@simulations-plus.com

Discuss my project needs with an expert
Schedule a software demo
Join our newsletter
Software
 * GastroPlus®
 * MonolixSuite™
 * ADMET Predictor®
 * DILIsym®
 * DDDPlus™
 * NAFLDsym®
 * MembranePlus™
 * PKanalix®
 * Simulx®
 * IPFsym®
 * ILDsym®
 * MITOsym®
 * MedChem Designer™
 * Custom QSP Software

Services
 * Early Drug Discovery
 * Global Regulatory Strategies
 * Liver Safety Modeling and Analysis
 * Noncompartmental PK/TK Analysis
 * PBPK Modeling and Simulation
 * PK/PD Support
 * PopPK & Exposure Response Modeling
 * QSP Modeling of NAFLD & NASH
 * Training and Workshops

Careers
 * Openings
 * Apply Online

Resource Center
 * Blog
 * Contact Support
 * Journal Articles
 * Posters
 * Product Brochures
 * Software Installation
 * Videos
 * Webinars

Investors
 * Board of Directors
 * Environmental, Social and Governance (ESG)
 * Latest Presentations
 * Press Releases
 * SEC Filings
 * Shareholder Information

About
 * Simulations Plus
 * Contact
 * Leadership
 * Partners and Collaborators
 * Privacy Notice
 * Cookie Notice
 * Vision, Mission & Values
 * FCOI Policy

 * 

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 * 

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