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Lei Sun （孙磊），PI

I started RNA strcuturome lab at Shandong University (Qingdao) in December of
2022. Our lab broadly interested in RNA biology, especially RNA structure
biology, RNA vaccine and adaptor design, and anti-RNA virus drug development
(such as SARS-CoV-2). Our lab will develop and use a combination of
computational and experimental methods to interpret the structural and
functional relationships of biological macromolecules, build the interaction
network, uncover the regulation mechanism and find the potential therapy for
diseases based on high-throughput sequencing, bioinformatics analysis,
artificial intelligence (AI) prediction, and experimental validation.



From 2019 to 2022， I was a Postdoc researcher at Tsinghua University,
cooperating with Prof. Qiangfeng Cliff Zhang. Before my Postdoc period, I
received my Ph.D. degree in the School of Life Science, Tsinghua University in
2019. Before I came to Tsinghua University, I received a bachelor's degree in
Taishan College, Shandong University in 2014.

Please feel free to directly contact me via e-mail for formal or informal
inquiries: sunlei0227 at sdu.edu.cn.

Research Interest




1. Technology development
Our lab is both interested in experimental and computational methods
development. We have taken part in the development of many technologies
including subcellular RNA structure determination (Sun et.al., NSMB, 2019 )and
RBP-RNA interaction prediction based on artificial intelligence (Sun et.al.,
Cell Research, 2021). We are also interested in single-cell RNA structure
determination, and co-transcriptional transient RNA structure determination in
the future.

2. Biological question
RNA structure and RBP-RNA interactions play key roles in post-transcriptional
regulation. The regulatory network of viruses can be studied from the
perspectives of RNA structure and RNA-protein interaction by icSHAPE, PrismNet,
CLIP, and other techniques. Antiviral drugs can be developed by targeting
important structural elements of viruses or interacting host proteins (Sun
et.al., Cell, 2021). It is important to note that the integration of
high-throughput sequencing, deep learning models, and experimental validation
provides a viable idea to systematically study the role of RNA-binding proteins.
For example, how do RBPs regulate gene expression during zebrafish development?

3. Technical applications
Based on previous work, we have identified a large number of conserved RNA
structural elements related to RNA translation, RNA degradation, etc. These RNA
structures can be exploited to design RNA molecules that better help the vaccine
and RNA targeting drug development. Moreover, the understanding of RNA structure
and the application of artificial intelligence can help us to design better gRNA
in the RNA therapy field.