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* Skip to Article Content * Skip to Article Information Search withinThis JournalAnywhere * Search term Advanced Search Citation Search * Search term Advanced Search Citation Search Login / Register * Individual login * Institutional login * REGISTER Obesity Volume 24, Issue 9 p. 1834-1841 Review Free Access THE EFFECT OF TOBACCO CESSATION ON WEIGHT GAIN, OBESITY, AND DIABETES RISK Terry Bush, Corresponding Author Terry Bush Alere Wellbeing, Inc., Seattle, Washington, USA Correspondence: Terry Bush (terry.bush@optum.com)Search for more papers by this author Jennifer C. Lovejoy, Jennifer C. Lovejoy Arivale, Inc, Seattle, Washington, USA. Search for more papers by this author Mona Deprey, Mona Deprey Alere Wellbeing, Inc., Seattle, Washington, USA Search for more papers by this author Kelly M. Carpenter, Kelly M. Carpenter Alere Wellbeing, Inc., Seattle, Washington, USA Search for more papers by this author Terry Bush, Corresponding Author Terry Bush Alere Wellbeing, Inc., Seattle, Washington, USA Correspondence: Terry Bush (terry.bush@optum.com)Search for more papers by this author Jennifer C. Lovejoy, Jennifer C. Lovejoy Arivale, Inc, Seattle, Washington, USA. Search for more papers by this author Mona Deprey, Mona Deprey Alere Wellbeing, Inc., Seattle, Washington, USA Search for more papers by this author Kelly M. Carpenter, Kelly M. Carpenter Alere Wellbeing, Inc., Seattle, Washington, USA Search for more papers by this author First published: 29 August 2016 https://doi.org/10.1002/oby.21582 Citations: 135 Funding agencies: Investigators' time was supported by Grant RO1DA031147 from the National Institute on Drug Abuse and Grant R21AT007845 from the National Center for Complementary and Integrative Health, as well as Alere Wellbeing and Arivale, Inc. Disclosure: The authors declared no conflict of interest. Author contribution: All authors contributed to conceptualizing the review paper, the literature reviews, and writing and editing the paper. About * REFERENCES * RELATED * INFORMATION * PDF Sections * Abstract * Introduction * Discussion * Recommendations and Directions for the Future * Acknowledgments * References * Citing Literature PDF Tools * Request permission * Export citation * Add to favorites * Track citation ShareShare Give access Share full text access Close modal Share full-text access Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use -------------------------------------------------------------------------------- Shareable Link Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Copy URL Share a link Share on * Email * Facebook * x * LinkedIn * Reddit * Wechat ABSTRACT OBJECTIVE Most smokers gain weight after quitting, and some develop new onset obesity and type 2 diabetes. The purpose of this paper is to synthesize the current science investigating the consequences of tobacco cessation on body weight and diabetes, as well as intervention strategies that minimize or prevent weight gain while still allowing for successful tobacco cessation. METHODS Systematic reviews and relevant studies that were published since prior reviews were selected. RESULTS Smoking cessation can cause excessive weight gain in some individuals and can be associated with clinically significant outcomes such as diabetes or obesity onset. Interventions that combine smoking cessation and weight control can be effective for improving cessation and minimizing weight gain but need to be tested in specific populations. CONCLUSIONS Despite the health benefits of quitting tobacco, post-cessation weight gain and new onset obesity and diabetes are a significant concern. Promising interventions may need to be more widely applied to reduce the consequences of both obesity and tobacco use. INTRODUCTION Tobacco use continues to be a major public health problem and the leading preventable cause of death. Unfortunately, most smokers will gain weight after quitting, and a significant minority of smokers will gain an excess amount which may increase their risk for diabetes onset. This article presents a narrative review of the prevalence and impact of cessation-related weight gain on obesity and diabetes and a summary of cessation interventions aimed at addressing post-cessation weight gain. We primarily used PubMed to search for English language articles describing the effects of tobacco cessation on weight, diabetes, and glucose control as well as studies examining mechanisms for those changes. We also searched for systematic reviews and meta-analyses of interventions for improving smoking cessation and mitigating weight gain in those quitting tobacco as well as recent articles or those not included in reviews or meta-analyses. The purpose of this review was to summarize the literature and provide recommendations for clinicians treating smokers with overweight or obesity. PREVALENCE AND IMPACT OF OBESITY AND TOBACCO USE Smoking and obesity are the two leading causes of death in the U.S. (1-5). Two thirds of adults in the U.S. have overweight or obesity, and approximately 9 million adults with obesity are smokers (6-8). Among adults screened for weight loss surgery, two thirds reported a history of smoking, and 27% were smoking at the time of a presurgical evaluation (9). Similarly, among treatment seeking smokers, two thirds had overweight or obesity (10-13). Both obesity and smoking increase the risk for type 2 diabetes, hypertension, and cardiopulmonary disease. Like smoking, obesity increases diabetes risk by increasing insulin resistance and decreasing glucose control (14). Most importantly, co-occurrence of obesity and smoking increases the mortality risk above and beyond either risk factor alone (15, 16). Furthermore, it has been estimated that people with obesity cost an average of $1,360 in additional health care expenses each year compared with the nonobese and that smokers require an average of $1,046 in additional health care expenses compared with nonsmokers. These estimates do not include the added costs to society due to absenteeism and loss of productivity (16, 17). PREVALENCE AND IMPACT OF WEIGHT GAIN IN SMOKERS Research has shown that while the majority of people who quit smoking gain weight, there is considerable variability in the amount of weight gain. The differences in weight gain between those who quit and those who continue to smoke range from 2.6 to 5.3 kg (3, 10, 18-24). Using data from 35 population-based prospective cohort studies worldwide and comparing 63,403 smokers who had quit smoking with 388,432 who continued to smoke, Tian et al. found that people who quit smoking gained an average of 4.1 kg over 5 years, compared with 1.5 kg for continuing smokers, a difference of 2.6 kg (19). The authors noted that studies with longer follow-up time and that were conducted in North America found higher levels of weight gain. An earlier meta-analysis by Aubin et al. focused on weight gain in those who quit smoking as part of randomized clinical trials of cessation treatment, including pharmacotherapy, exercise, and weight gain prevention studies. They reported that the average weight gain among successful quitters was 1.1 kg at 1 month, 2.3 kg at 2 months, 2.9 kg at 3 months, 4.2 kg at 6 months, and 4.7 kg at 12 months. They noted substantial variation among smokers with 16% to 21% losing weight and 13% to 14% gaining more than 10 kg at 12 months (23). Scherr et al. also reported large variability in weight change at 12 and 24 months among smokers who had successfully quit and that 10% gained more than 10 kg (25). In another study, the change in weight among quitters was higher than in previous studies. Over 8 years, successful quitters gained an average of 8.79 kg (SD = 6.36) while continuing smokers gained 2.24 kg (SD = 6.65), a difference of 6.55 kg (22). Importantly, for a small number of people, the amount of weight gain after tobacco cessation is significant enough to move them into an overweight or obesity categorization (body mass index, BMI >25 mg/m2 or >30 mg/m2) which could have a significant impact on health. One study reported an increased prevalence of overweight of 15% and an increased prevalence of obesity of 18% in recent quitters, whereas in continued smokers prevalence rates increased by 2% and 5%, respectively (22). According to a meta-analysis of cohort studies, a 2.5 kg/m2 increase in BMI for those with a starting BMI of 22 kg/m2 or higher increased mortality by 14%, but continued smoking far exceeded this mortality rate (26). In addition to increased weight, cessation can also result in an increase in waist circumference or central fat, which could attenuate some of the beneficial effects of smoking cessation, especially among quitters who reduced their physical activity and those who had been heavy smokers (27). It is unclear which smokers are most at risk for the larger weight gain after quitting. While one study among smokers seeking cessation treatment reported no correlation between baseline BMI and smoking cessation or cessation-related weight gain (24), the bulk of studies have reported higher weight gain in those with higher BMI before quitting (18, 19, 22, 25, 28, 29). For example, for a starting BMI of 18, 23, 29, or 36 kg/m2, Lycett et al. found that post-cessation weight gain was 9.8, 7.8, 10.2, and 19.4 kg, respectively, after 8 years (22). Others at the greatest risk of gaining higher amounts of weight or triggering a chronic condition after quitting include women, especially African American women (30, 31), those with lower socioeconomic status (29), and those with poor diet, limited physical activity, and greater amount of tobacco used (31-36). A recent study looking at 10-year outcomes and comparing those who quit tobacco with those who continued to smoke found that degree of tobacco addiction (i.e., number of cigarettes per day) was the primary predictor of excessive weight gain (18). Overall, about 10% of men and 13% of women gain 10 kg or greater after quitting (19, 29, 31, 32, 35, 37-39). Other groups that are at increased risk for weight gain after cessation include those with disordered eating patterns. For example, among overweight former smokers, those who reported regular binge eating were more likely to gain weight in the year following smoking cessation than overweight former smokers who were not binge eaters (40). WHY PEOPLE GAIN WEIGHT WHEN QUITTING Weight gain associated with quitting tobacco is largely due to increased energy intake and reduced energy expenditure. Smokers gain weight after they quit smoking primarily because of the removal of nicotine's effects on the central nervous system (35, 36, 41, 42). Some smokers also attempt to cope with nicotine withdrawal by substituting eating for the “hand to mouth” behavior of smoking which can lead to an increase in caloric intake (35, 43, 44). However, there are differences in opinion with regard to the relative impact of nicotine-related metabolism changes and increased caloric intake. Kleppinger et al. found in a study of women that neither calorie intake nor physical activity level changes differed significantly between those who quit and those who continued smoking (45). However, percentage of calories as sugar was increased which, over time, might lead to increased caloric intake and weight gain. Low satiety, emotional eating, calorie misperception, and short sleep might also contribute to post-cessation weight gain (46). Regardless of weight change, those who stop smoking report an increased preference for sweet tasting foods (44). According to a recent study, women who smoke had lower ability to perceive fat and sweetness in foods and derived less pleasure from foods, which could lead to overconsumption (47). It has also been suggested that the sudden drop in blood sugar in many people during the first 3 days of quitting could lead to common withdrawal symptoms such as headaches, dizziness, and craving for sweets which in turn could lead to overeating in an attempt to cope with these symptoms (35, 41, 43). Research on the neurobiology of nicotine addiction and withdrawal sheds some light on the problem of post-cessation weight gain. Specifically, the relationship between nicotine addiction and the neural reward mechanisms involved could mirror similar neural networks involved in some eating behaviors. In fact, food addiction appears to activate similar reward pathways in the brain as does smoking (48). Elevated response to reward has been linked to weight gain perhaps due to an increase in caloric intake or altered food composition (e.g., more sugar which can then increase the glycemic load of the diet) (49). In one study, Stice et al. compared reward surfeit versus reward deficit treatment models and suggested that gradual, healthy changes to dietary intake instead of dramatic weight loss diets may be better at minimizing the sense of deprivation or loss (50). This notion of deprivation (biological and psychological) could explain why strict dieting during an attempt to quit smoking can have a negative impact on cessation (51). Food deprivation can reduce extracellular dopamine levels, reduce positive mood, and increase drive to use nicotine (51). CONSEQUENCES OF SMOKING AND SMOKING CESSATION ON DIABETES Systematic reviews and the recent Surgeon General's Report have confirmed that active smoking is associated with an increased risk of type 2 diabetes (52-55). Smokers are 30% to 44% more likely to develop type 2 diabetes than nonsmokers (52) and the more cigarettes consumed, the higher the risk (52, 53, 55, 56). Multiple biological mechanisms for the causal connection between smoking and development of type 2 diabetes have been postulated, including the effects of smoking on cortisol concentrations, central obesity, inflammatory markers, oxidative stress, insulin resistance, and an increase in fasting blood glucose (55, 57-59). Smoking is particularly problematic in people who already have diabetes. People with diabetes who smoke have higher glycated hemoglobin (HbA1c) levels than nonsmokers who have diabetes (60), and they are more likely to experience severe hypoglycemia and to have trouble with insulin dosing and diabetes control (5, 61). Some of these consequences of smoking improve after cessation, including improved insulin sensitivity and glycemic control (53, 57-59, 61-63). Paradoxically, however, in some cases, quitting tobacco seems to worsen glycemic control and increase the risk for new onset type 2 diabetes (64-67). A recent review reported that the relative risk of developing type 2 diabetes compared with never smokers was 1.54 (95% CI 1.36-1.74) for those who quit in the past 5 years; 1.18 (95% CI 1.07-1.29) for those abstaining for 5 to 9 years; and 1.11 (95% CI 1.02-1.20) for long-term quitters (≥10 years) (67). The mechanism by which tobacco cessation leads to diabetes onset or poorer diabetes control is not clear. The increased risk may be due to increases in visceral fat accumulation or waist circumference, chronic inflammation, or excessive weight gain after quitting (56, 68, 69). An early study with Japanese men with diabetes reported that quitting smoking for at least 6 months was associated with weight gain along with significant worsening of blood pressure, total cholesterol, triglycerides, and fasting blood glucose (70). In contrast, according to a study by Lycett et al., glycemic control in patients with diabetes deteriorated for about 3 years after quitting smoking after which HbA1c levels were similar to smokers, and this association was independent of post-cessation weight gain (65). It has been suggested that the adverse effect of quitting tobacco on glycemic control may be due to greater consumption of sugary foods and carbohydrates (44, 71, 72). However, Komiyama et al. reported no significant change in HbA1c after successful cessation from baseline to 12 weeks in a sample of 132 men and 54 women, despite significant increases in BMI, LDL-C and HDL-C, and triglycerides (173 ± 105 mg/dL before vs. 199 ± 129 mg/dL) after cessation (35). In summary, it is apparent that tobacco cessation, while certainly an important health behavior change, can also lead to negative metabolic consequences for some smokers. Regardless of the reported negative effects of cessation on glycemic control and diabetes risk, quitting smoking has been proven to reduce the risk of cardiovascular disease and mortality even in people with diabetes (57, 73, 74). It is increasingly important to develop and test tobacco cessation interventions for those at risk of negative health consequences of cessation and to determine who might benefit from these interventions. TOBACCO CESSATION INTERVENTIONS TO PREVENT POST-CESSATION WEIGHT GAIN: SYSTEMATIC REVIEWS AND META-ANALYSES There are two problems with the weight gain that occurs with cessation. First, concerns about weight gain can be a barrier to cessation attempts. Second, for a significant minority of people the weight gain can be enough to trigger a chronic illness like obesity or diabetes. Interventions have been developed that address both the cognitive concern about weight gain before a quit attempt and to minimize actual weight gain during and after cessation. It should be emphasized that these two approaches are fundamentally very different: a “weight concerns” approach is addressing beliefs about weight gain that could interfere with quitting smoking and may even encourage tolerance of some weight gain, whereas a weight loss/weight management intervention is actually trying to prevent the weight gain that occurs with cessation. An early Cochrane review of interventions to reduce weight gain among those quitting tobacco was published in 2009 (75). Recommendations from this review indicated promise for individualized weight management, nicotine replacement therapy (NRT), and physical activity interventions when combined with cessation interventions. The same year Spring et al. conducted a meta-analysis of 10 RCTs that tested combined weight control and cessation interventions and found evidence of short-term increased abstinence for smokers and decreased post-cessation weight gain, but not in the long term (52 weeks). The review concluded that there was no evidence of harm from addressing weight along with tobacco (76). In 2012, Farley et al. updated the prior Cochrane review and added 5 studies for total of 16 studies reviewed (77). The results were similar to the prior 2009 reviews. However, when adding a second article looking at addressing weight concerns (78), the review concluded that there was no long-term weight suppressive effect of the weight concerns intervention and there was a possibility for weight gain. The review also concluded that interventions of weight education were not effective at any time point and reduced tobacco abstinence at 12 months (77). However, personalized weight management was associated with reduced weight gain and had no negative effects on cessation at 12 months (79, 80). Weight management with very-low-calorie meal replacement was effective at the end of treatment, but not at 12 months, but it increased tobacco abstinence at 12 months (80, 81). Physical activity interventions designed to increase cessation rates were also effective at reducing post-cessation weight gain at 12 months (5), and use of cessation medications such as NRT and varenicline reduced post-cessation weight gain in the short term but had no effects at 12 months. These results highlight the difference between weight concerns interventions, which strive to increase smoking cessation and not surprisingly are not associated with weight suppression after quitting, and weight loss/weight management interventions involving diet or targeted behavioral weight loss approaches, which do reduce weight gain. The most current systematic reviews (published in 2012) suggest that some interventions added to tobacco cessation treatment may be safe and effective such as very-low-calorie diets, physical activity, and NRT (77, 82). Below we describe some of the key intervention strategies targeting tobacco cessation and weight by categories, cognitive, behavioral (diet and exercise), and pharmacologic, and we add relevant studies published since the 2012 reviews. TOBACCO CESSATION AND WEIGHT MANAGEMENT COMBINED INTERVENTIONS—COGNITIVE AND BEHAVIORAL APPROACHES COGNITIVE APPROACHES TARGETING BODY IMAGE AND WEIGHT CONCERNS Several studies have tested interventions that elicited smokers’ beliefs about their weight and self-image and intervened on correcting unproductive thoughts about weight gain (i.e., “weight concern”). The theory behind this line of research was that excessive worry about weight gain interferes with ones’ effort and commitment to quit smoking. A number of studies have found that addressing weight concerns significantly improved smoking cessation compared with standard cessation treatments alone (79, 80, 83, 84). Many of these weight concerns studies also have shown a short-term weight suppressive effect of the intervention as described in three systematic reviews (75-77). Since the weight concerns intervention encouraged smokers not to worry about gaining weight but to focus on the benefits of quitting, it is not surprising that one of the trials showed a negative effect on post-cessation weight gain. The study recruited women smokers concerned about gaining weight for a 2 × 2 randomized trial offering standard cessation alone versus the weight concerns intervention crossed with placebo or bupropion. Results showed that among women offered bupropion to help with cessation, those randomized to the weight concerns intervention had significantly greater levels of abstinence at 6 months than did standard smoking cessation counseling combined with bupropion or placebo and a nonsignificant increase in weight gain at 6 months with no effect on weight at 12 months (78). This study appeared in the recent Cochrane review (77) which concluded that this second weight concerns study showed increased cessation at 6 but not 12 months and that the intervention significantly increased post-cessation weight gain (77). A more recent trial of the weight concerns intervention tested the effectiveness of this weight acceptance approach in a population-based setting of a national tobacco “quitline” among 2,000 male and female smokers seeking help to quit smoking (85). Results were published after the three systematic reviews (75-77) and showed that at 6 months the intervention had a weight suppressive effect without impacting cessation rates. Among those who quit smoking, 50.8% of standard versus 30.0% of those in the combined intervention gained weight (P = 0.0004), and the intervention group gained significantly less weight (P = 0.01); the intervention group lost a little weight overall and the standard group gained weight. Interestingly, planned subgroup analyses revealed a significant interaction between treatment group and having diabetes (P = 0.03), indicating that the weight concerns intervention was particularly successful for those with diabetes (versus smokers without diabetes). Among those with diabetes, 19.1% in standard versus 31.5% in the intervention quit smoking (P = 0.03), and the average change in weight among quitters was +6.8 lbs (+3.84 kg) for standard versus −5.2 lbs (−2.4 kg) for intervention (P = 0.009). Among those without diabetes, 22.6% in standard versus 21.7% in the intervention quit smoking. The intervention also produced a significant drop in weight concerns and this differential effect was a significant factor in producing the outcomes. A weakness of this study is that tobacco cessation and weight relied on self-report, a common approach in phone-based interventions. In another study, Copeland et al. found that individually tailored smoking cessation treatment for weight-concerned women was superior to group counseling sessions for smoking abstinence, but not for change in weight (37). The authors concluded that cognitive restructuring of attitudes about smoking, appetite control, and weight management should be incorporated into cessation counseling in addition to skills acquisition. In summary, results from multiple trials suggest that addressing smokers' concerns about their weight or body image during tobacco cessation counseling is feasible, acceptable, and important to smokers and, for some, can reduce post-cessation weight gain without harm to cessation efforts. However, in light of the 2012 Cochrane review, weight gain during and after cessation needs to be monitored and addressed. Moreover, the weight concerns quitline study needs to be replicated and further tested in smokers at risk for diabetes or obesity. EDUCATIONAL APPROACHES Systematic reviews have found that education alone had no significant effects on post-cessation weight gain but may reduce tobacco abstinence at 12 months (75-77). However, one study not included in prior reviews found that nutritional advice added to a smoking cessation program increased tobacco abstinence at 12 months but had no significant advantage over cessation treatment alone for preventing post-cessation weight gain (86). The authors postulated that reducing anxiety about weight gain and encouraging cessation despite weight gain was a potential mechanism for why the offer of nutritional advice as part of a smoking cessation program was successful in facilitating some sustained improvements in dietary habits and improved quit rates at 12 months. Limitations of this study include the small sample sizes and the study design. Overall, similar to weight loss treatments in general, education or nutritional advice alone is not recommended to prevent those quitting smoking from gaining weight (77). CALORIE-RESTRICTION APPROACHES Several studies have tested a combination of smoking cessation and traditional calorie-restriction interventions using meal replacement or low-calorie diets and had mixed results on cessation and weight gain. In an early study, Hall et al. compared two different weight gain prevention treatments with 158 smokers who completed a 2-week tobacco treatment program and found no effect on weight outcomes. The two weight-based treatments, however, increased tobacco relapse rates. The authors concluded that the treatment arms may have been too complex and time-consuming which may have diverted focus and attention away from maintaining tobacco abstinence (51). Subsequent studies and meta-analyses of behavioral weight control and tobacco cessation have found that this was the only negative trial (75-77). For example, one study involved a very-low-calorie diet added to standard tobacco cessation treatment. The trial recruited only women with weight concerns and involved 11 behavioral weight control sessions over 16 weeks plus nicotine gum and an intermittent very-low-calorie diet routine (81). Results showed that the very-low-calorie diet arm had a significant effect on reducing weight gain at the end of treatment but not at 12 months and had a significant effect on increasing abstinence at 12 months. Other trials have also shown that behavioral weight management programs delivered sequentially to tobacco cessation treatment provide an effective method for improving cessation and minimizing weight gain in quitters (80, 87). PHYSICAL ACTIVITY APPROACHES Several studies have demonstrated the benefit of increased physical activity and reduced sedentary activity on both smoking cessation and weight management and were included in at least one of the prior reviews. In one study, Marcus et al. found that the exercise group had significantly higher rates of continuous abstinence relative to the control group at the end of treatment (19.4% vs. 10.2%), at 3 months (16.4% vs. 8.2%), and at 12 months (11.9% vs. 5.4%) (88). Exercise is helpful for weight management and increases psychological well-being (88-92). Meta-analytic results of smoking cessation studies reveal that exercise, irrespective of changes in fitness or body composition, can improve body image, improve cessation rates, and significantly reduce postcessation weight gain at 12 months (76, 77, 82). TOBACCO CESSATION AND WEIGHT MANAGEMENT COMBINED INTERVENTIONS—PHARMACOLOGIC APPROACHES Current medications for tobacco cessation include NRT in the form of patches, gum, lozenges, and spray, as well prescription medications such as varenicline, bupropion, and cytosine. Combination NRT treatments such as adding nicotine gum to the patch have been shown to be a more effective cessation strategy than using only one medication (77). Systematic reviews concluded that some pharmacological interventions limited post-cessation weight gain in the short term, but this was not sustained by 6 and 12 months (36, 75, 77). More recently, Taniguchi et al. found that varenicline significantly reduced weight gain at 12 months as compared with NRT (1.67 kg vs. 2.55 kg gain in weight) (93). Others have shown that Bupropion SR and NRT, in particular 4 mg nicotine gum and 4 mg nicotine lozenge, delayed but did not prevent weight gain, but duration of medication use had a significant effect on weight. Compared with smokers who received 8 weeks of nicotine patch therapy, those who received 24 weeks of patches reported significantly less weight gain from pretreatment to week 24 (P = 0.002) and also from week 8 to week 24 (P = 0.03) (78, 94). Noteably, Schnoll et al. found that NRT was less effective for women with obesity compared with men with obesity or women and men who were not obese and that a fast-acting NRT such as the nasal spray was more effective as a cessation aid than the patch for smokers with obesity (95). In summary, smoking cessation medications have been shown to delay but not prevent weight gain associated with smoking cessation. However, there are a limited number of studies of extended treatment duration or with long-term follow-up and newer cessation medications have not been sufficiently studied with regard to weight change. Studies with new drugs available for the treatment of obesity such as sibutramine and orlistat may be needed to determine the effects of these medications on smoking cessation and cessation-related weight gain (36). TOBACCO CESSATION AND WEIGHT MANAGEMENT COMBINED INTERVENTIONS—FOR PEOPLE WITH DIABETES Smokers with diabetes have had less success quitting tobacco in some but not all studies. In a cross-sectional study of smokers who enrolled in a state quitline, Schauer et al. found that having diabetes had no impact on the effectiveness of smoking cessation treatment; 24.3% of those with diabetes versus 22.5% of those without diabetes quit smoking at 6 months and no significant differences existed between groups for weight gain, regardless of quit status. However, participants with diabetes reported more weight gain in previous quit attempts; 34.2% of those with diabetes vs. 22.4% of those without diabetes gained >20 lbs (8.84 kg) (P = 0.03) (96). By contrast, an earlier study evaluated 6-month cessation outcomes of state quitlines by chronic disease and reported that those with diabetes had lower quit rates than those who did not have diabetes (97). In the previous weight concerns study in quitlines cited above, addressing weight concerns, challenging maladaptive beliefs, and encouraging acceptance of a modest weight gain in smokers with diabetes had a significant effect on both increasing abstinence and minimizing weight gain associated with cessation (85). This study appears to be the only randomized trial of combined tobacco and weight interventions that specifically evaluated cessation and weight outcomes among smokers with diabetes. A recent review of randomized trials reporting the effects of tobacco treatments in smokers with diabetes found no evidence of the efficacy for more intensive versus less intensive tobacco cessation treatments. In all the eight trials, the tobacco treatment was delivered by health care providers and usually in clinics. Moreover, considerable heterogeneity existed between the trials which included counseling, referral, advice, and/or some diabetes-specific education. The review excluded a small number of trials of complex interventions targeting those with and without diabetes. While the authors suggested that more research and development is needed to determine if cessation treatments tailored to patients with diabetes are needed (98), it is clear that the positive outcomes of the weight concerns intervention among people with diabetes need to be replicated. ROLE OF PHYSICIANS IN HELPING SMOKERS MANAGE THEIR WEIGHT DURING TOBACCO CESSATION Health care providers have expressed concerns about asking their patients to tackle two difficult behaviors simultaneously, such as quitting smoking and losing weight (99). Providers also lack knowledge of a systematic integration of multiple behavioral treatments for people with comorbid conditions. Training opportunities for delivering such interventions or referring patients to effective treatments for smoking and integrated weight control are either rare or poorly utilized. Provider attitudes may also be inadvertently affecting their treatment of smokers with obesity. One study found that among smokers with overweight, obesity, and severe obesity, 3.7%, 3.4%, and 2.5%, respectively, were prescribed a smoking cessation medication as compared with 5.11% of normal-weight smokers (100). These findings of lower rates of prescribing smoking cessation medications could explain why smokers with obesity may have worse cessation outcomes. Despite three comprehensive reviews (75-77) indicating the safety and short-term efficacy of combining cessation and weight-based treatments, knowledge and availability of such programs have not been widely disseminated. The USPHS 2008 tobacco guideline which advises clinicians to help patients quit smoking first and then address weight gain either personally or by referral may need to be altered in light of new evidence of the safety and efficacy of combined tobacco cessation and weight control treatments (94). However, the following guideline recommendations are in line with current evidence: * Start or increase physical activity. * Reassure smokers that some weight gain after quitting is common and usually is self-limiting with lifestyle changes. * Suggest low-calorie substitutes to smoking such as sugarless chewing gum, vegetables, or mints. * Maintain patients on medication known to delay weight gain (e.g., bupropion SR, NRTs—particularly 4 mg nicotine gum and lozenge). * Refer smokers to a qualified weight loss professional or evidence-based commercial weight loss program for personalized dietary and exercise programs. DISCUSSION While this is not a systematic review, important studies have been highlighted and recommendations for improvements are identified. This narrative review on the broad topic of smoking cessation, weight gain, and diabetes highlights some of the seminal studies and knowledge gaps in line with the theme of the article. This appraisal of the research shows that there is evidence that combining personalized behavioral weight management interventions with tobacco cessation treatments (either simultaneously or sequentially) can provide a safe and successful approach for reducing weight gain and improving cessation outcomes for some individuals (75-77, 79, 82, 85). Overall, results of these trials suggest that reducing a smoker's excessive fear of gaining weight and providing personalized dietary and physical activity interventions may limit weight gain without reducing abstinence in the short term. While the most recent Cochrane review (77) states there are not enough studies to make strong recommendations for effective interventions to prevent weight gain, separating studies that focus on “weight concerns” (not targeting weight gain prevention) from those that employ evidence-based behavioral weight loss techniques provides reasons to believe that weight management during cessation can be effective. Smoking cessation medications can also improve cessation rates, but the long-term effectiveness on reducing weight gain is unknown. More research is needed with longer follow-up periods and high-risk populations such as smokers with obesity and diabetes. In conclusion, while 80% to 90% of smokers will gain weight after quitting without a weight management intervention, there is some evidence to suggest that combining weight management with cessation could improve these numbers. Of particular concern are the 10% to 20% of smokers who gain in excess of 10 kg. Unfortunately, current evidence does not provide clear ways to identify this population in advance, although individuals with more severe obesity or those with diabetes may be at greater risk and therefore should receive more aggressive weight management intervention during cessation. While it may be tempting to ask whether quitting is best for every smoker, it is important to note that the health benefits of abstaining from tobacco outweigh the health risks associated with quitting, including those of weight gain. Risk factors can be minimized by close monitoring and a sensible approach to dietary and lifestyles changes. RECOMMENDATIONS AND DIRECTIONS FOR THE FUTURE Although research has shown the short-term effectiveness of smoking cessation treatments that also address weight gain, the sustainability of these outcomes on weight and tobacco cessation in the long term warrants further research. Similarly, combinations of weight- and tobacco-based treatments need to be tested with smokers who are at high risk for, or currently have, diabetes and those who have obesity. Future research and development work should include economic evaluations of current and new combined treatments, long-term follow-up, and developing integrated interventions involving tobacco cessation, weight management, and diabetes risk reduction. For now, many of the key intervention components of combined tobacco and weight treatment could be integrated into current clinical and behavioral treatment and include encouraging smokers to add more physical activity, healthy foods, regular meals, and self-monitoring to their focus on quitting smoking. Multifaceted interventions informed by clinical, behavioral, pharmacological, and genetic research are needed and these interventions should integrate new learnings from tobacco control and obesity research. 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Artificially Sweetened Beverage Use and Long‐term Weight Gain Sharon P. Fowler, Ken Williams, Roy G. Resendez, Kelly J. Hunt, Helen P. Hazuda, Michael P. Stern, Obesity * Weight gain and obesity after liver transplantation James Richards, Bridget Gunson, Jill Johnson, James Neuberger, Transplant International * Cigarette Smoking, Nicotine, and Body Weight J Audrain-McGovern, NL Benowitz, Clinical Pharmacology & Therapeutics METRICS Citations: 135 DETAILS © 2016 The Obesity Society * Check for updates RESEARCH FUNDING * National Institute on Drug Abuse . Grant Number: RO1DA031147 * National Center for Complementary and Integrative Health as well as Alere Wellbeing and Arivale, Inc . Grant Number: R21AT007845 PUBLICATION HISTORY * Issue Online: 29 August 2016 * Version of Record online: 29 August 2016 * Manuscript accepted: 17 May 2016 * Manuscript revised: 21 April 2016 * Manuscript received: 05 October 2015 Close Figure Viewer Previous FigureNext Figure Caption Download PDF back ADDITIONAL LINKS ABOUT WILEY ONLINE LIBRARY * Privacy Policy * Terms of Use * About Cookies * Manage Cookies * Accessibility * Wiley Research DE&I Statement and Publishing Policies * Developing World Access HELP & SUPPORT * Contact Us * Training and Support * DMCA & Reporting Piracy OPPORTUNITIES * Subscription Agents * Advertisers & Corporate Partners CONNECT WITH WILEY * The Wiley Network * Wiley Press Room Copyright © 1999-2024 John Wiley & Sons, Inc or related companies. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. 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