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LOXCELL (ALBENDAZOLE)

Active Ingredient: Albendazole
Dosage: 400 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 10, 20, 30 per pack

Loxcell (Albendazole) is applied as the therapy of neurocysticercosis. It is an
infection caused by the pork tapeworm in the muscles, brain, and eyes. They may
cause seizures, brain swelling, and vision problems. This preparation is also
applied during with surgical operations to treat cystic hydatid disease
(infection caused by the dog tapeworm in the liver, lung, and lining of the
abdomen that may damage these organs). This drug belongs to the group of
anthelmintics.

Loxcell is not available at the moment but you can purchase its complete analog
on this page.


INDICATIONS

Loxcell (Albendazole) is used in the treatment of:

 * echinococcosis of the peritoneum, lungs and liver;
 * neurocysticercosis;
 * intragastric, arachnoid and racemic cysts;
 * trichoneosis;
 * ascariasis;
 * hookworm;
 * enterobiosis;
 * opisthorchiasis;
 * giardiasis;
 * toxocariasis;
 * microsporidosis;
 * trichinosis;
 * capillarose;
 * gnatostomosis.

In addition, the drug is used in the treatment of cystic echinococcosis, when
surgical treatment is contraindicated or before surgery to reduce the number of
cysts.


DOSAGE AND ADMINISTRATION

Loxcell is taken after meals with plenty of water. The dosage of the drug
depends on the type of helminth. When taking these tablets, laxatives are not
prescribed since this will facilitate the most rapid removal of the drug from
the patient’s digestive tract and reduce the effectiveness of the drug. In the
treatment of conventional helminthiases, Loxcell is prescribed once for adults
at a dosage of 400 mg, for children – 60 mg per 10 kg of body weight. In the
treatment of cysticercosis of the brain, the drug is taken by adults at a dosage
of 800 mg, children – 15 mg per kg of body weight from 8 to 30 days. In the
treatment of strongyloidosis, giardiasis and cestodosis, 400 mg or 200 mg are
taken for 3 days, it is recommended to repeat treatment after 3 weeks.
In the treatment of ascariasis, enterobiasis and hookworm, the drug is taken
once at a dosage of 400 mg or 200 mg, treatment is repeated after 3 weeks.


CONTRAINDICATIONS

The main contraindications for the use of Loxcell tablets are age under two
years, hypersensitivity to albendazole, lactation and pregnancy.

The drug is used with caution in:

 * cirrhosis of the liver;
 * retinal damage caused by cysticercosis;
 * violation of bone marrow hematopoiesis.


SIDE EFFECTS

 * Immune system: hypersensitivity reactions, including rash, itching and
   urticaria;
 * Nervous system: headache and dizziness;
 * Gastrointestinal tract: symptoms from the upper gastrointestinal tract (e.g.,
   epigastric pain, nausea, vomiting) and diarrhea;
 * Digestive system: increased levels of liver enzymes;
 * Skin and subcutaneous tissue: polymorphic erythema, Stevens-Johnson syndrome.
   Side effects that occur with prolonged treatment of systemic helminth
   infections;
 * Blood system and lymphatic system: leukopenia, pancytopenia, aplastic anemia,
   agranulocytosis;
 * Immune system: hypersensitivity reactions, including rash, itching and
   urticaria;
 * Nervous system: headache, dizziness;
 * Gastrointestinal tract: gastrointestinal disorders (abdominal pain, nausea,
   vomiting). These phenomena are associated with treatment with albendazole in
   patients with echinococcosis;
 * Digestive system: increased levels of liver enzymes of mild and moderate
   degree, hepatitis;
 * Skin and subcutaneous tissue: alopecia (thinning of hair and moderate hair
   loss), polymorphic erythema, Stevens-Johnson syndrome;
 * Common disorders: fever.


OVERDOSE

In acute overdose with Loxcell, a significant increase in side effects is
observed. When taking the drug in high doses, patients develop dyspeptic
disorders, dizziness, headaches, increased activity of liver enzymes, abdominal
pain. In especially severe cases, an acute violation of the kidneys is possible.

To reduce the toxic effect of the drug, the patient’s stomach is washed, a large
amount of liquid, salt laxatives and enterosorbents are prescribed.


INTERACTION

If you are taking any other medicines, be sure to inform your doctor!

The concentration of albendazole metabolites in the blood is increased by
dexamethasone, cimetidine and praziquantel.

Albendazole is an inducer of microsomal enzymes of cytochrome P450; it
accelerates the metabolism of many drugs.

Long-term use of albendazole inhibits the N-demethylation of aminopyrine and
leads to a gradual decrease in the concentration of albendazole sulfoxide, which
is caused by an increase in sulfonation.

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