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JUNO CO-FOUNDER LAUNCHES AMBITIOUS NEW STARTUP WITH FRED HUTCH COLLEAGUES TO
TREAT CANCER

by Charlotte Schubert on January 13, 2022 at 5:27 pmJanuary 14, 2022 at 11:20 am



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From left: Affini-T scientific co-founders and Fred Hutch investigators Philip
Greenberg, Aude Chapuis, and Thomas Schmitt. (Fred Hutch Photos)

A new cell therapy company is on the block, propelled by powerhouse scientific
co-founders from Fred Hutchinson Cancer Research Center with years of experience
investigating how to harness the immune system to treat cancer.

Affini-T Therapeutics, which emerged Wednesday in a presentation at the J.P.
Morgan Health Care Conference, is headquartered in Boston and has a research lab
in Seattle. 

The company’s scientific co-founders are Philip Greenberg, Fred Hutch head of
immunology, Thomas Schmitt, a research associate in his lab, and Hutch associate
professor Aude Chapuis. Greenberg previously co-founded cell therapy company
Juno Therapeutics, which was acquired by Celgene for more than $9 billion in
2018.



Co-founder Jak Knowles serves as Affini-T CEO and president. He was previously
chief business officer of gene editing startup Metagenomi, which he co-founded.
He was also VP of venture investments at Leaps by Bayer, the pharma giant’s
investment arm, and he co-founded Exonics Therapeutics, which was acquired by
Vertex Pharmaceuticals for $245 million.

Affini-T Therapeutics CEO Jak Knowles. (Affini-T Photo)

Affini-T is developing cancer treatments using a strategy called T cell receptor
(TCR) cancer immunotherapy.

The method involves engineering immune T cells to recognize tumor cells and
infusing them into the patient. After recognizing the tumor cells, the
engineered T cells mount a destructive immune response against them.   

The cancer cells are recognized by an engineered protein on the therapeutic
cells called a T cell receptor. Affini-T boosts the response by adding another
engineered protein, called a CD8 co-receptor. The company is also investigating
ways to soup up the T cells by adding or taking out other genes.



The approach holds the promise for targeting a wider range of tumor types than
more conventional CAR T cell therapies. CAR T cells can recognize only a limited
number of protein targets, which must be on the surface of cells. They are
approved for several types of blood cancer and a host of companies are
researching ways to expand their patient pool.

TCR therapy can target a wider range of proteins, including ones active on the
inside of the cell.

Affini-T is targeting two aberrant proteins that are found in many tumor cells
and propel cancer growth, called KRAS and Mutant P53. The company aims to treat
solid tumors.

“Greenberg really knows TCRs,” Marcela Maus, a cellular therapist at Mass
General Hospital Cancer Center, who is not involved in Affini-T, told STAT News.
GeekWire has reached out to Affini-T for comment.



Other companies are also investigating the TCR approach, including T-knife
Therapeutics and Lion TCR, whose therapy for liver cancer is in early clinical
trials.

Affini-T joins a growing list of Seattle area cell therapy operations with links
to Juno.

Juno co-founder and Seattle Children’s Research Institute investigator Michael
Jensen co-founded Umoja Biopharma which landed $210 million last summer. Former
Juno CEO Hans Bishop launched Sana Biotechnology, which pulled in $587 million
in its IPO last year; Juno veteran Steve Harr serves as CEO. Juno co-founders
Rick Klausner, former global health director of the Bill & Melinda Gates
Foundation, and Fred Hutch investigator Stan Riddell are co-founders of Lyell
Immunopharma, which has operations in the Seattle area and went public in a $425
million IPO this summer.

Bristol Myers Squibb inherited Juno’s pipeline when it bought Celgene in 2019.
The pharma giant oversaw the approval last year of Breyanzi, a CAR T cell
therapy, and is now expanding in the Seattle area.

In addition to the three Fred Hutch investigators, Affini-T’s scientific
advisory board includes Nobel Prize winner Jim Allison, chair of Immunology at
University of Texas MD Anderson Cancer Center and other immunotherapy
luminaries, including Rafi Ahmed, director of the Vaccine Center at Emory
University.

Investors listed on Affini-T’s website are Vida Ventures, Leaps by Bayer, the
Humboldt Fund, Agent Capital, and Alexandria.

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MORE STARTUPS

Acumatica names former Unify Square leader John Case as new CEO; Jon Roskill
shifts to EQT role

Temporal is a unicorn: Developer productivity startup lands $103M at $1.5B
valuation

Veteran video game developers, visual effects experts launch new Vancouver B.C.
studio Blinkmoon

Charlotte Schubert is a GeekWire reporter and science journalist with a focus on
biotech, healthcare, and life sciences. She is a Seattle native, former editor
at Nature Medicine, and recovering lab rat. Follow her on Twitter at @schubertcm
or reach her at charlotte@geekwire.com.

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communities. Uptake and awareness of the concept is growing exponentially as
business leaders and boardrooms around the world ask ‘What is my metaverse
strategy?’ ‘What opportunities should I consider?’ or ‘Is the metaverse all
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