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The QFR Newsletter - January 2022 Email not displaying correctly?
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Dear QFR enthusiast,

This month we bring you a variety of exciting new QFR related publications.
Additionally, we would like to remind you that if you would like to contribute
to the next Medis QFR newsletter by sharing a case study or if you have a
publication coming up about QFR, please get in touch with us!

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Post-PCI physiology, incl. post-PCI QFR

Dr LJC van Zandvoort and co-authors under the leadership of Dr J Daemen
published in JACC Interventions a state-of-the-art Review on the topic of
Improving PCI outcomes using postprocedural physiology and intravascular
imaging. In this overview the authors describe the currently available tools and
techniques, both intracoronary as well as image-based, such as the QFR with the
post-PCI QFR threshold of 0.89, to define suboptimal PCI and when to apply these
technologies to improve outcomes.

For further read, click here

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Coronary physiologic assessment based on
angiography and intracoronary imaging.

Dr Takahashi from Albert Einstein College of Medicine and colleagues under the
senior authorship of Dr Y Kobayashi published a paper in the Journal of
Cardiology under the above title. The authors wrote a comprehensive revision of
the current available techniques that, based on either physiology or imaging,
aim to estimate FFR and IMR from coronary angiography without pressure wires and
adenosine (QFR, vFFR, FFRangio and IMRangio), as well as FFR from IVUS and OCT.
The authors indicate that angio-based FFR have the potential to become the main
pre- and post-PCI physiological guidance depending on lesion location and vessel
characteristics. Both IVUS- and OCT-based FFR could be a valuable alternative to
wire-based FFR to confirm successful PCI from both anatomy and physiology.

For further read, click here

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Diagnostic agreement of QFR
in a Latin-American population.

Dr ME Pinto and many co-authors from Mexico published a paper in Research Square
under the supervision of Dr HM Garcia-Garcia. In this retrospective study 90
vessels from 63 patients were included in which the fixed-QFR and the
contrast-QFR were compared with FFR. Correlations of fQFR and cQFR with FFR were
strong. Diagnostic accuracy of cQFR was best with AuC of 0.92. The authors
concluded that the QFR was strongly associated with FFR and exhibited a high
diagnostic performance in this Latin-American population.

For further read, click here
 

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Review of QFR and FFR in 23 publications including > 4000 patients

Dr M Barauskas and co-authors from the Lithuanian University of Health Sciences
in Kaunas under the supervision of Dr Unikas published a systematic analysis of
diagnostic performance and agreement between fractional flow reserve and
quantitative flow ratio in the journal Cor Vasa. They investigated a total of 23
publications representing more than 4000 patients comparing QFR and FFR
reproducibility and agreement. They found agreement in non-culprit lesions in
patients with and without previous MI to be 0.88 and 0.94, respectively. The
agreement decreased in diabetic patients. Their own inter-observer correlation
was found to be 0.99. The authors concluded that QFR is a straightforward and
quick method for an experienced specialist. QFR is an accurate, specific and
reliable method for physiological evaluation which could become the first-line
choice in the near future.

For further read, click here

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Correlation between early biomechanics and late serial QFR in an ovine model

Dr X Wu and many co-authors under the leadership of Prof Serruys PW from the
National University of Ireland in Galway published a paper in Eur J
Cardio-Thoracic Surgery 2022 on the one-year performance of biorestorative
polymeric coronary bypass grafts in an ovine model. They were particualarly
interested in the correlation between early biomechanics and late serial
Quantitative Flow Ratio.

A total of 69 graft geometries of 7 animals were performed in this study. The
highest ΔQFR at 12 months was colocalized in graft segments with the largest
bending angles at baseline. High baseline endothelial shear stress (ESS) was
topographically associated with higher ΔQFR at the latest follow-up. This study
suggests an association between early abnormal mechanical factors and late flow
metrics of the grafts.

For further read, click here


NEWSLETTER COMMUNICATION

Thank you for subscribing to our Medis QFR newsletter. To stay in touch
with Medis Medical Imaging and find out more about our other solutions, visit
our website and follow us on social media. We are active on LinkedIn,
YouTube and Twitter.

    


If you would like to contribute to the next Medis QFR newsletter by sharing a
case study or if you have a publication coming up about QFR, please get in touch
with us! We would be delighted to feature your contribution in our
newsletter and upcoming blog.  Just send us an email
at info@medisimaging.com and we will get in touch with you as soon as possible!

If you would like to know more about QFR, please reach out to our team at
sales@medisimaging.com and we would be happy to schedule a demo for you.



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Tel.: +31715223244  Medis Medical Imaging Inc. 
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