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FREE HOOKUP SITES NEAR ICHIKAWA JAPAN

Ichikawa at the border of Tokyo and as Professor of Archaeology at the ling-
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Both by radiorespirometry and the mouse footpad assay, clarithromycin had been
found to be the most active macrolide against M. Clarithromycin was evaluated in
9 previously untreated lepromatous patients with the following regimen: mg x 2
on day l, no treatment on days , mg daily on days and mg daily on days Skin
biopsies and serum were collected just prior to initiation of therapy and after
1, 3, 5 and 8 weeks treatment. Clarithromycin was tolerated well with resolution
of skin lesions by the 4th week.

Serum PGL-1 antigen titers of all 9 patients deelined significantly during
therapy. Radiorespirometric activity also became undetectable at this time.
Clarithromycin appears to be very rapidly bactericidal and should be seriously
considered in any new multi-drug regimen for leprosy. Parrilla 1 ; S.
Sparfloxacin is a new fluoroquinolone which has demonstrated greater in vitro
and in vivo activity than ofloxacin against M. Based on these findings and known
human pharmacokinetics, sparfloxacin was evaluated in nine untreated lepromatous
patients.

Patients received a single mg loading dose followed by mg daily for 8 weeks.
Skin biopsies and serum were collected just prior to initiation ot treatment and
at 2, 4, o and y weeks post treatment. Patient response was monitored by
clinical photography, serum PGL-1 antigen, radiorespirometry and mouse footpad
assay. Radiorespirometric activity correlated well with the mouse footpad data;
all biopsies becoming negative by 4 weeks post-treatment.


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Serum PGL-1 antigen showed a time-dependent decline in all patients. Overall,
the results with daily mg sparfloxacin appear to be comparable with that found
previously in trials of mg ofloxacin.


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Michael F R Waters. Although WHO MDT covers the needs of most patients, some
refuse clofazimine because of its effect on skin colour, which they fear will
result in discovery of their diagnosis. We are also using minocycline in the two
year MDT course given before stopping chemotherapy to Longstanding LL and BL
patients, of whom many had received thiambutosine in the past, and therefore
night have developed cross resistance to the thioamides.

Side-effects encountered will be reported, and the different practical drug
combinations used and the duration of treatment with the minocycline component
will be discussed. National Institute of Immunology, New Delhi. P Safdarjung
Hospital, New Delhi. Phase III immunotherapeutic triais with the anti leprosy
vaccine, Mycobacterium w. Subjects inducted are untreated , BI positive,
lepromin negative MB patients. In double blind study, the patients are randomly
divided into 2 groups. At determined Intervals, patients are assessed by
clinical scores, BI, histopathology of lesions and lepromin reactivity.

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Over patients have been included in the study. Results on approximately patients
have been analysed and are presented. There was slightly higher incidence of
type 1 reactions, although type 2 reactions were less frequent and severe. The
incidence of neuritis and deformity wao lenn, associated with rapid regression
of lesions and shortening of treatment duration. Chemo-immunotherapy, thus
brings about rapid bacterial clearance and immunological upgrading without
exacerbation of tissue damage. Safdarjung Hospital, New Delhi. Immunotherapy
with Mycobacterium w M.

Detailed clinical charting and biopsy were done every 6 months, BI and lepromin
were performed every 3 months. The vaccine was given at 3-monthly intervals.


TZU CHI LAIYAO VILLAGE

These findings were in accordance with clinical improvement. Two experienced
mild to moderate Type 2 lepra reaction following vaccination. None of the 6
patients in the contro 1 group recorded appreciable improvement. Some had severe
reactions accompanied by neuritis. One of the important but not adequately
answered questions is whether anti-leprosy drugs reach a subcellular location
such as Schwann cells where there is preferential multiplication and persistence
of M.

Subcellular localization of dapsone and Rifampicin was carried out in skin and
nerve lesions obtained from MDT treated cases of leprosy using a
immunocytochemical technique. Intracellular localization of drugs specifically
in macrophages and Schwann cells was carried out with polyclonal rabbit anti-DDS
and Anti--Rifampicin antibodies in an indirect immunoperoxidase assay.

Our study records both intra and extracellular staining in the skin and nerve
lesions obtained from MDT treated MB and PB cases of leprosy. All the nerves
under investigation had moderate to severe pathology; hence a broken barrier
leading to free diffusion of the drug. A graded difference was seen in staining
intensity in relation to integrity and cellularity of the nerve lesion. Nata ,
M. Mahajan, R. Pedal edema as an adverse effect of clofazimine therapy in
leprosy was first described in Systemic causes of pedal edema were ruled out in
these patients on the basis of clinical and laboratory parameters.

Lymphangiography was done in ten of these patients. Lymphangiographic evaluation
showed lymphatic block, lymph node enlargement, nodal filling defects and
collateral lymphatic channel circulation.


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Lymphangiography evaluation on patients with tuberculoid leprosy showed normal
lymphatic drainage. The blockade of lymphatic vessels seems to be the probable
mechanism of pedal edema in the first group of patients. The kinetics of
clofazimine and the role of the lymphatic drainage in those patients will be
discussed. Three patients were seen with late reactions a involving the nerves
of the hands. Prednisolone treatment was given and besides the recovery of the
nerve function in the hands they also regained most of the sensation in their
feet which was loot for at least 4 to 8 years ballpoint method.

Since then we treated all new and some old patients with nerve function loss,
when willing with prednisolone, regardless the reported duration of the loss.
Out of 11 patients thus treated, who had reported loss for 1 year or longer, 3
did not improved only slightly, 4 improved moderately and 4 made good
improvement. In general sensation of the feet improved more than sensation of
the hands.

Muscle function ir. Four patients who had sensation loss on detection and could
not be treated with prednisolone cid not improve. We belief that although these
results need verification, there is an indication for more extensive use of
prednisolone in longer standing sensation loss.

Bhatia; Kiran Katoch; M. Natrajan; V. With the multidrug treatment MDT , the
overall results have been satisfactory. In this study, the data of over cases of
paucibacillary leprosy as defined by the WHO criteria of has been analysed using
multivariate statistical techniques to assess the relationship of the factors
like type and duration of treatment regimen, clinical type of leprosy, number of
lesions, lepromin status, Clinical type of leprosy, number ot lesions, lepromin
status, bacterial positivity with parameters like inactivity rates at different
treatment intervals, clinical course of residual persisting activity, late
reactions and relapses.

These patients were treated with WHO recommended regimen of 6 morth duration,
modified 12 month regimens as well as Prothionamide containing regimen reported
by us earlier. It was observed that the treatment duration as well as regimen
had statistically significant relationship with these assessment parameters. The
clinical type, immunological status, number of lesions and occasional
bacteriological positivity did not have close association as reported in the
dapsone monotherapy days and in some of the studies later. The significance of
these findings need to be debated and investigated by further studies.

A "quick" Voluntary Muscle Test VMT and Sensory Test ST for the ulnar and median
nerves has been used by the author in field programmes; the "quick" VMT compares
left and right muscle strength for the ulnar and median nerves while the "quick"
ST uses light moving touch with the examinor's finger, asking the patient to
compare sensation between areas innervated by the ulnar and the median nerves.

This non concurrent cohort study was done to estimate the risk of developing
neuritis among Multibacillary patients during MDT. They received treatment
ranging from 2 to 6 years. All patients were assessed for evidence of neuritis
during clinic visits. The data was subjected to survival analysis. The risk of
developing neuritis during treatment was Adult Males had 3 times the risk of
developing neuritis compared with Adult Female s.

During the course of surveillance we encountered interesting events among MB
leprosy patients after completion of W. Subsequent examinations turned out to bo
uneventful. These manifestations responded to steroid therapy without specific
chemotherapy for leprosy. Most of these events tend to occur during first three
years of surveillance. The risk of such events, and their management is
discussed. Frankel, M. University of Hawaii John A. We reported that Similar
results were noted in We showed that this loss of testicular function was
correlated with long-standing Hansen's disease, was not associated with
immunologic Hansen's disease reactions, and was strongly associated with
clinical symptoms of androgen deficiency.

Serum levels of testosterone, FSH and LH were measured approximately five years
after the previous measurements. The data were analyzed to assess the number of
patients who developed testicular insufficiency during the period of
observation. Clinical characteristics of Hansen's disease, including
antimicrobial therapy and immunologic reactions, were analyzed and compared to
those cases who did not develop this endocrine problem.

In outpatients in eastern Nepal we tested the hypothesis based on clinical
impress ion that in every clinically significant lagophthalmos also other facial
muscles are involved. We found that in lagonhthalmos padents the upper and lower
facial muscles are affected in the same proportion set that on clinical grounds
we did not find support for the hypothesis is that the superficial course of the
facial nerve over the zygomatic bone is decisive for the pattern of facial
paralysis in leprosy.

We found only one patient with bilateral anaesthetic cornea and noted that the
tyne of Bell's phenomenon and the way of blinking are important for the
functional protection of the eye in lapophthalnos. Early detection and therapy
are essential in lagophthalmos to save the eye. During the regular and long-term
follow-up of multibacillary patients included in trials for different combined
treatments, we diagnosed relapses.

This permit us to observe lot of cases clinicians in charge because lesions are
very mild or because they do not seem active leprosy. Photographes presented
here may incite cliniciany in charge of follow-up of patients , particularly
after therapeutic trials, to examine patients carefully.

At puberty 71 had a history of skin disease, 41 had clinical evidence of skin
disease.




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Brazil Clinical Trial on Head and Neck Cancer: Zalutumumab, Control - Clinical
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Altogether, and including the practice of child abduction, decapitation in Wari
is understood as a strategy adopted by military and ritual elites to legitimate
their authority in the eyes of their enemies. However, not all disembodied
skulls found in Wari contexts were trophy heads. In the site of Wari, a
non-modified skull wrapped in cloth and pinned with four copper tupus was found
under the floor of an architectural construction and was probably a dedicatory
offering [ 34 ].

During the Tiwanaku period ADAD , in the Titicaca basin in Bolivia, scenes
involving decapitation or disembodied human heads were a common theme in the
etchings of their rock sculptures and panels [ 35 ]. The osteoarchaeological
record for the corresponding period confirms that these were indeed a real
practice. In the high-status residential complex of Putuni west to the
Kalasasaya a total of fifteen articulated and disarticulated individuals were
buried as a dedicatory offering to the building, including a disembodied human
skull [ 36 , 37 ].

Several skulls were found isolated in one case, three skulls were grouped
together , and eighteen skeletons lacked their skulls [ 35 ]. In the site of
Wata Wata, human heads were presented as dedicatory offerings [ 38 ]. Three
disembodied skulls were found displaying different signs of perimortem violence,
including beheading, cranial and facial fracturing, defleshing, jaw removal, and
possible eye extraction.

The extreme violence characterizing these findings suggests this was done to
remove power from those individuals and legitimize the authority of the
expanding influence of Tiwanaku into the region [ 38 ]. Head removal is a common
theme in Moche ADAD iconography, in northern Peru [ 39 — 42 ], and
archaeological and osteological evidence abound to confirm this was not merely
figurative but a real practice.

In Plaza 3A and Plaza 3C of Huaca de la Luna [ 34 , 43 — 50 ], articulated
severed heads and decapitated bodies were found in a context of generalized
sacrifice of defeated warriors [ 49 , 51 , 52 ]. In Plaza 3C, in addition to the
ritual of sacrifice, the severed skulls were also subject to both peri and
postmortem intentional manipulation which could imply some sort of ritual
cannibalism [ 49 ].

Nearby, at the complex named ZUM 8, two disembodied skulls altered to function
as jars show the diversity of purposes head removal had among the Moche, going
beyond the immediate needs of sacrificing defeated warriors [ 45 , 48 ].

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In Huaca Dos Cabezas, a cache of 18 severed skulls with cut marks on the
anterior portion of the cervical vertebrae was found [ 41 ]. Nearby, the
complete skeleton of a tall man was found with a tumi ceremonial axe
characterized by a semi-circular blade in his left hand and a pottery human head
in his right hand, suggesting he was an actual decapitator. The presence of
several pottery artifacts related to shamanistic activities [ 54 ] suggests that
the skulls are grave offerings, possibly holding some supernatural power. During
the Moche period, human bones from reopened tombs were used as dedicatory
offerings.

Skulls were the most commonly selected anatomical part and therefore not all
disembodied heads or headless bodies are a product of decapitation i. During the
earlier Gallinazo period, in Huacas de Moche, a single case of skull removal is
known for burial G2. The skull was removed and replaced by a pottery jar with
the figure of a human head stamped on it.

It is not possible, however, to determine if this was a peri or postmortem
removal [ 60 ]. The Nazca BCAD , in southern coastal Peru, produced elaborate
trophy heads that were characterized by a drill hole in the front of the head
and an enlargement of the foramen magnum [ 61 — 67 ]. The lips and eyes were
usually sealed with spines and the head was equipped with a carrying string [ 34
]. The available iconography and the predominance of adult males among trophy
heads [ 34 ] indicates that decapitation took place in the battlefield, and that
the severed head functioned as a trophy of war.

Isotopic analysis indicates that these were intra-valley battles involving local
Nazca warriors [ 68 , 69 ]. The heads were commonly interred in caches in
numbers ranging from three to groups of 40 or more [ 66 , 70 ]. Therefore, their
significance went far beyond signaling military supremacy, and it is assumed
they were a central element in rituals aiming to control the forces of nature,
particularly concerning crop fertility [ 64 , 71 — 73 ]. Since the skulls were
from an old adult male, a young adult male, an adolescent female and an infant,
they are sometimes thought to represent an extended family [ 74 ].

The skulls show no signs of modification. Another isolated skull in Chavin de
Huantar was recovered from the Galeria de Ofrendas and, although a precise date
is not available, this could represent the earliest modified trophy head in the
Andes [ 31 , 75 ]. During the Formative period, five disembodied skulls were
found in the site of Wichquana, in Peru.

Buried in individual pits within a ceremonial structure these skulls still had
the cervical vertebrae articulated to them supporting the interpretation that
they were decapitated when soft tissue was still present, which suggests that
they were sacrificed [ 76 ]. The site of Asia 1 [ 77 ], in central coastal Peru,
is usually considered the oldest possible case of decapitation in South America
ca. However, in the absence of a detailed osteological description accounting
for the presence of cut marks in the cranium and associated cervical vertebrae,
it is not possible to determine if this in indeed a case of decapitation.

The findings consisted of three wrapped bundles containing a total of eight
disembodied heads that were found in separate graves. In addition, two headless
bodies were also present. One skull had cut marks on the frontal bone that were
interpreted as resulting from the scalping of the face [ 77 ]. Such an elaborate
treatment indicates that the practice of removing skulls in Asia 1 could have
been reserved to individuals of special status. Altogether, and considering the
lack of any further modification to the skulls, it seems they were less likely
trophy heads, but instead venerated members of this society.

Accordingly, it has been suggested that the flayed skull might represent a local
individual who was mutilated somewhere else and later brought back to Asia 1 [
34 ]. The site of Asia 1 is commonly mentioned as the first appearance of
disembodied heads in the South American archaeological record.


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However, Aguazuque — BP might be a better candidate. The site presents one of
the most elaborate funerary records of the Archaic period and the disembodiment
of the skulls were part of a broader mortuary context that was focused on the
manipulation of bones and body parts [ 78 — 80 ]. Long bones, for example, were
sectioned into diaphyses and epiphyses and further painted with geometric
motifs. Once again, in the absence of a detailed osteological description
accounting for the presence or absence of cut marks, it is not possible to
determine if these were true cases of decapitations.


AUTHOR INFORMATION

Notwithstanding, the fact that one of the disembodied skulls was articulated
with the cervical vertebrae is highly suggestive that the removal occurred while
soft tissue was still present and therefore characterizes a case of
decapitation. In Brazil, as far as we could determine, there is only one single
case of a possible decapitation reported for the entire pre-history of the
country. This finding comes from the shellmound of Forte Marechal Luz [ 81 ],
but no detailed chronology or osteological descriptions are available.

Therefore, it is clear that almost all reported archaeological cases of
decapitation and disembodied heads in South America are concentrated in the
Andean region [ 82 ]. For this reason it is commonly assumed that this was an
Andean phenomenon in both its origins and in its most unambiguous expression [ 2
, 24 , 40 , 72 ]. The purpose of the present publication is to contribute to the
field by reporting an early Holocene case of decapitation found in Lagoa Santa,
east-central Brazil.

Lagoa Santa is an environmentally protected area comprising km 2 located in
east-central Brazil Fig 1. The vegetation is dominated by cerrado a
savannah-like vegetation and semi-deciduous forest.


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The rivers Mocambo, Samambaia, Jaguara and Gordura make up a tributary net that
flows west to east towards the Velhas River, the main river in the area.
Geomorphologically, Lagoa Santa is a karstic terrain that can be divided into
four distinct domains [ 83 ]: 1 below meters above sea level masl , the terrain
is characterized by a fluvial plain connected with the regional base level
Velhas River ; 2 between and masl, there is a karstic plain with dolines and
lakes 3 between and masl, there are karstic plateaus characterized by the
presence of limestone outcrops reaching up to 75 meters in height ; 4 above
masl, residual peaks composed of the non-soluble meta-sedimentary rocks from the
Serra da Santa Helena Formation.

This cratonic cover metamorphosed during the Brazilian Cycle — million years ago
in a process that resulted in planar structures, such as lineation and
foliation, and sub-vertical structures, such as normal and revert faults. The
combination of these structures provides the path for the geomorphologic
evolution that leads to the rock shelter configurations found in the region.


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The regional rock shelters and outcrops are developed in the limestone of the
Sete Lagoas Formation. When evaporation is analyzed, the region presents an
annual deficit of mm [ 85 ]. Despite these particular variations, the regional
climate is classified as tropical, with a rainy summer and a dry winter [ 86 ].
During the dry period, the above ground water sources can become very scarce,
although underground drainages are capable of preserving the discharge in the
Velhas River.

The first prehistoric human bones in Lagoa Santa were found by the Danish
naturalist Peter Lund between and [ 87 — 91 ].

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Due to the putative coexistence of humans and megafauna, Lagoa Santa became a
well-known region for 19 th century scholars [ 92 — 95 ]. During the 20 th
century different teams went to the region to find evidence that could confirm
the coexistence hypothesis [ 96 — ]. As a result of more than years of
excavations, a large collection of early Holocene skeletons was gathered [ — ].

However, all those excavations were done without proper documentation and
therefore they lack detailed contextual information. Lapa do Santo was excavated
within the midst of these efforts. The site has an associated sheltered area of
ca. The floor of the shelter has a strong descending inclination towards the
north, which becomes flat again near a natural sinkhole located in the northern
extreme of the sheltered area. Purple and orange areas indicate excavated
surfaces. Pink area indicates the main excavation area MEA.

The bedrock is depicted in gray, and secondary deposits such as breccia and
stalagmites in beige.

The topographic lines are 10 cm equidistant and the associated values correspond
to the z-value of the site coordinate system. Black disk and the black arrow
indicate the position of Burial Numbers in the lower and right margin indicate
the x and y values, respectively, from the coordinate system of site. The
individual in panel 4b has given written informed consent as outlined in PLOS
consent form to publish this image. The chronology of the site is based on OSL
and radiocarbon dates and points to the human presence starting at Three
distinct periods of occupation were determined based on the radiocarbon dates.

Lithic technology [ , ], zooarchaeology [ ], and multi-isotopic analyses [ ]
indicate typical early Archaic groups of hunter-gathers with low mobility and a
subsistence strategy focused on gathering plant foods and hunting small and
mid-sized mammals [ ].


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