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Panasas
 * My Panasas

 * Products
   * Products
     
     PanFS is an integrated portable storage platform that combines a
     high-performance distributed and clustered parallel file system, volume
     manager and software-based erasure-coding data protection. It is the
     software product that powers our family of ActiveStor storage appliances
     and the ActiveStor director appliance. Panasas also provides the ActiveStor
     InfiniBand Router product to connect InfiniBand-based compute clusters and
     the Ethernet-based ActiveStor storage appliances. Explore Products
     
     Read White Paper
   * Overview
   * PanFS
     * PanFS
       
       Panasas® PanFS® is the fastest, most efficient distributed parallel file
       system at any price point. Built on the Linux OS, PanFS runs on commodity
       hardware. Explore PanFS
       
       Read Product Brief
   * ActiveStor Flash
     * ActiveStor Flash
       
       ActiveStor® Flash is an all-flash storage solution with a carefully
       balanced architecture to ensure leading performance density of NVMe SSDs
       that enable outstanding small- and random-file storage performance.
       Designed for AI/ML projects and scratch space environments with high rack
       density. Explore ActiveStor Flash
       
       Read Datasheet
   * ActiveStor Ultra
     * ActiveStor Ultra
       
       The industry’s leading price/performance in an appliance that maximizes
       simplicity, boosts reliability, and delivers the lowest TCO. Explore
       ActiveStor Ultra
       
       Read Datasheet
   * ActiveStor Ultra XL
     * ActiveStor Ultra XL
       
       ActiveStor® Ultra XL is a massive-capacity storage solution delivering
       performance for large file environments and cooler datasets with industry
       leading density up to 5.7PB of data in a single rack – and designed for
       cost-sensitive environments. Explore ActiveStor Ultra XL
       
       Read Datasheet
   * ActiveStor Director
     * ActiveStor Director
       
       ActiveStor Director intelligently processes metadata to orchestrate file
       system activity, applies legacy protocol gateways, and “realm” (storage
       cluster) management. Explore ActiveStor Director
       
       Read Datasheet
   * ActiveStor InfiniBand Router
     * ActiveStor InfiniBand Router
       
       Providing seamless connectivity between InfiniBand-based computer
       clusters and Ethernet-based ActiveStor storage solutions. Explore
       ActiveStor InfiniBand Router
       
       Read Datasheet
 * PanFS Architecture
   * PanFS Architecture
     
     The modular PanFS architecture with Dynamic Data Acceleration eliminates
     the complexity and manual intervention of tiered HPC storage, maximizing
     the performance of diverse storage media in a single, seamless storage
     system. PanFS optimizes performance across a wide variety of use-cases and
     mixed workloads, delivering the best total price-performance for your HPC
     and AI workflows. Explore PanFS Architecture
     
     Read White Paper
   * Overview
   * DirectFlow Client Software
     * DirectFlow Client Software
       
       Easy to install software that implements the DirectFlow protocol,
       enabling superior performance and full POSIX behavior. Explore DirectFlow
       Client Software
   * Exceptional Performance
     * Exceptional Performance
       
       ActiveStor delivers scale-out storage that transfers data between Storage
       Nodes and clients directly and in parallel. Explore Exceptional
       Performance
   * Data Protection
     * Data Protection
       
       ActiveStor’s multiple layers of advanced protection – like Erasure-Coded
       Data Protection, snapshots, and replication – provide confidence that
       grows with scale. Explore Data Protection
   * Linear Scalability
     * Linear Scalability
       
       PanFS® on ActiveStor® Ultra is designed to support linear growth,
       providing scalable performance, streamlined manageability, and
       unparalleled reliability. Explore Linear Scalability
   * Centralized Management
     * Centralized Management
       
       Panasas gives administrators complete realm management capabilities
       through an intuitive web-based GUI. Explore Centralized Management
   * Security
     * Security
       
       Safeguarding customer data through an extensive and efficient
       multi-layered security approach with zero performance impact is a pillar
       of the Panasas PanFS architecture. Explore Security
   * NFS and SMB/CIFS
 * Industries
   * Unique High-Performance Storage for Industries
     
     Panasas® PanFS® on ActiveStor® Ultra is optimized for demanding storage
     environments. No matter what industry you’re in, the solution delivers
     leading price/performance in an appliance that maximizes simplicity, boosts
     reliability, and delivers the lowest total cost of ownership. Explore
     Industries
   * Overview
   * Manufacturing
     * 
     * Overview
     * Computer Aided Engineering
       * Computer Aided Engineering
         
         Create highly accurate simulations and support complex design processes
         that meet the dynamic demands of your customers. The Panasas ActiveStor
         solution helps you accelerate product development while reducing time
         to market. Explore Computer Aided Engineering
     * Electronic Design Automation
       * Electronic Design Automation
         
         Support automated design and simulate conditions on today’s most
         advanced electronic products. The Panasas ActiveStor solution helps you
         run high-performance mixed workloads that support even the most complex
         electronics design and automation (EDA) processes. Explore Electronic
         Design Automation
   * Life Sciences
     * 
     * Overview
     * CryoEM
       * CryoEM
         
         CryoEM applications are demanding on file systems. The ActiveStor
         solution enables the reliability and scalability required handle the
         complex workloads of applications like RELION and cisTEM. Explore
         CryoEM
     * Genomic Sequencing and Bioinformatics
       * Genomic Sequencing and Bioinformatics
         
         Panasas is unique in that it provides the performance and scalability
         that only a parallel file system can provide for genomic analysis — but
         with the simplicity, reliability and mission critical support
         associated with enterprise scale-out NAS. Explore Genomic Sequencing
         and Bioinformatics
     * Computational Chemistry
       * Computational Chemistry
         
         Computing calculations for computational chemistry often take days,
         weeks, or even months. The ActiveStor solution is reliable enough to
         handle the long-term computing needs of researchers. Explore
         Computational Chemistry
   * Financial Services
     * 
     * Overview
     * Modeling & Analytics
       * Modeling & Analytics
         
         The financial services industry creates significant value by developing
         risk management, algorithmic trading, compliance checks, pricing, and
         tax systems strategies through modeling and analytics. With an
         innovative scale-out parallel file system architecture, Panasas
         ActiveStor Ultra delivers extreme performance that automatically adapts
         to financial service workloads and enables comprehensive, optimal
         higher order modeling for increased accuracy and precision. Explore
         Modeling & Analytics
     * Backtesting
       * Backtesting
         
         Financial services strategies are tested against historical data to
         determine how well they perform through a process called backtesting.
         Primarily conducted using the Monte Carlo Method, these simulations
         often involve hundreds of thousands of iterations. By utilizing the
         PanFS parallel file system, application clients have simultaneous and
         incredibly fast direct parallel access to storage nodes. This
         eliminates traditional bottlenecks, easing the strain on the storage
         and enabling faster backtesting. Explore Backtesting
     * Risk Analysis
       * Risk Analysis
         
         One key area of focus in financial services is risk analysis and
         management. Accurate modeling, testing and analysis of risks are
         critical to executing successful financial strategies. In trading
         strategies, modeling can be complex thus improving risk analysis can
         benefit from comprehensive models and increased simulation testing.
         With Panasas ActiveStor Ultra alleviating storage bottlenecks, risk
         analysts can more accurately and readily estimate the risk impacts and
         potential losses. Explore Risk Analysis
   * Energy
     * 
     * Overview
     * Seismic Processing
       * Seismic Processing
         
         Seismic analysis involves acquiring, generating, and recording massive
         data volumes. The ActiveStor solution processes huge data volumes so
         users can suppress noise, enhance signals, and better understand
         seismic events. Explore Seismic Processing
     * Reservoir Simulation
       * Reservoir Simulation
         
         Energy companies need to visualize reservoirs to analyze extraction or
         drilling alternatives. The ActiveStor solution supports process
         modeling and simulation for better forecasting. Explore Reservoir
         Simulation
     * Interpretation and Analysis
       * Interpretation and Analysis
         
         Analysis of seismic data generates models and predictions about
         subsurface properties and structures. Using the ActiveStor solution,
         analysts can make better use of data, improving their competitive
         advantage. Explore Interpretation and Analysis
     * Renewables
   * University
     * 
     * Overview
     * Climate Modeling
       * Climate Modeling
         
         Leading academic research institutions choose the ActiveStor solution
         to create highly accurate climate and weather models using complex
         simulation and analysis of huge data volumes. Explore Climate Modeling
     * Materials Science
       * Materials Science
         
         By streamlining access to computer modeling techniques and accelerating
         complex analysis, the ActiveStor solution helps academic researchers
         develop new materials faster. Explore Materials Science
     * High-Energy Physics
       * High-Energy Physics
         
         With the ActiveStor solution, researchers can unlock the secrets of our
         physical world by using large-scale computer simulation technologies to
         process huge volumes of data. Explore High-Energy Physics
     * Computational Sciences
       * Computational Sciences
         
         The ActiveStor solution helps researchers access, manage, simulate,
         model, and analyze the massive data sets needed to solve complex
         science and engineering problems. Explore Computational Sciences
   * Government
     * 
     * Overview
     * Climate Modeling
       * Climate Modeling
         
         Agencies that monitor, model, and analyze climate and weather changes
         rely on high performance storage solution to run simulations faster,
         even with growing data volumes. Explore Climate Modeling
     * Defense
       * Defense
         
         Leading defense organizations choose the ActiveStor solution to support
         highly accurate mission simulations and accelerate complex analysis for
         enhanced national security. Explore Defense
     * Intelligence
       * Intelligence
         
         To understand adversaries and risks, intelligence organizations count
         on the ActiveStor solution to support the collection, analysis, and
         storage of vast amounts of disparate information. Explore Intelligence
     * Financial Modeling
       * Financial Modeling
         
         Organizations select the ActiveStor solution to support fast, precise
         economic simulation, analysis, and modeling of the effects of interest
         rate changes, forecasts, and agricultural factors. Explore Financial
         Modeling
   * Media & Entertainment
     * 
   * AI/ML
     * Read eBook
     * Artificial Intelligence (Deep Learning)
     * Artificial Intelligence (Deep Learning)
       * Artificial Intelligence (Deep Learning)
         
         Most complex AI solutions make use of sophisticated neural networks
         that require and use the massive computing power of GPUs. This in turn
         demands more intelligence in the storage infrastructure that must
         support this never-ending need for increasing functionality and
         performance. Explore Artificial Intelligence (Deep Learning)
     * Machine Learning
       * Machine Learning
         
         When it comes to the statistical approaches to AI, accuracy and
         time-to-model matter, and the size of the data sets keeps growing.
         Training scales in a near-linear fashion which requires an optimized
         and linearly scalable storage infrastructure. Explore Machine Learning
 * Customers
 * Support
   * Enterprise-Class Support, Services, and Training
     
     Panasas has a reputation for high reliability, thanks to the redundancy and
     resilience built into our products. However, even the highest-quality
     products and the best-architected systems eventually require support.
     That’s why Panasas offers support, professional services, and training that
     will help you maximize your investment and stay within budget. Explore
     Support
   * Overview
   * Support Plans
     * Support Plans
       
       Help IT groups resolve issues quickly so they can meet availability
       requirements and get the most value from your storage system. Explore
       Support Plans
   * Professional Services
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AI AND ML ARE RAPIDLY COMING INTO FOCUS FOR CRYO-EM


Adam Marko | May 17, 2022

Estimated reading time: 3 minutes

Everyone knows by now that tech vendors love to hype artificial intelligence
(AI) and machine learning (ML).

The tendency is understandable when you think about the revolutionary ways these
technologies can enhance the work that humans do. But scientists are typically a
more skeptical and methodical crowd, less likely to get swept up in our periodic
bursts of enthusiasm. And I say this all as someone with experience from both
perspectives: I’ve spent half my career as a researcher and the other half
helping life sciences organizations navigate their complex IT needs.

But progress in high performance computing (HPC) data storage, alongside
promising developments in AI/ML, are ushering in a new frontier. As laboratories
become increasingly reliant on these technologies to keep up with data
generation and analysis, the life sciences community is starting to register
groundbreaking research advances.

I recently attended the 4th International Symposium on Cryo-3D Image Analysis,
which brought researchers from around the world together to talk about how these
changes are manifesting themselves in cryogenic electron microscopy (cryo-EM).
COVID-19 had forced the cancellation of the last conference originally planned
for 2020, so this was the first time in several years that these scientists
could gather in person to compare notes.

Since much of the research covered is still unpublished, I can’t divulge
specifics. But suffice to say that these technologies are driving progress
across the entire scientific pipeline, from sample preparation to data
transmission and analysis, and the excitement about the potential for new
breakthroughs was palpable.



F1. ATPsynthase molecule with the motor domain structure highlighted
Image Source: Sobti et al., “Cryo-EM reveals distinct conformations of E. coli
ATP synthase on exposure to ATP,” eLife (2019). Acquired at UOW Molecular
Horizons cryo-EM facility.

 

A FEW KEY TAKEAWAYS: 

 * We’re at a tipping point where the ability to crunch vast amounts of data
   with the help of AI and ML promises to automate many processes in cryo-EM
   labs and speed time to discovery. The previously labor- and time-intensive
   steps required to distinguish good datasets from bad ones, such as particle
   picking, noise reduction, and error correction, may soon benefit from these
   tools.
 * Cryo-EM holds immense opportunity for the pharmaceutical industry, since
   researchers can now visualize binding sites in proteins (a binding site is a
   region on a macromolecule that binds to another molecule with specificity) in
   record time. This is also good news for nanotechnology, as chip makers
   continue to use cryo-EM to analyze silicon and reduce the time to bring
   products to market.
 * The event reinforced that data storage and management remain pain points for
   many researchers, especially as new generations of microscopes and detectors
   generate more data than ever before. Some scientists don’t want to share
   their data. Others struggle to manage it altogether. In many cases, some
   can’t share, even if they want to, because the data is scattered across
   multiple storage systems. This also makes it difficult, if not impossible, to
   develop training datasets for ML workflows.
 * There’s an overarching urgency to fix that situation. In the future,
   researchers will require more flexible and performant storage systems. I
   anticipate higher demand for parallel file systems specifically, due to their
   unlimited scalability allowing for more performance capacity and data
   protection. Additionally, keeping data spread across silos is simply no
   longer feasible. Consolidating all the data onto one central, easy-to-manage
   system will enable collaboration by making it easier to share that data with
   external institutions, as well as allowing for data reuse and ML training.
 * 

We’re still in the early innings of this historic transition; however, as
researchers equip themselves with better storage and data management tools and
discover new AI/ML applications, we can expect rapid and exciting advancements
throughout the life sciences.

It’s taken a while to reach this point. But we’re on the cusp of witnessing
something big here, and it’s not just hype.

Tags:
 * AI
 * Cryo-Em
 * Life Sciences

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