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Learn About VectorBuilder

VectorBuilder is a global leader in gene delivery technologies. As a trusted
partner for thousands of labs and biotech/pharma companies across the globe,
VectorBuilder offers a full spectrum of gene delivery solutions covering
virtually all research and clinical needs from bench to bedside.  Learn More

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VectorBuilder Wins BioIndustrial Innovation of the Year Award
Study: High Prevalence of Errors Found in Lab-Made Plasmids Globally
VectorBuilder supported Lantu Biopharma's gene therapy drug for Menkes Disease
to receive FDA ODD
VectorBuilder in the News

As a global leader in gene delivery technologies, our innovation and scalability
often make the news. Check out the latest updates from the VectorBuilder
community.

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What Customers Say About VectorBuilder
    
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JAMES COX

Wolfson Inst for Biomedical Research, UK

For several years we have used VectorBuilder for generating expression
constructs and custom AAVs. Designing constructs is easy – either use the
website or send a request of what you want by email - detailed construct designs
are usually in your inbox within 24 hrs. Prices, turnaround times and quality of
product mean that ordering from VectorBuilder is just the obvious decision to
make when planning experiments. I recommend their services to all my friends.


DR. HIDEKI ENDO

Astellas Pharma Inc. /Modality Research Labs

Rich selection of epitope-tags and promoters help you quick design custom
vectors. I no longer waste my time to look into such information.
VectorBuilder's design portal is convenient and useful.


SHU-HSIEN SHEU

Janelia Research Campus, USA

Vectorbuilder's service is extremely consistent. We started with regular
plasmids and AAV plasmids. Since last year we have ordered many piggybac
plasmids. All worked as expected.


ALEXANDER GOGINASHVILI

University of California San Diego, USA

We have successfully generated several vectors with VectorBuilder and very much
hope there will be many more to come. Their website is very easy to navigate.
Timing is really appealing and the prices are convenient. Special thanks to
Shelley Wu, the service rep in San Diego. She is extremely helpful and
approachable. Overall, VectorBuilder is a huge help!


JULIUS BOGOMOLOVAS

UCSD School of Medicine, USA

The straightforward, intuitive interface allowed me to design my construct, by a
simply copying-and-pasting sequence of my gene and choosing the right promoter
and reporter from an impressive scroll down menu. The vector and recombinant
viruses were made on time at a very competitive price with no extra cost for
aliquoting into working aliquots. I highly recommend VectorBuilder for a
complete recombinant virus production pipeline.


EVGENIA SALTA

Katholieke Universiteit Leuven/VIB, Belgium

VectorBuilder has been the partner every researcher would wish for during those
dark moments of paper revision. They offer the complete package: a wide range of
viral vector design options, an extremely user-friendly and intuitive website,
direct communication, personal and knowledgeable step-by-step guidance
throughout the designing and ordering process, accountability, amazing
discounts, unique customer support, fast shipping, and guaranteed virus titers
and efficiency. So here’s my big thumbs up for a great product and service
provider who has proven indispensable in addressing my research questions!


FRANK BORRIELLO

Alloplex Biotherapeutics, USA

VectorBuilder has provided incredible value and customer service throughout the
entire process from product selection, custom design assistance, order
submission, status reports and ultimate delivery management. The custom products
I purchased from them performed exactly as advertised and in fact surpassed my
expectations. I would recommend VectorBuilder to anyone requiring this type of
product.


ORLANDO CHIRIKIAN

University of California, Santa Barbara, USA

It has been a great experience working with Vectorbuilder! Their assistance has
helped me concentrate on answering biological questions rather than dealing with
the hassle of cloning. Vectorbuilder's friendly representatives and timely
delivery make the processes easy.


MIKE MCDONALD

Maavrx Ltd, UK

I readily recommend a Vector Builder. My company has used them to produce
research great plasmids and AAV vectors. They are helpful and responsive and
have always delivered on time and on budget.


YING LIN

T-CURE, USA

We do frequent new vector design and creation for our products. I ordered
several custom vectors from Vector Builder using their evolutional platform.
That platform is easy to put my gene interested and indicator. They synthesis,
sequencing my genes to verify their sequence no mistake and make plasmid for me.
Everything is wonderful. More important is the vector expression at high level
to meet my requirement. I really recommend to use Vector Builder as your vector
designing and creating candidate.


SAEED-UL-HASSAN KHAN

Quaild-i-Azame University, Pakistan

The services provided by VectorBuilder are excellent. I had a few vector
constructs made by the VectorBuilder. The description of the constructs by their
software is excellent. The technical team of the company seems to have a sound
knowledge and the technical suggestion regarding vector construction given to me
by them were excellent.


DR. KEISUKE HITACHI

Fujita Health Univ.

I ordered the cloning of a large gene (about 6 kbp) to the plasmid.
VectorBuilder provided the construct with a correct sequence at a reasonable
price. So I strongly recommend VectorBuilder's services for cloning of large
genes.

View All Testimonials Provide Your Testimonials
Who Is Using VectorBuilder

Who Cited VectorBuilder

 * NLRP3 inflammasome activation through heart-brain interaction initiates
   cardiac inflammation and hypertrophy during pressure overload
   
   Products & Services:  vector cloning, AAV
   Circulation. 2023. doi: 10.1161/CIRCULATIONAHA.122.060860. IF: 39.918

 * Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
   
   Products & Services:  vector cloning, lentivirus, CRISPR
   Nat Genet. 2023. doi: 10.1038/s41588-023-01298-x. IF: 30.8

 * Schwann cell insulin-like growth factor receptor type-1 mediates metastatic
   bone cancer pain in mice
   
   Products & Services:  vector cloning, AAV9
   Brain Behav Immun. 2023. doi: 10.1016/j.bbi.2023.03.013. IF: 15.1

 * Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT
   activation to prevent insulin hyperresponsiveness
   
   Products & Services:  vector cloning, AAV8
   Cell Metab. 2023. doi: 10.1016/j.cmet.2023.03.021. IF: 29

 * Glioblastoma remodelling of human neural circuits decreases survival
   
   Products & Services:  vector cloning, lentivirus, shRNA gene knockdown
   Nature. 2023. doi: 10.1038/s41586-023-06036-1. IF: 64.8

 * DNp63/p73 drive metastatic colonization by controlling a regenerative
   epithelial stem cell program in quasi-mesenchymal cancer stem cells
   
   Products & Services:  vector cloning, lentivirus, inducible gene expression
   Dev Cell. 2023. doi: 10.1016/j.devcel.2022.11.015. IF: 13.417

 * In situ FRET-based localization of the N terminus of myosin binding protein-C
   in heart muscle cells
   
   Products & Services:  vector cloning, adenovirus
   PNAS. 2023. doi: 10.1073/pnas.2222005120. IF: 10.7

 * PHGDH-mediated endothelial metabolism drives glioblastoma resistance to
   chimeric antigen receptor T cell immunotherapy
   
   Products & Services:  vector cloning, MMLV
   Cell Metab. 2023. doi: 10.1016/j.cmet.2023.01.010. IF: 29

 * Genetic and pharmacological modulation of DNA mismatch repair heterogeneous
   tumors promotes immune surveillance
   
   Products & Services:  vector cloning, lentivirus, library construction,
   CRISPR
   Cancer Cell. 2023. doi: 10.1016/j.ccell.2022.12.003. IF: 50.3

 * An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species:
   Targeting neural oxytocin receptors as a proof of concept
   
   Products & Services:  vector cloning, AAV9, CRISPR
   Sci Adv. 2023. doi: 10.1126/sciadv.adf4950. IF:17.6

 * Plastin 3 rescues cell surface translocation and activation of TrkB in spinal
   muscular atrophy homeostasis
   
   Products & Services:  vector cloning, lentivirus, scAAV9
   J Cell Biol. 2023. doi: 10.1083/jcb.202204113. IF: 7.8

 * Dedifferentiation maintains melanocyte stem cells in a dynamic niche
   
   Products & Services:  vector cloning, lentivirus
   Nature. 2023. doi: 10.1038/s41586-023-05960-6. IF: 64.8

 * Antibody gene transfer treatment drastically improves epidermal pathology in
   a keratitis ichthyosis deafness syndrome model using male mice
   
   Products & Services:  vector cloning, AAV8
   EBioMedicine. 2023. doi: 10.1016/j.ebiom.2023.104453. IF: 11.1

 * SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis
   in heart diseases
   
   Products & Services:  vector cloning, AAV9
   Nat Commun. 2023. doi: 10.1038/s41467-023-39027-x. IF: 16.6

 * Chaperone-mediated autophagy promotes PCa survival during ARPI through
   selective proteome remodeling
   
   Products & Services:  vector cloning, shRNA gene knockdown, piggyBac
   Oncogene. 2023. doi: 10.1038/s41388-022-02573-7. IF: 8

 * The ion channel CALHM6 controls bacterial infection-induced cellular
   cross-talk at the immunological synapse
   
   Products & Services:  vector cloning, MMLV
   EMBO J. 2023. doi: 10.15252/embj.2022111450. IF: 11.4

 * Somatic mutations can induce a noninflflamed tumour microenvironment via
   their original gene functions, despite deriving neoantigens
   
   Products & Services:  vector cloning, MMLV, lentivirus, shRNA gene knockdown
   Br J Cancer. 2023. doi: 10.1038/s41416-023-02165-6. IF: 8.8

 * A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing
   of infected cells
   
   Products & Services:  stable cell line, S protein-pseudotyped lentivirus
   Front Immunol. 2023. doi: 10.3389/fimmu.2023.1204543. IF: 7.3

 * Noncanonical role of singleminded-2s in mitochondrial respiratory chain
   formation in breast cancer
   
   Products & Services:  vector cloning, lentivirus, CRISPR
   Exp Mol Med. 2023. doi: 10.1038/s12276-023-00996-0. IF: 12.8

 * An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau
   pathology
   
   Products & Services:  vector cloning, AAV-PHP.eB
   Neuron. 2023. doi: 10.1016/j.neuron.2023.05.006. IF: 16.2

 * Stromal changes in the aged lung induce an emergence from melanoma dormancy
   
   Products & Services:  vector cloning, lentivirus, inducible gene expression
   Nature. 2022. doi: 10.1038/s41586-022-04774-2. IF: 69.504

 * Lipolysis drives expression of the constitutively active receptor GPR3 to
   induce adipose thermogenesis
   
   Products & Services:  vector cloning, AAV
   Cell. 2021. doi: 10.1016/j.cell.2021.04.037. IF: 66.85

 * Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in
   a mouse model of hemochromatosis
   
   Products & Services:  vector cloning, adenovirus, CRISPR
   Blood. 2022. doi: 10.1182/blood.2021013452. IF: 25.476

 * Prenatal interleukin 6 elevation increases glutamatergic synapse density and
   disrupts hippocampal connectivity in offspring
   
   Products & Services:  vector cloning, lentivirus, shRNA gene knockdown
   Immunity. 2021. doi: 10.1016/j.immuni.2021.10.006. IF: 43.474

 * Indomethacin-induced oxidative stress enhances death receptor 5 signaling and
   sensitizes tumor cells to adoptive T-cell therapy
   
   Products & Services:  vector cloning, MSCV
   J Immunother Cancer. 2022. doi: 10.1136/jitc-2022-004938. IF: 12.469

View 5000+ Citations
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