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Menu Search * Home * News * Health Tech * Biopharma * Devices & Diagnostics * Consumer / Employer * Contributors * MedCity Influencers * MedCitizens * Events * Jobs * Research * About Us * Advertising * Contact us * Send Tips * Advertising * About * Twitter * Facebook * RSS * Subscribe via email X Close Signup Modal MEDCITY >> INBOX Get the latest industry news first when you subscribe to our daily newsletter. We will never sell or share your information without your consent. See our privacy policy. * Send Tips * Advertising * About * Twitter * Facebook * RSS * Subscribe via email MEDCITY NEWS GALVANI BIOELECTRONICS IMPLANTS FIRST NEUROSTIMULATOR FOR SPLENIC NERVE STIMULATION IN RHEUMATOID ARTHRITIS PATIENT INDEPENDENT VALIDATION SHOWS HELLO HEART CAN SAVE EMPLOYERS AN AVERAGE OF $1,865 PER PATIENT REPORT PREDICTS TOP GROWTH OPPORTUNITIES IN HEALTHCARE, LIFE SCIENCES ARCELLX’S IPO RAISES $124M TO FUEL CHASE OF BETTER CAR T-CELL THERAPY FOR CANCER CALIFORNIA’S SECRET DEAL WITH KAISER PERMANENTE JEOPARDIZES MEDICAID REFORMS, SHOWS PREFERENTIAL TREATMENT AI AND ANALYTIC TOOLS PLATFORM PARTNERS WITH RARE DISEASE ADVOCACY GROUPS AUDITS AND PENALTIES POSSIBLE FOR NONCOMPLIANCE WITH NEW NOTIFICATION, DIGITAL CONTACT RULES UNITY BIO SLASHES HEADCOUNT IN HALF TO SAVE CASH AHEAD OF EYE DRUG READOUTS ARE YOU LOOKING FOR LEADS TO FILL THE PIPELINE? STARTUPDATES: NEW DEVELOPMENTS FROM HEALTHCARE STARTUPS THE WAR FOR CLOUD AND CYBERSECURITY TALENT IS ON! BEYOND THE VIRTUAL VISIT: DELIVERING ON THE OPPORTUNITY OF DISTRIBUTED CARE CONCERTOCARE RAISES $105M TO EXPAND AT-HOME CARE FOR SENIORS MENTAL HEALTH THERAPISTS SEEK EXEMPTION FROM PART OF LAW TO BAN SURPRISE BILLING INTELLIA’S REWRITE THERAPEUTICS BUYOUT BRINGS NEW PRECISION TO GENE EDITING * News * Health Tech * BioPharma * Devices & Diagnostics * Consumer / Employer * Contributors * MedCity Influencers * MedCitizens * Events * INVEST * INVEST PharmaTech * INVEST Digital Health * INVEST Population Health * Jobs * Research Don’t miss MedCity INVEST 2022 – March 28-30 at the Ritz-Carlton Chicago Pharma, BioPharma UNITY BIO SLASHES HEADCOUNT IN HALF TO SAVE CASH AHEAD OF EYE DRUG READOUTS UNITY BIOTECHNOLOGY'S CORPORATE RESTRUCTURING IS A CASH-SAVING MOVE THAT ALLOWS THE COMPANY TO FOCUS RESOURCES ON ITS LEAD PROGRAM, A DRUG IN PHASE 2 TESTING FOR DIABETIC MACULAR EDEMA AND WET AGE-RELATED MACULAR DEGENERATION. UNITY PREVIOUSLY RESTRUCTURED IN 2020 FOLLOWING THE PHASE 2 FAILURE OF ITS OSTEOARTHRITIS DRUG. By Frank Vinluan Post a comment / Feb 4, 2022 at 12:17 PM 0Shares For the second time in 16 months, Unity Biotechnology is restructuring its operations. The developer of drugs to treat diseases of aging is cutting its headcount in half to ensure its cash reserves last through key data readouts for its lead therapeutic candidate, a drug in mid-stage development for two eye disorders. Promoted THE SUPPLY CHAIN CRISIS IS SPURRING COMPANIES TO TRANSFORM PRODUCTION AND SOURCING STRATEGIES TO REDUCE RISK The report, Resilience in volatility: Modernizing the supply chain, highlights three areas that Fortune 500 and mid-size companies need to address to implement technology such as machine learning, cloud computing and risk management tools to improve production and delivery. MedCity News and Microsoft The corporate shakeup will leave Unity with about 34 employees by mid-year, the South San Francisco-based company said in its announcement after the market close Thursday. In a regulatory filing, Unity said that it will incur a one-time benefits and severance charge of about $1.8 million. The company expects to save enough cash to carry the company into the first quarter of 2023. At the end of the third quarter of last year, Unity reported $21.9 million in cash and cash equivalents. Unity aims to treat diseases of aging by addressing the accumulation of senescent cells, which are older cells that have stopped dividing. These cells continue to secrete proteins that lead neighboring cells to also become senescent. According to the company, the result is aged or diseased tissue that underlies a variety of age-related conditions. In the eye, Unity’s target is the Bcl-2 family of proteins, which regulate the balance between cell survival and cell death. Unity says senescent cells rely on BcL-2 proteins to survive and accumulate in tissue. Lead drug candidate UBX1325 is a small molecule designed to block one particular protein called Bcl-xL; doing so is intended to lead to the death of senescent cells. Unity licensed rights to the molecule from Ascentage Pharma. That China-based biotech retains rights to the drug for applications in cancer. Unity had advanced UBX1352 to mid-stage clinical testing. The company expects 12-week data from a Phase 2a study in diabetic macular edema by mid-year, as well as 24-week safety and efficacy data from that same study by the end of the year. Separately, 16-week safety and efficacy data from a Phase 2 study in the wet form of age-related macular degeneration (AMD) are expected in the fourth quarter of this year. The drug is also being evaluated in an additional group of patients who have wet AMD. The company expects 24-week data from that Phase 1 study will become available in the first half of this year. Promoted HOW TO FIND PAPERS WHEN YOU DON’T HAVE A LIBRARY For researchers who aren’t affiliated with an academic library, finding scientific papers can be time-consuming and expensive—and organizing and sharing them with co-workers can be even harder. A new tool by DeepDyve looks to help researchers address this gap. DeepDyve Digital Library Team In addition to developing drugs that target senescent cells, Unity is also exploring other biological drivers of aging. A preclinical program is targeting Tie2, a protein associated with the function of the barrier that regulates the flow of materials into and out of the retina. The company said it expects to select a Tie2 candidate in the middle of this year. Unity said that most of the job cuts are in drug discovery research. The corporate restructuring is putting Unity’s neurological drugs on pause. The company’s pipeline has two neuro programs, one for cognitive disorders and another for neurodegenerative conditions. Both are preclinical. “It was a difficult but prudent decision to align our resources around our ophthalmology programs and I believe this sharpened focus will propel us forward to key milestones, including Phase 2 data inflection points this year,” Unity CEO Anirvan Ghosh said in a prepared statement. “These datasets could represent a transformative therapeutic option for patients based on UBX1325’s novel mechanism of action.” Ophthalmology was not the first target of Unity’s drug research. The company’s former lead program was a drug that targeted senescent cells associated with osteoarthritis. In 2020, that drug failed a Phase 2 study, sparking a corporate restructuring that slashed headcount by 30%. The restructuring refocused the company around its ophthalmology assets, including UBX1325, which was preclinical at that time. Photo: Karen Bleier/AFP, via Getty Images 0Shares TOPICS age-related macular degeneration, Aging, biopharma nl, Clinical Trials, diabetic macular edema, South San Francisco, Unity Biotechnology HEAR THE LATEST INDUSTRY NEWS FIRST. SIGN UP FOR OUR DAILY NEWSLETTER. We will never sell or share your information without your consent. See our privacy policy. Promoted THE EMERGING GOLDEN ERA OF NEUROSCIENCE Bill Martin, the Global Therapeutic Area Head of Neuroscience at The Janssen Pharmaceutical Companies of Johnson & Johnson, shared some of the promising developments in the neuroscience space, such as the rise of neuro-immunology and the industry’s embrace of digital health tools to support drug development in a recent interview. Stephanie Baum MEDCITY INVEST 2022 JOIN US AT MEDCITY INVEST 2022 MedCity INVEST, held March 28-30, 2022 at the Ritz-Carlton Chicago, is the premier national healthcare investing conference based in the Midwest, uniting active investors with corporate business development executives to facilitate investment opportunities with the most promising healthcare startups. Reserve your spot now.>> GOT NEWS? SEND US A TIP MEDCITY >> INBOX Get the latest industry news first when you subscribe to our newsletter. We will never sell or share your information without your consent. See our privacy policy. Promoted MEDICAL-COMMERCIAL COLLABORATING TO WIN IN THE DIGITAL ERA It’s clear that life science companies need to transform their approach to be much more collaborative in the way they work with healthcare professionals. Microsoft and MedCity News × HEAR THE LATEST INDUSTRY NEWS FIRST. SIGN UP FOR OUR DAILY NEWSLETTER. No thanks We will never sell or share your information without your consent. 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