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3D cell culture is an environment that allows cells to grow in interact in a
three-dimensional environment. In contrast to traditional 2D cutlures which
cells grow in a monolayer on a plate.


WHAT IS 3D CELL CULTURE?

We are distributors for all things 3D cell culture. We supply membrane extracts
media, with extracellular matrices such as neuronal cells, muscle cells,
endothelial cells, and epithelial cells.

3Dmatrix Basement Membrane Extract (BME) and Extracellular Matrices (ECM) are
between endothelial, epithelial, muscle, or neuronal cells and their adjacent
stroma. Products include a full range of matrices and purified proteins
including Basement Membrane Extracts, Laminin I, Collagen I, Collagen IV,
Vitronectin, and Fibronectin, as well as scaffolding equipment and other
molecular biology tools.

Basement membrane extracts (BME) are crude ECM mixtures that may contain
collagen, laminin, entactin and HSP. Which are isolated from the ECM (Engelbreth
Holm Swarm (EHS) sarcoma tumors in mice. BME’s provide a coating for numerous
cell types to grow and recapitulates the natural ECM environment found in
tissues hence mimicking a natural growth state.


APPLICATIONS:

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ANALYTICALCHEMISTRY

CELL CULTURE & ANALYSIS

CHEMISTRY & DIAGNOSTICS

CLINICAL & DIAGNOSTICS

PHARMA & BIOPHARMA

PROTEIN BIOLOGY

PRODUCTS

CELL MATRICS

Custom plate loaded with basement membrane extract with our proprietary mix. ECM
combination custom desighed for you our end users needs. Can contain Laminin,
Collagen, nections, Fibronections and other scaffolding regents.

CELL CULTURE

Please inquire as to our custom blend of ECM mixed use media. We also sell serum
and other media in small lots to bioprocess level needs

SERVICES

We offer customer blend of all reagents for your 3D cell culture needs.

CHARACTERIZATION

We offer specialty services for working with our customers for custom blens of
our hundreds of media product and ECM.

CONTRACT MANUFACTURING

We offer our customer custom solutions for your 3D cell culture needs

PLEASE CONTACT US FOR A CATALOG

Email Us

3D CELL CULTURE AND CANCER: A CASE STUDY

3-dimensional; address; adopted; attenuation; base; biological assay; biopsy;
cancer patient; cancer therapy; cancer type; cell adhesion; cell culture
techniques; cell nucleus; cell survival; cell type; cells; chemicals;
chemosensitivity assay; chemotherapy; clinical application; clinical trials;
combined modality therapy; cultured cells; data; data set; design; development;
diffusion; dimensions; dose; drug combinations; drug discovery; drug testing;
drug usage; end point assay; ethanol; fractals; future; genomics; guidelines;
hour; image; image processing; imaging study; imaging technology; in vitro; in
vivo; individual; individual patient; individualized medicine; innovation;
investigation; label; longitudinal dataset; lung; malignant breast neoplasm;
malignant neoplasm of liver; malignant neoplasms; measurement; measures;
medicine; membrane; metabolism; methods; microscopy; neoplastic cell; novel
strategies; oligomycins; oncology; optical coherence tomography; optics; optimal
treatments; outcome; paclitaxel; pancreas; patient monitoring; patient
population; patients; personalized medicine; pharmaceutical preparations;
physicians; pilot projects; population; precision medicine; precision medicine
initiative; precision oncology; prevent; process; research; response; sampling;
sensitivity and specificity; series; signal transduction; specificity;
statistics; surface; techniques; technology; testing;

three dimensional cell culture; time; tissue engineering; tissues; toxicity
tests; tumor; tumor cell line; tumor microenvironment; validation; variant;

summary when selecting cancer therapy, physicians generally begin with
first-line treatment options and monitor patient progress on a watch-and-wait
basis, following a set of guidelines based on clinical trials from a large
patient population. but this traditional method has been questioned on whether
it provides individual patients with the optimal treatment. to better find a
matching treatment individually, a concept called precision cancer medicine or
personalized cancer medicine has been studied. among other approaches,
functional precision medicine directly tests chemotherapy options on tumor cells
biopsied from a patient to find the best matching treatment for the specific
patient. this promising approach, however, has not been widely adopted by
clinicians because the tumor microenvironment in a lab differed from the one
within the patient?s body, leading to inconsistent drug responses between the
sample and patient, and the quantity of biopsied cells is generally insufficient
for a reliable number of options to be tested. the first problem is being
addressed by recent advances in three- dimensional (3d) cell culture techniques,
which better mimic the body?s microenvironment in a lab. but the second problem,
the limited number of testable options, is mainly due to limitations in the
current assay techniques that assess chemosensitivity in 3d culture. with most
current assays, a sample can only be tested once, and multiple drugs with
different mechanisms of action cannot be simultaneously tested by a single
assay. combined, these limitations exponentially reduce the number of testable
options when involving multiple assessment time points to design a sequential
therapy or when increasing the number of drugs to test a combination therapy.
here, we will develop a new technique for the assessment of chemosensitivity in
3d culture, by maximizing the potential of a label-free 3d microscopy
technology, called optical coherence tomography (oct). the majority of prior oct
research measured only one or two types of signals and showed the signals
corresponding to only a single type of cell viability disruption process in each
study. but this approach has led to a concern about specificity (i.e., other
types of processes than the one tested in the study can generate similar oct
signals). this low specificity, along with unclear mechanisms of viability
assessment, have prevented oct methods from being adopted for the promising
concept of functional precision medicine. therefore, we will develop at least 18
different types of oct signals and establish their sensitivity and specificity
to four major types of viability disruption processes. the feasibility of this
approach has been strongly supported by a pilot study where we imaged and
analyzed more than 6,000 3d-cultured cell spheroids. this r01 project will image
and analyze up to 100,000+ spheroids for an unprecedentedly systemic
investigation of the comprehensive range of oct signal types


CONTACT US

JILL MACCONNAGLE

Director of Marketing

Email

ANDREW CARION

Director of Sales

Email

COLLEEN KELLY

Sales

Email

DANA

Technical Support

Email

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