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IAVI Skip to content
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* Our Work
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AFFORDABLE, ACCESSIBLE VACCINES & ANTIBODIES
We are a nonprofit scientific research organization that develops vaccines and
antibodies for HIV, tuberculosis, and emerging infectious diseases.
About us
OUR APPROACH
--------------------------------------------------------------------------------
We take a full-circle approach to product development, from the grassroots level
to the lab to legislative bodies.
MISSION
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To translate scientific discoveries into affordable, globally accessible public
health solutions.
VISION
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A world where all people have equitable access to innovative vaccines and
therapeutics.
OUR HEALTH AREAS
* HIV
* Tuberculosis
* Lassa fever
* Marburg virus
* Sudan Ebolavirus
* COVID-19
HIV
THE CHALLENGE
HIV/AIDS remains one of the deadliest infectious diseases, with 1.3 million
people acquiring HIV in 2023. Given the complexities of HIV, traditional
approaches to vaccine development have so far failed to result in a vaccine that
provides protection against HIV. However, a vaccine is still needed to bring a
true end to the HIV pandemic. Source: UNAIDS
OUR SOLUTION
IAVI scientists and our collaborators are developing next-generation HIV
vaccines to address the challenges of HIV vaccine design. Together, we have
pioneered promising new vaccination strategies and the discovery of broadly
neutralizing antibodies (bnAbs) against HIV. IAVI and our partners are
developing HIV bnAbs to prevent HIV acquisition while we advance vaccine
candidates.
TUBERCULOSIS
THE CHALLENGE
Tuberculosis (TB) is the world’s leading infectious disease killer. In 2023,
10.8 million people fell ill with TB and 1.25 million people died of TB disease.
The only available TB vaccine is the century-old Bacille Calmette-Guérin, or
BCG. While this vaccine has efficacy in protecting against severe TB disease in
infants and young children, it is largely ineffective in adolescents and adults,
among whom most transmission and disease occurs. Source: WHO
OUR SOLUTION
IAVI works across our global hubs with a diverse network of partners to advance
the most promising TB vaccine candidates from discovery through clinical trials,
and eventually, to post-licensure access. Our work extends to policy and
advocacy initiatives that support TB vaccine development and access in regions
where new vaccines are needed most.
LASSA FEVER
THE CHALLENGE
Lassa fever is an acute viral hemorrhagic illness endemic to West Africa that
causes significant annual outbreaks of disease. Lassa fever is difficult to
diagnose, and surveillance data is limited. Current estimates range from 300,000
to 500,000 cases and 5,000 related deaths each year. No licensed vaccines for
Lassa fever exist. Source: WHO
OUR SOLUTION
IAVI is developing a single-dose vaccine candidate for Lassa that is based on a
recombinant vesicular stomatitis virus (rVSV) vector. This technology is similar
to that underlying an approved Ebola Zaire virus vaccine. IAVI’s Lassa vaccine
candidate was well tolerated and immunogenic over a wide dose range in a Phase I
clinical study. IAVI also conducts Lassa epidemiological studies and modeling to
support future vaccine access.
MARBURG VIRUS
THE CHALLENGE
Marburg virus is a filovirus and the causative agent of Marburg virus disease
(MVD), which has a case fatality ratio of up to 88%. Marburg virus has the
capacity to cause outbreaks with high fatality rates and is a potential
bioterror threat. No vaccines or antiviral treatments are approved for MVD. A
Marburg vaccine is urgently needed to respond to future outbreaks. Source: WHO
OUR SOLUTION
IAVI is developing a vaccine candidate for Marburg that is based on a
recombinant vesicular stomatitis virus (rVSV) vector. This technology is similar
to that underlying an approved Ebola Zaire virus vaccine, which is now approved
by the U.S. FDA and registered for use in several African countries. Preclinical
data demonstrates that IAVI’s Marburg vaccine candidate is highly protective in
an animal model with one dose.
SUDAN EBOLAVIRUS
THE CHALLENGE
Sudan ebolavirus is a filovirus and causes outbreaks of Ebola disease, most
recently in 2022 in Uganda. Case fatality rates of Ebola disease caused by Sudan
ebolavirus have varied from 41% to 100% in past outbreaks. The licensed vaccine
for Ebola Zaire virus does not provide cross protection against the Sudan
strain. An Ebola Sudan vaccine is urgently needed to prevent and respond to
future outbreaks. Source: WHO
OUR SOLUTION
IAVI is developing a vaccine candidate for Sudan ebolavirus that is based on a
recombinant vesicular stomatitis virus (rVSV) vector similar to the technology
underlying an approved Ebola Zaire virus vaccine. During the 2022 Ebola outbreak
in Uganda, the WHO selected IAVI’s Sudan ebolavirus vaccine candidate for a
planned ring vaccination trial. While the trial did not go forward due to
outbreak control, IAVI has continued clinical development to prepare for future
outbreaks.
COVID-19
THE CHALLENGE
Since December 2019, over 760 million cases of COVID-19 and 6.9 million deaths
have been recorded worldwide, but the actual number is thought to be higher.
While highly effective, approved COVID-19 vaccines do not fully block
transmission or breakthrough infection. Additional COVID-19 vaccines continue to
be an urgent need, particularly vaccines suitable for widespread use in middle
and low-income countries. Source: WHO
OUR SOLUTION
IAVI is developing a COVID-19 vaccine candidate that is based on a recombinant
vesicular stomatitis virus (rVSV) vector. The vaccine candidate has demonstrated
safety in humans when administered intramuscularly and has been produced at
scale to support larger future clinical trials. IAVI is also investigating an
intranasal formulation of our COVID-19 vaccine candidate to prevent infection.
OUR IMPACT
--------------------------------------------------------------------------------
WE CONDUCT PRECLINICAL AND CLINICAL TRIALS OF OUR OWN VACCINES AND ANTIBODIES.
OUR FOCUS IS ON DISEASES OF GLOBAL IMPORTANCE FOR WHICH THERE IS NO MARKET AND
LITTLE FINANCIAL INCENTIVE FOR DEVELOPMENT. WE ALSO COLLABORATE WITH AND SUPPORT
OTHER SCIENTIFIC ORGANIZATIONS TO CONDUCT THEIR OWN CLINICAL TRIALS OF PRIORITY
DISEASE PREVENTION AND THERAPEUTIC INTERVENTIONS.
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255 partners from academic, biotech, pharma sectors, civil society, and global
health initiatives
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53 biologics candidates supported by the IAVI Product Development Center, out of
which 25 advanced to clinical trials
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70,000 volunteers enrolled in observational epidemiology studies
OUR LOCATIONS
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IAVI AFRICA
* Cape Town Office, South Africa
* Nairobi Office, Kenya
IAVI EUROPE
* Amsterdam Office, The Netherlands
* Human Immunology Lab, London, U.K.
IAVI INDIA
* Gurugram, Haryana Office
* Antibody Translational Research Program, IAVI-THSTI, Faridabad
IAVI U.S.
* New York Office
* Vaccine Design & Development Lab, New York
* Neutralizing Antibody Center, California
RECENT NEWS & MEDIA
Previous Next
Features
MEET THE SCIENTIST: DR. GAUDENSIA MUTUA ON IAVI’S LASSA FEVER VACCINE
DEVELOPMENT PROGRAM
December 20, 2024
In this episode of Meet the Scientist, IAVI’s podcast series, we sat down with
Gaudensia Mutua, a medical director with IAVI in Nairobi, Kenya, to discuss her
work in support of IAVI’s Lassa fever vaccine program. We delved into the value
of community-engaged scientific research before looking ahead to the future of
global health and […]
Read More
Features
ACCESS TO MONOCLONAL ANTIBODIES IN AFRICA: A CALL TO ACTION
December 17, 2024
IAVI and Impact Global Health today published a new report evaluating the
current state of research and development (R&D) and access for monoclonal
antibodies (mAbs) and related products. The report, funded by Wellcome, is a
four-year retrospective on the availability of mAbs and biosimilars globally —
with new insights into the African region that could […]
Read More
Press Release
IAVI AND IPD SIGN AGREEMENT FORMALIZING COLLABORATION TO ADVANCE VACCINE
DEVELOPMENT, MANUFACTURING, AND ACCESS IN AFRICA
December 13, 2024
Dr. Amadou Alpha Sall & Dr. Mark Feinberg sign agreement at IPD Vaccinopole de
Diamniadio (Madiba). DAKAR, SENEGAL — December 13, 2024 — IAVI, a nonprofit
scientific research organization dedicated to addressing urgent global health
challenges including HIV, tuberculosis, and emerging infectious diseases (EIDs),
and the Institut Pasteur de Dakar (IPD), a non-profit foundation focused […]
Read More
IAVI Report
TB VACCINES: ACHIEVABLE NOT ASPIRATIONAL
December 05, 2024
The tuberculosis (TB) vaccine field has experienced a renaissance in recent
decades. Until the 1990s, no novel TB vaccine candidates had been developed
since the introduction of the Bacillus Calmette-Guérin vaccine in 1921. Since
then, the field has advanced slowly but surely against what is once again the
world’s deadliest infectious disease. These advances helped […]
Read More
Features
OUTTHINKING AND OUTSMARTING HIV TO OUTDO AN EPIDEMIC
December 03, 2024
By John Kimotho For over four decades, the world has fought tirelessly to close
the tap on new HIV infections. Yet, this relentless virus continues to plague
sub-Saharan Africa, draining health resources from systems stretched thin by the
burden of malaria and tuberculosis. Africa had hoped to end these diseases by
2030 under the AU […]
Read More
Features
IAVI COMMEMORATES WORLD AIDS DAY IN A LANDMARK YEAR FOR HIV PREVENTION
December 02, 2024
December 1 marks World AIDS Day. More than 40 years after HIV was first
identified, 1.3 million people still acquire HIV annually, and more than 600,000
lose their lives to AIDS-related causes. The burden of HIV remains inequitably
distributed, with a disproportionate burden on those in sub-Saharan Africa. The
theme of this year’s World AIDS […]
Read More
The state of vaccine science now is far more powerful and sophisticated than it
has ever been. And I am confident that many of these challenges that we face
will be solved by vaccine development.
Mark Feinberg
President & CEO
We are a nonprofit scientific research organization that develops vaccines and
antibodies for HIV, tuberculosis, and emerging infectious diseases.
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New York, NY 10004
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