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LIVE A LONGER, AND HEALTHIER LIFE!

Don’t settle for a single ingredient to support healthy aging. AEON™ is the only
product to offer an 11-compound longevity complex that addresses everything from
oxidative stress, glycation, telomere shortening, to side reactions, and
mutations [*].

New studies show each of these compounds when taken daily extend life in mice &
primates up to 30% [*]. Promising studies in humans are currently underway.

Furthermore, a synergistic effect happens when they're compounded that has been
associated with a reduced risk of all-cause mortality, diabetes, stroke, and
heart-disease-related death [*].

Below we'll break down the origin, and effects of each ingredient in AEON™ with
links to independent, peer-reviewed studies.

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LONGEVITY ESSENTIALS:

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COMPOUNDS IN AEON™:


NICOTINAMIDE DUO™

Nicotinamide DUO™ is a proprietary NAD+ precursor developed by Perpetua.Life®
Biotech based on a an 80/20 blend of Mono/Riboside (LNR) which has been found to
boost NAD+ level even higher than Riboside alone.

NAD+ is a compound found in every cell in your body and involved in many
critical processes, including energy metabolism, DNA repair, and gene expression
(22, 23).

NAD+ levels decline with age, and this decline is thought to be associated with
accelerated physical decline and the onset of age-related diseases like
Alzheimer’s (23).

Studies have shown that supplementing with NAD+ precursors like NR restores NAD+
levels and prevents age-related physical decline (24)

For example, a study in aging subjects demonstrated that supplementing orally
with Nicotinamide Mono prevented age-associated genetic changes and improved
energy metabolism, physical activity, and insulin sensitivity (24B).

A 2019 study in 12 men with an average age of 75 showed that supplementing with
up to 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal
muscle and reduced levels of inflammatory proteins in the body (25).


FISETIN

Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it
can kill senescent cells.

Fisetin as an anticancer agent targeting the growth signaling pathways (F01).

Fisetin and Its Role in Chronic Diseases (F02).

Fisetin: A bioactive phytochemical with potential for cancer prevention and
pharmacotherapy (F03).

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
(F03).

Rodent studies suggest that it may reduce the number of senescent cells in
tissues and extend lifespan (41).

Fisetin: a dietary antioxidant for health promotion (F04)

Exploring the molecular targets of dietary flavonoid fisetin in cancer (F05).






QUERCETIN

Quercetin is a plant pigment (flavonoid). It is found in many plants and foods,
such as red wine.

Quercetin has antioxidant and anti-inflammatory effects which might help reduce
inflammation, kill cancer cells, control blood sugar, and help prevent heart
disease (Q1).

Quercetin in cancer prevention and therapy (Q2).

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
(F03).

Quercetin: A functional dietary flavonoid with potential chemo-preventive
properties in colorectal cancer (Q3).

A preliminary investigation demonstrating the effect of quercetin on the
expression of genes related to cell-cycle arrest, apoptosis and xenobiotic
metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray (Q4).

Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and
aging-related genes in young and old human lung fibroblast cells (Q4).




RESVERATROL

Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may
promote longevity by activating certain genes called sirtuins. It has been shown
to increase the lifespan of fruit flies, yeasts, and nematodes (42).

Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain
Function During Aging (R4)

Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal
injury (R3)

Role of resveratrol in regulation of cellular defense systems against oxidative
stress (R2).

Effect of resveratrol and pterostilbene on aging and longevity (R1).

Resveratrol improves oxidative stress and prevents the progression of
periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant
defense pathways in a periodontitis model (R5).

Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and
aging-related genes in young and old human lung fibroblast cells (Q4).




ASTRAGALUS

Astragalus membranaceus is a stress-reducing herb used in traditional Chinese
medicine. It may help combat aging by reducing oxidative stress, promoting
immune function, and preventing cellular damage (40).

Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR
pathway to increase cellular autophagy level in vitro (A2).

Astragalus membranaceus: A Review of its Protection Against Inflammation and
Gastrointestinal Cancers (A1).

Discovery of potent telomerase activators: Unfolding new therapeutic and
anti-aging perspectives with astragalus (A3).

Experimental and clinical studies of mechanisms of the anti-aging effects of
chemical compounds in Astragalus membranaceus (A4).

Astragalus (a traditional Chinese medicine) for treating chronic kidney disease
(A5).


EPIGALLOCATECHIN GALLATE (EGCG)

Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated
in green tea. It offers impressive health benefits, with research supporting its
use to reduce the risk of certain cancers, as well as other health conditions
like heart disease (9, 10, 11).

Among EGCG’s diverse array of potential health-promoting properties is its
ability to promote longevity and protect against age-related disease
development.

EGCG may slow aging by restoring mitochondrial function in cells and acting on
pathways involved in aging, including the AMP-activated protein kinase signaling
pathway (AMPK).

It also induces autophagy, the process by which your body removes damaged
cellular material (12).

EGCG intake has been associated with a reduced risk of all-cause mortality,
diabetes, stroke, and heart-disease-related death. Plus, animal studies have
shown that it can protect against skin aging and wrinkles caused by ultraviolet
(UV) light (13, 14, 15).


TRIMETHYLGLYCINE

TMG has outstanding effects on controlling homocysteine levels in the blood.
Homocysteine significantly increases around the middle stage of life, and it's
linked to the development of heart disease and stroke.

In a breast cancer study, having more TMG in patients' diets was linked to fewer
deaths from cancer [source].

In another study of more than 2800 lung cancer patients, high betaine intake was
found to be protective against lung cancer [source].

A study including 193 senior citizens showed that an increase in TMG was linked
to improvements in response time, memory, and brain function. People whose TMG
levels went up the most also saw the most improvement in their memories
[source].

Additionally, TMG is also being explored as treatment for other neurological
disorders such as Alzheimer's disease [source].


L-THEANINE

L-theanine is an amino acid concentrated in certain teas, including green tea.
It may help protect against mental decline and has been shown to extend the
lifespan of roundworms by around 5% (35, 36).

l-Theanine attenuates liver aging by inhibiting advanced glycation end products
in d-galactose-induced rats and reversing an imbalance of oxidative stress and
inflammation (T1).

Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced
Inflammation and Acute Liver Injury (T2).

L-Theanine extends lifespan of adult Caenorhabditis elegans (T3).

The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible
neuroprotective and cognitive enhancing agent (T4).

l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent
Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal
Abnormalities in the Mesocorticolimbic Circuitry
(T5).


SPERMIDINE

Spermidine has anti-inflammatory and anti-antioxidant properties, and can also
enhance respiration and metabolic function. Increased dietary spermidine intake
is thought to reduce the risk of diseases like cancer, metabolic disease, heart
disease and neurodegeneration [1].

It can also improve memory and slow cognitive decline, as autophagy clears
Alzheimer’s-causing amyloid-beta plaques in the brain and can thereby be used to
prevent memory loss in older people suffering from mild dementia [2].



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Perpetua.Life® Biotech:

Las Vegas:
6565 Nascar St. Ste 300
North Las Vegas, NV 89115

Atlanta:
5300 Kennedy Rd.
Forrest Park, GA 30297

Melbourne, AU:
21/27 Marshall Ct,
Altona, VIC 3018 Australia

Help: support@perpetua.life


Stay up to date on Longevity Research:

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