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PACE ™


PROPELLING ALZHEIMER’S CARE ENHANCEMENT

This practice resource is supported by an educational grant from Lilly.




EDUCATIONAL ACTIVITIES

Dementia Specialists
June 20, 2024
Preparing Your Practice for the New Era of Amyloid-Targeting Therapies in
Alzheimer's Disease: Expert Insights on Key Evidence, Administrative and
Clinical Considerations, and Best Practices for Individualized, Patient-Centered
Care
Stephen Salloway, MD, MS
Sharon J. Sha, MD, MS
1.0 CME/MOC/NCPD/AAPA
Primary Care
April 26, 2023
Facilitating Cognitive Assessment in Primary Care for the Timely Detection of
Alzheimer’s Disease: Leveraging Medicare Reimbursement Mechanisms to Improve
Clinical Care
Anna Chodos, MD, MPH
Ian Neel, MD
Primary Care Genetic Counselors
March 2, 2023
Revisiting the Role of Genetic Testing in Patients at Risk for Late-Onset
Alzheimer’s Disease: How Will the Latest Evidence and Evolving Management
Paradigm Impact Treatment Decisions for Your Patients?
Robert C. Green, MD, MPH
Primary Care Dementia Specialists
February 2, 2023
Gearing Up for Plasma Biomarkers in the Clinic: Real-World Strategies to
Facilitate the Timely and Accurate Neuropathological Diagnosis of Alzheimer’s
Disease
Marwan Sabbagh, MD, FAAN
Radiology
November 28, 2022
Revealing the Neuropathology of Alzheimer’s Disease Through Novel Fluid and
Imaging Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment
Val J. Lowe, MD
Jonathan E. McConathy, MD, PhD
Radiology
May 29, 2024
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of
Neuroradiology in Diagnosis and Treatment
Val J. Lowe, MD
Cyrus A. Raji, MD, PhD
0.75 CME/AAPA
Dementia
May 21, 2024
Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for
Making an Early Diagnosis and Implementing Disease-Modifying Treatment
Sharon Cohen, MD, FRCPC
1.0 CME/MOC/AAPA
Radiology
May 16, 2024
Applying Advances in PET Imaging to Facilitate the Early Diagnosis of
Alzheimer’s Disease
Jonathan E. McConathy, MD, PhD
Gil Rabinovici, MD
1.0 CME/AAPA
Radiology
February 15, 2024
Improving the Recognition and Management of Amyloid-Related Imaging
Abnormalities (ARIA) in Alzheimer’s Disease Treatment: Practical Tools &
Strategies for Radiology & Neuroradiology Specialists
Jerome A. Barakos, MD
Tammie L.S. Benzinger, MD, PhD
1.0 CME/AAPA
Primary Care Dementia Specialists
July 17, 2023
Case by Case: Actioning Patient-Centered Strategies for Risk Assessment,
Diagnosis, and Management of Amyloid-Related Imaging Abnormalities (ARIA)
Stephen P. Salloway, MD, MS
Radiology
June 25, 2023
Navigating the New Era of Molecularly Defined Care in Alzheimer’s Disease:
Applying Nuclear Medicine to Quantify Neuropathology and Improve Diagnostic
Accuracy in the Earliest Stages of the AD Continuum
Ilya M. Nasrallah, MD, PhD
Gil Rabinovici, MD
Primary Care
April 26, 2023
Facilitating Cognitive Assessment in Primary Care for the Timely Detection of
Alzheimer’s Disease: Leveraging Medicare Reimbursement Mechanisms to Improve
Clinical Care
Anna Chodos, MD, MPH
Ian Neel, MD
Primary Care Genetic Counselors
March 2, 2023
Revisiting the Role of Genetic Testing in Patients at Risk for Late-Onset
Alzheimer’s Disease: How Will the Latest Evidence and Evolving Management
Paradigm Impact Treatment Decisions for Your Patients?
Robert C. Green, MD, MPH
Primary Care Dementia Specialists
February 2, 2023
Gearing Up for Plasma Biomarkers in the Clinic: Real-World Strategies to
Facilitate the Timely and Accurate Neuropathological Diagnosis of Alzheimer’s
Disease
Marwan Sabbagh, MD, FAAN
Radiology
November 28, 2022
Revealing the Neuropathology of Alzheimer’s Disease Through Novel Fluid and
Imaging Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment
Val J. Lowe, MD
Jonathan E. McConathy, MD, PhD
Radiology
May 29, 2024
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of
Neuroradiology in Diagnosis and Treatment
Val J. Lowe, MD
Cyrus A. Raji, MD, PhD
0.75 CME/AAPA
Dementia
May 21, 2024
Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for
Making an Early Diagnosis and Implementing Disease-Modifying Treatment
Sharon Cohen, MD, FRCPC
1.0 CME/MOC/AAPA
Radiology
May 16, 2024
Applying Advances in PET Imaging to Facilitate the Early Diagnosis of
Alzheimer’s Disease
Jonathan E. McConathy, MD, PhD
Gil Rabinovici, MD
1.0 CME/AAPA
Radiology
February 15, 2024
Improving the Recognition and Management of Amyloid-Related Imaging
Abnormalities (ARIA) in Alzheimer’s Disease Treatment: Practical Tools &
Strategies for Radiology & Neuroradiology Specialists
Jerome A. Barakos, MD
Tammie L.S. Benzinger, MD, PhD
1.0 CME/AAPA
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INFOGRAPHIC

Mechanisms of Action of the Main Anti-Aβ Drugs That Are in Clinical Development
for the Treatment of Alzheimer’s Disease.1-5



Download This Infographic


SLIDES

July 17, 2023
Case by Case: Actioning Patient-Centered Strategies for Risk Assessment,
Diagnosis, and Management of Amyloid-Related Imaging Abnormalities (ARIA)
June 25, 2023
Navigating the New Era of Molecularly Defined Care in Alzheimer’s Disease:
Applying Nuclear Medicine to Quantify Neuropathology and Improve Diagnostic
Accuracy in the Earliest Stages of the AD Continuum
April 26, 2023
Facilitating Cognitive Assessment in Primary Care for the Timely Detection of
Alzheimer’s Disease: Leveraging Medicare Reimbursement Mechanisms to Improve
Clinical Care
March 2, 2023
Revisiting the Role of Genetic Testing in Patients at Risk for Late-Onset
Alzheimer’s Disease: How Will the Latest Evidence and Evolving Management
Paradigm Impact Treatment Decisions for Your Patients?
February 2, 2023
Gearing Up for Plasma Biomarkers in the Clinic: Real-World Strategies to
Facilitate the Timely and Accurate Neuropathological Diagnosis of Alzheimer’s
Disease
November 28, 2022
Revealing the Neuropathology of Alzheimer’s Disease Through Novel Fluid and
Imaging Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment
June 20, 2024
Preparing Your Practice for the New Era of Amyloid-Targeting Therapies in
Alzheimer's Disease: Expert Insights on Key Evidence, Administrative and
Clinical Considerations, and Best Practices for Individualized, Patient-Centered
Care
May 29, 2024
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of
Neuroradiology in Diagnosis and Treatment
May 21, 2024
Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for
Making an Early Diagnosis and Implementing Disease-Modifying Treatment
May 16, 2024
Applying Advances in PET Imaging to Facilitate the Early Diagnosis of
Alzheimer’s Disease
February 15, 2024
Improving the Recognition and Management of Amyloid-Related Imaging
Abnormalities (ARIA) in Alzheimer’s Disease Treatment: Practical Tools &
Strategies for Radiology & Neuroradiology Specialists
July 17, 2023
Case by Case: Actioning Patient-Centered Strategies for Risk Assessment,
Diagnosis, and Management of Amyloid-Related Imaging Abnormalities (ARIA)
June 25, 2023
Navigating the New Era of Molecularly Defined Care in Alzheimer’s Disease:
Applying Nuclear Medicine to Quantify Neuropathology and Improve Diagnostic
Accuracy in the Earliest Stages of the AD Continuum
April 26, 2023
Facilitating Cognitive Assessment in Primary Care for the Timely Detection of
Alzheimer’s Disease: Leveraging Medicare Reimbursement Mechanisms to Improve
Clinical Care
March 2, 2023
Revisiting the Role of Genetic Testing in Patients at Risk for Late-Onset
Alzheimer’s Disease: How Will the Latest Evidence and Evolving Management
Paradigm Impact Treatment Decisions for Your Patients?
February 2, 2023
Gearing Up for Plasma Biomarkers in the Clinic: Real-World Strategies to
Facilitate the Timely and Accurate Neuropathological Diagnosis of Alzheimer’s
Disease
November 28, 2022
Revealing the Neuropathology of Alzheimer’s Disease Through Novel Fluid and
Imaging Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment
June 20, 2024
Preparing Your Practice for the New Era of Amyloid-Targeting Therapies in
Alzheimer's Disease: Expert Insights on Key Evidence, Administrative and
Clinical Considerations, and Best Practices for Individualized, Patient-Centered
Care
May 29, 2024
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of
Neuroradiology in Diagnosis and Treatment
May 21, 2024
Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for
Making an Early Diagnosis and Implementing Disease-Modifying Treatment
May 16, 2024
Applying Advances in PET Imaging to Facilitate the Early Diagnosis of
Alzheimer’s Disease
February 15, 2024
Improving the Recognition and Management of Amyloid-Related Imaging
Abnormalities (ARIA) in Alzheimer’s Disease Treatment: Practical Tools &
Strategies for Radiology & Neuroradiology Specialists
July 17, 2023
Case by Case: Actioning Patient-Centered Strategies for Risk Assessment,
Diagnosis, and Management of Amyloid-Related Imaging Abnormalities (ARIA)
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PRACTICE AIDS


RECOGNIZING AND MANAGING AMYLOID-RELATED IMAGING ABNORMALITIES (ARIA)

 * ARIA Management Algorithm
 * ARIA Reporting Templates Point of Care
 * Classifying ARIA by Radiographic Severity
 * Symptoms Consistent With ARIA That Should Trigger Out-of-Sequence MRI
 * MRI Acquisition Protocols to Detect and Monitor ARIA
 * Selected Images of Amyloid-Related Imaging Abnormalities (ARIA) and Its
   Mimics
 * Triage Strategy for Severe Symptomatic Cases of ARIA


CURRENT AND EMERGING AD BIOMARKERS

 * Alzheimer’s Disease Cerebrospinal Fluid Biomarkers
 * Appropriate Use of AD Biomarkers by Modality
 * Commercially Available Biomarkers for AD
 * Commercially Available Plasma Biomarkers for AD
 * Investigational Fluid Biomarkers


APOE GENOTYPE TESTING AND COUNSELING

 * APOE Genotype Testing and Counseling Patient Communication Tool for the
   Multidisciplinary AD Team Point of Care
 * APOE ε4 and Late-Onset Alzheimer’s Disease


SCREENING FOR COGNITIVE IMPAIRMENT

 * Clinical Stages of Alzheimer’s Disease
 * Cognitive Assessment and Care Planning Services (CACP) CPT 99483
 * Criteria for the Diagnosis of Mild Cognitive Impairment (MCI)
 * Screening for Cognitive Impairment in Primary Care
 * Standardized Tools for Assessing for Cognitive or Functional Impairment With
   Sensitivity to Detect MCI
 * Disclosing a Diagnosis of MCI or Early Dementia
 * FDA-Approved Digital Cognitive Assessment Tools


BIOLOGICAL DIAGNOSIS AND STAGING GUIDELINES

 * Integrated Biological and Clinical Staging of AD
 * AT(N) Biomarker Stage and Cognitive Stage Classification
 * Revised Criteria for Biomarker-Based Diagnosis and Staging of AD
 * Diagnosis of MCI Due to AD and Early AD- Stepwise Approach


DIAGNOSTIC PET IMAGING RESOURCES

 * Alzheimer’s Disease Internet Resources for Radiology and Nuclear Medicine
   Specialists
 * Amyloid PET Imaging Practice Aid
 * Amyloid PET Reporting Template Point of Care
 * Diagnostic Algorithm for Early and Differential Diagnoses of Dementia
 * Early Dementia Differential Diagnosis Using 18F-FDG PET Images
 * Structural and Functional Neuroimaging Techniques for Studying Brain Changes
   Associated With AD
 * Tau PET Imaging Practice Aid


INTEGRATING ATTS INTO PRACTICE

 * Anti-Amyloid Monoclonal Antibody Infusion Order Form Point of Care
 * Appropriate Use of Anti-Aβ Monoclonal Antibodies in Clinical Practice
 * Baseline MRI-Based Exclusion Criteria for ATTs
 * Mechanisms of Action of the Main Anti-Aβ Drugs That Are in Clinical
   Development for the Treatment of Alzheimer’s Disease
 * Prior Authorization Request Form for Anti-Amyloid Therapy Point of Care
 * Resources Needed by a Clinician or Medical Center for the Safe and Effective
   Use of Anti-Aβ Monoclonal Antibodies in Clinical Practice
 * Shared Decision-Making Discussion With Patients and Caregivers Regarding
   Current and Emerging Anti-Amyloid Monoclonal Antibodies
 * Workflow in a Collaborative, Multidisciplinary AD Care Team


FACULTY


GIL RABINOVICI, MD

UCSF Alzheimer’s Disease Research Center
University of California, San Francisco
San Francisco, California


CYRUS A. RAJI, MD, PHD

Washington University
St. Louis, Missouri


MARWAN SABBAGH, MD, FAAN

University of Arizona College of Medicine-Phoenix
Creighton University
Phoenix, Arizona


STEPHEN P. SALLOWAY, MD, MS

Alpert Medical School of Brown University
Brown Center for Alzheimer’s Disease Research
Providence, Rhode Island


SHARON J. SHA, MD, MS

Stanford Center for Memory Disorders
Palo Alto, California


LIANA G. APOSTOLOVA, MS, MD, FAAN

Indiana University School of Medicine
Indiana Alzheimer's Disease Center
Indianapolis, Indiana


JEROME A. BARAKOS, MD

California Pacific Medical Center
San Francisco, California


TAMMIE L.S. BENZINGER, MD, PHD

Mallinckrodt Institute of Radiology
Washington University School of Medicine
St. Louis, Missouri


ANNA CHODOS, MD, MPH

Zuckerberg San Francisco General Hospital
University of California
San Francisco, California


SHARON COHEN, MD, FRCPC

Toronto Memory Program
Toronto, Ontario, Canada


PROF. DR. MED. ALEXANDER DRZEZGA

University Hospital Cologne
University of Cologne
Cologne, Germany
Institute for Neurosciences and Medicine
Forschungszentrum Jülich
Jülich, Germany


ROBERT C. GREEN, MD, MPH

Mass General Brigham
Harvard Medical School
Boston, Massachusetts


VAL J. LOWE, MD

Mayo Clinic
Rochester, Minnesota


JONATHAN E. MCCONATHY, MD, PHD

University of Alabama at Birmingham Heersink School of Medicine
Birmingham, Alabama


MICHELLE M. MIELKE, PHD

Wake Forest University School of Medicine
Winston-Salem, North Carolina


CATHERINE MUMMERY, MD, PHD

Dementia Research Centre
Institute of Neurology
University College London
Head of Dementia Service
National Hospital for Neurology and Neurosurgery
University College London Hospital
London, England, United Kingdom


ILYA M. NASRALLAH, MD, PHD

University of Pennsylvania
Philadelphia, Pennsylvania


IAN NEEL, MD

Senior Behavioral Health
UC San Diego Medical Center
San Diego, California


GIL RABINOVICI, MD

UCSF Alzheimer’s Disease Research Center
University of California, San Francisco
San Francisco, California


CYRUS A. RAJI, MD, PHD

Washington University
St. Louis, Missouri


MARWAN SABBAGH, MD, FAAN

University of Arizona College of Medicine-Phoenix
Creighton University
Phoenix, Arizona


STEPHEN P. SALLOWAY, MD, MS

Alpert Medical School of Brown University
Brown Center for Alzheimer’s Disease Research
Providence, Rhode Island


SHARON J. SHA, MD, MS

Stanford Center for Memory Disorders
Palo Alto, California


LIANA G. APOSTOLOVA, MS, MD, FAAN

Indiana University School of Medicine
Indiana Alzheimer's Disease Center
Indianapolis, Indiana


JEROME A. BARAKOS, MD

California Pacific Medical Center
San Francisco, California


TAMMIE L.S. BENZINGER, MD, PHD

Mallinckrodt Institute of Radiology
Washington University School of Medicine
St. Louis, Missouri


ANNA CHODOS, MD, MPH

Zuckerberg San Francisco General Hospital
University of California
San Francisco, California


SHARON COHEN, MD, FRCPC

Toronto Memory Program
Toronto, Ontario, Canada


PODCASTS

May 21, 2024
Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for
Making an Early Diagnosis and Implementing Disease-Modifying Treatment
Sharon Cohen, MD, FRCPC



SUBSCRIBE:


Available Episodes
 * Sharon Cohen, MD, FRCPC - Specialty Training for the New Era in Alzheimer’s
   Disease: Building Skills for Making an Early Diagnosis and Implementing
   Disease-Modifying Treatment (May 21, 2024)
 * Jonathan E. McConathy, MD, PhD / Gil Rabinovici, MD - Applying Advances in
   PET Imaging to Facilitate the Early Diagnosis of Alzheimer’s Disease:
   Preparing Nuclear Medicine and Radiology Specialists for New Diagnostic
   Workflows (May 16, 2024)
 * Jerome A. Barakos, MD / Tammie L.S. Benzinger, MD, PhD - Improving the
   Recognition and Management of Amyloid-Related Imaging Abnormalities (ARIA) in
   Alzheimer’s Disease Treatment: Practical Tools and Strategies for Radiology
   and Neuroradiology Specialists (February 15, 2024)
 * Stephen P. Salloway, MD, MS - Case by Case: Actioning Patient-Centered
   Strategies for Risk Assessment, Diagnosis, and Management of Amyloid-Related
   Imaging Abnormalities (ARIA) (July 17, 2023)
 * Ilya M. Nasrallah, MD, PhD / Gil Rabinovici, MD - Navigating the New Era of
   Molecularly Defined Care in Alzheimer’s Disease: Applying Nuclear Medicine to
   Quantify Neuropathology and Improve Diagnostic Accuracy in the Earliest
   Stages of the AD Continuum (June 25, 2023)
 * Anna Chodos, MD, MPH / Ian Neel, MD - Facilitating Cognitive Assessment in
   Primary Care for the Timely Detection of Alzheimer’s Disease: Leveraging
   Medicare Reimbursement Mechanisms to Improve Clinical Care (April 26, 2023)
 * Robert C. Green, MD, MPH - Revisiting the Role of Genetic Testing in Patients
   at Risk for Late-Onset Alzheimer’s Disease: How Will the Latest Evidence and
   Evolving Management Paradigm Impact Treatment Decisions for Your Patients?
   (March 2, 2023)
 * Marwan Sabbagh, MD, FAAN - Gearing Up for Plasma Biomarkers in the Clinic:
   Real-World Strategies to Facilitate the Timely and Accurate Neuropathological
   Diagnosis of Alzheimer’s Disease (February 2, 2023)
 * Val J. Lowe, MD / Jonathan E. McConathy, MD, PhD - Revealing the
   Neuropathology of Alzheimer’s Disease Through Novel Fluid and Imaging
   Biomarkers: Ushering in a Precision Era of Diagnosis and Treatment (November
   28, 2022)

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