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Submitted URL: http://circinteractome.nia.nih.gov/
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Submission: On November 14 via api from US — Scanned from DE
Effective URL: https://circinteractome.nia.nih.gov/
Submission: On November 14 via api from US — Scanned from DE
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-------------------------------------------------------------------------------- Site updated: 2020-01-30, 16:52 EST Welcome to Circular RNA Interactome Hundreds of RNA-binding proteins and miRNAs has been shown to regulate gene expression in mammals. Recently, circular RNAs (circRNAs) have been reported to regulate gene expression by sponging miRNA. Here we have used 109 datasets of RNA-binding proteins (RBPs) and queried circRNAs (Glažar et al. 2014) for RNA-binding sites. CircInteractome predicts the miRNAs which can potentially target the circRNAs using the Targetscan prediction tool (Grimson et al., 2007). This computational tool enables the prediction and mapping of binding sites for RBPs and miRNAs on reported circRNAs. Highlights of CircInteractome: * Searches circRNAs name * Searches the genomic position and best-matching transcripts of the circRNA * Retrieves genomic and mature circRNA sequences * Searches RBPs binding to a circRNA and to sequences upstream/downstream of the circRNA * Identifies RBPs binding to the circRNA junctions * Identifies miRNAs targeting a circRNA * Designs divergent primers for circRNAs * Designs siRNAs Specific to circRNA Citing CircInteractome Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K, and Gorospe M. CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs. RNA Biology, 2016, Jan 2;13(1):34-42 [PDF Download] Caveats CircInteractome computationally identifies potential binding sites for RNA binding proteins within circRNAs. Authors emphasize that the binding sites identified here are only potential or predicted based on CLIP data sets and are subject to experimental validation. -------------------------------------------------------------------------------- Please send your questions/comments to Kotb Aly or Webmaster -------------------------------------------------------------------------------- [ NIH Home Page ] [ NIA Home Page ] [ NIA Intramural Research Program ] [ Vulnerability Disclosure Policy ]