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Skip to contentSkip to site index Search & Section Navigation Section Navigation SEARCH Health SUBSCRIBE FOR $1/WEEKLog in Thursday, February 22, 2024 Today’s Paper SUBSCRIBE FOR $1/WEEK Health|Study of Patients With a Chronic Fatigue Condition May Offer Clues to Long Covid https://www.nytimes.com/2024/02/21/health/chronic-fatigue-syndrome-long-covid.html * Share full article * * * 192 Advertisement SKIP ADVERTISEMENT Supported by SKIP ADVERTISEMENT STUDY OF PATIENTS WITH A CHRONIC FATIGUE CONDITION MAY OFFER CLUES TO LONG COVID N.I.H. researchers found notable differences between the immune systems and other physiological functions of patients with ME/CFS and those of healthy patients. * Share full article * * * 192 * Read in app Jennifer Caldwell in 2019, during a study by the National Institutes of Health. She has struggled for nearly 10 years with a condition known as myalgic encephalomyelitis/chronic fatigue syndrome.Credit...Jennifer Caldwell By Pam Belluck Published Feb. 21, 2024Updated Feb. 22, 2024, 8:52 a.m. ET Leer en español Jennifer Caldwell was active and energetic, working two jobs and taking care of her daughter and her parents, when she developed a bacterial infection that was followed by intense lightheadedness, fatigue and memory problems. That was nearly a decade ago, and she has since struggled with the condition known as myalgic encephalomyelitis/chronic fatigue syndrome, or ME/CFS. Ms. Caldwell, 56, of Hillsborough, N.C., said she went from being able to ski, dance and work two jobs as a clinical research coordinator and a caterer to needing to stay in bed most of every day. “I haven’t been right since, and I haven’t worked a day since,” said Ms. Caldwell, whose symptoms include severe dizziness whenever her legs are not elevated. The condition has also “messed me up cognitively,” she said. “I can’t read something and comprehend it very well at all, I can’t remember new things. It’s kind of like being in a limbo state. That’s how I describe it, lost in limbo.” Advertisement SKIP ADVERTISEMENT Seven years ago, the National Institutes of Health began a study of patients with ME/CFS, and Ms. Caldwell became one of 17 participants who engaged in a series of tests and evaluations of their blood, bodies and brains. Findings from the study, which was published on Wednesday in the journal Nature Communications, showed notable physiological differences in the immune system, cardio-respiratory function, gut microbiome and brain activity of the ME/CFS patients compared with a group of 21 healthy study participants. Subscribe to The Times to read as many articles as you like. Pam Belluck is a health and science reporter, covering a range of subjects, including reproductive health, long Covid, brain science, neurological disorders, mental health and genetics. More about Pam Belluck A version of this article appears in print on Feb. 22, 2024, Section A, Page 10 of the New York edition with the headline: Chronic Fatigue Study May Help With Long Covid. Order Reprints | Today’s Paper | Subscribe Read 192 Comments * Share full article * * * 192 * Read in app Advertisement SKIP ADVERTISEMENT COMMENTS 192 Study of Patients With a Chronic Fatigue Condition May Offer Clues to Long CovidSkip to Comments The comments section is closed. To submit a letter to the editor for publication, write to letters@nytimes.com. SITE INDEX SITE INFORMATION NAVIGATION * © 2024 The New York Times Company * NYTCo * Contact Us * Accessibility * Work with us * Advertise * T Brand Studio * Your Ad Choices * Privacy Policy * Terms of Service * Terms of Sale * Site Map * Canada * International * Help * Subscriptions Enjoy unlimited access to all of The Times. See subscription options