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NCG MOUSE

NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl
Coisogenic
Genetically Engineered
Immunodeficient



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Breeding Location
Select the Country
 * US

 * US

 * Description
 * Growth Chart
 * Health Report
 * Pricing


NCG MOUSE DETAILS

NCG mice are triple immunodeficient and lack functional/mature T, B, and NK
cells, and have reduced macrophage and dendritic cell function. These animal
models have the ability to host xenograft cells, tissue, and human immune system
components.

This mouse model is ideal for oncology, immunology, tumor biology, infectious
disease, graft-versus-host disease (GvHD), diabetes, regenerative medicine,
hematopoiesis and tissue transplant studies. The NCG mouse model can also be
utilized to create humanized mice by engrafting PBMCs or CD34 stem cells to
closely mimic the human immune system.

The NCG mouse is the foundation for further strains and variants including:

 * Pre-humanized CD34+ and PBMC NCG mice
 * The NCG Plus portfolio of NCG variant mouse models, capable of hosting human
   tissues and recapitulating the human immune system

Origin
Co-developed by Nanjing Biomedical Research Institute of Nanjing University and
Nanjing Galaxy Biopharma in 2014 and transferred to Charles River in 2016. The
NCG mouse model was created by sequential CRISPR-Cas9 editing of the Prkdc and
Il2rg loci in the NOD/Nju mouse, generating a mouse coisogenic to the NOD/Nju.

The NOD/Nju carries a mutation in the Sirpa (SIRP α) gene that allows for
engrafting of foreign hematopoietic stem cells. The Prkdc knockout generates a
SCID-like phenotype lacking proper T-cell and B-cell formation. The knockout of
the Il2rg gene further exacerbates the SCID-like phenotype while additionally
resulting in a decrease of NK cell production.

Coat Color
White (albino)

Strain Code
572
Ideal For
Oncology, immunology, infectious disease, graft vs. host disease, diabetes,
regenerative medicine and human organ transplantation



LOCATION: Hollister
UNIT: H45
Download the Report

LOCATION: Wilmington
UNIT: W08
Download the Report

Download the catalog to view our portfolio or log into our online ordering
system to view pricing.

Note: NCG mice available in North America only.

Stay Current with Our Expanding Triple-Immunodeficient Mouse Models Portfolio

Be first to learn about additional new models coming soon and sign up to receive
preordering information.  Sign Up Today



RESOURCES

 * Technical Information
    * NCG Mouse Information Sheet
    * NCG Mouse Scientific Sheet
    * Health Monitoring of Immunodeficient Rodents in Isolators in North America
      and Europe
    * Immunodeficient Models – North America

 * Posters
    * The single mouse trial format predicts the sensitivity towards checkpoint
    * Evaluation of in vivo anti-tumor response of solid tumors in a novel
      immune cell humanized NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl mouse model
    * Combination Immune Checkpoint Inhibitors for the Treatment of Human Colon
      Carcinoma in hPBMC-NCG Humanized Mouse Model
    * Humane end point refinement for total body irradiation and humanization of
      NCG mice
    * NCG/CRL as a novel (Charles River) humanized mouse model for pre-clinical
      oncology studies: immunophenotypic characterization and performance
      monitoring

 * Brochure
   
   Explore our NCG Portfolio brochure

 * Publications
   
   TARGETED INHIBITION OF THE E3 LIGASE SCFSKP2/CKS1 HAS ANTITUMOR ACTIVITY IN
   RB1-DEFICIENT HUMAN AND MOUSE SMALL-CELL LUNG CANCER (CANCER RES., 2020) 
   
   PRECLINICAL EFFICACY FOR A NOVEL TYROSINE KINASE INHIBITOR, ARQULE 531
   AGAINST ACUTE MYELOID LEUKEMIA (J HEMATOL ONCOL, 2020) 
   
   KRAS4A DIRECTLY REGULATES HEXOKINASE (NATURE, 2019) 
   
   5-METHYLCYTOSINE PROMOTES PATHOGENESIS OF BLADDER CANCER THROUGH STABILIZING
   MRNAS (NAT CELL BIOL, 2019) 
   
   ON-TARGET RESTORATION OF A SPLIT T CELL-ENGAGING ANTIBODY FOR PRECISION
   IMMUNOTHERAPY (NAT COMMUN., 2019) 
   
   HPN536, A T CELL-ENGAGING, MESOTHELIN/CD3-SPECIFIC TRITAC FOR THE TREATMENT
   OF SOLID TUMORS (HARPOON THERAPEUTICS, 2018)
   
   HARNESSING NOVEL IMMUNE ESCAPE MECHANISMS FOR CANCER THERAPEUTICS: OXAB1
   TARGET VALIDATION, PROOF OF CONCEPT AND PRECLINICAL DEVELOPMENT (OXFORD
   BIOTHERAPEUTICS, 2018)
   
   TARGETING THE HUMAN MUC1-C ONCOPROTEIN WITH AN ANTIBODY-DRUG CONJUGATE (JCI
   INSIGHT, 2018)
   
   CLODRONATE IMPROVES SURVIVAL OF TRANSPLANTED HOXB8 MYELOID PROGENITORS WITH
   CONSTITUTIVELY ACTIVE GMCSFR IN IMMUNOCOMPETENT MICE (MOLECULAR THERAPY –
   METHODS & CLINICAL DEVELOPMENT, 2017)
   
   ACCUMULATION OF CYTOPLASMIC CDC25A IN CUTANEOUS SQUAMOUS CELL CARCINOMA LEADS
   TO A DEPENDENCY ON CDC25A FOR CANCER CELL SURVIVAL AND TUMOR GROWTH. (CANCER
   LETTERS, 2017)
   
    

 * Webinar
    * Continuous Improvements in Humanized Mouse Models

 * Genetically vs. Immuno-Humanized Mice
   
   THE HACE-NCG MOUSE IS A GENETICALLY HUMANIZED MODEL USING CRISPR TECHNOLOGY
   WITH THE ABILITY TO BE IMMUNO-HUMANIZED WITH PBMC OR CD34+ CELLS.

 


HUMANIZATION

 * Our Humanization Portfolio
   
   The NCG mouse is the foundation for the Charles River Hu-Mouse™ portfolio
   
   Humanize your NCG mouse model

 * Humanization Options
   
   When your research requires humanized animal models, Charles River offers
   multiple options, both founded on the NCG triple-immunodeficient mouse. Note:
   NCG mice available in North America only.
   
    * CD34+ HUMANIZED MOUSE MODEL
   
    * PBMC HUMANIZED MOUSE MODEL
   
    * NCG/PBMC SELECT HUMANIZATION KIT
      

 


FREQUENTLY ASKED QUESTIONS (FAQS) ABOUT THE NCG MOUSE MODEL

 * How was the NCG mouse model created?
   
   NCG mice were created using CRISPR/Cas9* technology.
   
   *CRISPR/CAS9 is used under licenses to granted and pending US and
   international patents from The Broad Institute and ERS Genomics Limited.

 * What types of studies can NCG mice be used in?
   
   These characteristics enable researchers to further study tumor biology and
   immuno-oncology, hematopoiesis, infectious disease, GvHD, and organ
   development and function because of their capability of hosting xenograft
   cells, tissue, and human immune system components.

 * What types of NCG humanized mice are available?
    * Study-ready HuCD34-NCG mice
    * Study-ready HuPBMC-NCG mice
   
   You can also create your own humanized mice with our NCG/PBMC select
   humanization kit.

 * How can I evaluate a NCG mouse model?
   
   Our Animal Model Evaluation Program helps researchers find the most
   appropriate model for their studies.

 * Are NCG mice good for the creation of humanized mouse models?
   
   The NCG mouse model is the foundation of our humanized mouse model portfolio.
   NCG mice have a unique phenotype that allows it to host xenograft cells,
   tissue, and components of the human immune systems. It displays noticeable
   improvements of foreign tissue transplantation and engraftment, compared to
   previous generations of immunocompromised mice.
   

 * How should I house my immunocompromised animal?
   
   We recommend isolators for housing immunocompromised animals.

Animal Model Evaluation Program

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