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Effective URL: https://dgfulltext.docguide.com/article/unsupervised-machine-learning-algorithms-for-the-identification-of-clinical-phenotypes-i...
Submission: On February 08 via manual from US — Scanned from DE
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You need to enable JavaScript to run this app. ANAESTHESIOLOGY Anaesthesiology * Feedback / Contact Us -------------------------------------------------------------------------------- * Edit Profile -------------------------------------------------------------------------------- * Terms of Use -------------------------------------------------------------------------------- * Privacy Policy -------------------------------------------------------------------------------- * Log Out -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- View Full Text Article Feb 01, 2023 UNSUPERVISED MACHINE-LEARNING ALGORITHMS FOR THE IDENTIFICATION OF CLINICAL PHENOTYPES IN THE OSTEOARTHRITIS INITIATIVE DATABASE. David Demanse, Franziska Saxer, Patrick Lustenberger, László B Tankó OBJECTIVES Osteoarthritis (OA) is a complex disease comprising diverse underlying patho-mechanisms. To enable the development of effective therapies, segmentation of the heterogenous patient population is critical. This study aimed at identifying such patient clusters click or scroll down to continue reading the article ERIK P. SULMAN, MD, PHD 1.5 CME HARNESSING NOVEL SYNERGIES WITH TTFIELDS: EXPERT PANEL Learn how to improve outcomes in patients with aggressive solid tumors...read more article continues here using two different machine learning algorithms. METHODS Using the progression and incident cohorts of the Osteoarthritis Initiative (OAI) dataset, deep embedded clustering (DEC) and multiple factor analysis with clustering (MFAC) approaches, including 157 input-variables at baseline, were employed to differentiate specific patient profiles. RESULTS DEC resulted in 5 and MFAC in 3 distinct patient phenotypes. Both identified a "comorbid" cluster with higher body mass index (BMI), relevant burden of comorbidity and low levels of physical activity. Both methods also identified a younger and physically more active cluster and an elderly cluster with functional limitations, but low disease impact. The additional two clusters identified with DEC were subgroups of the young/physically active and the elderly/physically inactive clusters. Overall pain trajectories over 9 years were stable, only the numeric rating scale (NRS) for pain showed distinct increase, while physical activity decreased in all clusters. Clusters showed different (though non-significant) trajectories of joint space changes over the follow-up period of 8 years. CONCLUSION Two different clustering approaches yielded similar patient allocations primarily separating complex "comorbid" patients from healthier subjects, the latter divided in young/physically active vs elderly/physically inactive subjects. The observed association to clinical (pain/physical activity) and structural progression could be helpful for early trial design as strategy to enrich for patients who may specifically benefit from disease-modifying treatments. Source: Seminars in Arthritis and Rheumatism Like 2 Comment Email LinkedIn Twitter -------------------------------------------------------------------------------- JAY H. SHUBROOK, DO, FAAFP, FACOFP 0.5 CME HAVE A CLOSER LOOK AT THE AGA’S CLINICAL CARE PATHWAY FOR MANAGING NAFLD AND NASH Dr. Jay Shubrook discusses the latest management strategies for patients with NAFLD/NASH....read more -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- THE ONCOLOGIST Full Text BRAIN METASTASES FROM BILIARY TRACT CANCER: CASE SERIES AND CLINICOGENOMIC ANALYSIS. BACKGROUND Limited data from small series have suggested that brain metastases from biliary tract cancers (BrM-BTC) affect ≤2% of patients with BTC. We sought to review our experience with patients...read more -------------------------------------------------------------------------------- Like Comment Share -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- NEFROLOGIA Full Text TOCILIZUMAB IN THE TREATMENT OF ACTIVE CHRONIC HUMORAL REJECTION RESISTANT TO STANDARD THERAPY. INTRODUCTION There is no consensus on the most appropriate treatment for chronic active antibody-mediated rejection (cAMR). Recent studies suggest that treatment with tocilizumab (TCZ) may stabilize graft function, decrease the...read more -------------------------------------------------------------------------------- Like Comment Share -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- NEFROLOGIA Full Text ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE IN HLA-IDENTICAL NON-TWIN SIBLINGS. Anti glomerular basement membrane disease (AGBM) is an autoinmune disorder characterised by the presence of anti-glomerular basement membrane (Anti-GBM) antibodies, alveolar hemorrhage, necrotizing glomerulonephritis, and linear deposition of immunoglobulins through...read more -------------------------------------------------------------------------------- Like Comment Share -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION = TAIWAN YI ZHI Full Text IMMUNOGENICITY AND SAFETY OF THIRD-DOSE MRNA COVID-19 VACCINES IN HEALTHY ADULTS PREVIOUSLY VACCINATED WITH TWO DOSES OF THE CHADOX1 VACCINE. BACKGROUND/PURPOSE The efficacy and safety of coronavirus disease 2019 (COVID-19) booster vaccines remain limited. We investigated the immunogenicity and adverse events of the third dose of mRNA vaccines in healthy...read more -------------------------------------------------------------------------------- Like Comment Share -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- BRENDON M. STILES, MD 0.75 CME/MOC INTEGRATING EGFR-TARGETED THERAPY IN PERIOPERATIVE SETTINGS OF NSCLC Expert insights into optimal testing and perioperative treatment of patients with EGFR-mutated NSCLC...read more -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- RHEUMATOLOGY (OXFORD, ENGLAND) Full Text COVID-19 VACCINE AFFECTS NEITHER PROTHROMBOTIC ANTIBODY PROFILE NOR THROMBOSIS IN PRIMARY ANTI-PHOSPHOLIPID SYNDROME: A PROSPECTIVE STUDY. OBJECTIVE To explore whether inactivated coronavirus disease 2019 vaccine influences the profile of prothrombotic autoantibodies and induces thrombotic events in primary APS patients. METHODS We enrolled 39 primary APS patients...read more -------------------------------------------------------------------------------- Like Comment Share -------------------------------------------------------------------------------- © 2023 All rights reserved |Edit Profile|Terms of Use|Privacy Policy (updated January 1, 2022) We use cookies to improve your experience. By using this website, you accept cookies or have set your browser or device to not accept cookies.