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HUMAN CANCER MODELS INITIATIVE

Searchable Catalog
Search by Model Name

Search By Altered Gene(s)


Search by Research Somatic Variant

Primary Site

Colon 54
Pancreas 52
Brain 50
Esophagus 36
24 More
Research Somatic Variant Type


Missense Mutation 286
Silent 286
Nonsense Mutation 275
Intron 258
13 More
Consequence

Missense Variant 286
Synonymous Variant 286
Frameshift Variant 273
Stop Gained 273
65 More
Model Type

3-D: Organoid 216
2-D: Adherent 61
3-D: Other (e.g. neurosphere, air-liquid interface, etc.) 21
2-D: Conditionally reprogrammed cells 12
1 More
Has Multiple Models

Any
Yes26
No288
Acquisition Site

Brain 63
Lymph node(s) 26
Pancreatic head 23
Sigmoid colon 21
55 More
Clinical Tumor Diagnosis

Colorectal cancer 71
Pancreatic cancer 52
Glioblastoma 50
Esophageal cancer 37
16 More
Clinical Stage Grouping

Stage IV 41
Stage IIA 26
Stage III 25
Stage IIIB 20
17 More
Tissue Status

Primary 193
Metastasis 95
Recurrent 23
Pre-malignant 3
Histological Subtype

Adenocarcinoma 72
NOS 47
Adenocarcinoma ductal type 38
Esophagus adenocarcinoma (NOS) 37
44 More
Histological Grade

G2 90
G3 51
GX 28
GB 7
5 More
Age At Diagnosis (Years)
2
89
2

2

89

89
2
89
Set Age At Diagnosis (Years)
Gender

Male 184
Female 129
Unknown 1
Available Molecular Characterizations


RNA-seq of model 290
WGS of normal 288
WXS of model 288
WXS of normal 286
7 More
Neoadjuvant Therapy

No 225
Yes, pharmaceutical treatment 48
Yes, both radiation and pharmaceutical treatment 21
Unknown 16
2 More
Chemotherapeutic Drug List Available
Any
Yes207
No105
Licensing Required For Commercial Use
Any
Yes235
No72
Race

White 170
Unknown 105
Black or African American 21
Asian 16
1 More
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Models by Primary Site
28
Total

Has Multiple Models

2D versus 3D Growth


Most Frequently Mutated Genes
TP53TTNKRASMUC16SYNE1APCPCLOOBSCNZFHX4FLG0187# models affected
Showing 1 - 20 of 314 models
Include 274 unexpanded models

Columns
Export

Name

Primary Site

Clinical Tumor Diagnosis

Tissue Status

Age At Acquisition (Years)

Age At Diagnosis (Years)

Has Multiple Models


Expansion Status


# Mutated Genes


# Research Somatic Variants


# Clinical Variants


# Histo-pathological Biomarkers


HCM-BROD-0648-C71
Brain
Glioblastoma
Recurrent
68
63
No
EXPANDED
5326
7110
0
3
HCM-BROD-0227-C43
Skin
Melanoma
Metastasis
40
40
No
EXPANDED
3075
4187
0
0
HCM-SANG-0288-C18
Colon
Colorectal cancer
Primary
75

No
EXPANDED
3228
3908
0
0
HCM-BROD-0569-C43
Skin
Melanoma
Metastasis
79
78
No
EXPANDED
2886
3802
0
1
HCM-BROD-0594-C43
Skin
Melanoma
Metastasis
78
75
No
EXPANDED
2690
3555
0
0
HCM-CSHL-0426-C18
Colon
Colorectal cancer
Primary
73
72
No
EXPANDED
2701
3183
0
0
HCM-SANG-0273-C18
Colon
Colorectal cancer
Primary
78

No
EXPANDED
2597
2991
0
0
HCM-BROD-0027-C34
Bronchus and lung
Lung cancer
Metastasis
66
65
No
EXPANDED
2313
2868
0
0
HCM-CSHL-0459-C17
Small intestine
Rare cancers
Primary
57
57
No
EXPANDED
2426
2793
0
5
HCM-BROD-0223-C43
Skin
Melanoma
Metastasis
74
73
No
EXPANDED
2187
2679
0
0
HCM-SANG-0282-C18
Colon
Colorectal cancer
Primary
85

No
EXPANDED
2313
2636
0
0
HCM-BROD-0724-C43
Skin
Melanoma
Metastasis
74
74
No
EXPANDED
2013
2530
1
0
HCM-CSHL-0606-C17
Small intestine
Rare cancers
Metastasis
71
71
No
EXPANDED
2143
2383
0
3
HCM-BROD-0106-C71
Brain
Glioblastoma
Recurrent
56
52
No
EXPANDED
2122
2333
0
3
HCM-WCMC-0494-C16
Stomach
Stomach cancer
Primary
64
64
No
EXPANDED
1883
2107
0
2
HCM-SANG-0276-C18
Colon
Colorectal cancer
Primary
78

No
EXPANDED
1768
1976
0
0
HCM-BROD-0334-C43
Skin
Melanoma
Metastasis
72
70
No
EXPANDED
1619
1939
0
1
HCM-CSHL-0174-C22
Intrahepatic bile duct
Intrahepatic bile duct cancer
Primary
64
64
No
EXPANDED
1568
1713
0
0
HCM-BROD-0702-C43
Skin
Melanoma
Metastasis
70
69
No
EXPANDED
1367
1658
0
1
HCM-CSHL-0317-C18
Colon
Colorectal cancer
Primary
65
64
No
EXPANDED
1502
1639
0
0
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Updated: October 1, 2024

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