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Text Content

 * Visit Healthcare Professional Website
 * Medication Guide
 * Important Safety Information
 * Full Prescribing Information

Home Dupuytren’s Contracture XIAFLEX Videos Resources
Locate a Specialist

 * Full Prescribing Information
 * Medication Guide
 * Visit Healthcare Professional Website
 * Important Safety Information


ASK ABOUT XIAFLEX® FOR YOUR DUPUYTREN’S CONTRACTURE

Actual patients
compensated for their time


DOWNLOAD AND PRINT THESE RESOURCES
TO PREPARE FOR YOUR VISIT WITH A HAND SPECIALIST

Get more information about XIAFLEX, finger exercises, possible savings and
financial assistance, and more.

Additionally, please see the full Prescribing Information, including Medication
Guide.

Doctor Discussion Guide

This guide can help prepare you for your next appointment, so you and the Hand
Specialist can make an informed decision on treatment for your Dupuytren’s
contracture.

Download

XIAFLEX Patient Brochure

The more you know about Dupuytren’s contracture, the better prepared you will be
to talk with the Hand Specialist about your condition. This brochure explains
Dupuytren’s contracture and offers information about XIAFLEX.

Download

Finger Exercises

This PDF serves as a guide to the finger exercises you will be performing at
home, following your XIAFLEX treatment.

Download

XIAFLEX Copay Brochure

Learn more about the XIAFLEX® Copay Assistance Program with this brochure.
Eligible patients may save on their out-of-pocket costs for each vial of
XIAFLEX®. Terms and conditions apply.

Download

Copay Reimbursement Form

Complete and submit this form to help with copay reimbursement.

Download

Questions About Financial Assistance

Call 1-877-XIAFLEX (1-877-942-3539) for more information.

Get started by entering your ZIP code
to find a Hand Specialist trained in XIAFLEX now.

Locate a Specialist


or use my location



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Sign up for updates about XIAFLEX treatment for Dupuytren’s contracture



Locate a Specialist


Some helpful hints while your results load:

Ask for the Hand Specialist you see listed by name. Not all doctors in a
practice may be trained to administer XIAFLEX®.

Ask the Hand Specialist what to expect with nonsurgical recovery.

It is estimated that more than 190,000 adult patients with Dupuytren’s
contracture have been prescribed XIAFLEX®.**From February 2010 through May 2022.


Click for more Less

WHAT IS XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s
contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and
effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION FOR XIAFLEX

Do not receive XIAFLEX if you have had an allergic reaction to collagenase
clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other
collagenase product. See the end of the Medication Guide for a complete list of
ingredients in XIAFLEX.

XIAFLEX CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

 * Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may
   cause damage to a tendon or ligament in your hand and cause it to break or
   weaken. This could require surgery to fix the damaged tendon or ligament.
   Call your healthcare provider right away if you have trouble bending your
   injected finger (towards the wrist) after the swelling goes down or you have
   problems using your treated hand after your follow-up visit
 * Nerve injury or other serious injury of the hand. After finger procedures,
   some people developed tears in the skin (lacerations), and local skin and
   soft-tissue necrosis (death of skin cells). Some lacerations and necrosis
   required skin grafting, or other surgery including amputation. Call your
   healthcare provider right away if you get numbness, tingling, increased pain,
   or tears in the skin (laceration) in your treated finger or hand after your
   injection or after your follow-up visit
 * Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions
   can happen in people who receive XIAFLEX because it contains foreign
   proteins. Call your healthcare provider right away if you have any of these
   symptoms of an allergic reaction after an injection of XIAFLEX:
   * hives
   * swollen face
   * breathing trouble
   * chest pain
   * low blood pressure
   * dizziness or fainting
 * Fainting. Fainting (passing out) or near fainting can happen in people who
   receive XIAFLEX, especially following finger procedures
   If you have dizziness or feel faint after receiving XIAFLEX, lie down until
   the symptoms go away.
 * Increased chance of bleeding. Bleeding or bruising at the injection site can
   happen in people who receive XIAFLEX. Talk to your healthcare provider if you
   have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an
allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or
any other medical conditions. Tell your healthcare provider about all the
medicines you take, including prescription and non-prescription medicines,
vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can
cause serious side effects. Especially tell your healthcare provider if you take
medicines to thin your blood (anticoagulants). If you are told to stop taking a
blood thinner before your XIAFLEX injection, your healthcare provider should
tell you when to restart the blood thinner. Ask your healthcare provider or
pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s
contracture include:

 * swelling of the injection site or the hand
 * bruising or bleeding at the injection site
 * pain or tenderness of the injection site or the hand
 * swelling of the lymph nodes (glands) in the elbow or armpit
 * itching
 * breaks in the skin
 * redness or warmth of the skin
 * pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or
does not go away. These are not all of the possible side effects with XIAFLEX.
For more information, ask your healthcare provider or pharmacist.

Click for full Prescribing Information, including Medication Guide.

Intended for U.S. Residents Only

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Rx Only © 2024 Endo, Inc. or one of its affiliates. All rights reserved.
Privacy/Legal XD-06848; XD-07048/December 2023 www.xiaflex.com 1-800-462-ENDO
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