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BIOENERGETICS LABORATORY

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Bioenergetics Laboratory
Main Menu
 * Home
 * Contact
 * Our Team
 * Research Menu Toggle
   * Heme-Copper Oxygen Reductase
   * Alternative Complex III
   * Complex I
 * Publications


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BIOLOGICAL ENERGY TRANSDUCTION

Life depends on constant energy transduction mechanisms. In all free-living
organisms, from prokaryotes to eukaryotes, the obtained energy whether from
light, inorganic or organic compounds is transduced into a transmembrane
difference of electrochemical potential across the prokaryotic cytoplasmatic or
mitochondrial membranes. For example, non-photosynthetic organisms obtain energy
by the degradation of organic food components, such as proteins, carbohydrates,
and lipids, whose metabolisms provide substrates to the respiratory chain. Here
chemical reactions are coupled to the translocation of ions across the membrane
and the energy thus released by the favorable chemical reaction is transduced to
the form of a transmembrane difference of electrochemical potential. This
transmembrane potential is vital for solute/nutrient cell transport, synthesis
of ATP and motility.

 

The research in our group focuses on the elucidation of the mechanisms of energy
transduction in biological systems. We have been exploring different energy
transducing respiratory enzymes, namely their structural features and catalytic
characteristics enabling to dissect molecular mechanisms of electron transfer,
ion translocation and their coupling. We have been also scrutinizing non-energy
transducing respiratory enzymes since these are mostly present in pathogens and
may inspire novel drug targets. We perform a multidisciplinary approach using a
wide range of molecular biology, biochemical and biophysical methodologies. Our
studies involve isolated proteins (wild type and recombinants) as well as
reconstituted proteins or membrane vesicles and cell fitness and metabolomic
analyses, resulting, in this way, in a synergy of molecular and cellular
approaches.
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Heme-Copper Oxygen Reductase

 



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