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University of California San Francisco
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welcome to Delling Lab


 




ABOUT OUR LAB

About four billion years ago, while earth was covered with a primordial soup
enriched with the building blocks of life, the equal occurrence of chiral
molecules (non-superimposable “left-handed” vs “right-handed” molecules) fell
out of balance. As a consequence, today’s life is asymmetric.

In humans, our visceral organs such as heart, pancreas, and intestine are
asymmetrically positioned along the left-right axis. Fundamental molecular
mechanisms of asymmetrical development are poorly understood. Congenital heart
disease, autosomal dominant polycystic kidney disease (ADPKD), obesity, and
mental retardation are among some of the more severe human diseases that can be
attributed to improper cilia function.

My lab studies the molecular mechanisms of how primary cilia utilize ion
channels and GPCRs to sense their local environment and control such important
processes as left-right asymmetry formation. Our long-term goal is to understand
the signals activating ciliary Ca2+ channels and to identify the resulting
downstream cilia-dependent signaling cascades. We use a variety of different
approaches including mouse genetics, RNA sequencing, cutting edge primary cilia
Ca2+ imaging, electrophysiology and biochemistry.

Read More



FEATURED PUBLICATIONS

ANXIETY AND INCREASED 5-HT1A RECEPTOR RESPONSE IN NCAM NULL MUTANT MICE

Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. Anxiety
and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol.
1999 Sep 5; 40(3):343-55. PMID: 10440734.

112
CITATIONS
112 Total citations
1 Recent citation
n/a Field Citation Ratio
2.22 Relative Citation Ratio



COSIGNALING OF NCAM VIA LIPID RAFTS AND THE FGF RECEPTOR IS REQUIRED FOR
NEURITOGENESIS

Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M.
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for
neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32. PMID: 11980923; PMCID:
PMC2173281.

249
CITATIONS
249 Total citations
2 Recent citations
12 Field Citation Ratio
3.89 Relative Citation Ratio



WHAT CAN WE LEARN FROM EXPLANTED ENDOVASCULAR DEVICES?

Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H. What can
we learn from explanted endovascular devices? Eur J Vasc Endovasc Surg. 2002
Aug; 24(2):117-22. PMID: 12389232.

100
CITATIONS
100 Total citations
3 Recent citations
14 Field Citation Ratio
1.69 Relative Citation Ratio


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FEATURED NEWS

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Delling Lab
Department of Research
University of Medical Science
3167 Science Bldg
611 Medical Drive
Springfield, ST 55555
Tel: (555) 123-4567
E-mail: jjames@flora.com

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