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Endocrinology > Obesity


RESTRICTING EATING TO CERTAIN HOURS BOLSTERS WEIGHT LOSS


— TRIAL PARTICIPANTS LOST AN ADDITIONAL 5 LB VERSUS THOSE WHO DIDN'T RESTRICT
THEIR EATING TIME

by Kristen Monaco, Staff Writer, MedPage Today August 8, 2022


MedpageToday

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In addition to diet and exercise, eating within an 8-hour window helped people
with obesity lose weight, a randomized trial showed.

Compared with eating over 12-plus hours, those who kept all caloric intake to 8
hours -- from 7 a.m. to 3 p.m. -- lost an additional 2.3 kg (5.1 lb) over a
14-week study, reported Courtney Peterson, PhD, of the University of Alabama at
Birmingham, and colleagues.



This weight loss was equivalent to eating 214 fewer calories per day, they noted
in JAMA Internal Medicine.

When the eating time-restricted group received weight-loss treatment (energy
restriction), they saw an average drop of 6.3 kg (13.9 lb; P<0.001), while those
who underwent energy restriction alone saw a weight loss of 4.0 kg (8.8 lb;
P<0.001).

The 8-hour eating window wasn't much help for shedding body fat specifically.
While this group saw slightly more body fat loss (-1.4 kg/-3.1 lb), it wasn't
significantly more than with the calorie-restricted diet alone. Likewise, there
wasn't a significant difference seen in the ratio of fat loss to weight loss
(-4.2%).

However, in a secondary analysis of the 59 participants who finished the 14-week
trial, the 8-hour eating window did prove to be more effective for shedding body
fat (-1.8 kg [-4.0 lb], 95% CI -3.6 to 0.0 kg, P=0.047) and trunk fat (-1.2 kg
[-2.6 lb], 95% CI -2.2 to -0.1 kg, P=0.03).



Adding the eating time-restricted window to dieting also dropped diastolic blood
pressure (-4 mm Hg, 95% CI -8 to 0 mm Hg, P=0.04), though this was the only
cardiometabolic risk factor that seemed to improve with time-restriction. It
also bettered some mood and sleep parameters, including mood subscores for
vigor-activity, fatigue-inertia, and depression-dejection.

"Our data suggest that early time-restricted eating is feasible, as participants
adhered 6.0 days per week on average, and most participants adhered at least 5
days per week," Peterson's group pointed out.

In an accompanying commentary, Shalender Bhasin, MB, BS, of Brigham and Women's
Hospital in Boston, was quick to compare this trial to another recent
time-restricted trial published earlier this year in the New England Journal of
Medicine.


MEDICAL NEWS FROM AROUND THE WEB

Annals of Internal Medicine
1
How Would You Treat This Patient With Pulmonary Embolism? : Grand Rounds
Discussion From Beth Israel Deaconess Medical Center.
JAMA Internal Medicine
2
Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and
Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial.
Hepatology
3
TIGIT blockade elicits potent anti-tumor immunity in naturally occurring
hepatitis B virus-related hepatocellular carcinoma in mice.

Following a similar methodology, that trial found that following a
time-restricted diet in addition to calorie restriction did not result in a
significantly greater amount of weight loss compared with a calorie-restricted
diet alone (-1.8 kg [-4.0 lb] difference; P=0.11).



One key difference between the two trials included the earlier 8-hour timeframe
in the current study (7 a.m. to 3 p.m. vs 8 a.m. to 4 p.m.). Bhasin noted that
another difference was that the previous trial didn't set a specific window for
the comparator group, whereas Peterson's group instructed the other group to eat
over a timeframe of 12 or more hours each day. The current trial was also only
14 weeks in duration versus 1 year for the prior trial.

Regardless of these differences, Bhasin said both trials did see "high levels of
adherence with dietary prescriptions," which might be hard to achieve outside of
a trial setting and in a clinical setting.

"The scientific premise and the preclinical data of the effects of
time-restricted eating are promising, but the inconsistency among studies
renders it difficult to draw strong inferences from these well-conducted but
relatively small trials," said Bhasin.



For this study, Peterson and team randomized 90 adults (mean age 43 years, 80%
women) with a BMI of 30 to 60 into each of the two groups. All participants
received weight-loss counseling involving energy restriction at the UAB Weight
Loss Medicine Clinic, and followed a calorie-restricted diet of 500 calories per
day below their resting energy expenditure and exercised for 75 to 150 minutes
per week, depending on their baseline physical activity.



 * Kristen Monaco is a staff writer, focusing on endocrinology, psychiatry, and
   nephrology news. Based out of the New York City office, she’s worked at the
   company since 2015.

Disclosures

This study was supported by grants from the National Center for Advancing
Translational Sciences and from the National Institute of Diabetes and Digestive
and Kidney Diseases.

Peterson and co-authors reported relationships with the NIH, Wondr Health, and
Pennington Biomedical Research Center/Louisiana State University.

Bhasin reported relationships with AbbVie, MIB, OPKO Health, Aditum, FPT, and
XYOne.

Primary Source

JAMA Internal Medicine

Source Reference: Jamshed H, et al "Effectiveness of early time-restricted
eating for weight loss, fat loss, and cardiometabolic health in adults with
obesity: a randomized clinical trial" JAMA Intern Med 2022; DOI:
10.1001/jamainternmed.2022.3050.

Secondary Source

JAMA Internal Medicine

Source Reference: Bhasin S "Time-restricted eating to improve health -- a
promising idea in need of stronger clinical trial evidence" JAMA Intern Med
2022; DOI: 10.1001/jamainternmed.2022.3038.

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SYNOPSI

Annals of Internal Medicine
1
How Would You Treat This Patient With Pulmonary Embolism? : Grand Rounds
Discussion From Beth Israel Deaconess Medical Center.
JAMA Internal Medicine
2
Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and
Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial.
Hepatology
3
TIGIT blockade elicits potent anti-tumor immunity in naturally occurring
hepatitis B virus-related hepatocellular carcinoma in mice.






SYNOPSI

Annals of Internal Medicine
1
How Would You Treat This Patient With Pulmonary Embolism? : Grand Rounds
Discussion From Beth Israel Deaconess Medical Center.
JAMA Internal Medicine
2
Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and
Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial.
Hepatology
3
TIGIT blockade elicits potent anti-tumor immunity in naturally occurring
hepatitis B virus-related hepatocellular carcinoma in mice.
Pediatrics
4
Neonatal Outcomes of Mothers With a Disability.
Pharmacy Times
5
Using Immunoinformatics to Create a Clostridium Difficile Vaccine
NBC News
6
FDA clears the way for single monkeypox vaccine doses to be split into five


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