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Journal Article


SERRATIA ENDOCARDITIS: ANTIMICROBIAL MANAGEMENT STRATEGIES AND CLINICAL OUTCOMES

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Sunish Shah,
Sunish Shah
Antibiotic Management Program, University of Pittsburgh Medical Center,
Pittsburgh
,
Falk Medical Building, Suite 3A, Room 317, 3601 Fifth Avenue, Pittsburgh, PA
15213
,
USA
Department of Pharmacy, University of Pittsburgh Medical Center
,
Pittsburgh, PA
,
USA
Department of Pharmacy, Yale New Haven Hospital
,
New Haven, CT
,
USA
Corresponding author. E-mail: Sunishshah93@gmail.com@shahnanigans1
  https://orcid.org/0000-0002-8873-1451
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Madeline McCrary,
Madeline McCrary
Division of Infectious Diseases, University of North Carolina
,
Chapel Hill, NC
,
USA
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Asher J Schranz,
Asher J Schranz
Division of Infectious Diseases, University of North Carolina
,
Chapel Hill, NC
,
USA
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Lloyd Clarke,
Lloyd Clarke
Antibiotic Management Program, University of Pittsburgh Medical Center,
Pittsburgh
,
Falk Medical Building, Suite 3A, Room 317, 3601 Fifth Avenue, Pittsburgh, PA
15213
,
USA
Department of Pharmacy, University of Pittsburgh Medical Center
,
Pittsburgh, PA
,
USA
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Matthew W Davis,
Matthew W Davis
Department of Pharmacy, Yale New Haven Hospital
,
New Haven, CT
,
USA
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Ashley Marx,
Ashley Marx
Department of Pharmacy, University of North Carolina Medical Center
,
Chapel Hill, NC
,
USA
  https://orcid.org/0000-0002-5503-2523
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Douglas Slain,
Douglas Slain
Department of Clinical Pharmacy and Division of Infectious Diseases, West
Virginia University
,
Morgantown, WV
,
USA
  https://orcid.org/0000-0002-4318-7165
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Bobbi Jo Stoner,
Bobbi Jo Stoner
Department of Pharmacy, University of Kentucky Medical Center
,
Lexington, KY
,
USA
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Jeffrey Topal,
Jeffrey Topal
Department of Pharmacy, Yale New Haven Hospital
,
New Haven, CT
,
USA
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Ryan K Shields
Ryan K Shields
Antibiotic Management Program, University of Pittsburgh Medical Center,
Pittsburgh
,
Falk Medical Building, Suite 3A, Room 317, 3601 Fifth Avenue, Pittsburgh, PA
15213
,
USA
Department of Medicine, University of Pittsburgh
,
Pittsburgh, PA
,
USA
  https://orcid.org/0000-0001-9794-5665
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Journal of Antimicrobial Chemotherapy, dkad254,
https://doi.org/10.1093/jac/dkad254
Published:
11 August 2023
Article history
Received:
26 June 2023
Accepted:
29 July 2023
Published:
11 August 2023

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   Sunish Shah and others, Serratia endocarditis: antimicrobial management
   strategies and clinical outcomes, Journal of Antimicrobial Chemotherapy,
   2023;, dkad254, https://doi.org/10.1093/jac/dkad254
   
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ABSTRACT

Objectives

The incidence of Serratia endocarditis is increasing, yet optimal treatment has
not been defined. Our objective was to investigate the outcomes of patients with
Serratia endocarditis by treatment strategy.

Methods

We reviewed adult patients with definitive Serratia endocarditis at two
independent health systems between July 2001 and April 2023. Combination therapy
was defined as receipt of ≥2 in vitro active agents for ≥72 h.

Results

Seventy-five patients were included; 64% (48/75) were male and 85% (64/75) were
people who inject drugs. Compared with monotherapy, receipt of combination
therapy was associated with lower rates of microbiological failure (0% versus
15%, P = 0.026) and 90 day all-cause mortality (11% versus 31%, P = 0.049).
Antimicrobial discontinuation due to an adverse event was more common among
patients receiving combination therapy compared with monotherapy (36% versus 8%,
P = 0.058).

Conclusions

In the largest series of Serratia endocarditis to date, combination antibiotic
treatment was associated with improved outcomes. However, larger, prospective
studies are warranted.

Issue Section:
ORIGINAL RESEARCH

© The Author(s) 2023. Published by Oxford University Press on behalf of British
Society for Antimicrobial Chemotherapy. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com
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University Press, Standard Journals Publication Model
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