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Results Recalculated in 2019





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Retrospective view
 * CASP1
 * CASP2
 * CASP3
 * CASP4
 * CASP5
 * CASP6
 * CASP7
 * CASP8
 * CASP9
 * CASP10
 * CASP11
 * CASP12

    
 * Description of Experiment
 * Targets
 * CASP in numbers
 * Meeting
 * Results
 * Data Archive
 * Results recalculated in 2019

This first large-scale experiment to assess protein structure prediction methods
was held in 1994. It consisted of three parts: the collection of targets for
prediction from the experimental community, the collection of predictions from
the modeling community, and the assessment and discussion of the results.
Information was solicited from X-ray crystallographers and NMR spectroscopists
on structures about to be solved. In all 33 protein prediction targets were
obtained in three prediction categories: comparative modeling, fold recognition
or threading, and ab initio folding. Extensive efforts have been made to
publicize the experiment. In all 35 prediction groups took part submitting over
100 predictions.

Assessment of the results was done by three independent teams, one for each
category. The teams were led by Michael James, University of Alberta, for
comparative modeling; Shoshana Wodak, Free University of Brussels, for fold
recognition; and Fred Cohen, University of California at San Francisco, for ab
initio predictions. The first CASP meeting was held at the Asilomar conference
center in California in December of 1994. A special issue of PROTEINS:
Structure, Function, and Genetics (Volume 23, Number 3, 1995) has been dedicated
to the assessment of the prediction experiment.

CASP1 organizing team has been led by John Moult, University of Maryland
Biotechnology Institute, and included Jan Pedersen, UMBI, Richard Judson, Sandia
National Laboratories, and Krzysztof Fidelis, Lawrence Livermore National
Laboratory. Funding was provided by LLNL, Sandia, National Institute of
Standards and Technology, and the Department of Energy Office of Health and
Environmental Research.





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