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PRODUCT

TEAM

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PARTNERS

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NEW

Cradle raises $73m Series B




PROTEIN ENGINEERING WITHOUT THE GUESSWORK

Design improved variants of your target protein sequence with just a few clicks
— and some machine learning.

Request invite

Learn more

TRUSTED BY


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TARGET PROTEIN SEQUENCE

MLCDLKQGEPICVQKERKTPRDSGQQCHACIJKMGGHQ



STABILITY



ACTIVITY



GENERATE VARIANTS






Bring lab data or start fresh

Get started by importing assay data from an ongoing project – or start fresh
from just a single starting sequence.

No surprises in the lab

Each generated sequence comes with a predicted performance score. Less exciting
for some, more productive for everyone.

Reach objectives in half the time

Cradle learns with every experimental round, giving you better variants each
time – and dramatically cutting your time-to-market .

Optimize everything at once

Cradle lets you optimize multiple properties at once. You save time, the models
learn faster. It’s a win-win.


USED BY INDUSTRY
LEADERS AND #BIONEERS

The world’s leading biotech teams are using Cradle to accelerate new and ongoing
projects – and to revisit challenging ones.

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MULTI-PROPERTY.
NO-PROBLEM.

Unlike traditional methods, Cradle is engineered to handle multiple properties
and optimization tasks in a single round.

Enzymes

Vaccines

Peptides

Antibodies

Activity

Thermostability

Solvent stability

Solubility

Substrate specificity

Beta

E-coli expression

Beta

MSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGIGTINRPEPTIDESKGVTVLIKRYLNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNTGVYEYKYLSVHQTYFRLFVNSHGRSLSGQAYNFGRGVCYNDNFQKGYMNGRNSYENVAHIFCICGNVPEVACCINESMSTASGVEEQVIVNYQDSKNGEPICVQKESWLWEVTGPYRINYPDRKKQVVYYKEMTQHTAKGSFQATSVDRKTPRDSGQQGYPCCPIMKISQDWTDKAIFSENGVYVRNIGTINRKGVTVLIKRYLENZYMESNFNAKPMRYFEKLDEEPGDKTYVFRLFVNSHGRSLSGQAYNFGRGVCYNDNFQKGYMNGRNSYENVAHIFCICGNVPEMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKTQATSVDRKTPRDSGQQGYPCCPIMKISQDWTMDDANTIBODIESKAIFSNVYVRNYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKQVVQDWTDKAIFSENGVYVRNIG




PROTEINS ARE COMPLICATED.
USING CRADLE IS NOT.

We've designed Cradle to be as easy as possible to get started with – that means
it fits right into your existing workflow.

1

Set up assays and objectives

Getting started is easy, just tell Cradle what you plan to measure and where you
want those measurements to go for your project to be successful.

2

Generate sequences

3

Test in lab

4

Import lab results




PRIVATE. SECURE. YOURS.

With Cradle, your sequences and data are kept private and secure while giving
you full ownership of all intellectual property.

Private by design

Only you and people you invite can access your sequences and experimental data.
Your data is never used to train models for other users.

Safe & Secure

Cradle uses bank-grade level of security to keep your data safe.

Own your IP

You own your IP. Royalties? Nope. With Cradle you pay a flat fee per year for
using our tools for your project.

SYENVAHIFCICGNVPEMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKTQATSVDRKTPRDSGQQGYPCCPIMKISQDWTDAATNMODREAKAIFSENGVYVRNYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKQVVQDWTDKAIFSENGVYVRNIGTINRKGVTVYYKEMTQHTAKGSFQATSVDQDWTDKAIFSENGVYVRNIGTINRKGVTVYYKEMTQHTAKGSFQATSVDYQCDLKQGEPICVQKESWLWEVTGPYRINMSTASGVEEQVIVNYQDSKNGYKIIKKATLWAFNRGVDWKFYKYLRGKQTYQCDLKQGIGTINRPSQTIDLSKGVTVLIKRYLNFNAKPMRYFEKLDEEPGDKTYVTVLKKNGRKVMMFNNFNAKPMRYFEKLDEEPGDKT
GKQTYQCDLKQGEPICVQKESWLWEVTGPYRINYPDRKKTQATSVDRKTPRDSGQQGYPCCPIMKISQDWTDAATNMDLKQGEPICVQKESWLWEVTGPYRINYPDRKKQVVQDWTDKAIFSENGVYVRNIGTINRKGVTVYYKE




THE TEAM

At Cradle we believe biology can theoretically be used to produce almost
anything, from therapeutics to chemicals, materials and food. Designing proteins
is not easy, but with our tools and machine learning models we are changing
that.

Meet the team

Careers

Summer offsite

Stef at CogX

Co-working week

Lab day for ML team

NEW

Cradle raises $73m Series B




BACKED BY THE BEST



We are funded by leading investors IVP, Index Ventures, and Kindred Capital, as
well as long list of world-class advisors and angel investors

IVP

IVP have helped grow breakout like companies Slack, Netflix, Github and many
others into enduring market leaders.

Index Ventures

Index helps entrepreneurs turn bold ideas into businesses that have a
long-lasting positive impact on the world.

Kindred Capital

Kindred is an early investor in LabGenius, Ori, Eleven Tx, and others.



Emily Leproust

CEO at Twist Biosciences

Steve Crossan

SVP AI at GSK, former Head of Product at Google Deepmind and co-founder of
Alphafold project

Adriaan Mol

Founder at Mollie & Messagebird

John Zimmer

CEO & Founder at Lyft

Tim Geistlinger

Chief Scientific Officer at Perfect Day

Mehdi Ghissassi

Director of Product at Google Deepmind

Patrick Hsu

Professor at Berkley & Founder of Arc Institute

Feike Sijbesma

Honorary Chairman and former CEO at Royal DSM

Sylvain Gariel

Founder & COO at DNA Script

Chris Gibson

Co-founder & CEO at Recursion

Tom Glocer

Former CEO of Thomson Reuters and Lead Director at Merck

Project lead

Protein engineer

Bioinformatician


READY TO TRY CRADLE?

Join the world's leading biotech teams and request your early access invite
today.

Request invite

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