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Submitted URL: https://www.postswitch.fi/
Effective URL: https://postswitch.fi/
Submission: On September 02 via automatic, source certstream-suspicious — Scanned from FI
Effective URL: https://postswitch.fi/
Submission: On September 02 via automatic, source certstream-suspicious — Scanned from FI
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Text Content
PostSwitch * Principal Investigators * Selected Publications * Contact POSTSWITCH Our cutting-edge research delves into the intricate process of protein formation post-translation. Utilizing advanced proteomics methods, we aim to uncover the secrets of protein modifications and their implications for cellular functions and disease mechanisms. Join us on this journey to revolutionize our understanding of biology at the molecular level. About DALL-E – PHOTOREALISTIC PAINTING OF PROTEINS EXCHANGING HIGH FIVES UNVEILING THE MYSTERIES OF PROTEIN MODIFICATIONS: ADVANCED PROTEOMICS IN ACTION Our research focuses on the fascinating journey of proteins after translation. By leveraging state-of-the-art proteomics techniques, we aim to unravel the complexities of protein modifications and their roles in cellular processes and diseases. Discover how our findings could pave the way for groundbreaking advancements in medical and biotechnological fields. Research leaders PRINCIPAL INVESTIGATORS Our project is spearheaded by a team of distinguished leaders with extensive expertise in proteomics and protein research. With a rich background in both clinical and translational research, our leaders have made significant contributions in academia and industry. Their combined experience and innovative approaches drive our mission to decode the complexities of protein formation and its implications for health and disease. JUKKA WESTERMARCK CoE director Profile MARKKU VARJOSALO CoE co-director Profile JUHA HUISKONEN Professor Profile ANNIINA FÄRKKILÄ Assistant Professor Profile OTTO KAUKO Head of Proteiomics core at Turku Bioscience Centre Profile VIVEK SHARMA Associate Professor Profile PIONEERING INSIGHTS IN PROTEOMICS AND PROTEIN RESEARCH The leaders of our project have made significant scientific contributions through their extensive publications in top-tier journals. Their research has advanced the field of proteomics and protein research, providing critical insights into protein structure, function, and interactions. Their work has not only enhanced our understanding of fundamental biological processes but also paved the way for innovative therapeutic approaches to treat various diseases. Their publications are widely cited, reflecting the impact and importance of their research in both academia and industry. Selected publications TITLES OF OUR RECENT PUBLICATIONS BY WORDLE KEY PUBLICATIONS 1. Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex. Nature, 2023 2. Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I. Chemical Science, 2023 3. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature Communications, 2023 4. A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites. Nature Biotechnology, 2023 5. Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. Nature Communications, 2022 6. Optimized detection of somatic allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in cancer. NPJ Precision Oncology, 2022 7. Human transcription factor protein interaction networks. Nature Communications, 2022. 8. Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Reports, 2022 9. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Cell, 2021 10. The hantavirus surface glycoprotein lattice and its fusion control mechanism. Cell, 2020 11. Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Nature, 2019 12. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Science Translational Medicine, 2018 Firstname * Lastname * Email * Please specify your need * Message * * These fields are required. © PostSwitch 2024