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Text Content

PostSwitch
 * Principal Investigators
 * Selected Publications
 * Contact


POSTSWITCH

Our cutting-edge research delves into the intricate process of protein formation
post-translation. Utilizing advanced proteomics methods, we aim to uncover the
secrets of protein modifications and their implications for cellular functions
and disease mechanisms. Join us on this journey to revolutionize our
understanding of biology at the molecular level.

About

DALL-E – PHOTOREALISTIC PAINTING OF PROTEINS EXCHANGING HIGH FIVES


UNVEILING THE MYSTERIES OF PROTEIN MODIFICATIONS: ADVANCED PROTEOMICS IN ACTION

Our research focuses on the fascinating journey of proteins after translation.
By leveraging state-of-the-art proteomics techniques, we aim to unravel the
complexities of protein modifications and their roles in cellular processes and
diseases. Discover how our findings could pave the way for groundbreaking
advancements in medical and biotechnological fields.

Research leaders


PRINCIPAL INVESTIGATORS

Our project is spearheaded by a team of distinguished leaders with extensive
expertise in proteomics and protein research. With a rich background in both
clinical and translational research, our leaders have made significant
contributions in academia and industry. Their combined experience and innovative
approaches drive our mission to decode the complexities of protein formation and
its implications for health and disease.

JUKKA WESTERMARCK

CoE director

Profile

MARKKU VARJOSALO

CoE co-director

Profile

JUHA HUISKONEN

Professor

Profile

ANNIINA FÄRKKILÄ

Assistant Professor

Profile

OTTO KAUKO

Head of Proteiomics core at Turku Bioscience Centre

Profile

VIVEK SHARMA

Associate Professor

Profile


PIONEERING INSIGHTS IN PROTEOMICS AND PROTEIN RESEARCH

The leaders of our project have made significant scientific contributions
through their extensive publications in top-tier journals. Their research has
advanced the field of proteomics and protein research, providing critical
insights into protein structure, function, and interactions. Their work has not
only enhanced our understanding of fundamental biological processes but also
paved the way for innovative therapeutic approaches to treat various diseases.
Their publications are widely cited, reflecting the impact and importance of
their research in both academia and industry.

Selected publications

TITLES OF OUR RECENT PUBLICATIONS BY WORDLE


KEY PUBLICATIONS

 1.  Structural basis of mitochondrial membrane bending by the I–II–III2–IV2
     supercomplex. Nature, 2023
 2.  Horizontal proton transfer across the antiporter-like subunits in
     mitochondrial respiratory complex I. Chemical Science, 2023
 3.  Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
     Nature Communications, 2023
 4.  A competitive precision CRISPR method to identify the fitness effects of
     transcription factor binding sites. Nature Biotechnology, 2023
 5.  Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade
     serous ovarian cancer. Nature Communications, 2022
 6.  Optimized detection of somatic allelic imbalances specific for homologous
     recombination deficiency improves the prediction of clinical outcomes in
     cancer. NPJ Precision Oncology, 2022
 7.  Human transcription factor protein interaction networks. Nature
     Communications, 2022.
 8.  Physical and functional interactome atlas of human receptor tyrosine
     kinases. EMBO Reports, 2022
 9.  The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted
     therapeutically in cancer. Cell, 2021
 10. The hantavirus surface glycoprotein lattice and its fusion control
     mechanism. Cell, 2020
 11. Multiple liquid crystalline geometries of highly compacted nucleic acid in
     a dsRNA virus. Nature, 2019
 12. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in
     KRAS-mutant lung cancer cells. Science Translational Medicine, 2018

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