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DE | EN
2019-04-29


DISC-SHAPED POINT-OF-CARE PLATFORM FOR INFECTIOUS DISEASE DIAGNOSIS
(DISCOGNOSIS)


THE PROJECT AIMS TO DEVELOP A FULLY INTEGRATED, AUTOMATED AND USER-FRIENDLY
PLATFORM FOR INFECTIOUS DISEASE DIAGNOSIS

Goals and objectives

The FP7 research project “DiscoGnosis” (“Disc-shaped Point-of-Care platform for
infectious disease diagnosis”) was launched beginning of November 2012 in
University of Freiburg, at the Department of Microsystems Engineering (IMTEK).
Its core objective was to develop a fully integrated, automated and
user-friendly platform that would allow the detection of malaria and other
tropical diseases causing acute fever in a rapid, multiplexed and non-invasive
way. The selected pathogens for the project demonstration included: (i)
parasites: Plasmodium falciparum, ovale, vivax, malariae, responsible for
malaria; (ii) viruses: dengue (serotypes 1-4), chikungunya, zika; (iii)
bacteria: Salmonella Typhi/Paratyphi, Streptococcus pneumoniae.


The technological approach
The DiscoGnosis platform operates similarly to a CD player: a disc-shaped
plastic disposable chip handles the injected blood sample, distributing it among
integrated microfluidic chambers using centrifugal forces. All necessary
(bio)chemical components that are needed for the genetic identification of the
pathogens are pre-stored on the disc, namely buffers and magnetic beads for DNA
& RNA extraction and purification; amplification enzymes in a lyophilized form;
primers and probes for the specific target amplification. Loop mediated
isothermal amplification (LAMP) enables a sample to answer time between 70 and
120 min (depending on each specific assay reaction).  The involved technologies
enable diagnosis to be conducted closely to the patient and provide large
populations with a modern diagnostic Point-of-Care tool in regions with low
medical infrastructure.

The outcome
The 3-year project resulted in successful demonstration of the developed
platform in two small scale studies, at the Institut Pasteur de Dakar, Senegal,
and at the Central Laboratory Khartoum, Sudan, where samples were tested with
the LabDisk and the results were confirmed by reference methods. Overall, the
platform has a high potential to (i) contribute to patient management through
diagnosis of diseases with similar clinical symptoms by detecting the genetic
profile of the pathogen, and (ii) further enhance the “shield” of Europe against
potential spread of the examined diseases due to climate change and
globalisation.

The project is supported by the European Commission through the 7th Framework
Programme on Research and Technological Development within the Objective FP7
ICT-2011.3.2 and under Grant Agreement No. 318408.

Dr. Cheikh Fall handling the LabDisk at the Institut Pasteur de Dakar, Senegal.
Source: Benjamin Lopez-Jimena, University of Stirling
PreviousNext

Funding NumberGrant Agreement No. 318408Duration01.11.2012 to
30.04.2016Cooperation PartnerDepartment of Microsystems Engineering (IMTEK),
Germany, Rohrer AG, Switzerland, University Medical Center Göttingen,
MagnaMedics Diagnostics BV, The Netherlands, University Hospital Basel,
Switzerland, European Foundation for Clinical Nanomedicine, Switzerland,
University of Sterling, UK, MAST Group Ltd, United KingdomMaturity Level
Research

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CONTACT

Dr.


KONSTANTINOS MITSAKAKIS

+49 761 203 73252 Contact


COMPETENCES

 * Point-of-need applications
 * Infectious diseases
 * Vector control
 * One Health
 * Nucleic acid + protein assay integration

RELATED EXTERNAL LINKS

 * DiscoGnosis @YouTube
 * DiscoGnosis @ Blogpost
 * Article for general public
 * Mitsakakis, et al, 2018. Diagnostic tools for tackling febrile illness and
   enhancing patient management:
 * Mitsakakis, et al, 2018. Converging Human and Malaria Vector Diagnostics with
   Data Management towards an Integrated Holistic One Health Approach
 * Project presentation at the 7th European Conference for Clinical Nanomedicine
   2014, Basel, Switzerland
 * Hin/Lopez-Jimena/Bakheit, et al, 2021. Fully automated point-of-care
   differential diagnosis of acute febrile illness

SHARE


 * Research + development
 * Development of sensor solutions
 * Sensor integration
 * Electronics + microelectronics
 * Bioanalytical testing procedures
 * Laboratory automation
 * Microfluidics + microdosing
 * 3D electronics + MID
 * Micro-energy harvesting
 * Information technology
 * Communication technology / IoT
 * Artificial intelligence
 * Measurement and analysis laboratory
 * Modeling + simulation

 * Production technologies
 * Silicon technology
 * Precision machining
 * High-tech functions in plastic
 * Microstructuring of surfaces
 * Film technologies
 * Additive manufacturing + printing technologies
 * Integrated circuit packaging technology

 * Production
 * MEMS foundry
 * Lab-on-a-chip foundry
 * Microassembly + packaging
 * Tool making + injection molding

 * Applications
 * Industrial + process technology
 * Bioanalytics
 * Medical technology
 * Energy + environment
 * Smart Home

 * Hahn-Schickard
 * Projects
 * Spin-off companies
 * Media library
 * Carreers
 * About Us
 * Newsletter
 * Contact + directions

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