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REPAGLINIDE AND EXERCISE REHABILITATION EFFECTIVE COMBO FOR TREATING DIABETES


By Dr. Shravani DaliPublished On 9 Apr 2022 4:30 AM  |  Updated On 9 Apr 2022
6:43 AM

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Repaglinide plus exercise rehabilitation is an effective combination therapy to
treat diabetes, according to the latest study published in the Disease Markers.


Diabetes, a common endocrine and metabolic disease in clinical practice,
generally manifests a certain defect in insulin secretion due to several
factors, thereafter leading to a metabolic disorder such as hyperglycemia. This
study was conducted to explore the clinical effects of repaglinide combined with
exercise rehabilitation on improving the blood glucose of patients with
diabetes.


Also Read - Calorie restricted diet added to time-restriction fails to boost
weight loss: NEJM
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In this retrospective study, 100 patients with diabetes treated in our hospital
from January 2018 to January 2020 were assessed for eligibility and recruited.
They were assigned at a ratio of 1 : 1 to receive either repaglinide (control
group) or repaglinide plus exercise rehabilitation (experimental group). Outcome
measures include fasting blood glucose, 2 h postprandial blood glucose,
glycosylated haemoglobin, time to normal blood glucose, blood glucose
fluctuation, insulin dosage, adverse reactions, and blood glucose adequate rate.


Also Read - Novel treatment Exendin-(9-39) Prevents Hypoglycemia in Children
with Hyperinsulinism
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Results:

All eligible patients showed similar pretreatment fasting blood glucose,
glycosylated haemoglobin, and 2 h postprandial blood glucose (P > 0.05). After
treatment, repaglinide plus exercise rehabilitation resulted in lower levels of
fasting blood glucose, glycosylated haemoglobin, and 2 h postprandial blood
glucose versus repaglinide alone (P < 0.05). Repaglinide plus exercise
rehabilitation was associated with a significantly shorter time to normal blood
glucose and a milder fluctuation versus repaglinide (P < 0.05). The incidence of
adverse reactions and blood glucose adequate rate was 6% and 94% in the
experimental group and 50% and 52% in the control group, respectively (P <
0.05).


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Thus, Repaglinide plus exercise rehabilitation results in effective blood
glucose control and reduced incidence of adverse reactions and yields a
promising efficacy, so it is worthy of clinical promotion and application.

Reference:

Clinical Effects of Exercise Rehabilitation Combined with Repaglinide in the
Treatment of Diabetes by Yan Li et al. published in the Disease Markers.

https://pubmed.ncbi.nlm.nih.gov/35371345/

Keywords:

Yan Li, Xi Wang, Ying Zhang, Clinical Effects, Exercise Rehabilitation,
Combination, Repaglinide, Treatment of Diabetes, Disease Markers, adverse
reactions, blood glucose control, efficacy, fasting blood glucose




glycosylated hemoglobin Exercise
Rehabilitation Repaglinide Treatment Diabetes disease markers 
Source : Disease Markers



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content/information on this website does not replace the advice of medical
and/or health professionals and should not be construed as medical/diagnostic
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use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt
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Dr. Shravani Dali


Dr. Shravani Dali has completed her BDS from Pravara institute of medical
sciences, loni. Following which she extensively worked in the healthcare sector
for 2+ years. She has been actively involved in writing blogs in field of health
and wellness. Currently she is pursuing her Masters of public health-health
administration from Tata institute of social sciences.


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