dsimb.inserm.fr Open in urlscan Pro
193.52.78.29  Public Scan

Form analysis
0 forms found in the DOM

Text Content

   
 * Home
 * Team
 * Teaching
 * Research
 * Tools
 * Publications
 * News
 * Contacts
   


DYNAMICS OF STRUCTURES AND
INTERACTIONS OF MACROMOLECULES IN BIOLOGY

WE ARE PART OF THE RED BLOOD CELL INTEGRATED BIOLOGY LAB
LOCATED AT HÔPITAL NECKER - ENFANTS MALADES.


ABOUT US

DSIMB is a bioinformatics team in the Inserm unit UMR-S1134 part of the
Laboratory of Excellence GR-Ex, whose focus is the study of membrane proteins
involved in red blood cell. The long-term scientific goal of DSIMB is to
elucidate the mechanisms governing important functions of proteins of the RBC
membrane, using information from protein structure and dynamics. Both membrane
protein structure and dynamics determine RBC function, but they are difficult to
characterize experimentally. Our expertise in structural bioinformatics and
molecular simulations enables us to tackle both aspects: the prediction of 3D
protein structures and the exploration of their dynamics.

Part of our activity is devoted to the development of methodologies to
characterize membrane systems. These methodologies aim at predicting structural
and functional properties of membrane proteins from sequence and at elucidating
dynamics and thermodynamics properties starting from 3D structures. We also
apply those methodologies to specific cases of interest for our unit and for
GR-Ex. We consider with particular interest systems relevant for diseases
studied by GR-Ex members, and we plan to contribute to the design of drugs able
to interfere with the disease mechanisms.

Our lab also works on the development of new methods for the prediction of
protein 3D structures based on their amino acid sequence. New methods based on
machine and deep learning techniques were and are currently being developed.


OUR TEAM CONTRIBUTES TO

 * The development of bioinformatics tools for predicting structural and
   dynamics properties of proteins. Tools are available here.
 * A better understanding of Duffy Antigen/Receptor for Chemokines (DARC): These
   chemokine receptors are erythrocyte transmembrane receptors for Plasmodium
   knowlesi and Plasmodium vivax merozoites, two major agents of malaria. We
   elaborated 3D structural models for DARC using experimental data provided by
   partner 2. These models were further used to predict potential binding zones
   between DARC and CXCL8 natural ligand and P. vivax partners. Once identified,
   these zones could be targeted with new designed molecules preventing
   interaction.
 * DARC VHHs: We modelled the structure of VHH sequences able to bind Nterminus
   of DARC and we identified important amino acids involved in VHH binding. This
   work was conducted in collaboration with O. Bertrand (Team 1) and Dr. Mr.
   Czerwinski, Wroclaw, Poland, on camel VHHs. This model system allows the
   development of new tools in transfusion medicine (agglutination tests in
   routine) and could serve as blocking agents against P. vivax and HIV.

We will study transporter proteins in red blood cells with the aim at providing
an insight into substrates transport mechanisms, understanding inhibition and
predicting impact of mutations involved in pathological diseases, at an
atomistic level. We will explore adhesion proteins in RBC in particular,
integrins for gaining a molecular view on pathological cell adhesion to design
anti-adhesive molecules.



Previous Next


EUROPEAN REGIONAL DEVELOPMENT FUND

The European Regional Development Fund (ERDF, FEDER in french) operates as part
of the Economic, Social and Territorial Cohesion Policy. It aims to strengthen
economic and social cohesion in the European Union by correcting imbalances
between its regions. In France, the ERDF allocation is of 9.5 billion euros for
the 2014-2020 programming period.

--------------------------------------------------------------------------------


https://siakad.unipra.ac.id/sass/view/laskar138/
https://dev.news.makassarkota.go.id/public/pgsoft-demo/
https://kpp.ambon.go.id/pg-slot-gacor/
https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/
https://dev.news.makassarkota.go.id/public/slot-gacor/
http://pbb.tanahbumbukab.go.id/-/slot-gacor/
https://simpatda.banjarnegarakab.go.id/slot-gacor-jp/