pubmed.ncbi.nlm.nih.gov
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2600:1901:0:c831::
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URL:
https://pubmed.ncbi.nlm.nih.gov/28209298/
Submission: On April 25 via manual from US — Scanned from DE
Submission: On April 25 via manual from US — Scanned from DE
Form analysis 10 forms found in the DOM
GET /
<form action="/" method="get" autocomplete="off" class="usa-search usa-search-big search-form content-page-layout" id="search-form" role="search">
<div class="inner-wrap">
<a class="pubmed-logo" aria-label="Pubmed Logo" href="/" data-ga-category="featured_link" data-ga-action="pubmed_logo">
<img src="https://cdn.ncbi.nlm.nih.gov/pubmed/3999abda-1aa9-4f90-8288-2c8a20b4769d/core/images/pubmed-logo-blue.svg" alt="pubmed logo">
</a>
<a href="#" class="search-input-trigger" data-alt-title="Hide search bar" title="Show search bar" aria-label="Show search bar" aria-hidden="true" tabindex="-1">
</a>
<div role="search" class="search-input">
<div class="form-field ">
<label class="usa-sr-only" for="id_term"> Search: </label>
<span class="twitter-typeahead ncbi-autocomplete"><input type="search" name="term" data-skip-ie-scroll-to-top="" data-replace-term-with-exact="" data-exact-query="" placeholder="" class="term-input tt-input" required="required" id="id_term"
spellcheck="false" dir="auto" style="position: relative; vertical-align: top;" aria-owns="id_term_listbox" role="combobox" aria-autocomplete="list" aria-expanded="false"><span role="status" aria-live="polite"
style="position: absolute; padding: 0px; border: 0px; height: 1px; width: 1px; margin-bottom: -1px; margin-right: -1px; overflow: hidden; clip: rect(0px, 0px, 0px, 0px); white-space: nowrap;"></span>
<pre aria-hidden="true"
style="position: absolute; visibility: hidden; white-space: pre; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; word-spacing: 0px; letter-spacing: 0px; text-indent: 0px; text-rendering: auto; text-transform: none;"></pre>
<div role="listbox" class="tt-menu" id="id_term_listbox" aria-expanded="false" style="position: absolute; top: 100%; left: 0px; z-index: 100; display: none;">
<div role="presentation" class="tt-dataset tt-dataset-0"></div>
</div>
</span><a href="#" class="clear-btn" title="Clear search input" role="button" data-pinger-ignore=""></a><button type="submit" class="search-btn" aria-label="Search" data-pinger-ignore=""><span
class="usa-search-submit-text">Search</span></button>
</div>
</div>
<!-- Create alert and Create RSS are buttons that look like links -->
<!-- Better for them to look like buttons but no space -->
<div class="search-links-wrapper content-page-layout">
<div class="search-links">
<a href="/advanced/" class="search-input-link adv-search-link" data-ga-category="featured_link" data-ga-action="adv_search">Advanced</a>
<a href="/clipboard/" class="search-input-link clipboard-link hidden" data-ga-category="featured_link" data-ga-action="clipboard">
Clipboard <span class="amount-in-clipboard"></span>
</a>
</div>
<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
<a href="/help/" data-ga-category="featured_link" data-ga-action="user_guide">
User Guide
</a>
</span>
</div>
</div>
</form>POST /results-export-ids/
<form id="save-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post"
data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="action-panel-control-wrap">
<label for="save-action-format" class="action-panel-label"> Format: </label>
<select id="save-action-format" name="results-format" class="action-panel-selector">
<option value="summary-text">Summary (text)</option>
<option value="pubmed-text">PubMed</option>
<option value="pmid">PMID</option>
<option value="abstract">Abstract (text)</option>
<option value="csv">CSV</option>
</select>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="save" data-ga-label="save"> Create file </button>
<button class="action-panel-cancel" aria-label="Close 'Save citations to file' panel" ref="linksrc=close_save_panel" aria-controls="save-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="save"
data-ga-label="cancel"> Cancel </button>
</div>
</form>POST /send-email/
<form id="email-action-panel-form" class="action-panel-content action-form" action="/send-email/" data-by-search-action="/results-export-email-by-search-data/" data-by-ids-action="/send-email/" data-by-search-method="post" data-by-ids-method="post"
method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="action-panel-control-wrap">
<span class="action-panel-label"> Subject: </span>
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 28209298 - PubMed</span>
<input type="hidden" name="email-subject" value="1 selected item: 28209298">
<input type="hidden" name="email-subject-hash" value="57b5dee0a9e988270b748308c8dab8d5afa8e027c5d2c995802911ff776a5e76">
</div>
<div class="action-panel-control-wrap">
<label for="email-to" class="action-panel-label required-field-asterisk"> To: </label>
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required="">
</div>
<div class="action-panel-control-wrap">
<label for="email-from" class="action-panel-label"> From: </label>
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
</div>
<div class="action-panel-control-wrap">
<label for="email-citation-format" class="action-panel-label"> Format: </label>
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
<option selected="selected" value="summary">Summary</option>
<option value="summary-text">Summary (text)</option>
<option value="abstract">Abstract</option>
<option value="abstract-text">Abstract (text)</option>
</select>
</div>
<div class="include-supplemental-container" style="display: none;">
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
</div>
<div class="form-field recaptcha ">
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
</div>
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="email" data-ga-label="send"> Send email </button>
<button class="action-panel-cancel" aria-label="Close 'Email citations' panel" ref="linksrc=close_email_panel" aria-controls="email-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="email" data-ga-label="cancel">
Cancel </button>
</div>
<input type="hidden" name="email-search-details" value="">
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524">
</form><form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li>
<input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new">
<label for="collections-action-panel-new">Create a new collection</label>
</li>
<li>
<input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing">
<label for="collections-action-panel-existing">Add to an existing collection</label>
</li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls">
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label>
<input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>/]*" title="The following characters are not allowed in the Name field: "&=<>/"
maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection">
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div>
</div>
<div class="action-panel-control-wrap existing-collections-controls">
<label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label>
<select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection"
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
</select>
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br>
<a href="#">Please try again</a>
</div>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore="" data-ga-category="save_share" data-ga-action="collections" data-ga-label="add" disabled=""> Add </button>
<button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections"
data-ga-label="cancel"> Cancel </button>
</div>
</form><form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10"
data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="action-panel-control-wrap bibliographies-controls">
<div class="choice-group">
<ul class="bibliographies-action-add radio-group-items">
<li>
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked="">
<label for="my-bibliography">My Bibliography</label>
</li>
</ul>
</div>
</div>
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br>
<a href="#">Please try again</a>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore=""> Add </button>
<button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib"
data-ga-label="cancel"> Cancel </button>
</div>
</form><form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/"
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="action-panel-control-wrap">
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label>
<input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required="" pattern="[^"&=<>/]*" title="The following characters are not allowed in the Name field: "&=<>/">
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label>
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required=""></textarea>
</div>
<div class="test-search-term-wrap">
<a href="#" class="try-search-term">Test search terms</a>
</div>
<div class="choice-group action-panel-extra-margin-top">
<span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span>
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
<ul class="radio-group-items">
<li>
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked="">
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
</li>
<li>
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
<label for="saved-search-alert-no" class="action-panel-label">No</label>
</li>
</ul>
</fieldset>
</div>
<div class="alert-schedule-wrap">
<div class="action-panel-control-wrap">
<label class="action-panel-label"> Email: </label>
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
</div>
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="saved-search-frequency" class="action-panel-label"> Frequency: </label>
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
<option value="monthly">Monthly</option>
<option value="weekly">Weekly</option>
<option value="daily">Daily</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-monthly-additional">
<label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label>
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
<option value="Sunday">The first Sunday</option>
<option value="Monday">The first Monday</option>
<option value="Tuesday">The first Tuesday</option>
<option value="Wednesday">The first Wednesday</option>
<option value="Thursday">The first Thursday</option>
<option value="Friday">The first Friday</option>
<option value="Saturday">The first Saturday</option>
<option value="day">The first day</option>
<option value="weekday">The first weekday</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-weekly-additional" style="display: none;">
<label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label>
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
<option value="Sunday">Sunday</option>
<option value="Monday">Monday</option>
<option value="Tuesday">Tuesday</option>
<option value="Wednesday">Wednesday</option>
<option value="Thursday">Thursday</option>
<option value="Friday">Friday</option>
<option value="Saturday">Saturday</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-report" class="action-panel-label"> Report format: </label>
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
<option value="DocSum">Summary</option>
<option value="DocSumText">Summary (text)</option>
<option value="Abstract">Abstract</option>
<option value="AbstractText">Abstract (text)</option>
<option value="MEDLINE">PubMed</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-amount" class="action-panel-label"> Send at most: </label>
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
<option value="1">1 item</option>
<option value="5" selected="">5 items</option>
<option value="10">10 items</option>
<option value="20">20 items</option>
<option value="50">50 items</option>
<option value="100">100 items</option>
<option value="200">200 items</option>
</select>
</div>
<div>
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label>
</div>
<div class="action-panel-control-wrap option-text-in-email-wrap">
<label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label>
<textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button>
<button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert"
data-ga-label="cancel"> Cancel </button>
</div>
</form>POST /results-export-ids/
<form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post"
data-by-search-method="post" data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<input name="results-format" type="hidden" value="pubmed">
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button>
<button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share"
data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button>
</div>
</form><form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value="">
<input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="action-panel-control-wrap">
<label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label>
<input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value="" required="" pattern="[^"&=<>/]*" title="The following characters are not allowed in the Name field: "&=<>/">
</div>
<div class="rss-limit-wrap">
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="rss-limit" class="action-panel-label"> Number of items displayed: </label>
<select id="rss-limit" class="no-border-panel-selector rss-limit">
<option value="5">5</option>
<option value="10">10</option>
<option value="15" selected="selected">15</option>
<option value="20">20</option>
<option value="50">50</option>
<option value="100">100</option>
</select>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button>
<button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel
</button>
</div>
<div class="action-panel-control-wrap rss-link-copy-wrap">
<label for="rss-link" class="usa-sr-only">RSS Link</label>
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
<button type="button" disabled="" class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button>
</div>
</form><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="NEv28JBakUBMIH4AgqnHxCV788gWGtZBBGaiuCi2hCFnrR2Y4H25dFdEZ2mgCNYQ">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label
for="collections-action-dialog-new">Create a new collection</label></li>
<li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click"
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection"
id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100"
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Clinical Trial
Lancet Oncol
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. 2017 Mar;18(3):371-383.
doi: 10.1016/S1470-2045(17)30088-8. Epub 2017 Feb 11.
UTIDELONE PLUS CAPECITABINE VERSUS CAPECITABINE ALONE FOR HEAVILY PRETREATED
METASTATIC BREAST CANCER REFRACTORY TO ANTHRACYCLINES AND TAXANES: A
MULTICENTRE, OPEN-LABEL, SUPERIORITY, PHASE 3, RANDOMISED CONTROLLED TRIAL
Pin Zhang 1 , Tao Sun 2 , Qingyuan Zhang 3 , Zhongyu Yuan 4 , Zefei Jiang 5
, Xiao Jia Wang 6 , Shude Cui 7 , Yuee Teng 8 , Xi-Chun Hu 9 , Junlan Yang
10 , Hongming Pan 11 , Zhongsheng Tong 12 , Huiping Li 13 , Qiang Yao 14
, Yongsheng Wang 15 , Yongmei Yin 16 , Ping Sun 17 , Hong Zheng 18 , Jing
Cheng 19 , Jinsong Lu 20 , Baochun Zhang 21 , Cuizhi Geng 22 , Jian Liu 23
, Roujun Peng 4 , Min Yan 7 , Shaohua Zhang 5 , Jian Huang 6 , Li Tang 24
, Rongguo Qiu 24 , Binghe Xu 25 ; BG01-1323L study group
Affiliations Expand
AFFILIATIONS
* 1 Department of Medical Oncology, National Cancer Center/Cancer Hospital,
Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing, China.
* 2 Liaoning Cancer Hospital and Institute, Shenyang, China.
* 3 Department of Medical Oncology, Harbin Medical University Cancer Hospital,
Harbin, China.
* 4 Department of Medical Oncology, Sun Yat-sen University Cancer Center,
Guangzhou, China.
* 5 The 307th Hospital of Chinese PLA, Beijing, China.
* 6 Zhejiang Cancer Hospital, Hangzhou, China.
* 7 Breast Cancer Center, Henan Cancer Hospital, Zhengzhou, China.
* 8 Department of Medical Oncology, the First Hospital of China Medical
University, Shenyang, China.
* 9 Fudan University Cancer Center, Shanghai, China.
* 10 The 301st Hospital of Chinese PLA, Beijing, China.
* 11 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,
Hangzhou, China.
* 12 Department of Breast Oncology, Tianjin Medical University Cancer Hospital,
Tianjin, China.
* 13 Peking University Cancer Hospital, Beijing, China.
* 14 Nankai University Tianjin People's Hospital, Tianjin, China.
* 15 Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
* 16 The First Affiliated Hospital of Nanjing Medical University, Nanjing,
China.
* 17 Qingdao University Yantai Yuhuangding Hospital, Yantai, China.
* 18 Sichuan University West China Hospital, Chengdu, China.
* 19 Tongji Medical College Wuhan Union Hospital, Wuhan, China.
* 20 Shanghai Jiaotong University Renji Hospital, Shanghai, China.
* 21 Nantong Tumor Hospital, Nantong, China.
* 22 Hebei Medical University Tumor Hospital, Shijiazhuang, China.
* 23 Fujian Medical University Cancer Hospital, Fuzhou, China.
* 24 Beijing Biostar Technologies, Beijing, China.
* 25 Department of Medical Oncology, National Cancer Center/Cancer Hospital,
Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing, China. Electronic address: bhxu@hotmail.com.
* PMID: 28209298
* DOI: 10.1016/S1470-2045(17)30088-8
Item in Clipboard
Clinical Trial
UTIDELONE PLUS CAPECITABINE VERSUS CAPECITABINE ALONE FOR HEAVILY PRETREATED
METASTATIC BREAST CANCER REFRACTORY TO ANTHRACYCLINES AND TAXANES: A
MULTICENTRE, OPEN-LABEL, SUPERIORITY, PHASE 3, RANDOMISED CONTROLLED TRIAL
Pin Zhang et al. Lancet Oncol. 2017 Mar.
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Lancet Oncol
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. 2017 Mar;18(3):371-383.
doi: 10.1016/S1470-2045(17)30088-8. Epub 2017 Feb 11.
AUTHORS
Pin Zhang 1 , Tao Sun 2 , Qingyuan Zhang 3 , Zhongyu Yuan 4 , Zefei Jiang 5
, Xiao Jia Wang 6 , Shude Cui 7 , Yuee Teng 8 , Xi-Chun Hu 9 , Junlan Yang
10 , Hongming Pan 11 , Zhongsheng Tong 12 , Huiping Li 13 , Qiang Yao 14
, Yongsheng Wang 15 , Yongmei Yin 16 , Ping Sun 17 , Hong Zheng 18 , Jing
Cheng 19 , Jinsong Lu 20 , Baochun Zhang 21 , Cuizhi Geng 22 , Jian Liu 23
, Roujun Peng 4 , Min Yan 7 , Shaohua Zhang 5 , Jian Huang 6 , Li Tang 24
, Rongguo Qiu 24 , Binghe Xu 25 ; BG01-1323L study group
AFFILIATIONS
* 1 Department of Medical Oncology, National Cancer Center/Cancer Hospital,
Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing, China.
* 2 Liaoning Cancer Hospital and Institute, Shenyang, China.
* 3 Department of Medical Oncology, Harbin Medical University Cancer Hospital,
Harbin, China.
* 4 Department of Medical Oncology, Sun Yat-sen University Cancer Center,
Guangzhou, China.
* 5 The 307th Hospital of Chinese PLA, Beijing, China.
* 6 Zhejiang Cancer Hospital, Hangzhou, China.
* 7 Breast Cancer Center, Henan Cancer Hospital, Zhengzhou, China.
* 8 Department of Medical Oncology, the First Hospital of China Medical
University, Shenyang, China.
* 9 Fudan University Cancer Center, Shanghai, China.
* 10 The 301st Hospital of Chinese PLA, Beijing, China.
* 11 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University,
Hangzhou, China.
* 12 Department of Breast Oncology, Tianjin Medical University Cancer Hospital,
Tianjin, China.
* 13 Peking University Cancer Hospital, Beijing, China.
* 14 Nankai University Tianjin People's Hospital, Tianjin, China.
* 15 Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
* 16 The First Affiliated Hospital of Nanjing Medical University, Nanjing,
China.
* 17 Qingdao University Yantai Yuhuangding Hospital, Yantai, China.
* 18 Sichuan University West China Hospital, Chengdu, China.
* 19 Tongji Medical College Wuhan Union Hospital, Wuhan, China.
* 20 Shanghai Jiaotong University Renji Hospital, Shanghai, China.
* 21 Nantong Tumor Hospital, Nantong, China.
* 22 Hebei Medical University Tumor Hospital, Shijiazhuang, China.
* 23 Fujian Medical University Cancer Hospital, Fuzhou, China.
* 24 Beijing Biostar Technologies, Beijing, China.
* 25 Department of Medical Oncology, National Cancer Center/Cancer Hospital,
Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing, China. Electronic address: bhxu@hotmail.com.
* PMID: 28209298
* DOI: 10.1016/S1470-2045(17)30088-8
Item in Clipboard
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ABSTRACT
Background: Utidelone, a genetically engineered epothilone analogue, has shown
promise as a potential treatment for breast cancer in phase 1 and 2 trials. The
aim of this phase 3 trial was to compare the efficacy and safety of utidelone
plus capecitabine versus capecitabine alone in patients with metastatic breast
cancer.
Methods: We did a multicentre, open-label, superiority, phase 3, randomised
controlled trial in 26 hospitals in China. Eligible participants were female
patients with metastatic breast cancer refractory to anthracycline and taxane
chemotherapy regimens. We randomly assigned participants (2:1) using computer
based randomisation and block sizes of 6 to a 21-day cycle of either utidelone
(30 mg/m2 intravenously once per day on days 1-5) plus capecitabine (1000 mg/m2
orally twice per day on days 1-14), or capecitabine alone (1250 mg/m2 orally
twice per day on days 1-14), until disease progression or unacceptable toxicity
occurred. Patients, physicians, and assessors were not masked to treatment
allocation; however, an independent radiology review committee used to
additionally assess response was masked to allocation. The primary endpoint was
centrally assessed (by an independent radiology review committee)
progression-free survival, and analysed using the Kaplan-Meier product-limit
method in the intention-to-treat population. Safety was assessed in all
participants who received at least one dose of study drug. Follow-up is ongoing.
This study is registered at ClinicalTrials.gov, number NCT02253459.
Findings: Between Aug 8, 2014, and Dec 14, 2015, we enrolled and randomly
assigned 270 patients to treatment with utidelone plus capecitabine, and 135 to
capecitabine alone. Median follow-up for progression-free survival was 6·77
months (IQR 3·81-10·32) for the utidelone plus capecitabine group and 4·55
months (2·55-9·39) for the capecitabine alone group. Median progression-free
survival by central review in the utidelone plus capecitabine group was 8·44
months (95% CI 7·95-9·92) compared with 4·27 months (3·22-5·68) in the
capecitabine alone group; hazard ratio 0·46, 95% CI 0·36-0·59; p<0·0001.
Peripheral neuropathy was the most common grade 3 adverse event in the utidelone
plus capecitabine group (58 [22%] of 267 patients vs 1 [<1%] of 130 patients in
the capecitabine alone group). Palmar-plantar erythrodysaesthesia was the most
prominent grade 3 adverse event in the capacitabine alone group (in 10 [8%] of
130 patients) and was the next most frequent grade 3 event in the utidelone plus
capecitabine group (in 18 [7%] of 267 patients). 16 serious adverse events were
reported in the combination therapy group (diarrhoea was the most common, in
three [1%] patients) and 14 serious adverse events were reported in the
monotherapy group (the most common were diarrhoea, increased blood bilirubin,
and anaemia, in two [2%] patients for each event). 155 patients died (99 in the
combination therapy arm, 56 in the monotherapy arm). All deaths were related to
disease progression except for one in each group (attributed to pericardial
effusion in the combination therapy group and dyspnoea in the monotherapy group)
that were considered possibly or probably treatment-related.
Interpretation: Despite disease progression with previous chemotherapies,
utidelone plus capecitabine was more efficacious compared with capecitabine
alone for the outcome of progression-free survival, with mild toxicity except
for peripheral sensory neuropathy, which was manageable. The findings from this
study support the use of utidelone plus capecitabine as an effective option for
patients with metastatic breast cancer.
Funding: Beijing Biostar Technologies, Beijing, China.
Copyright © 2017 Elsevier Ltd. All rights reserved.
COMMENT IN
* Classic cytotoxic drugs: a narrow path for regulatory approval.
Pivot X. Pivot X. Lancet Oncol. 2017 Mar;18(3):279-281. doi:
10.1016/S1470-2045(17)30089-X. Epub 2017 Feb 11. Lancet Oncol. 2017. PMID:
28209299 No abstract available.
* Breast cancer: Utidelone: burden relief in pretreated women.
Hutchinson L. Hutchinson L. Nat Rev Clin Oncol. 2017 Apr;14(4):199. doi:
10.1038/nrclinonc.2017.29. Epub 2017 Mar 2. Nat Rev Clin Oncol. 2017. PMID:
28252004 No abstract available.
SIMILAR ARTICLES
* Phase II trial of utidelone as monotherapy or in combination with
capecitabine in heavily pretreated metastatic breast cancer patients.
Zhang P, Tong Z, Tian F, Wang Y, Yang J, Li W, Di L, Liu W, Tang L, Qiu R, Xu
B. Zhang P, et al. J Hematol Oncol. 2016 Aug 11;9(1):68. doi:
10.1186/s13045-016-0297-7. J Hematol Oncol. 2016. PMID: 27516093 Free PMC
article. Clinical Trial.
* Trastuzumab emtansine versus capecitabine plus lapatinib in patients with
previously treated HER2-positive advanced breast cancer (EMILIA): a
descriptive analysis of final overall survival results from a randomised,
open-label, phase 3 trial.
Diéras V, Miles D, Verma S, Pegram M, Welslau M, Baselga J, Krop IE,
Blackwell K, Hoersch S, Xu J, Green M, Gianni L. Diéras V, et al. Lancet
Oncol. 2017 Jun;18(6):732-742. doi: 10.1016/S1470-2045(17)30312-1. Epub 2017
May 16. Lancet Oncol. 2017. PMID: 28526536 Free PMC article. Clinical Trial.
* Efficacy of utidelone plus capecitabine versus capecitabine for heavily
pretreated, anthracycline- and taxane-refractory metastatic breast cancer:
final analysis of overall survival in a phase III randomised controlled
trial.
Xu B, Sun T, Zhang Q, Zhang P, Yuan Z, Jiang Z, Wang X, Cui S, Teng Y, Hu XC,
Yang J, Pan H, Tong Z, Li H, Yao Q, Wang Y, Yin Y, Sun P, Zheng H, Cheng J,
Lu J, Zhang B, Geng C, Liu J, Shen K, Yu S, Li H, Tang L, Qiu R; study group
of BG01-1323L. Xu B, et al. Ann Oncol. 2021 Feb;32(2):218-228. doi:
10.1016/j.annonc.2020.10.600. Epub 2020 Nov 11. Ann Oncol. 2021. PMID:
33188874 Clinical Trial.
* Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as
first-line treatment for HER2-negative metastatic breast cancer (TURANDOT):
primary endpoint results of a randomised, open-label, non-inferiority, phase
3 trial.
Zielinski C, Láng I, Inbar M, Kahán Z, Greil R, Beslija S, Stemmer SM,
Zvirbule Z, Steger GG, Melichar B, Pienkowski T, Sirbu D, Petruzelka L, Eniu
A, Nisenbaum B, Dank M, Anghel R, Messinger D, Brodowicz T; TURANDOT
investigators. Zielinski C, et al. Lancet Oncol. 2016 Sep;17(9):1230-9. doi:
10.1016/S1470-2045(16)30154-1. Epub 2016 Aug 5. Lancet Oncol. 2016. PMID:
27501767 Clinical Trial.
* Ixabepilone plus capecitabine with capecitabine alone for metastatic breast
cancer.
Li L, Li J, Yang K, Tian J, Sun T, Jia W, Zhang P, Yi K. Li L, et al. Future
Oncol. 2010 Feb;6(2):201-7. doi: 10.2217/fon.09.162. Future Oncol. 2010.
PMID: 20146579 Review.
See all similar articles
CITED BY
* Efficacy of electroacupuncture in the treatment of peripheral neuropathy
caused by Utidelone: Study protocol for a randomized controlled trial.
Lu C, Li G, Deng D, Li R, Li X, Feng X, Wu T, Shao X, Chen W. Lu C, et al.
Front Neurol. 2023 Feb 9;14:1065635. doi: 10.3389/fneur.2023.1065635.
eCollection 2023. Front Neurol. 2023. PMID: 36846114 Free PMC article.
* Current Therapeutic Strategies for Metastatic Triple-Negative Breast Cancer:
From Pharmacists' Perspective.
Li S, Bao C, Huang L, Wei JF. Li S, et al. J Clin Med. 2022 Oct
12;11(20):6021. doi: 10.3390/jcm11206021. J Clin Med. 2022. PMID: 36294342
Free PMC article. Review.
* Breast cancer: an up-to-date review and future perspectives.
Hong R, Xu B. Hong R, et al. Cancer Commun (Lond). 2022 Oct;42(10):913-936.
doi: 10.1002/cac2.12358. Epub 2022 Sep 8. Cancer Commun (Lond). 2022. PMID:
36074908 Free PMC article. Review.
* Cost-Effectiveness of Pharmacologic Treatment Options for Women With
Endocrine-Refractory or Triple-Negative Metastatic Breast Cancer.
Wheeler SB, Rotter J, Gogate A, Reeder-Hayes KE, Drier SW, Ekwueme DU,
Fairley TL, Rocque GB, Trogdon JG. Wheeler SB, et al. J Clin Oncol. 2023 Jan
1;41(1):32-42. doi: 10.1200/JCO.21.02473. Epub 2022 Sep 2. J Clin Oncol.
2023. PMID: 36054865
* Treatment of HR+/HER2- breast cancer in urban mainland China: results from
the CancerMPact Survey 2019.
Murali B, Durbin L, Vijaykumar S, Yang L, Li S, Zhao L, Hawthorne S, Kanas G,
Davis C, Clark O. Murali B, et al. Breast Cancer Res Treat. 2022
Oct;195(3):441-451. doi: 10.1007/s10549-022-06709-x. Epub 2022 Aug 20. Breast
Cancer Res Treat. 2022. PMID: 35986800 Free PMC article.
See all "Cited by" articles
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