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ALEX'S LEMONADE STAND FOUNDATION FOR CHILDHOOD CANCER
Fighting childhood cancer, one cup at a time.
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1. The Crazy 8 Initiative
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WHERE THE MONEY GOES
FOR SOME CHILDHOOD CANCERS, TREATMENT PLANS HAVE NOT CHANGED FOR DECADES. FOR
SOME CHILDREN, THERE WILL BE NO CURE. WE HAVE A PLAN TO CHANGE THIS—AND THE PLAN
IS THE CRAZY 8 INITIATIVE.
THE COMMITMENT
Since our founding, Alex’s Lemonade Stand Foundation (ALSF) has promoted
collaboration and working together to find cures.
In the spirit of growing scientific collaboration, ALSF has launched the Crazy 8
Initiative to detail roadmaps toward cures for specific, hard-to-treat childhood
cancers. In addition to its current grant opportunities, the Crazy 8 Initiative
creates a new funding pillar for ALSF, allowing the Foundation to tackle
explicit challenges in pediatric cancer research that require substantial
support for collaborative teams. ALSF has committed the first $25 million to
support the Crazy 8 Initiative, funding six projects so far. In 2022, ALSF made
an additional commitment to bring the total to $50 million, which will fund at
least 10 game-changing collaborative projects that connects researchers across
the globe.
The Crazy 8 Initiative will fund research into innovative and rigorous
approaches that directly address the most intractable issues in pediatric cancer
research today. Project teams of cross-disciplinary scientists work
collaboratively, accelerating the pace of new cure discovery, and
each grant will provide funding for large-scale collaborative projects in the
$1-5 million range.
We will create a future free of childhood cancer.
Support the Crazy 8 Initiative
THE CRAZY 8 INITIATIVE MEETING
The Crazy 8 Initiative kicked off in the fall of 2018 with a meeting that
brought together more than 90 top scientists from around the world to contribute
their expertise in eight key areas of need:
1. Embryonal brain cancers
2. High-grade gliomas
3. Fusion-positive sarcomas
4. Fusion-negative sarcomas
5. Leukemias
6. Neuroblastoma
7. Big data
8. Catalyzing clinical trials
The meeting was chaired by Nada Jabado, MD/PhD of McGill University and John
Maris, MD of Children’s Hospital of Philadelphia. The group aimed to undertake
the big question: How can we tackle major obstacles impeding progress towards
cures for childhood cancer through multidisciplinary collaborative research?
To jump start the research ideas that came out of the Crazy 8 Initiative
Meeting, ALSF supported 11 pilot projects in 2019, with at least one project for
each Crazy 8 area of need. Learn more about the exciting Crazy 8 pilot projects
here.
THE 2020 CRAZY 8 INITIATIVE AWARD SELECTION PROCESS
The outcomes of the Crazy 8 Initiative Meeting included a list of addressable
problems and proposed pathways forward to overcome these obstacles to make cures
a reality. Four cross-cutting research themes were identified:
1. Developmental Origins of Pediatric Cancers
2. Drugging Currently Undruggable Pediatric Cancer Drivers
3. Developing Novel Immunotherapies
4. Discovery of Novel Pediatric Cancer Drug Targets
Coupling the eight key areas of need with the four research themes allowed ALSF
to develop Crazy 8 application guidelines and request from the scientific
community, grant applications responsive to the spirit of the Crazy 8
Initiative.
After submission of letters of intent, 100 applicants were asked to submit full
applications in January 2020. A rigorous peer-review of the applications
resulted in the selection of 10 finalists for the award. The finalists presented
their proposed project to the Crazy 8 Scientific Review Board and ALSF
Leadership in Fall 2020. Final grant selections were then made for four
outstanding projects which can be viewed here.
Learn About The Crazy 8 Projects
THE 2021 CRAZY 8 INITIATIVE AWARD SELECTION PROCESS AND NEXT STEPS
ALSF has committed $25 million to support research through the Crazy 8
Initiative. Approximately $18.5 million was allocated in the first round of
funding in 2020, and ALSF is pleased to announce $6.1 million has been awarded
in 2022 to two new projects.
Priority was given to projects involving innovative studies of high-grade
gliomas, non-medulloblastoma embryonal brain tumors, non-Ewing Sarcoma
fusion-positive sarcomas, fusion-negative sarcomas, big data and/or catalyzing
clinical trials. ALSF received over 50 letters of intent from investigators with
proposals focusing on leukemias, neuroblastoma, sarcomas and medulloblastoma. Of
those, fourteen submissions were invited to submit a full proposal.
After a rigorous scientific review process, four finalists presented their
proposed projects to the Crazy 8 Scientific Review Board and ALSF Leadership.
Two exceptional projects focusing on osteosarcoma were selected. They can be
viewed here.
ALSF has increased its commitment to $50 million total, which will fund at least
10 game-changing collaborative projects that connects researchers across the
globe. We have already raised and allocated $25 million toward 6 projects that
are taking on the deadliest of childhood cancers with one singular focus: curing
the incurable.
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