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Oral Candidiasis + HCP Resources
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EN
EN
FR
A QUICK TOOL FOR CANADIAN HCPS
Everything you need to know about oral candidiasis for managing your patients.
Download Tool
A TOOL TAILOR MADE
FOR YOUR PRACTICE
See More
Read Publication
Review and Practical Guidance on Managing Fungal Infections in Patients With
Psoriasis Receiving Anti-IL-17 Therapies
PUBLICATION
Oral Thrush Presentation
Oral Thrush
When you wipe off the white patches, they leave red spots that can bleed.
IMAGES
What does oral candidiasis look like?
ABOUT
About
Oral Candidiasis + HCP Resources
Welcome to a practical and quick resource, designed specifically for
busy Canadian healthcare providers.
This platform is dedicated to supporting your practice with a focus on the
diagnosis and treatment of oral candidiasis, including a comprehensive and
accessible comparison tool for download.
Brought to you by a multidisciplinary faculty from across Canada with
practitioners from rheumatology, dermatology, and pharmacy.
Our goal is to equip you with the latest insights, research findings, and
clinical strategies to enhance patient care,
efficiently.
Click here to see by Province who can prescribe for oral candidiasis treatments
in Canada.
APPROACH
Drug-Drug Interactions.
* ITRACONIZOLE
*High interaction potential.
Itraconazole is a potent inhibitor of cytochrome P450 3A4 (CYP3A4),
associated with numerous drug-drug interactions (DDI). This may lead to
increased plasma concentrations of drugs metabolized by this pathway which
may increase or prolong both therapeutic and adverse effects to such an
extent that a potentially serious situation may occur. Please refer to an
interaction checker to assess drug-drug interactions on a case by case basis.
Contraindications: methadone, disopyramide, dronedarone, quinidine,
ticagrelor, ergot alkaloids, such as dihydroergotamine, ergometrine
(ergonovine), ergotamine, irinotecan, lurasidone, pimozide, triazolam,
felodipine, ivabradine, ranolazine, eplerenone, domperidone, naloxegol,
lomitapide, lovastatin, simvastatin, fesoterodine (in subjects with moderate
to severe renal impairment, or moderate to severe hepatic impairment),
solifenacin (in subjects with severe renal impairment or moderate to severe
hepatic impairment), eletriptan, colchicine (in subjects with renal or
hepatic impairment).
PLEASE NOTE: LIST ABOVE IS NOT EXHAUSTIVE AND WE ENCOURAGE YOU TO ASSESS CASE
BY CASE
* FLUCONIZOLE
Fluconazole is a potent inhibitor of cytochrome CYP2C9 and a moderate CYP3A4
inhibitor.
There is a risk of increased plasma concentration compounds metabolized by
CYP2C9 and CYP3A4 co-administered with fluconazole. Therefore, caution should
be exercised when using these combinations and the patients should be
carefully monitored.
The enzyme inhibiting effect of fluconazole persists 4-5 days after
discontinuation of fluconazole treatment due to the long half-life of
fluconazole
Statins (ie. atorvastatin, lovastatin, and simvastatin), benzodiazepines (ie.
midazolam, triazolam, and diazepam), warfarin, systemic calcineurin
inhibitors (ie. cyclosporine and tacrolimus), system corticosteroids (ie.
prednisone), phenytoin.
PLEASE NOTE: LIST ABOVE IS NOT EXHAUSTIVE AND WE ENCOURAGE YOU TO ASSESS CASE
BY CASE
* QT Prolonging Medications
QT-Prolonging Medications (Note: List below is not exhaustive)
Antipsychotics: Haloperidol, ziprasidone, quetiapine, thioridazine,
olanzapine, risperidone, droperidol
Antiarrhythmics: Amiodarone, sotalol, dofetilide, procainamide, quinidine,
flecainide
Antibiotics: Macrolides, fluoroquinolones
Antidepressants: Amitriptyline, imipramine, citalopram, amitriptyline
Others: Methadone, sumatriptan, ondansetron, cisapride
FACULTY
Meet the Faculty
JON CHAN
Rheumatologist
Vancouver, BC
LARA KASSAM
Pharmacist
Montreal, QC
LAUREN LAM
Dermatologist
Calgary, AB
IRINA TURCHIN
Dermatologist
St.John's, NFLD
CAROLYN WHISKEN
Pharmacist
Hamilton, ON
AARON WONG
Dermatologist
Vancouver, BC
JENSEN YEUNG
Dermatologist
Toronto, ON
POWERED BY A MULTIDISCIPLINARY TEAM OF EXPERTS.
FAQ
You're probably
wondering...
ARE YOU A CANADIAN
HCP WITH A QUESTION WE HAVEN'T ANSWERED HERE?
First name*
Last name*
Email*
Phone
How can we help?
Submit
REFERENCES CITED
* Armstrong AW, Blauvelt A, Mrowietz U, Strober B, Gisondi P, Merola JF,
Langley RG, Ståhle M, Lebwohl M, Netea MG, Nunez Gomez N. A practical guide
to the management of oral candidiasis in patients with plaque psoriasis
receiving treatments that target interleukin-17. Dermatology and Therapy.
2022 Mar;12(3):787-800.
* CPS [Internet]. Ottawa (ON): Canadian Pharmacists Association; c2016 [updated
2020 01 29; citef 2024 05 01]. Itraconazole[product monograph]. Available
from:https://cps-pharmacists-ca.eu1.proxy.openathens.net/search
* [Internet]. Kirkland (QC):Pfizer Canada Inc; c2018 [updated 2018 01 06; cited
2024 05 01].Fluconazole [product monograph]. Available
from:https://pdf.hres.ca/dpd_pm/00045911.PDF
* Yeung J, Bunce PE, Lynde CW, Turchin I, Vender RB. Review and practical
guidance on managing fungal infections in patients with psoriasis receiving
anti-IL-17 therapies. Journal of Cutaneous Medicine and Surgery. 2022
Jul;26(1_suppl):3S-23S.
Clinical Presentation
Clinical Presentation
IMAGES
WHAT DOES ORAL CANDIDIASIS LOOK LIKE?
* May be asymptomatic or associated with localized mucosal pain, altered taste,
or a sensation of oral fullness
* Whitish plaques can be visualized on the tongue, as well as buccal and
palatal surfaces
* Plaques are not firmly affixed to the mucosa and can easily be scraped off
* When white patches wiped off, they may leave red spots that can bleed.
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