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Submission: On February 28 via manual from AU — Scanned from AU
Submission: On February 28 via manual from AU — Scanned from AU
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<option value="97367">10th Anniversary of Antioxidants-Advances in Health Outcomes of Oxidative Stress</option>
<option value="99222">Advances in Anticancer Drugs based on Phytocompounds with Antioxidant Properties</option>
<option value="139984">Advances in Mitochondrial Redox Biology</option>
<option value="85288">Advances in Oxidative Stress and Eye Diseases</option>
<option value="140512">Aging, Mitochondria, and Antioxidants</option>
<option value="99729">Airway Inflammation Induced by Oxidative Stress</option>
<option value="167640">Airway Inflammation Induced by Oxidative Stress, 2nd Edition</option>
<option value="139960">Alcohol-Induced Oxidative Stress in Health and Disease</option>
<option value="83056">Alcohol-Induced Oxidative Stress in Health and Disease and the Role of Antioxidants</option>
<option value="25948">Anti-Inflammatory and Antioxidant Effects of Dietary Supplementation and Lifestyle Factors</option>
<option value="81305">Anti-inflammatory and Antioxidant Effects of Exercise and Training with the Mechanisms and Modulations</option>
<option value="42620">Anticancer Antioxidants</option>
<option value="19183">Antioxidant Activity and Disease-Modifying Potential of Medicinal Herbs</option>
<option value="48798">Antioxidant Activity of “Polyphenolic Food” and Human Health</option>
<option value="87761">Antioxidant Activity of “Polyphenolic-Food” and Human Health – 2nd Edition</option>
<option value="164674">Antioxidant Activity of Polyphenolic-Food and Human Health—3rd Edition</option>
<option value="54569">Antioxidant Agents for the Prevention and Therapy of Oxidative Stress in Hepatic Diseases</option>
<option value="178289">Antioxidant and Anti-inflammatory Effects of Hydrogen-Enriched Water</option>
<option value="189715">Antioxidant and Anti-Inflammatory Potential of Plants in Cancer Treatment</option>
<option value="61322">Antioxidant and Anti-Inflammatory Properties of Incretin-Based Therapies—Implications for Acute and Chronic Disease</option>
<option value="172565">Antioxidant and Cytotoxic Effects of Phytochemicals</option>
<option value="8786">Antioxidant and Neuroprotection</option>
<option value="178983">Antioxidant Biomarkers and Oxidative Stress in Aquatic Organisms</option>
<option value="140294">Antioxidant Capability and Physical Exercise in Neurobiology: A Focus in Neurodegeneration II</option>
<option value="178462">Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition</option>
<option value="94866">Antioxidant Defence in Type 2 Diabetes</option>
<option value="146311">Antioxidant Defence System during Arthritis and Osteoarthritis</option>
<option value="140938">Antioxidant Defenses in Fish</option>
<option value="186778">Antioxidant Defenses in Fish—2nd Edition</option>
<option value="53902">Antioxidant Foods and Cardiometabolic Health</option>
<option value="118966">Antioxidant Foods and Cardiometabolic Health - 2nd Edition</option>
<option value="81620">Antioxidant Improvements by Nrf2 and PPAR Gamma Activation in Cardiovascular and Neurodegenerative Diseases</option>
<option value="49720">Antioxidant Micronutrients in Animal Diet: From Health to Meat Quality</option>
<option value="192287">Antioxidant Response in Skeletal Muscle</option>
<option value="160889">Antioxidant Status in Tumor Progression</option>
<option value="134198">Antioxidant Supplementation on Fertility</option>
<option value="187744">Antioxidant System Efficiency in Kidney Diseases</option>
<option value="179297">Antioxidant Therapies for Oxidative Stress-Related Diseases in Newborns</option>
<option value="82539">Antioxidant Therapy for Cardiovascular Diseases</option>
<option value="99293">Antioxidant Therapy for Management of Oxidative Stress Induced Hypertension</option>
<option value="38550">Antioxidant Therapy in Cardiovascular Medicine: Bench to Bedside</option>
<option value="131699">Antioxidant Treatment Strategies-Photobiomodulation Therapy in Diseases</option>
<option value="92595">Antioxidant Treatment Strategies: Photobiomodulation in Pain Management and Tissue Regeneration</option>
<option value="185981">Antioxidant–Drug Interactions and Their Effects on Oxidative Stress</option>
<option value="48947">Antioxidants and Age-Related Ocular Diseases</option>
<option value="72869">Antioxidants and Anti-inflammatory Effects in Neurodegenerative Diseases</option>
<option value="130554">Antioxidants and Bioactive Compounds in the Mediterranean Diet Foods: Bridging the Gap between Their Mode of Action and Health-Protective Effects</option>
<option value="180342">Antioxidants and Bioactive Compounds in the Mediterranean Diet Foods: Bridging the Gap between Their Mode of Action and Health-Protective Effects—2nd Edition</option>
<option value="46071">Antioxidants and Cancer</option>
<option value="41906">Antioxidants and Chronic Inflammation</option>
<option value="90062">Antioxidants and Food Allergy / Food Intolerance</option>
<option value="134852">Antioxidants and Hypoxia in Cancer Therapy</option>
<option value="64345">Antioxidants and Lung Diseases</option>
<option value="49119">Antioxidants and Male Infertility</option>
<option value="92181">Antioxidants and Multifunction Photoprotection</option>
<option value="15012">Antioxidants and Oxidative Stress in Active, Diseased, and Sedentary Individuals</option>
<option value="151148">Antioxidants and Oxidative Stress in the Development of Diseases and Therapy</option>
<option value="108977">Antioxidants and Oxidative Stress: Implication in Muscle Diseases</option>
<option value="3752">Antioxidants and Periodontal Diseases</option>
<option value="15514">Antioxidants and Retinal Disease</option>
<option value="26393">Antioxidants and Skin Protection</option>
<option value="74926">Antioxidants and Their Role in Kidney Machine Perfusion and Kidney Injury</option>
<option value="60577">Antioxidants and Their Role in the Prevention and Treatment of Chronic Kidney Disease</option>
<option value="111739">Antioxidants and their Role in the Prevention and Treatment of Chronic Kidney Disease-II</option>
<option value="166867">Antioxidants as Anti-Aging Interventions</option>
<option value="109282">Antioxidants Benefits in Aquaculture</option>
<option value="158209">Antioxidants Benefits in Aquaculture 2.0</option>
<option value="46520">Antioxidants for Breast Cancer</option>
<option value="150495">Antioxidants for Skin Health</option>
<option value="76261">Antioxidants in Age-Related Diseases and Anti-Aging Strategies</option>
<option value="159431">Antioxidants in Age-Related Diseases and Anti-Aging Strategies - 2nd Edition</option>
<option value="39476">Antioxidants in Animal Nutrition</option>
<option value="50464">Antioxidants in Cancer in 2021</option>
<option value="188224">Antioxidants in Cardiovascular Diseases</option>
<option value="48807">Antioxidants in Chronic Pain</option>
<option value="84101">Antioxidants in Chronic Pain II</option>
<option value="129395">Antioxidants in Chronic Pain Volume 3</option>
<option value="66992">Antioxidants in Diabetes</option>
<option value="158059">Antioxidants in Diabetes and Other Endocrine Disorders</option>
<option value="181127">Antioxidants in Ferroptosis and Human Diseases</option>
<option value="126859">Antioxidants in Fruits and Their Health-Promoting Effects</option>
<option value="57452">Antioxidants in Fruits and Vegetables</option>
<option value="80060">Antioxidants in Human Health and Disease</option>
<option value="123173">Antioxidants in Male Human and Animal Reproduction: In Vitro and In Vivo Studies</option>
<option value="78270">Antioxidants in Mitochondrial Dysfunction Disease</option>
<option value="119063">Antioxidants in Nutraceuticals and Functional Foods: Challenges and Perspectives on Future Nutrition</option>
<option value="19651">Antioxidants in Oxidative Stress Diseases</option>
<option value="85632">Antioxidants in Radiation Protection, Radiobiology and Radiation Therapy</option>
<option value="143689">Antioxidants in Radiation Protection, Radiobiology and Radiation—2nd Edition</option>
<option value="102272">Antioxidants in Skeletal Muscle Physiological and Pathological Conditions</option>
<option value="122442">Antioxidants in Skin Aging</option>
<option value="33812">Antioxidants in the Prevention and Treatment of Chronic Diseases</option>
<option value="155588">Antioxidants in the Protection of Liver Injuries</option>
<option value="176991">Antioxidants Therapy and Oxidative Stress in Non-alcoholic Fatty Liver Disease</option>
<option value="183402">Antioxidants to Overcome Resistance in Cancer Therapy</option>
<option value="75305">Antioxidants, Oxidative Stress and Non-communicable Diseases</option>
<option value="10489">Antioxidants: Infant Nutrition</option>
<option value="173857">Ascorbic Acid: An Antioxidant and Much More</option>
<option value="107471">Autophagy-Mediated Cellular Oxidative Stress Regulations</option>
<option value="43766">Beneficial Effects on Oxidative Stress and Human Health by Dietary Polyphenols</option>
<option value="106247">Berries in Human Health: Antioxidation, Anti-inflammation and Other Modes of Action</option>
<option value="4730">Berry Antioxidants in Health and Disease</option>
<option value="69735">Bilirubin and Oxidative Stress</option>
<option value="167157">Bioaccessible and Bioavailable Natural Bioactive Compounds for the Management of Metabolic Syndrome</option>
<option value="71936">Biomarkers of Oxidative Stress in Acute and Chronic Diseases</option>
<option value="170229">Blood Cells and Redox Homeostasis in Health and Disease</option>
<option value="24921">Botanical Antioxidants and Neurological Diseases</option>
<option value="162523">Bridging Oxidative Stress and Aberrant Nutrient Metabolism in Metabolic Diseases</option>
<option value="171968">Cardiomyopathy, Inflammation and Oxidative Stress</option>
<option value="128729">Carotenoids, Oxidative Stress and Disease II</option>
<option value="132849">Cell Therapy and Redox Regulation in Diseases: Potential and Implications</option>
<option value="107224">Cellular and DNA Damage in Oxidative Stress Conditions: Cytoprotective and Genoprotective Potential of Antioxidant Molecules</option>
<option value="39753">Cellular Oxidative Stress</option>
<option value="182198">Cellular Reactive Oxygen Species in Cancer Chemotherapy</option>
<option value="169848">Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research</option>
<option value="73597">Cellular-Redox-Related Stress Responses in Renal Disease and Their Related Complications</option>
<option value="88641">Challenges of CoQ10 Deficiency in Diagnostic, New Models of Disease and Therapy</option>
<option value="138583">Cigarette Smoke-Induced Oxidative Stress and Its Related Molecular/Cellular Events</option>
<option value="97019">Cigarette Smoking: Associated Oxidative Stress and Health Hazards</option>
<option value="137305">Clinical Relevance of Biomarkers of Oxidative Stress</option>
<option value="71732">Connecting the Dots between Oxidative Stress, Gut-Brain Axis and Neurodegenerative Diseases</option>
<option value="113644">Connection between Oxidative Stress and Hemorrhagic/Ischemic Cerebral Vascular Diseases</option>
<option value="65378">CoQ10 and Aging and Age-Related Diseases</option>
<option value="15701">CoQ10 in Longevity</option>
<option value="98961">Cross Talk between Hormones, Programming and Oxidative Stress</option>
<option value="94682">Cross-Connection between Oxidative Stress Attenuation Effects and Chronic Disease Prevention Effects of Dietary Antioxidants</option>
<option value="193823">Crosstalk between Autophagy and Oxidative Stress</option>
<option value="150813">Crosstalk between Cell Redox Homeostasis and Synaptic Functions in Physiological and Pathological Conditions</option>
<option value="156597">Crosstalk Between Oxidative Stress and Inflammation in Cardiovascular Diseases, Cancer and Neurodegeneration</option>
<option value="82832">Development and Validation of Methods for Analysis of Oxidative Stress in Humans and Animals</option>
<option value="171043">Development and Validation of Methods for Analysis of Oxidative Stress in Humans and Animals—2nd Edition</option>
<option value="93936">Diet and Resident Microbiota: The Protective Effects of Natural Antioxidants on the Intestinal Mucosa</option>
<option value="172980">Dietary Advanced Lipid Oxidation End-Products and Their Risk to Human Health: Prevention by Polyphenols</option>
<option value="154439">Dietary Antioxidants and Animal Nutrition</option>
<option value="35961">Dietary Antioxidants and Brain Health: Focus on Cognitive and Affective Disorders</option>
<option value="97848">Dietary Antioxidants and Cardiovascular Health</option>
<option value="174834">Dietary Antioxidants and Cardiovascular Health, 2nd Edition</option>
<option value="84334">Dietary Antioxidants and Chronic Diseases</option>
<option value="108456">Dietary Antioxidants and Gut Health</option>
<option value="7912">Dietary Antioxidants and Health Promotion</option>
<option value="125044">Dietary Antioxidants and Inflammation-Induced Chronic Diseases</option>
<option value="9950">Dietary Antioxidants and Prevention of Non-Communicable Diseases</option>
<option value="42368">Dietary Antioxidants for Modulating the Aging Processes</option>
<option value="163056">Dietary Antioxidants, Age-Associated Diseases, and Active Ageing: An Update</option>
<option value="146283">Dietary Antioxidants, Epigenetics and Aging</option>
<option value="21035">Dietary Antioxidants: Micronutrients and Antinutrients in Physiology and Pathology</option>
<option value="61313">Dietary Bioactives and Their Metabolites as Modulators of Oxidative Stress and Inflammation</option>
<option value="46203">Dietary Polyphenols and Neuroprotection</option>
<option value="132553">Dietary Polyphenols and Neuroprotection II</option>
<option value="16315">Dietary Polyphenols in Contemporary Disease</option>
<option value="72679">Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid and Energy Metabolism</option>
<option value="132751">Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid and Energy Metabolism-II</option>
<option value="126923">Dietary Supplements and Oxidative Stress</option>
<option value="132561">Disentangling the Association between Chronic Diseases and Oxidative Stress through Metabolomics</option>
<option value="158433">Disentangling the Complexity of Cardiometabolic Diseases through Omics Techniques</option>
<option value="187916">Early Metabolic Programming Mediated by Oxidative Stress</option>
<option value="43173">Effect of Antioxidant Therapy on Oxidative Stress In Vivo</option>
<option value="69418">Effect of Antioxidant Therapy on Oxidative Stress in Vivo 2021</option>
<option value="154492">Effect of Nutritional Antioxidants on Health and Disease—The Advance</option>
<option value="36238">Effect of Oxidative Stress on Reproduction and Development</option>
<option value="192880">Effect of Oxidative Stress on Reproduction and Development—2nd Edition</option>
<option value="113847">Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidative Stress</option>
<option value="85485">Energy Disorders in Neurodegenerative Diseases</option>
<option value="169344">Environmental Pollution and Oxidative Stress</option>
<option value="72580">Exercise in Aging and Chronic Diseases: Focus on Oxidative Stress/Inflammation and Antioxidants</option>
<option value="7292">Exercise Induced Muscle Damage and Oxidative Stress</option>
<option value="104505">Exercise-Induced Antioxidant Response and Oxidative Stress</option>
<option value="150962">Exercise-Induced Oxidative Stress in Health and Disease</option>
<option value="75787">Exercise-Induced Oxidative Stress: Are Plant-Derived Extracts and Antioxidants Supplementation Really Helpful?</option>
<option value="173894">Exploring Recent Advances in Plant Extracts: Understanding Antioxidant Mechanisms and Health Benefits</option>
<option value="196724">Exploring the Interplay of Antioxidant Activity and Phytochemical Composition in Plant Extracts and Bee Products</option>
<option value="138849">Exploring the Molecular Networking of Antioxidants and ROS Homeostasis Using Imaging Technology: Relevance for PD</option>
<option value="180781">Exploring the Role of Redox Biology in Skeletal Muscle-Related Diseases</option>
<option value="41757">Fate of Antioxidants in Gut and Interaction of Gut Metabolites and Gut Microbiota</option>
<option value="125431">Ferroptosis and Its Potential Role in the Physiopathology of Brain Injury</option>
<option value="149187">Flavonoids and Chronic Diseases - 2nd Edition</option>
<option value="19893">Free Radical Research in Cancer</option>
<option value="82226">Free Radicals, Antioxidants and Melanoma: Where Do We Stand?</option>
<option value="180243">Free Radicals, Antioxidants and Oxidative Stress in Aging and Age-Related Diseases</option>
<option value="43394">From Marine Organisms to High Value Products with Health Benefits</option>
<option value="86344">Frontiers in Oxidative Stress and Metabolic Diseases</option>
<option value="158530">Genetics and Epigenetic Modifications on Metabolic Diseases Oxidative Related</option>
<option value="63536">Gestational and Lactational Redox Signaling and Oxidative Stress in Dairy Cows</option>
<option value="78292">Glutathione in Health and Disease</option>
<option value="122070">Gut Microbiota and Oxidative Stress</option>
<option value="47468">Health Effects of Coenzyme Q10</option>
<option value="60024">Heme Oxygenase in Physiology and Pathology</option>
<option value="117105">Hormetic Nutrition and Redox Regulation in Gut-Brain Axis Disorders</option>
<option value="158207">Impact of Antioxidant and Anti-Inflammatory Functions of HDL in Diseases—2nd Edition</option>
<option value="188020">Impact of Oxidative Stress and Mitochondrial Dysfunction on the Regulation of Brain, Heart, Lung and Vascular Functions</option>
<option value="196983">Impact of Physical Activity on Oxidative Stress in Muscle Aging</option>
<option value="113199">Implication of Oxidative Stress in Promoting Cell Senescence and Associated Pathologies</option>
<option value="101224">Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection</option>
<option value="75554">Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators</option>
<option value="149177">Iron Metabolism, Oxidative Stress and Cellular Dysfunction</option>
<option value="129593">Iron Metabolism, Redox Balance and Neurological Diseases</option>
<option value="91050">Iron, Oxidative Stress, Skin Ageing and Disorders</option>
<option value="151168">Lipid Metabolic Stress in Neurodegeneration</option>
<option value="128270">Lipid Metabolism and Redox Regulation in Diseases</option>
<option value="43390">Lipid Peroxidation in Neurodegeneration</option>
<option value="80069">Lipid-Binding Proteins and Oxidative Stress in Health and Disease</option>
<option value="36192">Melatonin and Redox Signaling</option>
<option value="74866">Melatonin and Vitamin D in Diseases and Health</option>
<option value="162327">Melatonin Metabolism and Aging</option>
<option value="67147">Metabolomics, Oxidative, and Nitrosative Stress in the Perinatal Period</option>
<option value="178544">Microbiota, Oxidative Stress and Epithelial Diseases</option>
<option value="90373">Mineral Element, Antioxidant Responses and Metabolism in Vertebrates</option>
<option value="45934">Mitochondria Biology in Reproductive Function</option>
<option value="180258">Mitochondrial Dysfunction and Immuno-Oxidative Stress in Neuropsychiatric Disorders</option>
<option value="65332">Mitochondrial Dysfunction and Oxidative Stress in Diabetes and Associated Diseases</option>
<option value="170383">Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Neurodegenerative Disease</option>
<option value="192970">Mitochondrial Dysfunction in Corneal Diseases</option>
<option value="136087">Mitochondrial Functions and Oxidative Stress during Cardiorespiratory and Muscular Diseases</option>
<option value="52151">Mitochondrial Metabolism in Neural Regeneration</option>
<option value="158469">Mitochondrial Oxidative and Nitrosative Stress as a Therapeutic Target in Diseases III</option>
<option value="149168">Mitochondrial Oxidative Metabolism in Heart and Muscle</option>
<option value="169351">Mitochondrial Oxidative Stress and Inflammation</option>
<option value="122622">Mitochondrial Oxidative Stress in Aging and Disease</option>
<option value="196845">Mitochondrial Oxidative Stress in Aging and Disease—2nd Edition</option>
<option value="95857">Mitochondrial Oxidative Stress in Kidney Injury</option>
<option value="62107">Mitochondrial Redox in Cardio-Metabolic Disease and Cardio-Oncology</option>
<option value="49843">Mitochondrial Redox Regulations</option>
<option value="136340">Mitophagy and Oxidative Stress</option>
<option value="81670">Modulation Mechanisms of the Signalling Pathways in the Redox System by Natural Products</option>
<option value="38795">Modulation of Autophagy by Dietary Polyphenols: Mechanisms and Health Benefits</option>
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<span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 1564 KiB </span>
<a href="/2076-3921/13/1/59/pdf?version=1703833625" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="A Prunus avium L. Infusion Inhibits Sugar Uptake and Counteracts Oxidative Stress-Induced Stimulation of Glucose Uptake by Intestinal Epithelial (Caco-2) Cells" data-journal="antioxidants">
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<a class="title-link" href="/2076-3921/13/1/59">A <i>Prunus avium</i> L. Infusion Inhibits Sugar Uptake and Counteracts Oxidative Stress-Induced Stimulation of Glucose Uptake by Intestinal Epithelial (Caco-2) Cells</a>
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<em>Antioxidants</em> <b>2024</b>, <em>13</em>(1), 59; <a href="https://doi.org/10.3390/antiox13010059">https://doi.org/10.3390/antiox13010059</a> - 29 Dec 2023
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<strong>Abstract </strong>
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<div class="abstract-cropped inline"> Sweet cherry (<i>Prunus avium</i> L.) is among the most valued fruits due to its organoleptic properties and nutritional worth. Cherry stems are rich in bioactive compounds, known for their
anti-inflammatory and antioxidant properties. Innumerable studies have indicated that some bioactive compounds can
<a href="#" data-counterslink="https://www.mdpi.com/2076-3921/13/1/59/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a>
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<div class="abstract-full "> Sweet cherry (<i>Prunus avium</i> L.) is among the most valued fruits due to its organoleptic properties and nutritional worth. Cherry stems are rich in bioactive compounds, known for their anti-inflammatory and
antioxidant properties. Innumerable studies have indicated that some bioactive compounds can modulate sugar absorption in the small intestine. In this study, the phenolic profile of a cherry stem infusion was investigated, as well as its
capacity to modulate intestinal glucose and fructose transport in Caco-2 cells. Long-term (24 h) exposure to cherry stem infusion (25%, <i>v</i>/<i>v</i>) significantly reduced glucose (<sup>3</sup>H-DG) and fructose (<sup>14</sup>C-FRU)
apical uptake, reduced the apical-to-basolateral P<sub>app</sub> to <sup>3</sup>H-DG, and decreased mRNA expression levels of the sugar transporters <i>SGLT1</i>, <i>GLUT2</i> and <i>GLUT5</i>. Oxidative stress (induced by
<i>tert</i>-butyl hydroperoxide) caused an increase in <sup>3</sup>H-DG uptake, which was abolished by the cherry stem infusion. These findings suggest that cherry stem infusion can reduce the intestinal absorption of both glucose and
fructose by decreasing the gene expression of their membrane transporters. Moreover, this infusion also appears to be able to counteract the stimulatory effect of oxidative stress upon glucose intestinal uptake. Therefore, it can be a
potentially useful compound for controlling hyperglycemia, especially in the presence of increased intestinal oxidative stress levels. <a href="/2076-3921/13/1/59">Full article</a>
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<div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href="
/journal/antioxidants/special_issues/DQ13WB88IC
">The Interaction of Redox Potential Modulators with Membrane Transporters</a>)<br>
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<p>Effect of cherry stem infusion on the uptake of (<b>a</b>) <sup>3</sup>H-DG and (<b>b</b>) <sup>14</sup>C-FRU by Caco-2 cells. Caco-2 cells were exposed for 24 h to the cherry stem infusion (250 µL/mL) or the respective vehicle (control) (n = 10). Data are shown as mean ± S.E.M., by Student’s <span class="html-italic">t</span>-test. ** <span class="html-italic">p</span> &lt; 0.01; **** <span class="html-italic">p</span> &lt; 0.0001 significantly different from control.</p>
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<strong>Figure 2</strong><br/>
<p>Effect of cherry stem infusion on the apical-to-basolateral (AP−BL) apparent permeability (P<sub>app</sub>) to (<b>a</b>) <sup>3</sup>H-DG and (<b>b</b>) <sup>14</sup>C-FRU and on the cellular content of (<b>c</b>) <sup>3</sup>H-DG and (<b>d</b>) <sup>14</sup>C-FRU (n = 6–7) Data are shown as mean ± S.E.M., by Student’s <span class="html-italic">t</span>-test. * <span class="html-italic">p</span> &lt; 0.05; ** <span class="html-italic">p</span> &lt; 0.01 significantly different from control.</p>
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<strong>Figure 3</strong><br/>
<p>Effect of cherry stem infusion on sodium-dependent glucose cotransporter (<span class="html-italic">SGLT1</span>), facilitative glucose transporter 2 (<span class="html-italic">GLUT2</span>) and facilitative glucose transporter 5 (<span class="html-italic">GLUT5</span>) mRNA levels in Caco-2 cells (n = 6–7). Data were normalized to the expression of β-actin. Data are shown as mean ± S.E.M., by Student’s <span class="html-italic">t</span>-test. * <span class="html-italic">p</span> &lt; 0.05; ** <span class="html-italic">p</span> &lt; 0.01 significantly different from control.</p>
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<strong>Figure 4</strong><br/>
<p>Effect of cherry stem infusion, N−acetylcysteine (NAC) and ascorbic acid, on the uptake of <sup>3</sup>H-DG by Caco-2 cells, in the presence and absence of <span class="html-italic">tert</span>−butylhydroperoxide (TBH) (n = 8). Uptake was measured by incubating Caco-2 cells at 37 °C with <sup>3</sup>H-DG (10 nM) for 6 min. Data are shown as mean ± S.E.M., by two-way ANOVA with Newman-Keuls post hoc test. ** <span class="html-italic">p</span> &lt; 0.01; *** <span class="html-italic">p</span> &lt; 0.001; **** <span class="html-italic">p</span> &lt; 0.0001 significantly different from control; # <span class="html-italic">p</span> &lt; 0.01 significantly different from TBH.</p>
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<em>Antioxidants</em> <b>2024</b>, <em>13</em>(2), 221; <a href="https://doi.org/10.3390/antiox13020221">https://doi.org/10.3390/antiox13020221</a> - 09 Feb 2024
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<div class="abstract-cropped inline"> Membrane transporters are proteins that mediate the entry and exit of substances through the plasma membrane and organellar membranes and are capable of recognizing and binding to specific substances,
thereby facilitating substance transport. Membrane transporters are divided into different types, e.g., ion transporters,
<a href="#" data-counterslink="https://www.mdpi.com/2076-3921/13/2/221/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a>
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<div class="abstract-full "> Membrane transporters are proteins that mediate the entry and exit of substances through the plasma membrane and organellar membranes and are capable of recognizing and binding to specific substances, thereby
facilitating substance transport. Membrane transporters are divided into different types, e.g., ion transporters, sugar transporters, amino acid transporters, and aquaporins, based on the substances they transport. These membrane
transporters inhibit reactive oxygen species (ROS) generation through ion regulation, sugar and amino acid transport, hormone induction, and other mechanisms. They can also promote enzymatic and nonenzymatic reactions in plants, activate
antioxidant enzyme activity, and promote ROS scavenging. Moreover, membrane transporters can transport plant growth regulators, solute proteins, redox potential regulators, and other substances involved in ROS metabolism through
corresponding metabolic pathways, ultimately achieving ROS homeostasis in plants. In turn, ROS, as signaling molecules, can affect the activity of membrane transporters under abiotic stress through collaboration with ions and involvement
in hormone metabolic pathways. The research described in this review provides a theoretical basis for improving plant stress resistance, promoting plant growth and development, and breeding high-quality plant varieties.
<a href="/2076-3921/13/2/221">Full article</a>
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<div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href="
/journal/antioxidants/special_issues/DQ13WB88IC
">The Interaction of Redox Potential Modulators with Membrane Transporters</a>)<br>
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<strong>Figure 1</strong><br/>
<p>Classification diagram of ion transporters, sugar transporters, amino acid transporters, hormone transporters, and secondary metabolite transporters in plants. Arrow pointing represents the direction of transportation.</p>
<strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2076-3921/13/2/221'>Full article</a></strong>
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<p>Model of membrane transporters involved in ROS generation and scavenging.</p>
<strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2076-3921/13/2/221'>Full article</a></strong>
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<strong>Figure 3</strong><br/>
<p>Regulation of ROS signaling on membrane transporters under abiotic stress.</p>
<strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2076-3921/13/2/221'>Full article</a></strong>
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<li class=""><label for="ms-opt-184" style="padding-left: 23px;"><input type="checkbox" value="healthcare" title="Healthcare" id="ms-opt-184">Healthcare</label></li>
<li class=""><label for="ms-opt-185" style="padding-left: 23px;"><input type="checkbox" value="hearts" title="Hearts" id="ms-opt-185">Hearts</label></li>
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<li class=""><label for="ms-opt-206" style="padding-left: 23px;"><input type="checkbox" value="ijerph" title="International Journal of Environmental Research and Public Health" id="ms-opt-206">International Journal of Environmental Research
and Public Health</label></li>
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and Power</label></li>
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</li>
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Medicine</label></li>
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<li class=""><label for="ms-opt-243" style="padding-left: 23px;"><input type="checkbox" value="jsan" title="Journal of Sensor and Actuator Networks" id="ms-opt-243">Journal of Sensor and Actuator Networks</label></li>
<li class=""><label for="ms-opt-244" style="padding-left: 23px;"><input type="checkbox" value="jtaer" title="Journal of Theoretical and Applied Electronic Commerce Research" id="ms-opt-244">Journal of Theoretical and Applied Electronic
Commerce Research</label></li>
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<li class=""><label for="ms-opt-246" style="padding-left: 23px;"><input type="checkbox" value="jox" title="Journal of Xenobiotics" id="ms-opt-246">Journal of Xenobiotics</label></li>
<li class=""><label for="ms-opt-247" style="padding-left: 23px;"><input type="checkbox" value="jzbg" title="Journal of Zoological and Botanical Gardens" id="ms-opt-247">Journal of Zoological and Botanical Gardens</label></li>
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<li class=""><label for="ms-opt-250" style="padding-left: 23px;"><input type="checkbox" value="kinasesphosphatases" title="Kinases and Phosphatases" id="ms-opt-250">Kinases and Phosphatases</label></li>
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<li class=""><label for="ms-opt-315" style="padding-left: 23px;"><input type="checkbox" value="optics" title="Optics" id="ms-opt-315">Optics</label></li>
<li class=""><label for="ms-opt-316" style="padding-left: 23px;"><input type="checkbox" value="oral" title="Oral" id="ms-opt-316">Oral</label></li>
<li class=""><label for="ms-opt-317" style="padding-left: 23px;"><input type="checkbox" value="organics" title="Organics" id="ms-opt-317">Organics</label></li>
<li class=""><label for="ms-opt-318" style="padding-left: 23px;"><input type="checkbox" value="organoids" title="Organoids" id="ms-opt-318">Organoids</label></li>
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<li class=""><label for="ms-opt-328" style="padding-left: 23px;"><input type="checkbox" value="pharmacoepidemiology" title="Pharmacoepidemiology" id="ms-opt-328">Pharmacoepidemiology</label></li>
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<li class=""><label for="ms-opt-357" style="padding-left: 23px;"><input type="checkbox" value="radiation" title="Radiation" id="ms-opt-357">Radiation</label></li>
<li class=""><label for="ms-opt-358" style="padding-left: 23px;"><input type="checkbox" value="reactions" title="Reactions" id="ms-opt-358">Reactions</label></li>
<li class=""><label for="ms-opt-359" style="padding-left: 23px;"><input type="checkbox" value="realestate" title="Real Estate" id="ms-opt-359">Real Estate</label></li>
<li class=""><label for="ms-opt-360" style="padding-left: 23px;"><input type="checkbox" value="receptors" title="Receptors" id="ms-opt-360">Receptors</label></li>
<li class=""><label for="ms-opt-361" style="padding-left: 23px;"><input type="checkbox" value="recycling" title="Recycling" id="ms-opt-361">Recycling</label></li>
<li class=""><label for="ms-opt-362" style="padding-left: 23px;"><input type="checkbox" value="religions" title="Religions" id="ms-opt-362">Religions</label></li>
<li class=""><label for="ms-opt-363" style="padding-left: 23px;"><input type="checkbox" value="remotesensing" title="Remote Sensing" id="ms-opt-363">Remote Sensing</label></li>
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<li class=""><label for="ms-opt-368" style="padding-left: 23px;"><input type="checkbox" value="risks" title="Risks" id="ms-opt-368">Risks</label></li>
<li class=""><label for="ms-opt-369" style="padding-left: 23px;"><input type="checkbox" value="robotics" title="Robotics" id="ms-opt-369">Robotics</label></li>
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<li class=""><label for="ms-opt-371" style="padding-left: 23px;"><input type="checkbox" value="safety" title="Safety" id="ms-opt-371">Safety</label></li>
<li class=""><label for="ms-opt-372" style="padding-left: 23px;"><input type="checkbox" value="sci" title="Sci" id="ms-opt-372">Sci</label></li>
<li class=""><label for="ms-opt-373" style="padding-left: 23px;"><input type="checkbox" value="scipharm" title="Scientia Pharmaceutica" id="ms-opt-373">Scientia Pharmaceutica</label></li>
<li class=""><label for="ms-opt-374" style="padding-left: 23px;"><input type="checkbox" value="sclerosis" title="Sclerosis" id="ms-opt-374">Sclerosis</label></li>
<li class=""><label for="ms-opt-375" style="padding-left: 23px;"><input type="checkbox" value="seeds" title="Seeds" id="ms-opt-375">Seeds</label></li>
<li class=""><label for="ms-opt-376" style="padding-left: 23px;"><input type="checkbox" value="sensors" title="Sensors" id="ms-opt-376">Sensors</label></li>
<li class=""><label for="ms-opt-377" style="padding-left: 23px;"><input type="checkbox" value="separations" title="Separations" id="ms-opt-377">Separations</label></li>
<li class=""><label for="ms-opt-378" style="padding-left: 23px;"><input type="checkbox" value="sexes" title="Sexes" id="ms-opt-378">Sexes</label></li>
<li class=""><label for="ms-opt-379" style="padding-left: 23px;"><input type="checkbox" value="signals" title="Signals" id="ms-opt-379">Signals</label></li>
<li class=""><label for="ms-opt-380" style="padding-left: 23px;"><input type="checkbox" value="sinusitis" title="Sinusitis" id="ms-opt-380">Sinusitis</label></li>
<li class=""><label for="ms-opt-381" style="padding-left: 23px;"><input type="checkbox" value="smartcities" title="Smart Cities" id="ms-opt-381">Smart Cities</label></li>
<li class=""><label for="ms-opt-382" style="padding-left: 23px;"><input type="checkbox" value="socsci" title="Social Sciences" id="ms-opt-382">Social Sciences</label></li>
<li class=""><label for="ms-opt-383" style="padding-left: 23px;"><input type="checkbox" value="siuj" title="Société Internationale d’Urologie Journal" id="ms-opt-383">Société Internationale d’Urologie Journal</label></li>
<li class=""><label for="ms-opt-384" style="padding-left: 23px;"><input type="checkbox" value="societies" title="Societies" id="ms-opt-384">Societies</label></li>
<li class=""><label for="ms-opt-385" style="padding-left: 23px;"><input type="checkbox" value="software" title="Software" id="ms-opt-385">Software</label></li>
<li class=""><label for="ms-opt-386" style="padding-left: 23px;"><input type="checkbox" value="soilsystems" title="Soil Systems" id="ms-opt-386">Soil Systems</label></li>
<li class=""><label for="ms-opt-387" style="padding-left: 23px;"><input type="checkbox" value="solar" title="Solar" id="ms-opt-387">Solar</label></li>
<li class=""><label for="ms-opt-388" style="padding-left: 23px;"><input type="checkbox" value="solids" title="Solids" id="ms-opt-388">Solids</label></li>
<li class=""><label for="ms-opt-389" style="padding-left: 23px;"><input type="checkbox" value="spectroscj" title="Spectroscopy Journal" id="ms-opt-389">Spectroscopy Journal</label></li>
<li class=""><label for="ms-opt-390" style="padding-left: 23px;"><input type="checkbox" value="sports" title="Sports" id="ms-opt-390">Sports</label></li>
<li class=""><label for="ms-opt-391" style="padding-left: 23px;"><input type="checkbox" value="standards" title="Standards" id="ms-opt-391">Standards</label></li>
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and Treatment of Chronic Kidney DiseaseAntioxidants and their Role in the
Prevention and Treatment of Chronic Kidney Disease-IIAntioxidants as Anti-Aging
InterventionsAntioxidants Benefits in AquacultureAntioxidants Benefits in
Aquaculture 2.0Antioxidants for Breast CancerAntioxidants for Skin
HealthAntioxidants in Age-Related Diseases and Anti-Aging StrategiesAntioxidants
in Age-Related Diseases and Anti-Aging Strategies - 2nd EditionAntioxidants in
Animal NutritionAntioxidants in Cancer in 2021Antioxidants in Cardiovascular
DiseasesAntioxidants in Chronic PainAntioxidants in Chronic Pain IIAntioxidants
in Chronic Pain Volume 3Antioxidants in DiabetesAntioxidants in Diabetes and
Other Endocrine DisordersAntioxidants in Ferroptosis and Human
DiseasesAntioxidants in Fruits and Their Health-Promoting EffectsAntioxidants in
Fruits and VegetablesAntioxidants in Human Health and DiseaseAntioxidants in
Male Human and Animal Reproduction: In Vitro and In Vivo StudiesAntioxidants in
Mitochondrial Dysfunction DiseaseAntioxidants in Nutraceuticals and Functional
Foods: Challenges and Perspectives on Future NutritionAntioxidants in Oxidative
Stress DiseasesAntioxidants in Radiation Protection, Radiobiology and Radiation
TherapyAntioxidants in Radiation Protection, Radiobiology and Radiation—2nd
EditionAntioxidants in Skeletal Muscle Physiological and Pathological
ConditionsAntioxidants in Skin AgingAntioxidants in the Prevention and Treatment
of Chronic DiseasesAntioxidants in the Protection of Liver InjuriesAntioxidants
Therapy and Oxidative Stress in Non-alcoholic Fatty Liver DiseaseAntioxidants to
Overcome Resistance in Cancer TherapyAntioxidants, Oxidative Stress and
Non-communicable DiseasesAntioxidants: Infant NutritionAscorbic Acid: An
Antioxidant and Much MoreAutophagy-Mediated Cellular Oxidative Stress
RegulationsBeneficial Effects on Oxidative Stress and Human Health by Dietary
PolyphenolsBerries in Human Health: Antioxidation, Anti-inflammation and Other
Modes of ActionBerry Antioxidants in Health and DiseaseBilirubin and Oxidative
StressBioaccessible and Bioavailable Natural Bioactive Compounds for the
Management of Metabolic SyndromeBiomarkers of Oxidative Stress in Acute and
Chronic DiseasesBlood Cells and Redox Homeostasis in Health and DiseaseBotanical
Antioxidants and Neurological DiseasesBridging Oxidative Stress and Aberrant
Nutrient Metabolism in Metabolic DiseasesCardiomyopathy, Inflammation and
Oxidative StressCarotenoids, Oxidative Stress and Disease IICell Therapy and
Redox Regulation in Diseases: Potential and ImplicationsCellular and DNA Damage
in Oxidative Stress Conditions: Cytoprotective and Genoprotective Potential of
Antioxidant MoleculesCellular Oxidative StressCellular Reactive Oxygen Species
in Cancer ChemotherapyCellular Responses of Antioxidants Related to Degenerative
Eye Disease ResearchCellular-Redox-Related Stress Responses in Renal Disease and
Their Related ComplicationsChallenges of CoQ10 Deficiency in Diagnostic, New
Models of Disease and TherapyCigarette Smoke-Induced Oxidative Stress and Its
Related Molecular/Cellular EventsCigarette Smoking: Associated Oxidative Stress
and Health HazardsClinical Relevance of Biomarkers of Oxidative StressConnecting
the Dots between Oxidative Stress, Gut-Brain Axis and Neurodegenerative
DiseasesConnection between Oxidative Stress and Hemorrhagic/Ischemic Cerebral
Vascular DiseasesCoQ10 and Aging and Age-Related DiseasesCoQ10 in LongevityCross
Talk between Hormones, Programming and Oxidative StressCross-Connection between
Oxidative Stress Attenuation Effects and Chronic Disease Prevention Effects of
Dietary AntioxidantsCrosstalk between Autophagy and Oxidative StressCrosstalk
between Cell Redox Homeostasis and Synaptic Functions in Physiological and
Pathological ConditionsCrosstalk Between Oxidative Stress and Inflammation in
Cardiovascular Diseases, Cancer and NeurodegenerationDevelopment and Validation
of Methods for Analysis of Oxidative Stress in Humans and AnimalsDevelopment and
Validation of Methods for Analysis of Oxidative Stress in Humans and Animals—2nd
EditionDiet and Resident Microbiota: The Protective Effects of Natural
Antioxidants on the Intestinal MucosaDietary Advanced Lipid Oxidation
End-Products and Their Risk to Human Health: Prevention by PolyphenolsDietary
Antioxidants and Animal NutritionDietary Antioxidants and Brain Health: Focus on
Cognitive and Affective DisordersDietary Antioxidants and Cardiovascular
HealthDietary Antioxidants and Cardiovascular Health, 2nd EditionDietary
Antioxidants and Chronic DiseasesDietary Antioxidants and Gut HealthDietary
Antioxidants and Health PromotionDietary Antioxidants and Inflammation-Induced
Chronic DiseasesDietary Antioxidants and Prevention of Non-Communicable
DiseasesDietary Antioxidants for Modulating the Aging ProcessesDietary
Antioxidants, Age-Associated Diseases, and Active Ageing: An UpdateDietary
Antioxidants, Epigenetics and AgingDietary Antioxidants: Micronutrients and
Antinutrients in Physiology and PathologyDietary Bioactives and Their
Metabolites as Modulators of Oxidative Stress and InflammationDietary
Polyphenols and NeuroprotectionDietary Polyphenols and Neuroprotection IIDietary
Polyphenols in Contemporary DiseaseDietary Selenium and Its Antioxidant
Properties Related to Growth, Lipid and Energy MetabolismDietary Selenium and
Its Antioxidant Properties Related to Growth, Lipid and Energy
Metabolism-IIDietary Supplements and Oxidative StressDisentangling the
Association between Chronic Diseases and Oxidative Stress through
MetabolomicsDisentangling the Complexity of Cardiometabolic Diseases through
Omics TechniquesEarly Metabolic Programming Mediated by Oxidative StressEffect
of Antioxidant Therapy on Oxidative Stress In VivoEffect of Antioxidant Therapy
on Oxidative Stress in Vivo 2021Effect of Nutritional Antioxidants on Health and
Disease—The AdvanceEffect of Oxidative Stress on Reproduction and
DevelopmentEffect of Oxidative Stress on Reproduction and Development—2nd
EditionEndothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidative
StressEnergy Disorders in Neurodegenerative DiseasesEnvironmental Pollution and
Oxidative StressExercise in Aging and Chronic Diseases: Focus on Oxidative
Stress/Inflammation and AntioxidantsExercise Induced Muscle Damage and Oxidative
StressExercise-Induced Antioxidant Response and Oxidative StressExercise-Induced
Oxidative Stress in Health and DiseaseExercise-Induced Oxidative Stress: Are
Plant-Derived Extracts and Antioxidants Supplementation Really Helpful?Exploring
Recent Advances in Plant Extracts: Understanding Antioxidant Mechanisms and
Health BenefitsExploring the Interplay of Antioxidant Activity and Phytochemical
Composition in Plant Extracts and Bee ProductsExploring the Molecular Networking
of Antioxidants and ROS Homeostasis Using Imaging Technology: Relevance for
PDExploring the Role of Redox Biology in Skeletal Muscle-Related DiseasesFate of
Antioxidants in Gut and Interaction of Gut Metabolites and Gut
MicrobiotaFerroptosis and Its Potential Role in the Physiopathology of Brain
InjuryFlavonoids and Chronic Diseases - 2nd EditionFree Radical Research in
CancerFree Radicals, Antioxidants and Melanoma: Where Do We Stand?Free Radicals,
Antioxidants and Oxidative Stress in Aging and Age-Related DiseasesFrom Marine
Organisms to High Value Products with Health BenefitsFrontiers in Oxidative
Stress and Metabolic DiseasesGenetics and Epigenetic Modifications on Metabolic
Diseases Oxidative RelatedGestational and Lactational Redox Signaling and
Oxidative Stress in Dairy CowsGlutathione in Health and DiseaseGut Microbiota
and Oxidative StressHealth Effects of Coenzyme Q10Heme Oxygenase in Physiology
and PathologyHormetic Nutrition and Redox Regulation in Gut-Brain Axis
DisordersImpact of Antioxidant and Anti-Inflammatory Functions of HDL in
Diseases—2nd EditionImpact of Oxidative Stress and Mitochondrial Dysfunction on
the Regulation of Brain, Heart, Lung and Vascular FunctionsImpact of Physical
Activity on Oxidative Stress in Muscle AgingImplication of Oxidative Stress in
Promoting Cell Senescence and Associated PathologiesInhibition of Oxidative
Stress and Related Signaling Pathways in NeuroprotectionIonizing Radiation,
Antioxidant Response and Oxidative Damage: RadiomodulatorsIron Metabolism,
Oxidative Stress and Cellular DysfunctionIron Metabolism, Redox Balance and
Neurological DiseasesIron, Oxidative Stress, Skin Ageing and DisordersLipid
Metabolic Stress in NeurodegenerationLipid Metabolism and Redox Regulation in
DiseasesLipid Peroxidation in NeurodegenerationLipid-Binding Proteins and
Oxidative Stress in Health and DiseaseMelatonin and Redox SignalingMelatonin and
Vitamin D in Diseases and HealthMelatonin Metabolism and AgingMetabolomics,
Oxidative, and Nitrosative Stress in the Perinatal PeriodMicrobiota, Oxidative
Stress and Epithelial DiseasesMineral Element, Antioxidant Responses and
Metabolism in VertebratesMitochondria Biology in Reproductive
FunctionMitochondrial Dysfunction and Immuno-Oxidative Stress in
Neuropsychiatric DisordersMitochondrial Dysfunction and Oxidative Stress in
Diabetes and Associated DiseasesMitochondrial Dysfunction and Oxidative Stress
in the Pathogenesis of Neurodegenerative DiseaseMitochondrial Dysfunction in
Corneal DiseasesMitochondrial Functions and Oxidative Stress during
Cardiorespiratory and Muscular DiseasesMitochondrial Metabolism in Neural
RegenerationMitochondrial Oxidative and Nitrosative Stress as a Therapeutic
Target in Diseases IIIMitochondrial Oxidative Metabolism in Heart and
MuscleMitochondrial Oxidative Stress and InflammationMitochondrial Oxidative
Stress in Aging and DiseaseMitochondrial Oxidative Stress in Aging and
Disease—2nd EditionMitochondrial Oxidative Stress in Kidney InjuryMitochondrial
Redox in Cardio-Metabolic Disease and Cardio-OncologyMitochondrial Redox
RegulationsMitophagy and Oxidative StressModulation Mechanisms of the Signalling
Pathways in the Redox System by Natural ProductsModulation of Autophagy by
Dietary Polyphenols: Mechanisms and Health BenefitsModulation of Oxidative and
Inflammatory Stress by Diet: Role of Functional and Novel FoodsModulation of
Oxidative Stress and Inflammation in the Cardio-Renal AxisModulation of Reactive
Oxygen Species in Health and DiseaseModulators of Oxidative Stress: Chemical and
Pharmacological AspectsModulators of Oxidative Stress: Chemical and
Pharmacological Aspects 2021Molecular Targets of Oxidative Stress: Focus on the
Nrf2 Signaling Pathway in Health and DiseaseMulti-Target Profile of Antioxidant
Compounds, including Repurposing and Combination StrategiesMultileveled
Molecular Mechanisms Related to Oxidative Stress in Retinitis
PigmentosaMultileveled Molecular Mechanisms Related to Oxidative Stress in
Retinitis Pigmentosa IIMultitarget Directed Antioxidants for StrokeNADPH Oxidase
and Redox SignalingNADPH Oxidases and Chronic Inflammation-Associated
CancersNADPH Oxidases and Reactive Species in Tissue Protective and Pathological
SignalingNatural Antioxidant in Cardiovascular and Cerebrovascular
DiseasesNatural Antioxidants and ExerciseNatural Antioxidants and Metabolic
DiseasesNatural Antioxidants and the Immunomodulation of Chronic and
Transmissible DiseasesNatural Antioxidants for Cardiovascular and
Cerebrovascular DiseaseNatural Antioxidants in Functional Foods: Their Role in
the Prevention of Cardiovascular Disease and CancerNatural Antioxidants in
Obesity and Related DiseasesNatural Antioxidants in Obesity and Related
Diseases—2nd EditionNatural Antioxidants: Multiple Mechanisms for Skin
ProtectionNatural Products in Health Promotion and Disease PreventionNatural
Products Targeting on Oxidative Stress-Related DiseasesNatural Products:
Biological-, Antioxidant Properties and Health EffectsNatural Products:
Biological-, Antioxidant Properties and Health Effects - 2nd EditionNew Insights
into Antioxidants Properties of Agri-Food Compounds for Therapeutic and
Prophylactic ApplicationsNew Mechanisms of Action of Natural Antioxidants in
Health and DiseaseNew Mechanisms of Action of Natural Antioxidants in Health and
Disease IINew Strategies in Preventing Inflammatory and/or
Oxidative-Stress-Induced Damages in Ischemia–Reperfusion InjuryNew Treatments
with Antioxidants for Chronic Pain and Mood Disorders
AssociatedNon-pharmaceutical Antioxidant Agents for Animal and Human HealthNot
Just Stress: The Role of Oxidation from Blood and Tissue Disorders to
HomeostasisNovel Advances on Gut Microbiota Dysbiosis, Neurodegenerative and
Cardiovascular Diseases: Connecting Dots and Antioxidant StrategiesNovel
Antioxidant Mechanisms and Lifestyle Interventions for the Management of
Oxidative Stress in Obesity and Related Adverse Health EffectsNovel Antioxidants
for Animal NutritionNovel Therapies of Oxidative Stress-Induced Age-Related
Neurodegenerative DiseasesNrf2 Antioxidative Pathway and NF-κB SignalingNrf2 in
Acute and Chronic Neurological DisordersNRF2 in Health and DiseasesNrf2 in
Kidney Injury and PhysiologyNrf2 Signaling Pathway: Biological Function,
Clinical Implications and Therapeutic AgentsNrf2 Signaling Pathway: Biological
Function, Clinical Implications and Therapeutic Agents—2nd EditionNrf2: A
Critical Regulator of the Innate Immune ResponseOptimizing Physical Exercise:
Post-exercise Recovery and Management of Oxidative and Nitrosative
StressOxidants and Antioxidants in Eye DiseaseOxidation of Lipids and Proteins
in Various DiseasesOxidative and Nitrosative Stress in SpermatozoaOxidative and
Nitrosative Stress Related to Mitochondrial Dysfunction in Traumatic Brain
InjuryOxidative and Nitrosative Stress-Related Mechanisms and Antioxidant
Therapy in Respiratory DisordersOxidative Balance and Heart Function: A
Physiological Lifelong ChallengeOxidative Damage in Korean MedicineOxidative
Metabolism and Mitochondrial Dysfunction in Metabolic DiseasesOxidative
Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—2nd
EditionOxidative Metabolism, Mitochondrial Damage and Neurodegenerative
Disease: A Complex TriumviratOxidative Sress, Metabolomics and Other Biological
Biomarkers in Congenital Heart Disease and Cardiac SurgeryOxidative Stress and
Aging: Past, Present and Future ConceptsOxidative Stress and Alzheimer’s
DiseaseOxidative Stress and Antioxidant Defense in InsectsOxidative Stress and
Antioxidant Response in Marine OrganismsOxidative Stress and Antioxidants in
AgingOxidative Stress and Antioxidants in Computational ChemistryOxidative
Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings: Novel
Pharmacological TargetsOxidative Stress and Antioxidants in Neurodegenerative
DisordersOxidative Stress and Antioxidants in Neurodegenerative Disorders 2nd
EditionOxidative Stress and Antioxidants in Nutrition, Exercise and
Toxicology/PharmacologyOxidative Stress and Arterial Blood PressureOxidative
Stress and AtherosclerosisOxidative Stress and Biomarkers in Metabolic
DisordersOxidative Stress and Bowel DiseasesOxidative Stress and Cancer: The
Nrf2 EnigmaOxidative Stress and Cardiac Turnover CapacityOxidative Stress and
Cell Senescence ProcessOxidative Stress and Cell Senescence Process—2nd
EditionOxidative Stress and Chronic Liver DiseasesOxidative Stress and
Environmental ToxicologyOxidative Stress and Epigenetic Changes in Rare
DiseasesOxidative Stress and ExerciseOxidative Stress and Eye DiseasesOxidative
Stress and Fetal-Maternal HealthOxidative Stress and Gene RegulationOxidative
Stress and GliaOxidative Stress and Hearing LossOxidative Stress and Hepatic
InflammationOxidative Stress and Inflammation as Targets for Novel Preventive
and Therapeutic Approaches in Non-Communicable Diseases IIIOxidative Stress and
Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non
Communicable DiseasesOxidative Stress and Inflammation as Targets for Novel
Preventive and Therapeutic Approaches in Non Communicable Diseases IIOxidative
Stress and Inflammation in CancerOxidative Stress and Inflammation in
Cardiovascular DiseasesOxidative Stress and Inflammation in Cardiovascular
Diseases - 3rd EditionOxidative Stress and Inflammation in Cardiovascular
Diseases IIOxidative Stress and Inflammation in Deafness: Current and Future
TherapyOxidative Stress and Inflammation in Diabetic Micro and Macrovascular
ComplicationsOxidative Stress and Inflammation in Exercise Training and
SportsOxidative Stress and Inflammation in Health and DiseasesOxidative Stress
and Inflammation in Metabolic SyndromeOxidative Stress and Inflammation in
Movement DisordersOxidative Stress and Inflammation in ObesityOxidative Stress
and Inflammation in Retinal DegenerationOxidative Stress and Inflammation in
Retinal Degeneration 2022Oxidative Stress and Inflammation in the Nervous
SystemOxidative Stress and Inflammation in the Pathogenesis of Reproductive
DisordersOxidative Stress and Inflammation: A Mutual Relationship in
Cardiometabolic DiseasesOxidative Stress and Its Role in Ischemic
StrokeOxidative Stress and Lung InflammationOxidative Stress and Metabolite
Signaling in the Heart and CancerOxidative Stress and Mitochondrial Dysfunction
in DiseaseOxidative Stress and Mitochondrial Dysfunctions in Neurological
Diseases, Preventive Effects of Bioactive Natural CompoudsOxidative Stress and
Neurodegenerative DiseasesOxidative Stress and Neurodegenerative Disorders
IIOxidative Stress and Neuroinflammation in Neurodegenerative Diseases:
Mechanisms and TherapiesOxidative Stress and Neuroinflammation in Neurological
and Neurodegenerative DisordersOxidative Stress and NewbornsOxidative Stress and
NRF2 in Health and DiseaseOxidative Stress and Nrf2 in NeuroprotectionOxidative
Stress and Nutrition in Aquatic AnimalsOxidative Stress and Obesity- and Type-2
Diabetes-Induced Heart FailureOxidative Stress and Pathophysiology of
StrokeOxidative Stress and Psychiatric ResearchOxidative Stress and Rare
DiseasesOxidative Stress and Reactive Oxygen Species in Cardiovascular
DiseaseOxidative Stress and Redox Regulation in Chronic Inflammatory
DisordersOxidative Stress and Redox Regulation in Hematological Malignancies:
Pro-oxidant Strategy or Antioxidant Approach?Oxidative Stress and Redox
Signaling in Neuro-OncologyOxidative Stress and Retinal DiseasesOxidative Stress
and Skeletal Muscle AtrophyOxidative Stress and Skin Disease: Genetics,
Etiopathogenesis, Possible Therapeutic Approaches of Antioxidant
TherapiesOxidative Stress and Sleep DisordersOxidative Stress and Sperm:
Technical, Biological and Clinical AspectsOxidative Stress and the Central
Nervous SystemOxidative Stress and Vascular DiseaseOxidative Stress as a Crucial
Factor in Liver Diseases: From Basic Research to Clinical TrialsOxidative Stress
Biomarkers in Cardiovascular Risk and DiseaseOxidative Stress Damage and
Antioxidant Natural Products in Colorectal DiseasesOxidative Stress Impact on
Protein Synthesis and Protein Degradation Systems in Health and DiseaseOxidative
Stress in Adipose TissueOxidative Stress in Aging and Associated Chronic
DiseasesOxidative Stress in Alzheimer's DiseaseOxidative Stress in Brain
FunctionOxidative Stress in Cardiac DiseaseOxidative Stress in Cardiorenal
SystemOxidative Stress in Cardiovascular Disease and ComorbiditiesOxidative
Stress in Cardiovascular DiseasesOxidative Stress in Cataracts: Mechanisms and
TherapiesOxidative Stress in Chronic and Age-Related DiseasesOxidative Stress in
Chronic Obstructive Pulmonary DiseaseOxidative Stress in Diabetes and
ComplicationsOxidative Stress in Ear DamageOxidative Stress in Environmental
ToxicologyOxidative Stress in Fetuses and NewbornsOxidative Stress in
FishOxidative Stress in Gastrointestinal Diseases: Challenges and
OpportunitiesOxidative Stress in Genitourinary CancersOxidative Stress in
Hepatic InjuryOxidative Stress in Human Diseases: Focus on Redox Status
Assessment in Biological Fluids, Tissues and CellsOxidative Stress in Human
ToxicologyOxidative Stress in Inflammatory Skin and Tissue DisordersOxidative
Stress in Ischemia–Reperfusion InjuryOxidative Stress in Kidney DiseaseOxidative
Stress in Liver Disease and Cardiovascular RiskOxidative Stress in Liver
DiseasesOxidative Stress in Liver Diseases - 2nd EditionOxidative Stress in
Livestock and Poultry—2nd EditionOxidative Stress in Lung Diseases and Cancer:
Focus on Drug DevelopmentOxidative Stress in Metabolic CardiomyopathyOxidative
Stress in Metabolic DiseaseOxidative Stress in Metabolic Syndrome and
Cardiovascular DiseasesOxidative Stress in Metabolic Syndrome: The Role of Gut
MicrobiotaOxidative Stress in Microbial InfectionsOxidative Stress in
NeurodegenerationOxidative Stress in Neurodegeneration and
NeuroinflammationOxidative Stress in Neurodegenerative DiseaseOxidative Stress
in NeuronsOxidative Stress in Newborns and ChildrenOxidative Stress in
ObesityOxidative Stress in Obesity-IIOxidative Stress in Obesity—3rd
EditionOxidative Stress in OsteoclastsOxidative Stress in ParasitesOxidative
Stress in Parasitic InfectionsOxidative Stress in Poultry Reproduction and
NutritionOxidative Stress in Pregnancy and ChildhoodOxidative Stress in
Proteomics and Metabolomics Studies of Cardiovascular DiseasesOxidative Stress
in Red Blood CellsOxidative Stress in Renal HealthOxidative Stress in
ReproductionOxidative Stress in Respiratory DiseasesOxidative Stress in Retinal
DegenerationOxidative Stress in Rheumatic DiseasesOxidative Stress in Skeletal
MuscleOxidative Stress in the Retina DiseasesOxidative Stress in Tumor Genesis,
Progression and TherapyOxidative Stress in Tumor Genesis, Progression and
Therapy—2nd EditionOxidative Stress in Vascular Disease Oxidative Stress in
Vascular PathophysiologyOxidative Stress in Vascular Regulation, Disease and
TreatmentOxidative Stress in Wound HealingOxidative Stress Induced by Air
PollutionOxidative Stress Induced by Environmental and Lifestyle Stressors:
Impact on Reproductive Health and DevelopmentOxidative Stress Induced by High
Salt DietOxidative Stress Induced DNA Damage in Cancer TreatmentOxidative Stress
Inflammation in Oral and Systemic HealthOxidative Stress Markers and Endothelial
Dysfunction in Pre- and Perinatal PeriodOxidative Stress of Aquatic
AnimalsOxidative Stress-Induced by Environmental and Lifestyle Stressors: Impact
on Reproductive Health and Development 3rd EditionOxidative Stress-Induced by
Environmental and Lifestyle Stressors: Impact on Reproductive Health and
Development IIOxidative Stress-Induced Eye Diseases and Therapeutic
InterventionsOxidative Stress-Induced Neurotoxicity and Mitochondrial
DysfunctionOxidative Stress-Mediated Vascular DiseaseOxidative Stress-Related
Biomarkers in Toxicology and Risk AssessmentOxidative Stress-Related Mechanisms
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THE INTERACTION OF REDOX POTENTIAL MODULATORS WITH MEMBRANE TRANSPORTERS
* Special Issue Editors
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A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to
the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 1953
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SPECIAL ISSUE EDITOR
Prof. Dr. Fátima Martel
E-Mail Website
Guest Editor
Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine of Porto,
Porto, Portugal
Interests: transmembrane transport mechanisms; epithelial transport of organic
compounds; plasma membrane transport of nutrients in cancer cells; modulation of
membrane transport by xenobiotics; changes in membrane transport in pathological
conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue in Nutrients: Dietary Folate and Human Health
Special Issue in Antioxidants: The Interaction of Polyphenols with Membrane
Transporters
SPECIAL ISSUE INFORMATION
Dear Colleagues,
Membrane transport systems are essential components of cellular and body
homeostasis, as they control the traffic of most biomolecules across membranes.
They are fundamental to cellular processes, such as cell nutrition, ionic
balance and metabolism, and at the organism level, they control nutrition,
excretion, drug therapeutic effects and the toxicity of xenobiotics. Mutations
in transport protein genes have been identified in the pathogenesis of a number
of hereditary diseases, including cystic fibrosis, glucose/galactose
malabsorption and Wilson's disease. Moreover, several human conditions are
associated with functional changes in specific transporters. For instance, in
cancer cells, changes in membrane transporters for important nutrients have been
described.
The cellular redox potential interferes with membrane transport systems, but our
knowledge about this is still very limited. In this context, several dietary
compounds with antioxidant properties, such as polyphenolic compounds, present
as interesting modulators of membrane transport activity with a potential
beneficial effect on humans’ health.
In this Special Issue, the interaction between compounds able to interfere with
the cellular or mitochondrial redox potentials and membrane transporters will be
explored.
Potential topics include, but are not limited to, the following:
* The effect of antioxidants or pro-oxidants on membrane transporters;
* The mechanisms involved in the regulation of membrane transporters by the
redox potential;
* The effect of dietary compounds with antioxidant or pro-oxidant properties on
membrane transport in cancer cells.
Prof. Dr. Fátima Martel
Guest Editor
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KEYWORDS
* dietary compounds
* membrane transport
* pathologies
* modulation
PUBLISHED PAPERS (2 PAPERS)
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RESEARCH
Jump to: Review
14 pages, 1564 KiB
Open AccessArticle
A Prunus avium L. Infusion Inhibits Sugar Uptake and Counteracts Oxidative
Stress-Induced Stimulation of Glucose Uptake by Intestinal Epithelial (Caco-2)
Cells
by
Juliana A. Barreto-Peixoto
,
Cláudia Silva
,
Anabela S. G. Costa
,
Gerardo Álvarez-Rivera
,
Alejandro Cifuentes
,
Elena Ibáñez
,
M. Beatriz P. P. Oliveira
,
Rita C. Alves
,
Fátima Martel
and
Nelson Andrade
Antioxidants 2024, 13(1), 59; https://doi.org/10.3390/antiox13010059 - 29 Dec
2023
Viewed by 1033
Abstract
Sweet cherry (Prunus avium L.) is among the most valued fruits due to its
organoleptic properties and nutritional worth. Cherry stems are rich in
bioactive compounds, known for their anti-inflammatory and antioxidant
properties. Innumerable studies have indicated that some bioactive compounds can
[...] Read more.
Sweet cherry (Prunus avium L.) is among the most valued fruits due to its
organoleptic properties and nutritional worth. Cherry stems are rich in
bioactive compounds, known for their anti-inflammatory and antioxidant
properties. Innumerable studies have indicated that some bioactive compounds can
modulate sugar absorption in the small intestine. In this study, the phenolic
profile of a cherry stem infusion was investigated, as well as its capacity to
modulate intestinal glucose and fructose transport in Caco-2 cells. Long-term
(24 h) exposure to cherry stem infusion (25%, v/v) significantly reduced glucose
(3H-DG) and fructose (14C-FRU) apical uptake, reduced the apical-to-basolateral
Papp to 3H-DG, and decreased mRNA expression levels of the sugar transporters
SGLT1, GLUT2 and GLUT5. Oxidative stress (induced by tert-butyl hydroperoxide)
caused an increase in 3H-DG uptake, which was abolished by the cherry stem
infusion. These findings suggest that cherry stem infusion can reduce the
intestinal absorption of both glucose and fructose by decreasing the gene
expression of their membrane transporters. Moreover, this infusion also appears
to be able to counteract the stimulatory effect of oxidative stress upon glucose
intestinal uptake. Therefore, it can be a potentially useful compound for
controlling hyperglycemia, especially in the presence of increased intestinal
oxidative stress levels. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential
Modulators with Membrane Transporters)
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21 pages, 7207 KiB
Open AccessReview
Types of Membrane Transporters and the Mechanisms of Interaction between Them
and Reactive Oxygen Species in Plants
by
Ding Yuan
,
Xiaolei Wu
,
Xiangqun Jiang
,
Binbin Gong
and
Hongbo Gao
Antioxidants 2024, 13(2), 221; https://doi.org/10.3390/antiox13020221 - 09 Feb
2024
Viewed by 620
Abstract
Membrane transporters are proteins that mediate the entry and exit of substances
through the plasma membrane and organellar membranes and are capable of
recognizing and binding to specific substances, thereby facilitating substance
transport. Membrane transporters are divided into different types, e.g., ion
transporters, [...] Read more.
Membrane transporters are proteins that mediate the entry and exit of substances
through the plasma membrane and organellar membranes and are capable of
recognizing and binding to specific substances, thereby facilitating substance
transport. Membrane transporters are divided into different types, e.g., ion
transporters, sugar transporters, amino acid transporters, and aquaporins, based
on the substances they transport. These membrane transporters inhibit reactive
oxygen species (ROS) generation through ion regulation, sugar and amino acid
transport, hormone induction, and other mechanisms. They can also promote
enzymatic and nonenzymatic reactions in plants, activate antioxidant enzyme
activity, and promote ROS scavenging. Moreover, membrane transporters can
transport plant growth regulators, solute proteins, redox potential regulators,
and other substances involved in ROS metabolism through corresponding metabolic
pathways, ultimately achieving ROS homeostasis in plants. In turn, ROS, as
signaling molecules, can affect the activity of membrane transporters under
abiotic stress through collaboration with ions and involvement in hormone
metabolic pathways. The research described in this review provides a theoretical
basis for improving plant stress resistance, promoting plant growth and
development, and breeding high-quality plant varieties. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential
Modulators with Membrane Transporters)
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