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For Moderate to Severe Binge Eating Disorder in Adults For Healthcare
Professionals Medication Guide
Sign Up for More Information
* ADHD in Adults
* What is ADHD?
* Doctor Discussion Guide
* How is ADHD Diagnosed?
* About Vyvanse
* What is Vyvanse?
* Dosing & Administration
* Study Results
* Side Effects & Safety
* Talking to your Doctor

* Savings

* Life with ADHD

* ADHD in Children (Ages 6-17)

By prescription only.

VYVANSE IS THE #1 PRESCRIBED BRANDED ADHD MEDICATION

REDEFINE YOUR ADHD

ADHD shouldn’t define you. Learn more about treating
Attention-Deficit/Hyperactivity Disorder (ADHD) with Vyvanse. It all starts by
having a conversation with your doctor and exploring this site.

FOR ADHD IN ADULTS
FOR ADHD IN CHILDREN (AGES 6-17)
FOR MODERATE TO SEVERE B.E.D. IN ADULTS

B.E.D. = Binge Eating Disorder

Patient portrayal

V IS FOR VYVANSE

PROVEN TO HELP CONTROL
ADHD IN ADULTS

LEARN MORE ABOUT VYVANSE

*Vyvanse has been approved to treat ADHD in adults since 2008.

DO YOU RECOGNIZE
THE SYMPTOMS OF ADHD?

Learn about the core symptoms of ADHD: Inattention, Hyperactivity/Impulsivity.
If these sound familiar, consider talking to your doctor. Remember, only a
doctor or other healthcare provider can diagnose ADHD.

INATTENTION

PATIENT PORTRAYAL

HYPERACTIVITY/IMPULSIVITY

PATIENT PORTRAYAL

LEARN MORE ABOUT ADHD IN ADULTS
LEARN MORE ABOUT ADHD IN CHILDREN

Patient portrayal

A IS FOR IMPROVED ADHD SYMPTOMS

Vyvanse was shown to improve attention and reduce hyperactivity and impulsivity
in adults with ADHD.

LEARN MORE ABOUT VYVANSE

SAVINGS THAT
GO WITH YOU

Saving on your prescription has never been more convenient. Download a Vyvanse
savings card to your mobile wallet on your smartphone for easy access, anywhere.

SAVINGS CARD OFFER

See details. Restrictions may apply.

Kabara, an adult patient diagnosed with moderate B.E.D.

BEFORE I WAS DIAGNOSED, I DIDN'T EVEN KNOW THAT B.E.D. EXISTED.”

Vyvanse is the first treatment for moderate to severe Binge EatingDisorder
(B.E.D.) in adults.

LEARN MORE

STAY INFORMED

IMPORTANT SAFETY INFORMATION

Abuse & Dependence. Vyvanse, other amphetamine containing medicines, and
methylphenidate have a high chance for abuse and may cause physical and
psychological dependence. Your healthcare provider (HCP) should check you or
your child for signs of abuse and dependence before and during treatment with
Vyvanse.

Tell your HCP if you or your child have ever abused or been dependent on
alcohol, prescription medicines, or street drugs. Your HCP can tell you more
about the differences between physical and psychological dependence and drug
addiction.

Vyvanse is a federally controlled substance (CII) because it contains
lisdexamfetamine dimesylate that can be a target for people who abuse
prescription medicines or street drugs. Keep Vyvanse in a safe place to protect
it from theft. Never sell or give your Vyvanse to anyone else because it may
cause death or harm to them and it is against the law.

Who should not take Vyvanse?
Do not take Vyvanse if you or your child are:

* allergic to amphetamine products or any of the ingredients in Vyvanse. See
Medication Guide for a list of ingredients.
* taking, or have stopped taking in the last 14 days, a medicine called a
Monoamine Oxidase Inhibitor (MAOI).
* being treated with the antibiotic linezolid or intravenous methylene blue.

Vyvanse may cause serious side effects, including:

* Heart-related problems including: sudden death, stroke, and heart attack in
adults; sudden death in children who have heart problems or heart defects;
increased blood pressure and heart rate. Your HCP should check you or your
child carefully for heart problems before starting treatment with Vyvanse.
Tell your HCP if you or your child have any heart problems, heart defects,
high blood pressure, or a family history of these problems. Your HCP should
check your or your child’s blood pressure and heart rate regularly during
treatment with Vyvanse. Call your HCP or go to the ER right away if you or
your child have any signs of heart problems such as chest pain, shortness of
breath, or fainting during treatment with Vyvanse.
* Mental (psychiatric) problems, including: new or worse behavior and thought
problems; new or worse bipolar illness; new psychotic symptoms (such as
hearing voices, or seeing or believing things that are not real) or new manic
symptoms. Tell your HCP about any mental problems you or your child have or
about a family history of suicide, bipolar illness, or depression. Call your
HCP right away if you or your child have any new or worsening mental symptoms
or problems during treatment with Vyvanse, especially hearing voices, seeing
or believing things that are not real, or new manic symptoms.
* Slowing of growth (height and weight) in children. Children should have their
height and weight checked often during treatment with Vyvanse. Vyvanse
treatment may be stopped if your child is not growing or gaining weight.
* Circulation problems in fingers and toes (Peripheral vasculopathy, including
Raynaud’s phenomenon). Tell your HCP if you or your child’s fingers or toes
feel numb, cool, painful, change color from pale, to blue, to red, or if they
are sensitive to temperature. Call your HCP right away if you or your child
have any signs of unexplained wounds appearing on fingers or toes during
treatment with Vyvanse.
* Serotonin Syndrome. A potentially life-threatening problem called serotonin
syndrome may happen when Vyvanse is taken with certain other medicines. Stop
taking Vyvanse and call your HCP or go to the nearest hospital ER right away
if you or your child develop any of the following signs and symptoms of
serotonin syndrome: agitation, flushing, coma, loss of coordination,
dizziness, seeing or hearing things that are not real (hallucination), high
body temperature (hyperthermia), fast heartbeat, seizures, sweating,
confusion, tremors, stiff muscles, or muscle twitching, changes in blood
pressure, nausea, vomiting, diarrhea.

Before taking Vyvanse, tell your HCP about all medical conditions, including if
you or your child:

* are pregnant or plan to become pregnant. Vyvanse may harm the unborn baby.
* are breastfeeding or plan to breastfeed. Vyvanse passes into breast milk. You
or your child should not breastfeed during treatment with Vyvanse. Talk to
your HCP about the best way to feed the baby during treatment with Vyvanse.

What are possible side effects of Vyvanse?
The most common side effects of Vyvanse in children 6 to 17 and adults with ADHD
include:

* loss of appetite (anorexia)
* decreased appetite
* diarrhea

* dry mouth

* trouble sleeping
* stomach pain
* anxiety
* weight loss

* dizziness
* irritability
* nausea
* vomiting

The most common side effects of Vyvanse in adults with moderate to severe B.E.D.
include:

* dry mouth
* decreased appetite
* constipation
* anxiety

* trouble sleeping
* increased heart rate
* feeling jittery

What is Vyvanse?
Vyvanse is a prescription medicine used for the treatment of
Attention-Deficit/Hyperactivity Disorder (ADHD) in patients 6 years and above,
and for the treatment of moderate to severe binge eating disorder (B.E.D.) in
adults. Vyvanse is not for use in children under 6 years of age with ADHD.
Vyvanse is not for weight loss. It is not known if Vyvanse is safe and effective
for the treatment of obesity. It is not known if Vyvanse is safe and effective
for use in children with B.E.D.

For additional safety information, click here for Prescribing Information and
Medication Guide and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Takeda is committed to helping ensure the proper use of stimulant medication.
Please see the Proper Use of Prescription Stimulant Medication for additional
information.

There is a pregnancy registry for females who are exposed to VYVANSE during
pregnancy. The purpose of the registry is to collect information about the
health of females exposed to VYVANSE and their baby. If you or your child
becomes pregnant during treatment with VYVANSE, talk to your healthcare provider
about registering with the National Pregnancy Registry for Psychostimulants at
1-866-961-2388 or visit online at
https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/adhd-medications/.

* Medication Guide
* Proper Use of Prescription Stimulant Medication
* Prescribing Information
* Takeda Patient Assistance Program
* Privacy Notice
* Contact Takeda

VYVANSE and the VYVANSE logo are registered trademarks of Takeda Pharmaceuticals
U.S.A., Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda
Pharmaceutical Company Limited. ©2022 Takeda Pharmaceuticals U.S.A., Inc. All
rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

All content of this website, including text, images, graphics, sound files, and
their arrangement, is copyrighted and owned by Takeda Pharmaceuticals U.S.A.,
Inc. and is protected by international copyright laws. All other intellectual
property rights are reserved. The content may not be copied for commercial use
or distribution, nor may these objects be downloaded, modified, or posted to
other sites. This site is intended solely for US residents and is governed
solely by US laws and government regulations. Please see our Terms of Use for
more information. While Takeda makes reasonable efforts to include accurate,
up-to-date information on this site, Takeda makes no warranties or
representations as to its accuracy. Takeda assumes no liability for any errors
or omissions in the content of this site. The information on this site is not
intended to make a diagnosis or to take the place of talking to a US healthcare
professional.

US-LIS-1122v1.0 01/22

SCROLL FOR FULL MEDICATION GUIDE

MEDICATION GUIDE

VYVANSE® (VI'- VANS)

(lisdexamfetamine dimesylate)

Capsules and Chewable Tablets, CII

What is the most important information I should know about VYVANSE?

VYVANSE may cause serious side effects, including:

* Abuse and dependence. VYVANSE, other amphetamine containing medicines, and
methylphenidate have a high chance for abuse and may cause physical and
psychological dependence. Your healthcare provider should check you or your
child for signs of abuse and dependence before and during treatment with
VYVANSE.
* Tell your healthcare provider if you or your child have ever abused or been
dependent on alcohol, prescription medicines, or street drugs.
* Your healthcare provider can tell you more about the differences between
physical and psychological dependence and drug addiction.
* Heart-related problems including:
* sudden death, stroke, and heart attack in adults
* sudden death in children who have heart problems or heart defects
* increased blood pressure and heart rate

Your healthcare provider should check you or your child carefully for heart
problems before starting treatment with VYVANSE. Tell your healthcare provider
if you or your child have any heart problems, heart defects, high blood
pressure, or a family history of these problems.

Your healthcare provider should check your or your child’s blood pressure and
heart rate regularly during treatment with VYVANSE.

Call your healthcare provider or go to the nearest hospital emergency room right
away if you or your child have any signs of heart problems such as chest pain,
shortness of breath, or fainting during treatment with VYVANSE.

* Mental (psychiatric) problems, including:
* new or worse behavior and thought problems
* new or worse bipolar illness
* new psychotic symptoms (such as hearing voices, or seeing or believing
things that are not real) or new manic symptoms

Tell your healthcare provider about any mental problems you or your child have
or about a family history of suicide, bipolar illness, or depression.

Call your healthcare provider right away if you or your child have any new or
worsening mental symptoms or problems during treatment with VYVANSE, especially
hearing voices, seeing or believing things that are not real, or new manic
symptoms.

What Is VYVANSE?

VYVANSE is a central nervous system (CNS) stimulant prescription medicine used
for the treatment of:

* Attention Deficit Hyperactivity Disorder (ADHD) in adults and children 6
years of age and older. VYVANSE may help increase attention and decrease
impulsiveness and hyperactivity in people with ADHD.
* Moderate to severe binge eating disorder (BED) in adults. VYVANSE may help
reduce the number of binge eating days in people with BED.

VYVANSE is not for use in children under 6 years of age with ADHD.

VYVANSE is not for weight loss. It is not known if VYVANSE is safe and effective
for the treatment of obesity.

It is not known if VYVANSE is safe and effective for use in children with BED.

VYVANSE is a federally controlled substance (CII) because it contains
lisdexamfetamine dimesylate that can be a target for people who abuse
prescription medicines or street drugs. Keep VYVANSE in a safe place to protect
it from theft. Never give your VYVANSE to anyone else because it may cause death
or harm them. Selling or giving away VYVANSE may harm others and is against the
law.

Do not take VYVANSE if you or your child are:

* allergic to amphetamine products or any of the ingredients in VYVANSE. See
the end of this Medication Guide for a complete list of ingredients in
VYVANSE.
* taking, or have stopped taking in the last 14 days, a medicine called a
Monoamine Oxidase Inhibitor (MAOI).
* being treated with the antibiotic linezolid or intravenous methylene blue.

Before taking VYVANSE, tell your healthcare provider about all medical
conditions, including if you or your child:

* have heart problems, heart defects, or high blood pressure
* have mental problems including psychosis, mania, bipolar illness, or
depression or have a family history of suicide, bipolar illness, or
depression
* have circulation problems in fingers and toes
* are pregnant or plan to become pregnant. VYVANSE may harm the unborn baby.
* There is a pregnancy registry for females who are exposed to VYVANSE during
pregnancy. The purpose of the registry is to collect information about the
health of females exposed to VYVANSE and their baby. If you or your child
becomes pregnant during treatment with VYVANSE, talk to your healthcare
provider about registering with the National Pregnancy Registry for
Psychostimulants at 1-866-961-2388 or visit online
at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/adhd-medications/.
* are breastfeeding or plan to breastfeed. VYVANSE passes into breast milk. You
should not breastfeed during treatment with VYVANSE. Talk to your healthcare
provider about the best way to feed the baby during treatment with VYVANSE.

Tell your healthcare provider about all the medicines that you or your child
take, including prescription and over-the-counter medicines, vitamins, and
herbal supplements.

VYVANSE can affect the way other medicines work and other medicines may affect
how VYVANSE works. Taking VYVANSE with other medicines can cause serious side
effects. Sometimes the doses of other medicines will need to be changed while
taking VYVANSE.

Especially tell your healthcare provider if you or your child take:

selective serotonin reuptake inhibitors (SSRIs) serotonin norepinephrine
reuptake inhibitors (SNRIs) medicines used to treat migraine headaches
called triptans tricyclic antidepressants lithium fentanyl tramadol tryptophan
buspirone St. John’s Wort

Keep a list of all medicines to show your healthcare provider and pharmacist
when you get a new medicine. Your healthcare provider will decide if VYVANSE can
be taken with other medicines.

Do not start any new medicine during treatment with VYVANSE without talking to
your healthcare provider first.

How should VYVANSE be taken?

* Take VYVANSE exactly as prescribed by your healthcare provider.
* Your healthcare provider may change the dose if needed.
* Take VYVANSE 1 time each day in the morning with or without food.
* Your healthcare provider may sometimes stop VYVANSE treatment for a while to
check ADHD or BED symptoms.
* VYVANSE comes in capsules or chewable tablets.

Taking VYVANSE Capsules:

* VYVANSE capsules may be swallowed whole.
* If VYVANSE capsules cannot be swallowed whole, the capsule may be opened and
the entire contents sprinkled onto yogurt, or poured into water or orange
juice.
* Using a spoon, break apart any powder that is stuck together. Stir the
VYVANSE powder and yogurt, water, or orange juice until they are completely
mixed together.
* Swallow all the yogurt, water, or orange juice mixture right away. Do
not store the yogurt, water, or orange juice mixture.
* It is normal to see a filmy coating on the inside of your glass or
container after you eat or drink all the VYVANSE mixture.

Taking VYVANSE Chewable Tablets:

* Chew VYVANSE tablets completely before swallowing.

If you or your child take too much VYVANSE, call your healthcare provider or
poison control center at 1-800-222-1222 or go to the nearest hospital emergency
room right away.

What should I avoid while taking VYVANSE?

Do not drive, operate machinery, or do other dangerous activities until you know
how VYVANSE affects you.

What are possible side effects of VYVANSE?

VYVANSE may cause serious side effects, including:

* See "What is the most important information I should know about VYVANSE?"
* Slowing of growth (height and weight) in children. Children should have their
height and weight checked often during treatment with VYVANSE. VYVANSE
treatment may be stopped if your child is not growing or gaining weight.
* Circulation problems in fingers and toes (Peripheral vasculopathy, including
Raynaud’s phenomenon). Signs and symptoms may include:
* Fingers or toes may feel numb, cool, painful
* Fingers or toes may change color from pale, to blue, to red

Tell your healthcare provider if you or your child have numbness, pain, skin
color change, or sensitivity to temperature in your fingers or toes.

Call your healthcare provider right away if you or your child have any signs of
unexplained wounds appearing on fingers or toes during treatment with VYVANSE.

* Serotonin Syndrome. A potentially life-threatening problem called serotonin
syndrome may happen when VYVANSE is taken with certain other medicines. Stop
taking VYVANSE and call your healthcare provider or go to the nearest
hospital emergency room right away if you or your child develop any of the
following signs and symptoms of serotonin syndrome:

agitation fast heartbeat flushing seizures coma sweating loss of coordination
confusion dizziness tremors, stiff muscles, or muscle twitching seeing or
hearing things that are not real (hallucination) changes in blood pressure high
body temperature (hyperthermia) nausea, vomiting, diarrhea

The most common side effects of VYVANSE in children 6 to 17 years old and adults
with ADHD include:

loss of appetite (anorexia) anxiety decreased appetite weight loss diarrhea
dizziness dry mouth irritability trouble sleeping nausea stomach pain vomiting

The most common side effects of VYVANSE in adults with BED include:

dry mouth trouble sleeping decreased appetite increased heart rate constipation
feeling jittery anxiety

These are not all the possible side effects of VYVANSE.

Call your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.

How should I store VYVANSE?

* Store VYVANSE in a safe place (like a locked cabinet) and in a tightly closed
container at room temperature between 68°F to 77°F (20°C to 25°C).
* Protect VYVANSE from light.
* Dispose of remaining, unused, or expired VYVANSE by a medicine take-back
program at authorized collection sites such as retail pharmacies, hospital or
clinic pharmacies, and law enforcement locations. If no take-back program or
authorized collector is available, mix VYVANSE with an undesirable, nontoxic
substance such as dirt, cat litter, or used coffee grounds to make it less
appealing to children and pets. Place the mixture in a container such as a
sealed plastic bag and throw away (discard) VYVANSE in the household trash.

Keep VYVANSE and all medicines out of the reach of children.

General information about the safe and effective use of VYVANSE.

Medicines are sometimes prescribed for purposes other than those listed in a
Medication Guide. Do not use VYVANSE for a condition for which it was not
prescribed. Do not give VYVANSE to other people, even if they have the same
symptoms that you have. It may harm them and it is against the law. You can ask
your pharmacist or healthcare provider for information about VYVANSE that is
written for health professionals.

What are the ingredients in VYVANSE?

Active Ingredient: lisdexamfetamine dimesylate

Capsule Inactive Ingredients: microcrystalline cellulose, croscarmellose sodium,
and magnesium stearate. The capsule shells (imprinted with S489) contain
gelatin, titanium dioxide, and one or more of the following: FD&C Red #3, FD&C
Yellow #6, FD&C Blue #1, Black Iron Oxide, and Yellow Iron Oxide.

Chewable Tablet Inactive Ingredients: colloidal silicon dioxide, croscarmellose
sodium, guar gum, magnesium stearate, mannitol, microcrystalline cellulose,
sucralose, artificial strawberry flavor.

Distributed by: Takeda Pharmaceuticals America, Inc., Lexington, MA 02421.

VYVANSE® and the VYVANSE Logo® are registered trademarks of Takeda
Pharmaceuticals U.S.A., Inc.

For more information, go to www.vyvanse.com or call 1-877-TAKEDA-7
(1-877-825-3327).

This Medication Guide has been approved by the U.S. Food and Drug
Administration.

Revised: 10/2021
SPI-0338 Reformatted for US-LIS-1122

CONTINUE TO THE SITE

IMPORTANT SAFETY INFORMATION

Who should not take Vyvanse?
Do not take Vyvanse if you or your child are:

Vyvanse may cause serious side effects, including:

Before taking Vyvanse, tell your HCP about all medical conditions, including if
you or your child:
* are pregnant or plan to become pregnant. Vyvanse may harm the unborn baby.
* are breastfeeding or plan to breastfeed. Vyvanse passes into breast milk. You
or your child should not breastfeed during treatment with Vyvanse. Talk to
your HCP about the best way to feed the baby during treatment with Vyvanse.

What are possible side effects of Vyvanse?
The most common side effects of Vyvanse in children 6 to 17 and adults with ADHD
include:

* loss of appetite (anorexia)
* decreased appetite
* diarrhea
* diarrhea

* trouble sleeping
* stomach pain
* anxiety
* weight loss

* dizziness
* irritability
* nausea
* vomiting

The most common side effects of Vyvanse in adults with moderate to severe B.E.D.
include:

* dry mouth
* decreased appetite
* constipation
* anxiety

* trouble sleeping
* increased heart rate
* feeling jittery

For additional safety information, click here for Prescribing Information and
Medication Guide and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Takeda is committed to helping ensure the proper use of stimulant medication.
Please see the Proper Use of Prescription Stimulant Medication for additional
information.

SCOLL FOR MORE IMPORTANT SAFETY INFORMATION. SEE THE MEDICATION GUIDE.

WHAT IS VYVANSE?

Vyvanse is for the treatment of ADHD in patients ≥6 years and for adults with
moderate to severe B.E.D. It is not for ADHD patients <6 years and not for
B.E.D. in patients <18 years. Vyvanse is not for weight loss or to treat
obesity.

MORE IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Abuse & Dependence. Vyvanse has a high chance for abuse and may cause physical
and psychological dependence. Your healthcare provider (HCP) should check you or
your child for signs of abuse and dependence before and during treatment.
Vyvanse is a federally controlled substance (CII) because it contains
lisdexamfetamine dimesylate that can be a target for people who abuse
prescription medicines or street drugs. Keep Vyvanse in a safe place to protect
it from theft. Never sell or give your Vyvanse to anyone else because it may
cause death or harm to them and it is against the law. MORE IMPORTANT SAFETY
INFORMATION

Go Back

IMPORTANT SAFETY INFORMATION

Who should not take Vyvanse?
Do not take Vyvanse if you or your child are:

Vyvanse may cause serious side effects, including:

Before taking Vyvanse, tell your HCP about all medical conditions, including if
you or your child:

What are possible side effects of Vyvanse?
The most common side effects of Vyvanse in children 6 to 17 and adults with ADHD
include:

* loss of appetite (anorexia)
* decreased appetite
* diarrhea
* dry mouth

* trouble sleeping
* stomach pain
* anxiety
* weight loss

* dizziness
* irritability
* nausea
* vomiting

The most common side effects of Vyvanse in adults with moderate to severe B.E.D.
include:

* dry mouth
* decreased appetite
* constipation
* anxiety

* trouble sleeping
* increased heart rate
* feeling jittery

For additional safety information, click here for Prescribing Information and
Medication Guide and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Takeda is committed to helping ensure the proper use of stimulant medication.
Please see the Proper Use of Prescription Stimulant Medication for additional
information.

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