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 * Full Prescribing Information
 * Important Safety Information
 * Urology Resources
 * Patient Site
 * Request a Rep

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 * Mechanism
   of Action
 * Efficacy
   * Study Design
   * Efficacy Results
   * Adults ≥65 (PILLAR):
     Study Design
   * Adults ≥65 (PILLAR):
     Efficacy Results
 * Safety
   * Safety Results
   * Adults ≥65 (PILLAR):
     Safety Results
 * Dosing &
   Administration
   * Dosing
   * Drug-to-Drug Interactions
 * Combination
   Treatment
   * MOA
   * Combination Therapy
   * Add-on Therapy
   * Safety
   * Dosing
 * Support
   * Patient Support
   * Savings & Support
   * Physician Support

 * Full Prescribing Information
 * Important Safety Information
 * Urology Resources
 * Patient Site
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Study Design
Efficacy Results
Adults ≥65 (PILLAR): Study Design
Adults ≥65 (PILLAR): Efficacy Results
Safety Results
Adults ≥65 (PILLAR): Safety Results
Dosing
Drug-to-Drug Interactions
MOA
Combination Therapy
Add-on Therapy
Safety
Dosing
Patient Resources
Savings & Support
Physician Resources
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Mechanism
of Action


It’s time to reduce her overactive bladder (OAB) symptoms


SHE HAS PLACES TO GO.

For your patients with symptoms of OAB, Myrbetriq® (mirabegron) offers
meaningful reductions in urge urinary incontinence, urgency, and
urinary frequency1

See How Myrbetriq Works


MYRBETRIQ IS THE #1 PRESCRIBED BRANDED OAB MEDICATION2*

*Based on 24-month TRx shares for all OAB medications, IMS Health National
Prescription Audit, March 2018-February 2020.

THIS INFORMATION DOES NOT IMPLY SAFETY OR EFFICACY OF ANY PRODUCT; NO
COMPARISONS SHOULD BE MADE.

EVALUATED IN ADULTS ≥65 YEARS OLD

PILLAR is the first prospective study of Myrbetriq in adults ≥65

See Study Results

THE FEDERAL AVIATION ADMINISTRATION (FAA) ACCEPTS MYRBETRIQ FOR OAB TREATMENT3

View Safety Profile
Next section
Mechanism of Action

INDICATIONS AND USAGE

Myrbetriq® (mirabegron), a beta-3 adrenergic agonist, is indicated as
monotherapy or in combination with the muscarinic antagonist solifenacin
succinate for the treatment of overactive bladder (OAB) with symptoms of urge
urinary incontinence, urgency, and urinary frequency.

IMPORTANT SAFETY INFORMATION

Do not use Myrbetriq in patients who have known hypersensitivity reactions to
mirabegron or any component of the tablet.

Myrbetriq alone or in combination with solifenacin succinate can increase blood
pressure. Periodic blood pressure determinations are recommended, especially in
hypertensive patients. Myrbetriq is not recommended for use in severe
uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm
Hg and/or diastolic blood pressure ≥ 110mm Hg). Worsening of hypertension was
reported infrequently in Myrbetriq clinical trial patients with OAB.

Do not use Myrbetriq® (mirabegron) in patients who have known hypersensitivity
reactions to mirabegron or any component of the tablet.

Myrbetriq alone or in combination with solifenacin succinate can increase blood
pressure. Periodic blood pressure determinations are recommended, especially in
hypertensive patients. Myrbetriq is not recommended for use in severe
uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm
Hg and/or diastolic blood pressure ≥ 110mm Hg). Worsening of hypertension was
reported infrequently in Myrbetriq clinical trial patients with OAB.

In patients taking Myrbetriq, urinary retention has been reported in patients
with bladder outlet obstruction (BOO) and in patients taking antimuscarinic
medications for the treatment of OAB. A controlled clinical safety study in
patients with BOO did not demonstrate increased urinary retention in Myrbetriq
patients; however, Myrbetriq should still be administered with caution to
patients with clinically significant BOO. For example, monitor these patients
for signs and symptoms of urinary retention. Myrbetriq should also be
administered with caution to patients taking antimuscarinic medications for the
treatment of OAB, including solifenacin succinate.

Angioedema of the face, lips, tongue and/or larynx has been reported with
Myrbetriq. Cases of angioedema have been reported to occur after the first dose,
hours after the first dose, or after multiple doses. Angioedema associated with
upper airway swelling may be life threatening. If involvement of the tongue,
hypopharynx, or larynx occurs, promptly discontinue Myrbetriq and initiate
appropriate therapy and/or measures necessary to ensure a patent airway.

Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6
substrates such as metoprolol and desipramine is increased when co-administered
with Myrbetriq. Therefore, appropriate monitoring and dose adjustment may be
necessary, especially with narrow therapeutic index drugs metabolized by CYP2D6,
such as thioridazine, flecainide, and propafenone.

In clinical trials, the most commonly reported adverse reactions (> 2% and >
placebo) for Myrbetriq 25mg and 50mg versus placebo, respectively, were
hypertension (11.3%, 7.5% vs. 7.6%), nasopharyngitis (3.5%, 3.9% vs. 2.5%),
urinary tract infection (4.2%, 2.9% vs. 1.8%), and headache (2.1%, 3.2% vs.
3.0%).

In clinical trials, the most commonly reported adverse reactions (> 2% and >
placebo and > comparator) for Myrbetriq in combination with solifenacin
succinate 25mg + 5mg and 50mg + 5mg versus Myrbetriq 25mg, Myrbetriq 50mg,
solifenacin succinate 5mg and placebo, respectively, were dry mouth (9.3%, 7.2%
vs. 3.8%, 3.6%, 6.5%, 2.2%), urinary tract infection (7.0%, 4.0% vs. 4.0%, 4.2%,
3.6%, 5.3%), constipation (4.2%, 3.9% vs. 1.2%, 2.8%, 2.4%, 1.2%), and
tachycardia (2.2%, 0.9% vs. 1.6%, 1.6%, 0.7%, 0.8%).

In postmarketing experience with mirabegron, the following events have also
occurred: atrial fibrillation, nausea, constipation, diarrhea, and dizziness.

Please refer to prescribing information for solifenacin succinate when
prescribing Myrbetriq in combination with solifenacin succinate.

Please click here for complete Prescribing Information for Myrbetriq®
(mirabegron).

REFERENCES

1. Myrbetriq [Prescribing Information]. Northbrook, IL: Astellas Pharma US, Inc.
2. Astellas. Myrbetriq. Data on File. 3. Federal Aviation Administration.
Federal Air Surgeon’s Medical Bulletin. Oklahoma City, OK: Federal Aviation
Administration. 2013‑2014;51(4):6.

 * Home
 * Mechanism
   of Action
 * Efficacy
   * Study Design
   * Efficacy Results
   * Adults ≥65 (PILLAR):
     Study Design
   * Adults ≥65 (PILLAR):
     Efficacy Results
 * Safety
   * Safety Results
   * Adults ≥65 (PILLAR):
     Safety Results
 * Dosing &
   Administration
   * Dosing
   * Drug-to-Drug Interactions
 * Combination
   Treatment
   * MOA
   * Combination Therapy
   * Add-on Therapy
   * Safety
   * Dosing
 * Support
   * Patient Support
   * Savings & Support
   * Physician Support

To learn more about patient assistance programs for Myrbetriq, please call
Astellas Pharma Support SolutionsSM at 1‑800‑477‑6472 or go to
www.astellaspharmasupportsolutions.com.

Myrbetriq, VESIcare, Astellas, and the flying star logo are registered
trademarks of Astellas Pharma, Inc. All other trademarks or registered
trademarks are the property of their respective owners.

This site is intended for US Healthcare Professionals only.
©2020 Astellas Pharma US, Inc.

055-0310-PM

 * Privacy Policy
 * Legal Disclaimer
 * Request a Rep
 * Contact Us
 * Medical Information

Important Safety Information,
Indications and Usage

INDICATIONS AND USAGE

Myrbetriq® (mirabegron), a beta-3 adrenergic agonist, is indicated as
monotherapy or in combination with the muscarinic antagonist solifenacin
succinate for the treatment of overactive bladder (OAB) with symptoms of urge
urinary incontinence, urgency, and urinary frequency.

IMPORTANT SAFETY INFORMATION

Do not use Myrbetriq in patients who have known hypersensitivity reactions to
mirabegron or any component of the tablet.

Myrbetriq alone or in combination with solifenacin succinate can increase blood
pressure. Periodic blood pressure determinations are recommended, especially in
hypertensive patients. Myrbetriq is not recommended for use in severe
uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm
Hg and/or diastolic blood pressure ≥ 110mm Hg). Worsening of hypertension was
reported infrequently in Myrbetriq clinical trial patients with OAB.

Do not use Myrbetriq® (mirabegron) in patients who have known hypersensitivity
reactions to mirabegron or any component of the tablet.

Myrbetriq alone or in combination with solifenacin succinate can increase blood
pressure. Periodic blood pressure determinations are recommended, especially in
hypertensive patients. Myrbetriq is not recommended for use in severe
uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm
Hg and/or diastolic blood pressure ≥ 110mm Hg). Worsening of hypertension was
reported infrequently in Myrbetriq clinical trial patients with OAB.

In patients taking Myrbetriq, urinary retention has been reported in patients
with bladder outlet obstruction (BOO) and in patients taking antimuscarinic
medications for the treatment of OAB. A controlled clinical safety study in
patients with BOO did not demonstrate increased urinary retention in Myrbetriq
patients; however, Myrbetriq should still be administered with caution to
patients with clinically significant BOO. For example, monitor these patients
for signs and symptoms of urinary retention. Myrbetriq should also be
administered with caution to patients taking antimuscarinic medications for the
treatment of OAB, including solifenacin succinate.

Angioedema of the face, lips, tongue and/or larynx has been reported with
Myrbetriq. Cases of angioedema have been reported to occur after the first dose,
hours after the first dose, or after multiple doses. Angioedema associated with
upper airway swelling may be life threatening. If involvement of the tongue,
hypopharynx, or larynx occurs, promptly discontinue Myrbetriq and initiate
appropriate therapy and/or measures necessary to ensure a patent airway.

Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6
substrates such as metoprolol and desipramine is increased when co-administered
with Myrbetriq. Therefore, appropriate monitoring and dose adjustment may be
necessary, especially with narrow therapeutic index drugs metabolized by CYP2D6,
such as thioridazine, flecainide, and propafenone.

In clinical trials, the most commonly reported adverse reactions (> 2% and >
placebo) for Myrbetriq 25mg and 50mg versus placebo, respectively, were
hypertension (11.3%, 7.5% vs. 7.6%), nasopharyngitis (3.5%, 3.9% vs. 2.5%),
urinary tract infection (4.2%, 2.9% vs. 1.8%), and headache (2.1%, 3.2% vs.
3.0%).

In clinical trials, the most commonly reported adverse reactions (> 2% and >
placebo and > comparator) for Myrbetriq in combination with solifenacin
succinate 25mg + 5mg and 50mg + 5mg versus Myrbetriq 25mg, Myrbetriq 50mg,
solifenacin succinate 5mg and placebo, respectively, were dry mouth (9.3%, 7.2%
vs. 3.8%, 3.6%, 6.5%, 2.2%), urinary tract infection (7.0%, 4.0% vs. 4.0%, 4.2%,
3.6%, 5.3%), constipation (4.2%, 3.9% vs. 1.2%, 2.8%, 2.4%, 1.2%), and
tachycardia (2.2%, 0.9% vs. 1.6%, 1.6%, 0.7%, 0.8%).

In postmarketing experience with mirabegron, the following events have also
occurred: atrial fibrillation, nausea, constipation, diarrhea, and dizziness.

Please refer to prescribing information for solifenacin succinate when
prescribing Myrbetriq in combination with solifenacin succinate.

Please click here for complete Prescribing Information for Myrbetriq®
(mirabegron).

The information contained on this site is intended for
healthcare professionals in the United States only.
It is not intended for the general public.

I AM a US healthcare professional I am NOT a US healthcare professional
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ELIGIBILITY RESTRICTIONS, TERMS & CONDITIONS

TO THE PATIENT: This offer is not valid for patients whose prescription claims
are reimbursed, in whole or in part, by any state or federal government program,
including, but not limited to, Medicaid, Medicare, Medigap, Department of
Defense (DoD), Veterans Affairs (VA), TRICARE, CHAMPUS, Puerto Rico Government
Health Insurance, or any State Patient or Pharmaceutical Assistance Program.
This offer is void where prohibited by law. Certain rules and restrictions
apply.

Note: If you use a mail-order pharmacy, please contact your pharmacy provider to
ensure that this offer will be accepted. If the mail-order pharmacy will not
process your voucher, please call 1‑866‑666‑8244 (Monday-Friday, 8 a.m.-8 p.m.
ET, excluding holidays) and request to speak to an agent. An agent will mail a
Direct Member Reimbursement (DMR) form to you. The form should be completed and
returned to the address on the form, along with your pharmacy receipt. If you
are eligible, you will receive your benefit in the mail. You can also visit
www.patientrebateonline.com to obtain a DMR form.

TO THE PHARMACIST: By redeeming this coupon, I certify that (i) I have received
this coupon from an eligible patient, (ii) I have dispensed the products
indicated, (iii) I have not submitted, and will not submit, a claim for
reimbursement to Part D of Medicare, Medicaid, or any similar federal or state
program, including a state pharmaceutical assistance program, and (iv) I will
otherwise comply with the terms hereof.

I further certify that my participation in this program is consistent with all
applicable state laws and any obligations, contractual or otherwise, that I have
as a pharmacy provider. Please submit the amount of co‑pay authorized by the
patient's primary insurance as a secondary transaction to McKesson. For pharmacy
processing assistance or questions, please call the Help Desk at 1-866-666-8244.

HOURS OF OPERATION: Monday-Friday, 8 a.m.-8 p.m. ET, excluding holidays.