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 * Overview
 * Team
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DERMATLAS: THE GENOMIC ATLAS OF SKIN TUMOURS

Dermatlas: the world’s most comprehensive resource for exploring the complexity
of somatic and germline genetic alterations found in human skin tumours



THE DERMATLAS PROJECT

We aim to understand the genetics and genomics of skin cancers to improve
dermatology practice, patient management and treatment (targeted therapies).

LEADERSHIP & TEAM

Dermatlas brings together an international team of pathologists, geneticists and
computational biologists with the aim of understanding skin cancers.

PROJECT PARTNERS

Our project partners are central to the delivery of the project and are situated
in leading hospitals around the world.




VIRTUALLY NO OTHER ORGAN IS ASSOCIATED WITH SO MANY DIFFERENT TUMOUR TYPES AS
SKIN.

Histologically, skin tumours may arise from different skin structures, including
epidermis, hair follicle, sebaceous or sweat gland, melanocytes,
dermal-associated mesenchymal structures or tissue resident immune cells, making
for a diversity of clinical presentations.

Importantly, skin tumours can have an extremely poor prognoses.

               


THE DERMATLAS PROJECT

Our overarching hypotheses for the Dermatlas Project are that: 1). Most skin
tumour subtypes can be defined by a discrete set of genetic drivers, some of
which can be targeted therapeutically; 2). Some skin tumours are caused by
germline predisposing alleles, chemical exposures or viruses and these can be
revealed by DNA/RNA sequencing and analysis, which can help define new screening
and public health approaches. We will address each of these hypotheses with the
following specific objectives/aims:

 * For 70 key skin tumour subtypes defined by the World Health Organization
   (WHO), that have not undergone whole genome or whole exome sequencing
   previously, we will sequence up to 50 cases (exome & transcriptome) from a
   range of body sites to build a genomic atlas of skin tumours, including
   detailed maps of single nucleotide variants (SNVs), copy number alterations,
   genome-wide methylation and expression profiles.

 * With these sequence data we will use state-of-the-art analytical tools to
   identify driver genes, mutational signatures and hence exposures or
   endogenous processes that might promote disease development. We will also
   look for evidence of other factors such as viruses not previously identified
   in these neoplasms.

 * Using germline data from each case we will define the possible contribution
   of germline alleles to tumour development, thus facilitating clinical
   genetics and diagnostic services.

Skin tumours are derived from a range of cell and tissue types.

Working at scale, we will profile the molecular landscape of these conditions.
These studies will prime our whole community to explore the fundamental biology
of skin malignancies.

Dermatlas has the potential to make a monumental contribution to our
understanding of these diseases and to the precision of patient diagnosis and
management.

Tumours to be sequenced as part of the Dermatlas project and their structures of
origin are shown below.

 * MELANOCYTIC TUMOURS
   
   CONJUNCTIVAL NEVI
   PIGMENTED SPINDLE CELL NEVUS
   

 * PAGET DISEASE OF THE SKIN
   
   EXTRAMAMMARY PAGET
   

 * APPENDAGEAL TUMOURS
   
    * HAIR FOLLICLE
      
      MELANOCYTIC MATRICOMA
      PILOMATRICOMA
      PILOMATRIX CARCINOMA
      PROLIFERATING PILAR TUMOUR
      TRICHILEMMAL CARCINOMA
      TRICHILEMMOMA
      TRICHADENOMA
      TRICHOBLASTIC CARCINOMA
      TRICHOBLASTOMA/TRICHOEPITHELIOMA
      TRICHOFOLLICULOMA
      
   
    * SWEAT GLANDS
      
      APOCRINE CARCINOMA
      CRIBRIFORM CARCINOMA
      CUTANEOUS MIXED TUMOUR (CHONDROID SYRINGOMA)
      DIGITAL PAPILLARY ADENOCARCINOMA
      ECCRINE DUCTAL CARCINOMA
      ENDOCRINE MUCIN PRODUCING SWEAT GLAND CARCINOMA
      HIDRADENOCARCINOMA
      HIDRADENOMA
      HIDRADENOMA PAPILLIFERUM
      HISTIOCYTOID CARCINOMA
      MALIGNANT MIXED TUMOUR
      MICROCYSTIC ADNEXAL CARCINOMA
      MUCINOUS CARCINOMA
      MYOEPITHELIOMA
      POLYMORPHOUS SWEAT GLAND CARCINOMA
      POROCARCINOMA
      POROMA
      SQUAMOID ECCRINE DUCTAL CARCINOMA
      SYRINGOCYSTADENOMA PAPILLIFERUM
      SYRINGOMA
      TUBULAR ADENOMA
      
   
    * ADIPOSE TISSUE
      
      PLEOMORPHIC LIPOMA
      PLEOMORPHIC LIPOSARCOMA
      SPINDLE CELL LIPOMA
      

 * MESENCHYMAL TUMOURS
   
    * FIBROUS, FIBROBLASTIC AND MYOFIBROBLASTIC TISSUE
      
      DERMATOMYOFIBROMA
      MYOFIBROMA
      MYXOINFLAMMATORY FIBROBLASTIC SARCOMA
      SUPERFICIAL ACRAL FIBROMYXOMA
      
   
    * FIBROHISTIOCYTIC TISSUE
      
      PLEXIFORM FIBROHISTIOCYTIC TUMOUR
      
   
    * NEUROECTODERMAL ORIGIN
      
      CELLULAR NEUROTHEKEOMA
      CUTANEOUS EWING SARCOMA
      EPITHELIOID MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR (MPNST)
      EPITHELIOID SCHWANNOMA
      PERINEURIOMA
      SOLITARY CIRCUMSCRIBED NEUROMA
      
   
    * MUSCLE TISSUE
      
      CUTANEOUS LEIMYOMA
      CUTANEOUS LEIOMYOSARCOMA
      RHABDOMYOSARCOMA
      
   
    * VASCULAR ORIGIN
      
      ANGIOLEIOMYOMA
      ATYPICAL VASCULAR LESION
      CUTANEOUS ANGIOSARCOMA
      EPITHELIOID ANGIOMATOUS NODULE
      EPITHELIOID ANGIOSARCOMA
      GLOMERULOID HEMANGIOMA
      GLOMUS TUMOUR
      HOBNAIL HEMANGIOMA
      KAPOSIFORM HEMANGIOENDOTHELIOMA
      MICROVENULAR HEMANGIOMA
      MYOPERICYTOMA
      RETINIFORM HEMANGIOENDOTHELIOMA
      SPINDLE CELL HEMANGIOMA
      TUFTED HEMANGIOMA
      
   
    * MISCELLANEA
      
      CUTANEOUS MYXOMA
      NON NEURAL GRANULAR CELL TUMOUR
      


LEADERSHIP & TEAM

Dermatopathologists, geneticists and bioinformaticians

DR. DAVID ADAMS

Senior Group Leader

Project Lead



DR. LOUISE VAN DER WEYDEN

Senior Staff Scientist

Sample Co-ordinator



LIZ ANDERSON

Scientific Manager

Sequencing Co-ordinator



DR. INGRID FERREIRA

Senior Dermatopathologist

Dermatopathologist



PROF. THOMAS BRENN

Professor of Pathology

Dermatopathologist



PROF. MARK ARENDS

Professor of Pathology

Pathologist



DR. ALASTAIR DROOP

Principal Bioinformatician

Bioinformatician



DR. KIM WONG

Principal Bioinformatician

Bioinformatician



MARTIN DEL CASTILLO VELASCO-HERRERA

Senior Bioinformatician

Bioinformatician



VICTORIA OFFORD

Principal Bioinformatician

Bioinformatician



JACQUELINE BOCCACINO

Bioinformatician

Bioinformatician




PROJECT PARTNERS

World-leading team of pathologists based in major clinical centres and
laboratories around the world.

PROF. THOMAS BRENN

University of Calgary
Calgary, Canada

DR. PAUL HARMS

University of Michigan
Michigan, USA

PROF. MARK ARENDS

University of Edinburgh
Edinburgh, UK

PROF. STEVEN BILLINGS

The Cleveland Clinic
Cleveland, USA

DR. SYLVIE FRAITAG

Necker Hospital
Paris, France

DR EMILY CLARKE

University of Leeds
Leeds, UK

DR. PETER FERGUSON

Melanoma Institute of Australia & RPA Hospital
Sydney, Australia

DR. PATRICA POSSIK

Brazilian National Cancer Institute
Rio de Janeiro, Brazil

DR. MIRNA TOLEDO

Hospital Infantil de Mexico Federico Gomez
Mexico City, Mexico

DR. MICHIEL VAN DER HORST

Maasstad Ziekenhuis Rotterdam
Rotterdam, Netherlands

DR. NEIL RAJAN

University of Newcastle
Newcastle, UK

DR. NICOLAS DE SAINT AUBAIN

Institut Jules Bordet
Brussels, Belgium

PROF. EDUARDO NAGORE

Instituto Valenciano de Oncología
Valencia, Spain

DR. DEREK FREW

Cleveland Clinic
Cleveland, USA

DR. CARLOS E. BACCHI

Laboratorio de Patologia Bacchi
Sao Paulo, Brazil

PROF. KLAUS BUSAM

Memorial Sloan Kettering Cancer Center
New York, USA

DR ELENI IEREMIA

University of Oxford
Oxford, UK

DR. INGRID FERREIRA

Université libre de Bruxelles
Brussels, Belgium

DR. WILL MERCHANT

University of Leeds
Leeds, UK

PROF. CARLOS MONTEAGUDO

University of Valencia
Valencia, Spain

DR. DANIELA ROBLES-ESPINOZA

International Laboratory for Human Genome Research
Juriquilla, Mexico

DR. REMCO VAN DOORN

Leiden University Medical Center
Leiden, Netherlands

PROF. WILKO WEICHERT

Technical University of Munich
Munich, Germany

PROF. AHMED ALOMARI

University of Indiana
Indiana, USA


WANT TO GET IN TOUCH?

Do you have questions about the Dermatlas project? We'd love to hear from you.
Here's how you can reach us...

CLICK HERE TO EMAIL THE DERMATLAS PROJECT

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