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 * Home
 * Contents
 * Superfamilies
   
 * TC-System
 * HELP


TCDB is operated by the Saier Lab Bioinformatics Group

Software/Tools  
 * BLAST
 * Substrate Search Tool
 * TMS Statistics Tool
 * PSIBLAST
 * Bio-Tools
 * Mapping Files
 * TC-DOMS

Quick Access  
 * Structure data
 * Human Transporters
 * Transporters & Diseases
 * Predicted Evolutionary Pathways

What do you think of TCDB?

You can EMAIL us any questions, comments, or suggestions. Alternatively, you can
also send us a message through the CONTACT page of the Saier lab's website.

Functional and Phylogenetic Classification of Membrane Transport Proteins

The database details a comprehensive IUBMB approved classification system for
membrane transport proteins known as the Transporter Classification (TC) system.
The TC system is analogous to the Enzyme Commission (EC) system for
classification of enzymes, except that it incorporates both functional and
phylogenetic information. Curated annotations, TC numbers, and external
references for 1999 families of transport proteins are provided. Transport
systems are classified on the basis of five criteria, and each of these criteria
corresponds to one of the five numbers or letters within the TC accession for a
particular type of transporter.
(you can find more detailed information about the TC system HERE.)


SOME FACTS ABOUT TCDB:

 * » TCDB is a curated database of factual information from 24843 published
   references
 * » The database contains 23847 protein sequences
 * » These proteins are classified into 1999 transporter families based on the
   TC-System

 * [1] Saier MH, Reddy VS, Moreno-Hagelsieb G, Hendargo KJ, Zhang Y, Iddamsetty
   V, Lam KJK, Tian N, Russum S, Wang J, Medrano-
        Soto A. (2021). The Transporter Classification Database (TCDB): 2021
   update. Nucleic Acids Res. 49(D1):D461-7 [33170213]
 * [2] Saier MH, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G. (2016).
   The Transporter Classification Database (TCDB):
       recent advances. Nucleic Acids Res. 44(D1):D372–9 [26546518]
 * [3] Saier MH, Reddy VS, Tamang DG, Vastermark A. (2014). The transporter
   classification database.
        Nucl. Acids Res. 42(D1):D251-8 [24225317]
 * [4] Saier MH Jr, Yen MR, Noto K, Tamang DG, Elkan C. (2009). The Transporter
   Classification Database: recent advances,
        Nucl. Acids Res. 37:D274-8. [19022853]
 * [5] Saier MH Jr, Tran CV, Barabote RD. (2006). TCDB: the Transporter
   Classification Database for membrane transport protein
        analyses and information, Nucl. Acids Res. 34:D181-6. [16381841]
 * 



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