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Biomedical Engineering

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Neurological Biomaterials and

Cancer Therapeutics Laboratory


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   BELLAMKONDA LAB
   
   NEUROLOGICAL BIOMATERIALS AND CANCER THERAPEUTICS LABORATORY
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
    
   
   

 * IMMUNOENGINEERING NERVE REPAIR
   
   PUBLISHED IN THE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS)
   
   Read the Paper
   
   TUMOR MONORAIL DEVICE RECEIVES FDA BREAKTHROUGH DEVICE DESIGNATION
   
   
   
   Link
   
   NEW PAPER: ELECTROTAXIS OF GLIOBLASTOMA AND MEDULLOBLASTOMA SPHEROIDAL
   AGGREGATES
   
   CHECK OUT OUR NEW PAPER IN SCIENTIFIC REPORTS
   
   LINK
   
   NEW PAPER: ENGINEERING CONTROLLED PERITUMORAL INFLAMMATION TO CONSTRAIN BRAIN
   TUMOR GROWTH
   
   CHECK OUT OUR NEW PAPER IN ADVANCED HEALTHCARE MATERIALS
   
   Link
   
   AUGMENTING HEALING WITH ANTI-INFLAMMATORY RECRUITING APTAGELS
   
   PUBLISHED IN BIOMATERIALS
   
   Read our new paper in Biomaterials
   
   REVIEW: ENGINEERING CHALLENGES FOR BRAIN TUMOR IMMUNOTHERAPY
   
   PUBLISHED IN ADVANCED DRUG DELIVERY REVIEWS
   
   Read the paper
   
   IMMUNOENGINEERING NERVE REPAIR
   
   PUBLISHED IN THE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS)
   
   Read the Paper
   
   TUMOR MONORAIL DEVICE RECEIVES FDA BREAKTHROUGH DEVICE DESIGNATION
   
   
   
   Link
   
   
   

 * FEATURED PUBLICATIONS
   
    * FALCONE JD, SOHAL HS, KYRIAKIDES TR, BELLAMKONDA RV. 2019. THE IMPACT OF
      MODULATING THE BLOOD-BRAIN BARRIER ON THE ELECTROPHYSIOLOGICAL AND
      HISTOLOGICAL OUTCOMES OF INTRACORTICAL ELECTRODES. JOURNAL OF NEURAL
      ENGINEERING. [LINK]
    * LYON JG, CARROLL SL, MOKARRAM N, BELLAMKONDA RV. 2019. ELECTROTAXIS OF
      GLIOBLASTOMA AND MEDULLOBLASTOMA SPHEROIDAL AGGREGATES. SCIENTIFIC
      REPORTS. [LINK]
    * SAXENA T, LYON JG, PAI SB, PARE D, AMERO J, KARUMBAIAH L, CARROLL SL,
      GAUPP E, BELLAMKONDA RV. 2018. ENGINEERING CONTROLLED PERITUMORAL
      INFLAMMATION TO CONSTRAIN BRAIN TUMOR GROWTH. ADVANCED HEALTHCARE
      MATERIALS. [LINK]
    * FALCONE JD, CARROLL SL, SAXENA T, MANDAVIA D, CLARK A, YARABARIA V,
      BELLAMKONDA RV. 2018. CORRELATION OF MRNA EXPRESSION AND SIGNAL
      VARIABILITY IN CHRONIC INTRACORTICAL ELECTRODES. FRONTIERS IN
      BIOENGINEERING AND BIOTECHNOLOGY. [LINK]
    * LYON JG* , MOKARRAM N*, SAXENA T*, CARROLL SL, BELLAMKONDA RV. ENGINEERING
      CHALLENGES FOR BRAIN TUMOR IMMUNOTHERAPY. 2017. ADV. DRUG DELIV. REV.
      [PUBMED]
    * MOKARRAM N, DYMANUS K, SRINIVASAN A, LYON JG, TIPTON J, CHU J, ENGLISH AW,
      BELLAMKONDA RV. 2017. IMMUNOENGINEERING NERVE REPAIR. PNAS. [PUBMED]
    * MEHTA N*, LYON JG*, PATIL K, MOKARRAM N, KIM C, BELLAMKONDA RV. 2017.
      BACTERIAL CARRIERS FOR GLIOBLASTOMA THERAPY. MOLECULAR THERAPY -
      ONCOLYTICS. [PUBMED]
    * ENAM SF, KRIEGER JR, SAXENA T, WATTS BE, OLINGY CE, BOTCHWEY EA,
      BELLAMKONDA RV. 2017. ENRICHMENT OF ENDOGENOUS FRACTALKINE AND
      ANTI-INFLAMMATORY CELLS VIA APTAMER-FUNCTIONALIZED HYDROGELS.
      BIOMATERIALS. [PUBMED]
    * JAIN A, BETANCUR M, PATEL GD, VALMIKINATHAN CM, MUKHATYAR VJ, VAKHARIA A,
      PAI SB, BRAHMA B, MACDONALD TJ, BELLAMKONDA RV. 2014. GUIDING
      INTRACORTICAL BRAIN TUMOUR CELLS TO AN EXTRACORTICAL CYTOTOXIC HYDROGEL
      USING ALIGNED POLYMERIC NANOFIBRES. NATURE MATERIALS. [PUBMED]
    * KARUMBAIAH L, SAXENA T, CARLSON D, PATIL K, PATKAR R, GAUPP EA, BETANCUR
      M, STANLEY GB, CARIN L,BELLAMKONDA RV. 2013. RELATIONSHIP BETWEEN
      INTRACORTICAL ELECTRODE DESIGN AND CHRONIC RECORDING
      FUNCTION. BIOMATERIALS. [PUBMED]
    * SAXENA T, KARUMBAIAH L, GAUPP EA, PATKAR R, PATIL K, BETANCUR M, STANLEY
      GB, BELLAMKONDA RV. 2013. THE IMPACT OF CHRONIC BLOOD-BRAIN BARRIER BREACH
      ON INTRACORTICAL ELECTRODE FUNCTION. BIOMATERIALS. [PUBMED]
    * MUNSON JM, BELLAMKONDA RV, SWARTZ, MA.  2012.  INTERSTITIAL FLOW IN A 3D
      MICROENVIRONMENT INCREASES GLIOMA INVASION BY A CXCR4-DEPENDENT
      MECHANISM.  CANCER RESEARCH. [PUBMED]
   
    * MOKARRAM N, MERCHANT A, MUKHATYAR V, PATEL G, BELLAMKONDA RV. 2012. EFFECT
      OF MODULATING MACROPHAGE PHENOTYPE ON PERIPHERAL NERVE REPAIR.
      BIOMATERIALS. [PUBMED]
   
    * MUNSON JM, FRIED L, ROWSON SA, BONNER MY, KARUMBAIAH L, DIAZ B,
      COURTNEIDGE SA, KNAUS UG, BRAT DJ, ARBISER JL,BELLAMKONDA RV. 2012.
      ANTI-INVASIVE ADJUVANT THERAPY WITH IMIPRAMINE BLUE ENHANCES
      CHEMOTHERAPEUTIC EFFICACY AGAINST GLIOMA. SCI. TRANSL. MED.  [PUBMED]
    * AGARWAL A, MACKEY MA, EL-SAYED MA, BELLAMKONDA RV. 2011. REMOTE TRIGGERED
      RELEASE OF DOXORUBICIN IN TUMORS BY SYNERGISTIC APPLICATION OF
      THERMOSENSITIVE LIPOSOMES AND GOLD NANORODS. ACS NANO. [PUBMED]
      
      
    *  
   
   * CO-FIRST AUTHOR
   
   Full List of Publications
   

 * OUR RESEARCH
   
   SPECIFIC PROJECTS/AREAS OF ACTIVE RESEARCH IN THE BELLAMKONDA LAB INCLUDE:
   
   DEVELOPING BRAIN CANCER THERAPIES
   
   
   
   Using nanocarrier encapsulation of drugs efficacious treatments for
   glioblastoma multiforme (GBM) a major form of brain cancer has been
   successfully developed. One of the approaches `showed that GBM could
   effectively be treated with the novel drug, Imipramine Blue (IB) an
   anti-invasive agent and doxorubicin, an anticancer chemotherapeutic. The
   generality of this approach is being currently evaluated in metastatic tumors
   of other tissue origin. Nanocarrier technology is also exploited to demarcate
   tumor margins to aid neurosurgeons in surgical removal of brain tumors. Also,
   based on the EUREKA NIH award, Prof Bellamkonda lab is developing new tumor
   cell “exvasion” methodologies to reduce tumor burden as well as controlling
   tumor cell migration along white matter tracts.
   
    
   
   For more information about our ongoing clinical canine trial on this device
   please refer to: https://www.caninegliomatrial.com
   
    
   
   Exvade Bioscience
   
   https://www.exvadebio.com
   
   PERIPHERAL NERVE REGENERATION
   
   
   
   Using a biomaterial approach and using biomimetic 3D scaffold that draw their
   design inspiration from principles of contact guidance, haptotaxis/
   chemotaxis, regeneration of injured nerves are promoted. Studies are done to
   enhance regeneration across long gaps (>25 mm). Studies from Prof.
   Bellamkonda group have shown that tissue-energized scaffolds are comparable
   to the autografts in their performance. A wealth of information is also
   generated from these studies with respect to the response to topographical
   cues as well as cellular and molecular mechanisms that take place in the
   regeneration microenvironment. More recently, strategies based on an
   immunological approach has been adopted to facilitate the regeneration
   process. Creating an anti-inflammatory macrophage phenotype subsequent to
   peripheral nerve injury has shown to favorably bias the regenerative process.
   Efforts are directed towards using the body’s endogenous repair mechanisms
   including the participation of glial cells. Another active area in this realm
   is the fabrication of multi-channel devices for implantation to aid
   restoration of lost function in amputees.
   
   BRAIN ELECTRODE INTERFACING
   
   
   
   The major focus in the are a of brain-electrode interfacing is to unravel the
   reasons for the failure of the electrodes in a short period of time after
   implantation. To understand the causation of the failure, an investigation is
   carried out using a multidisciplinary approach. The sequences of cellular and
   molecular events that follow the electrode implantation are examined and a
   correlation is made to the ability to record from these devices. This should
   lead to predicting, at an earlier time point, the potential for these devices
   to fail. Alternatively, a new class of electrodes with biomaterial-based
   compounds is designed to minimize tissue/electrode mismatch to prolong the
   functional life of the electrodes. Also, novel electrode arrays are designed
   to overcome some of the drawbacks of the current electrodes. Our recent work
   has brought to light the role of compromised blood brain barrier (BBB) and
   the failure of implanted electrodes. Future strategies will focus on
   implementing strategies to cause healing to increase the life of the
   electrode interfaces. Additionally, for helping TBI patients, stem cell
   therapeutic approach is designed by creating “immune-privilege”
   microenvironment for stem cell survival in vivo.

 * PEOPLE
   
   WE'VE GOT A TOP NOTCH TEAM!
   
   PROF. RAVI BELLAMKONDA
   
   PRINCIPAL INVESTIGATOR
   
   Vinik Dean of the Pratt School of Engineering at Duke University.
   
   Professor in the Department of Biomedical Engineering.
   
   Learn More
   
    
   
   DR. NASSIR MOKARRAM
   
   ASSISTANT RESEARCH PROFESSOR
   
   My research focuses on modulating immune response for enhancing neural tissue
   repair as well as advanced immunoengineering approaches to treat brain tumor.
   
   Learn More
   
   DR. JOHNATHAN LYON
   
   RESEARCH SCIENTIST
   
   My research focus is on managing brain tumors, particularly the discovery of
   novel cancer therapies using electric fields. Learn More
   
   DR. NALINI MEHTA
   
   RESEARCH SCIENTIST
   
    
   
   Learn More
   
   DR. ALEXA BRAMALL
   
   VISITING MEDICAL RESIDENT
   
   My research focuses on improving devices and therapies for brain tumors.
   
   Learn More
   
   DR. TARUN SAXENA
   
   CTSI PROGRAM MANAGER - RESEARCH AFFILIATE WITH BELLAMKONDA LAB
   
   My research focuses on immune modulation in central nervous system trauma.
   
   Learn More
   
   SEAN MEEHAN
   
   LAB MANAGER
   
   I manage the day to day function of the lab and my research involves
   exploring directed cancer cell motility and material analysis of implantable
   devices.
   
   Learn More
   
   MARTHA BETANCUR
   
   SR. RESEARCH TECHNOLOGIST
   
   My research focuses on developing and studying animal models for brain cancer
   therapies, nerve regeneration and immunomodulation of the central nervous
   system.
   
   MELISSA ALVARADO-VELEZ
   
   PHD STUDENT
   
   My research focus in the localized immune-suppression of T-Cells at the site
   of traumatic brain injury to enhance the the efficacy of stem cell therapy.
   Learn More
   
   DR. SYED FAAIZ ENAM
   
   PHD STUDENT
   
   My research focuses on immunoengineering brain repair and therapies for brain
   cancer.
   
   Learn More
   
   SHERIDAN CARROLL
   
   PHD STUDENT
   
   I conduct high throughput gene expression and transcriptome analysis for lab
   projects.
   
   Learn More
   
   EKATERINA ILICH
   
   RESEARCH ASSOCIATE
   
   My major interest is in translational medicine and research utilizing novel
   molecular biology tools to develop new treatment or diagnostic approaches. In
   recent years I have been working on application of epigenomic tools to
   discover new therapies in neurooncology and neurodegenerative disorders.
   Learn More

 * MEDIA
   
   
   
   IMMUNOENGINEERING NERVE REPAIR
   
   LECTURE AT THE 5TH ANNUAL SYMPOSIUM ON REGENERATIVE REHABILITATION
   
   http://www.ar3t.pitt.edu/education/webinar_20161219_Bellamkonda.html
   
   TUMOR MONORAIL
   
   CANCER: 'TUMOUR MONORAIL' CAN LEAD CANCERS TO THEIR DOOM
   
   http://www.bbc.com/news/health-26189827
   
   CONGRESS BRIEF
   
   AIMBE PRESIDENT RAVI BELLAMKONDA BRIEFS CONGRESS ON BRAIN CANCER DISCOVERIES
   
   
   
   TEDXGEORGIA TECH
   
   TECHNOLOGY TO DANCE WITH NATURE
   
   
   
   TUMOR NANOFIBER DEVICE
   
   GUIDING INTRACORTICAL BRAIN TUMOUR CELLS TO AN EXTRACORTICAL CYTOTOXIC
   HYDROGEL
   
   
   
   ATLANTA'S WSB-TV ONE ON ONE
   
   BME @ GEORGIA TECH & EMORY
   
   
   
   UNITE 2 FIGHT PARALYSIS
   
   ALLEVIATING CS-GAG MEDIATED INHIBITION OF SPINAL CORD REGENERATION
   
   

 * BELLAMKONDA LAB ALUMNI
   
   
   
   DR. JESSICA FALCONE
   
   Postdoctoral Researcher at The Feinstein Institute
   
   ASHLEY ALVA
   
   Graduate Student at Georgia Tech
   
   DR. ADRIANA NICHOLSON VEST
   
   Postdoctoral Fellow at Emory University
   
   DR. KRISTIN LOOMIS
   
   The Johns Hopkins University Applied Physics Laboratory
   
   DR. AKHIL SRINIVASAN
   
   Medtronic
   
   DR. JENNY MUNSON
   
   Assistant Professor at the University of Virginia
   
   DR. LOHITASH KARUMBAIAH
   
   Assistant Professor at the University of Georgia
   
   DR. ANJANA JAIN
   
   Assistant Professor at the Worcester Polytechnic Institute
   
   DR. KATHLEEN MCNEELEY
   
   Teaching Faculty at the University of Texas at Dallas
   
   DR. CHANDRA VALMIKINATHAN
   
   Capgemini Consulting
   
   DR. SHYAM ARAVAMUDHAN
   
   Assistant Professor at the University of North Carolina at Greensboro
   
   DR. YOONSU "PAUL" CHOI
   
   Assistant Professor at the University of Texas-Pan American
   
   DR. VIVEK MUKHATYAR
   
   LifeCell
   
   DR. ISAAC CLEMENTS
   
   Axion Biosystem
   
   DR. CLARE GOLLNICK
   
   Novetta
   
   DR. ABHIRUCHI AGARWAL
   
   Novartis
   
   MARTHA BETANCUR
   
   PhD Candidate at UGA
   
   GAURANG PATEL
   
   Regeneration Matrix
   
   DR. STATHIS KARATHANASIS
   
   Assistant Professor at Case Western Reserve
   
   DR. HYUNJUNG LEE
   
   Postdoctoral Fellow
   
   ANANTA LAXMI AYYAGAARI
   
   
   
   WEI HE
   
   Associate Professor at University of Tennessee Knoxville
   
   GEORGE MCCONNELL
   
   Associate Professor at Stevens Institute of Technology
   
   YOUNG-TAE KIM
   
   Associate Professor at UT Arlington
   
   DR. JUSTIN SAUL
   
   Associate Professor at Ohio University
   
   DR. MAHESH DODLA
   
   Sigma Aldrich
   
   DR. YINGHUI ZHONG
   
   Assistant Professor at Drexel University
   
   DR. RYAN GILBERT
   
   Associate Professor at RPI
   
   DR. NANCY MEILANDER
   
   National Institute of Standards and Technology
   
   DR. AMIT BALGUDE, M.D.
   
   Radiologist
   
   GEORGE DILLON
   
   
   
   DR. XIAOJUN YU
   
   Associate Professor at Stevens Institute of Technology
   
   DR. KHALID KADER
   
   US Navy

 * FUNDING SOURCES
   
   PLEASE CONTACT US IF YOU WOULD LIKE TO CONTRIBUTE TO OUR GROUND-BREAKING
   RESEARCH OR TOUR OUR LAB!
   
   

 * CONTACT US!
   
   BELLAMKONDA LAB AT DUKE UNIVERSITY
   
   PHONE: (919) 613-7429
   
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