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Submitted URL: http://www.medchemexpress.com//targets//hdac.html
Effective URL: https://www.medchemexpress.com/search.html?q=/targets//hdac&ft=&fa=&fp=
Submission: On September 17 via api from US — Scanned from DE
Effective URL: https://www.medchemexpress.com/search.html?q=/targets//hdac&ft=&fa=&fp=
Submission: On September 17 via api from US — Scanned from DE
Form analysis 3 forms found in the DOM
Name: searchInfo — /search.html
<form name="searchInfo" id="searchInfo" action="/search.html" onsubmit="return checkSearchParam();">
<input type="text" id="search_txt" placeholder="z.B. Name, CAS, Target, Gene ID, Unipro" name="q" autocomplete="off">
<input type="hidden" id="cq" value="/targets//hdac">
<input type="hidden" name="ft" id="ft">
<input type="hidden" name="fa" id="fa">
<input type="hidden" name="fp" id="fp">
<input type="hidden" name="fsp" id="fsp">
<input type="hidden" name="ftag" id="ftag">
<input type="hidden" name="fsc" id="fsc">
<input type="hidden" name="fcc" id="fcc">
<input type="hidden" name="fol" id="fol">
<input type="submit" id="search_btn" value=" ">
<div class="suggest-container" style="display: none;">
<ul class="suggest-options"></ul>
</div>
</form>Name: InquiryForm — POST /mce_search.shtml
<form id="InquiryForm" name="InquiryForm" action="/mce_search.shtml" method="post" class="inquiry_forms">
<input type="hidden" name="iqDetail.catalogNo" size="30" value="">
<input type="hidden" name="countryType" value="">
<input type="hidden" name="emailCountry" size="30" value="Germany">
<input type="hidden" name="proType" value="0">
<table>
<tbody>
<tr>
<th width="117">
<p>Salutation</p>
</th>
<td width="190"><select name="cmInqriry.salutation" id="InquiryForm_cmInqriry_salutation" class="sel_185 empty">
<option value="9003001">Dr.</option>
<option value="9003003">Prof.</option>
<option value="9003005">Mr.</option>
<option value="9003007">Ms.</option>
<option value="9003009">Mrs.</option>
<option value="9003011">Miss.</option>
</select>
</td>
<th width="38"> </th>
<th width="120">
<p>Country or Region<span class="fc_red"> *</span></p>
</th>
<td width="195">
<select id="countryNamePro" onchange="selCou($('#countryNamePro option:selected').text())" class="sel_country sel_185 nonempty">
<option value="USA">United States</option>
<option value="USA">Canada</option>
<option value="EU">United Kingdom</option>
<option value="USA">Australia</option>
<option value="USA">China</option>
<option value="EU" selected="selected">Germany</option>
<option value="EU">France</option>
<option value="USA">Japan</option>
<option value="USA">Korea South</option>
<option value="EU">Switzerland</option>
<option value="no">------------------------------</option>
<option value="EU">Albania</option>
<option value="USA">Algeria</option>
<option value="USA">Argentina</option>
<option value="EU">Armenia</option>
<option value="USA">Australia</option>
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<option value="USA">Bahrain</option>
<option value="USA">Bangladesh</option>
<option value="USA">Barbados</option>
<option value="EU">Belarus</option>
<option value="EU">Belgium</option>
<option value="USA">Bolivia</option>
<option value="EU">Bosnia Herzegovina</option>
<option value="USA">Brazil</option>
<option value="EU">Bulgaria</option>
<option value="USA">Cameroon</option>
<option value="USA">Canada</option>
<option value="USA">Chile</option>
<option value="USA">China</option>
<option value="USA">Colombia</option>
<option value="EU">Croatia</option>
<option value="EU">Cyprus</option>
<option value="EU">Czech Republic</option>
<option value="EU">Denmark</option>
<option value="USA">Ecuador</option>
<option value="USA">Egypt</option>
<option value="EU">Estonia</option>
<option value="USA">Fiji</option>
<option value="EU">Finland</option>
<option value="EU">France</option>
<option value="EU">Georgia</option>
<option value="EU" selected="selected">Germany</option>
<option value="EU">Gibraltar</option>
<option value="EU">Greece</option>
<option value="USA">Hong Kong, China</option>
<option value="EU">Hungary</option>
<option value="EU">Iceland</option>
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<option value="USA">Indonesia</option>
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<option value="USA">Israel</option>
<option value="EU">Italy</option>
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<option value="USA">Jordan</option>
<option value="EU">Kazakhstan</option>
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<option value="EU">Malta</option>
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<option value="EU">Moldova</option>
<option value="EU">Monaco</option>
<option value="USA">Mongolia</option>
<option value="EU">Montenegro</option>
<option value="USA">Morocco</option>
<option value="USA">Nepal</option>
<option value="EU">Netherlands</option>
<option value="USA">New Zealand</option>
<option value="USA">Nigeria</option>
<option value="EU">Norway</option>
<option value="USA">Oman</option>
<option value="USA">Pakistan</option>
<option value="USA">Paraguay</option>
<option value="USA">Peru</option>
<option value="USA">Philippines</option>
<option value="EU">Poland</option>
<option value="EU">Portugal</option>
<option value="USA">Puerto Rico</option>
<option value="USA">Qatar</option>
<option value="USA">Republic of Benin</option>
<option value="EU">Romania</option>
<option value="USA">Russia</option>
<option value="USA">Saudi Arabia</option>
<option value="EU">Serbia</option>
<option value="USA">Singapore</option>
<option value="EU">Slovakia</option>
<option value="EU">Slovenia</option>
<option value="USA">South Africa</option>
<option value="EU">Spain</option>
<option value="USA">Sri Lanka</option>
<option value="USA">Suriname</option>
<option value="EU">Sweden</option>
<option value="EU">Switzerland</option>
<option value="USA">Syria</option>
<option value="USA">Taiwan, China</option>
<option value="USA">Thailand</option>
<option value="USA">Tunisia</option>
<option value="EU">Turkey</option>
<option value="EU">Ukraine</option>
<option value="USA">United Arab Emirates</option>
<option value="EU">United Kingdom</option>
<option value="USA">United States</option>
<option value="USA">Uruguay</option>
<option value="USA">Uzbekistan</option>
<option value="USA">Venezuela</option>
<option value="USA">Vietnam</option>
<option value="USA">Zambia</option>
<option value="USA">Zimbabwe</option>
<option value="USA">Other Countries</option>
<option value="USA">Macao, China</option>
</select>
</td>
</tr>
<tr>
<th>
<p>Name des Bewerbers <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" data-name="your name" name="cmInqriry.lastName" class="txt_185 nonempty">
<p id="msgApplicantName"></p>
</td>
<th> </th>
<th>
<p>Name der Organisation <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" data-name="organization name" name="cmInqriry.companyName" class="txt_185 nonempty">
<p id="msgOrganization"></p>
</td>
</tr>
<tr>
<th>
<p>Department <span class="fc_red">*</span></p>
</th>
<td><input data-reset="" type="text" data-name="department" name="cmInqriry.department" class="txt_185 nonempty" onblur="checkMsg('cmInqriry_department','msgCmInqriryDepartment','Field is required.');">
<p id="msgCmInqriryDepartment"></p>
</td>
<th> </th>
<th class="inquiry_state_th">
<p style="margin-top:6px;">Bundesland</p>
</th>
<td class="inquiry_state_td"><select class="inquiry_state_sel sel_185 empty" name="cmInqriry.state">
<option value=""></option>
<option value="Baden-Württemberg">Baden-Württemberg</option>
<option value="Bavaria">Bayern</option>
<option value="Berlin">Berlin</option>
<option value="Brandenburg">Brandenburg</option>
<option value="Bremen">Bremen</option>
<option value="Hamburg">Hamburg</option>
<option value="Hesse">Hessen</option>
<option value="Mecklenburg-Vorpommern">Mecklenburg-Vorpommern</option>
<option value="Lower Saxony">Niedersachsen</option>
<option value="North Rhine-Westphalia">Nordrhein-Westfalen</option>
<option value="Rhineland-Palatinate">Rheinland-Pfalz</option>
<option value="Saarland">Saarland</option>
<option value="Saxony">Sachsen</option>
<option value="Saxony-Anhalt">Sachsen-Anhalt</option>
<option value="Schleswig-Holstein">Schleswig-Holstein</option>
<option value="Thuringia">Thüringen</option>
</select></td>
</tr>
<tr>
<th>
<p>E-Mail-Addresse <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" data-name="email address" name="cmInqriry.addrEmail1" class="txt_185 nonempty">
<p id="msgEmail"></p>
</td>
<th> </th>
<th>
<p>Produktname <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" class="txt_185 nonempty" name="iqDetail.productName" value="">
<p id="" class=""></p>
</td>
</tr>
<tr>
<th>
<p>Art. -Nr.</p>
</th>
<td>
<input data-reset="" type="text" class="txt_185 empty" name="iqDetail.catalogNo" value="">
</td>
<th> </th>
<th>
<p>Requested quantity <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" data-name="the requested quantity" name="iqDetail.productCount" class="txt_100 nonempty" onblur="checkMsg('iqDetail_productCount','msgRequired','Field is required.');">
<select name="iqDetail.amountUnit" class="nonempty" style="width:70px;">
<option value="9001101">μg</option>
<option value="9010035">mg</option>
<option value="9010031">g</option>
<option value="9010032">kg</option>
<option value="9010030">t</option>
<option value="9007003">μL</option>
<option value="9010033">mL</option>
<option value="9010034">L</option>
</select>
<p id="msgRequired" class="msgProductCount"></p>
</td>
</tr>
<tr>
<th>
<p>Telefonnummer <span class="fc_red"> *</span></p>
</th>
<td><input data-reset="" type="text" data-name="phone number" name="cmInqriry.tel" class="txt_185 nonempty">
<p></p>
</td>
<th> </th>
<th> </th>
<td> </td>
</tr>
<tr class="inquiryAgent" style="display: none">
<th colspan="5" class="jp-dis-item">
<b>MCE Japan Authorized Agent</b>
<div class="jp-dis-inq">
<label onclick="checkAgentJP(0);"><img id="checkImage-0" src="//file.medchemexpress.com/new/images/web/ckb-unchecked.png"><span id="checkAgentName-0">ナミキ商事株式会社</span></label>
<label onclick="checkAgentJP(1);"><img id="checkImage-1" src="//file.medchemexpress.com/new/images/web/ckb-unchecked.png"><span id="checkAgentName-1">コスモ・バイオ株式会社</span></label>
<input type="hidden" name="cmInqriry.agentName" value="">
</div>
</th>
</tr>
<tr>
<th>
<p>Remarks</p>
</th>
<td colspan="4"><textarea data-reset="" name="cmInqriry.inquiryContent" class="empty"></textarea></td>
</tr>
</tbody>
</table>
<input type="button" style="margin: 32px 0 0 278px;padding: 0 35px;" value="Submit" class="btn_inquiry btn_inquiry_submit">
</form>Name: ftr_letter — POST /mce_search.shtml
<form id="ftr_letter" name="ftr_letter" action="/mce_search.shtml" method="post">
<table>
<tbody>
<tr>
<th>Name</th>
<td><input id="txt_ltr_name" type="text" class="txt_letter bor_radius" name="unsubscribeEmailInfo.emailLinkman"></td>
</tr>
<tr>
<th>Email <span>*</span></th>
<td><input id="txt_ltr_email" type="text" class="txt_letter bor_radius" name="unsubscribeEmailInfo.emailAddress">
</td>
</tr>
<tr>
<th></th>
<td><input type="button" id="btn_letter_sub" value="Anmelden" class="btn_letter bor_radius"></td>
</tr>
<tr>
<th></th>
<td id="ftr_letter_notice">Sorry, but the email address you supplied was invalid.</td>
</tr>
</tbody>
</table>
</form>Text Content
From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly. — Master of Bioactive Molecules cc Recent Search: Hallo, Anmelden Finden Sie Ihren Händler vor Ort Your local distributor: BIOZOL Diagnostica Vertrieb GmbHHölzel Diagnostika Handels GmbHHycultec GmbH Mein Konto +49-89-37 99 666-6+49-(0)221-126 02 66+49 8543 916182 Cart (0) Germany DE * EN - English * FR - Français * DE - Deutsch * ES - Español * JA - 日本語 * KO - 한국어 info@hycultec.deinfo@biozol.deinfo@hoelzel.de * United States * Canada * United Kingdom * Australia * Germany * France * Japan * Korea South * Switzerland * Algeria * Argentina * Austria * Belgium * Brazil * Chile * Croatia * Czech Republic * Denmark * Finland * Hong Kong, China * Hungary * India * Iraq * Ireland * Israel * Italy * Lebanon * Luxembourg * Malaysia * Mexico * Morocco * Netherlands * New Zealand * Norway * Pakistan * Peru * Philippines * Poland * Portugal * Qatar * Russia * Saudi Arabia * Serbia * Singapore * Slovakia * Slovenia * South Africa * Spain * Sweden * Taiwan, China * Thailand * Tunisia * Turkey * Ukraine * Macao, China * Other Countries Signalwege Home Produkte One-stop Drug Screening Recombinant Proteins Kits Uns Kontaktieren Unsere Service Resources * Anti-infection * Antibody-drug Conjugate/ADC Related * Apoptosis * Autophagy * Cell Cycle/DNA Damage * Cytoskeleton * Epigenetics * GPCR/G Protein * Immunology/Inflammation * JAK/STAT Signaling * MAPK/ERK Pathway * Membrane Transporter/Ion Channel * Metabolic Enzyme/Protease * Neuronal Signaling * NF-κB * PI3K/Akt/mTOR * PROTAC * Protein Tyrosine Kinase/RTK * Stem Cell/Wnt * TGF-beta/Smad * Vitamin D Related/Nuclear Receptor * Others Anti-infection * Antibiotic * Arenavirus * Bacterial * Beta-lactamase * CMV * Dengue virus * EBV * Enterovirus * Filovirus * Flavivirus * Fungal * HBV * HCV * HCV Protease * HIV * HIV Protease * HPV * HSV * Influenza Virus * Orthopoxvirus * Parasite * Penicillin-binding protein (PBP) * More... Antibody-drug Conjugate/ADC Related * ADC Antibody * ADC Cytotoxin * ADC Linker * Antibody-Drug Conjugates (ADCs) * Drug-Linker Conjugates for ADC * PROTAC-Linker Conjugates for PAC Apoptosis * Apoptosis * Bcl-2 Family * c-Myc * Caspase * Cuproptosis * DAPK * Ferroptosis * FKBP * Glutathione Peroxidase * IAP * MDM-2/p53 * Necroptosis * Paraptosis * PKD * Pyroptosis * RIP kinase * Survivin * Thymidylate Synthase * TNF Receptor * Transferrin Receptor Autophagy * Atg4 * Atg7 * Atg8/LC3 * ATTECs * AUTACs * Autophagy * Beclin1 * FKBP * LRRK2 * Mitophagy * p62 * PINK1/Parkin * ULK Cell Cycle/DNA Damage * Antifolate * APC * ATF6 * ATM/ATR * Aurora Kinase * Casein Kinase * CDK * Checkpoint Kinase (Chk) * ClpP * CRISPR/Cas9 * Cyclin G-associated Kinase (GAK) * Deubiquitinase * DNA Alkylator/Crosslinker * DNA Stain * DNA-PK * DNA/RNA Synthesis * Early 2 Factor (E2F) * Endonuclease * Eukaryotic Initiation Factor (eIF) * FKBP * G-quadruplex * Haspin Kinase * More... Cytoskeleton * Annexin A * Arp2/3 Complex * Dynamin * Gap Junction Protein * Integrin * Kinesin * MARCKS * MASTL * Microtubule/Tubulin * Mps1 * Myosin * PAK * ROCK Epigenetics * AMPK * Aurora Kinase * DNA Methyltransferase * Epigenetic Reader Domain * Glycosyltransferase * HDAC * Histone Acetyltransferase * Histone Demethylase * Histone Methyltransferase * HuR * JAK * Methionine Adenosyltransferase (MAT) * METTL3 * MicroRNA * PARP * PKC * Protein Arginine Deiminase * SF3B1 * Sirtuin * Small Interfering RNA (siRNA) * TET Protein * WDR5 GPCR/G Protein * 5-HT Receptor * Adenylate Cyclase * Adrenergic Receptor * Amylin Receptor * Angiotensin Receptor * Apelin Receptor (APJ) * Arrestin * Bombesin Receptor * Bradykinin Receptor * Cannabinoid Receptor * CaSR * CCR * CGRP Receptor * Chemerin Receptor * Cholecystokinin Receptor * CRFR * CXCR * EBI2/GPR183 * Endothelin Receptor * Formyl Peptide Receptor (FPR) * Free Fatty Acid Receptor * G protein-coupled Bile Acid Receptor 1 * More... Immunology/Inflammation * AIM2 * ALCAM/CD166 * AP-1 * Arginase * Aryl Hydrocarbon Receptor * BCL6 * CCR * CD19 * CD2 * CD20 * CD22 * CD276/B7-H3 * CD28 * CD3 * CD38 * CD47 * CD6 * CD73 * CD74 * Complement System * COX * CTLA-4 * More... JAK/STAT Signaling * EGFR * JAK * Pim * STAT MAPK/ERK Pathway * ERK * JNK * KLF * MAP3K * MAP4K * MAPKAPK2 (MK2) * MEK * Mixed Lineage Kinase * MNK * p38 MAPK * Raf * Ras * Ribosomal S6 Kinase (RSK) Membrane Transporter/Ion Channel * Apical Sodium-Dependent Bile Acid Transporter * Aquaporin * ASCT * ATP Synthase * BCRP * Calcium Channel * Calmodulin * CFTR * Chloride Channel * CRAC Channel * CRM1 * EAAT * FATP * Ferroportin * GABA Receptor * GLUT * GlyT * HCN Channel * iGluR * Monoamine Transporter * Monocarboxylate Transporter * Na+/Ca2+ Exchanger * More... Metabolic Enzyme/Protease * 11β-HSD * 15-PGDH * 17β-HSD * 5 alpha Reductase * Acetolactate Synthase (ALS) * Acetyl-CoA Carboxylase * Acyltransferase * ADAMTS * Adiponectin Receptor * Aldehyde Dehydrogenase (ALDH) * Aldose Reductase * Aminoacyl-tRNA Synthetase * Aminopeptidase * Amylases * Angiotensin-converting Enzyme (ACE) * ANGPTL * Arginase * ATGL * ATP Citrate Lyase * Carbonic Anhydrase * Carboxylesterase * Carboxypeptidase * More... Neuronal Signaling * 5-HT Receptor * AAK1 * Adrenergic Receptor * Amyloid-β * Beta-secretase * Calcineurin * Calcium Channel * CaMK * Cannabinoid Receptor * CGRP Receptor * Cholecystokinin Receptor * Cholinesterase (ChE) * COMT * FAAH * GABA Receptor * Glucosylceramide Synthase (GCS) * GlyT * GPR119 * GPR139 * GPR55 * Histamine Receptor * Huntingtin * More... NF-κB * IKK * Keap1-Nrf2 * MALT1 * NF-κB * RANKL/RANK * Reactive Oxygen Species PI3K/Akt/mTOR * Akt * AMPK * ATM/ATR * DNA-PK * GSK-3 * MELK * mTOR * PDK-1 * PI3K * PI4K * PIKfyve * PIN1 * PTEN PROTAC * ATTECs * AUTACs * AUTOTACs * E3 Ligase Ligand-Linker Conjugates * Ligands for E3 Ligase * Ligands for Target Protein for PROTAC * LYTACs * Molecular Glues * PROTAC Linkers * PROTAC-Linker Conjugates for PAC * PROTACs * SNIPERs * Target Protein Ligand-Linker Conjugates Protein Tyrosine Kinase/RTK * Ack1 * Anaplastic lymphoma kinase (ALK) * Bcr-Abl * BMX Kinase * BRK * Btk * c-Fms * c-Kit * c-Met/HGFR * Discoidin Domain Receptor * DYRK * EGFR * Ephrin Receptor * FAK * FGFR * FLT3 * GDNF Receptor * IGF-1R * Itk * JAK * PDGFR * Pyk2 * More... Stem Cell/Wnt * BMI1 * Casein Kinase * ERK * Gli * GSK-3 * Hedgehog * Hippo (MST) * JAK * Notch * Oct3/4 * Organoid * PKA * PKG * Porcupine * ROCK * sFRP-1 * Smo * STAT * TGF-beta/Smad * Wnt * YAP * β-catenin * More... TGF-beta/Smad * PKA * PKC * ROCK * TGF-beta/Smad * TGF-β Receptor Vitamin D Related/Nuclear Receptor * Androgen Receptor * Constitutive Androstane Receptor * Estrogen Receptor/ERR * Glucocorticoid Receptor * LXR * Mineralocorticoid Receptor * Nuclear Hormone Receptor 4A/NR4A * PPAR * Progesterone Receptor * RAR/RXR * REV-ERB * ROR * Thyroid Hormone Receptor * VD/VDR Others * Amino Acid Derivatives * Biochemical Assay Reagents * Fluorescent Dye * Isotope-Labeled Compounds * Others MCE Signalwege OligonucleotidesIsotope-Labeled CompoundsNatürliche ProdukteFluoreszierende FarbstoffePeptideInhibitorische AntikörperBiochemische TestreagenzienAntibodiesEnzymeGene Forschungsgebiete Cancer Cardiovascular Disease Endocrinology Infection Inflammation/Immunology Metabolic Disease Neurological Disease Others Compound Screening Libraries Bioactive Screening Libraries •Bioactive Compound Library Drug Repurposing Series •FDA-Approved Drug Library •Drug Repurposing Compound Library Natural Products Series •Natural Product Library •Natural Product-like Compound Library Metabolism Series •Human Endogenous Metabolite Compound Library Disease Related Compound Libraries Signaling Pathway Series Fragment Libraries Diversity Compound Libraries •50K Diversity Library •5K Scaffold Library •3D Diverse Fragment Library Virtual Screening •50K Virtual Diversity Library •10M Virtual Diversity Library Recombinant Proteins Cytokines and Growth FactorsImmune Checkpoint ProteinsCAR-T Related ProteinsCD AntigensFc ReceptorsReceptor ProteinsEnzymes & RegulatorsComplement SystemUbiquitin Related ProteinsViral ProteinsBiotinylated Proteins Fluorescent-labeled ProteinsGMP-grade ProteinsAnimal-free Recombinant Proteins Protein Expression Service Custom Synthesis Service ADC-Related Custom Services PROTAC-Related Custom Services MCE-Kits Molecular Biology * •Nucleic Acid Gel Electrophoresis * •Vector Construction * •Restriction Endonuclease * •Materials * •PCR & qPCR * •RT-PCR * •Sequencing Protein 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Search Result Search Result Results for " /TARGETS//HDAC " in MedChemExpress (MCE) Product Catalog: By Targets: HDAC (30) Ligands for Target Protein for PROTAC (1) Adenosine Receptor (1) Akt (1) Apoptosis (9) Caspase (2) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Estrogen Receptor/ERR (1) G-quadruplex (1) Histone Demethylase (1) Histone Methyltransferase (2) JAK (2) Microtubule/Tubulin (1) Oxidative Phosphorylation (1) PARP (2) PROTACs (6) Reactive Oxygen Species (1) Topoisomerase (1) VD/VDR (1) By Research Areas: Cancer (27) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (2) 31 INHIBITORS & AGONISTS 2 SCREENING-BIBLIOTHEKEN 1 FLUORESCENT DYE 1 PEPTIDES Targets Recommended: * HDAC * Target Protein Ligand-Linker Conjugates * Ligands for Target Protein for PROTAC Art. -Nr. Produktname Target Forschungsgebiete Chemical Structure * HY-18712 BG45 3 Publications Verification HDAC Apoptosis Caspase Cancer BG45 is a potent HDAC3 inhibitor with IC50 values of 0.289, 2, 2.2 and ﹥20 μM for HDAC3, HDAC1, HDAC2 and HDAC6, respectively. BG45 selectively targets multiple myeloma (MM) cells and induces caspase-dependent apoptosis . * HY-163921 HDAC8-IN-11 Ligands for Target Protein for PROTAC Cancer HDAC8-IN-11 is a ligand for target protein for pROTAC. * HY-162349 PARP7/HDACs-IN-1 HDAC PARP Cancer PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC50s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6) . br/ . * HY-163846 HDAC8-IN-10 HDAC Cancer HDAC8-IN-10 (compound 15) is a potent inhibitor of HDAC8, with the IC50 of 7.6 nM. HDAC8-IN-10 is a HDAC8 target protein ligand that can be used to synthesize PROTAC YX862 (HY-163845) . * HY-144292 HDAC-IN-30 HDAC Cancer HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC50=13.4 nM),HDAC2 (IC50=28.0 nM), HDAC3 (IC50=9.18 nM), HDAC6 (IC50=42.7 nM), HDAC8 (IC50=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy . * HY-158075 DNMT/HDAC-IN-1 HDAC DNA Methyltransferase Cancer DNMT/HDAC-IN-1 (Compund 15a) is a dual DNMT and HDAC inhibitor with IC50 values for HDAC1 and HDAC6 are 56.84 nM and 17.39 nM respectively. DNMT/HDAC-IN-1 can induce apoptosis and be used in tumor research. * HY-162319 Tubulin/HDAC-IN-4 Apoptosis HDAC Microtubule/Tubulin Reactive Oxygen Species Cancer Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC50 values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity . * HY-149283 JAK/HDAC-IN-2 JAK HDAC Apoptosis Cancer JAK/HDAC-IN-2 is a potent 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitor. JAK/HDAC-IN-2 potently inhibits HDAC3/6 and JAK1/2 at nanomolar levels. JAK/HDAC-IN-2 has proapoptotic activity and inhibits histone deacetylation and STAT3 phosphorylation. JAK/HDAC-IN-2 presents remarkable antiproliferative activity in both hematological malignancies and solid cancers . * HY-146160 PARP-1/HDAC-IN-1 PARP HDAC Cancer PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities . * HY-151263 G4/HDAC-IN-1 HDAC G-quadruplex Cancer G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer . * HY-D2280 Estrogen receptor β/HDAC probe 1 HDAC Estrogen Receptor/ERR Others Estrogen receptor β/HDAC probe 1 (compound P1) is a near-infrared fluorescent probe that dual-targets the estrogen receptor (Estrogen Receptor/ERR) β/histone deacetylase HDAC . * HY-124295 MPT0E028 HDAC Akt Apoptosis Cancer MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively . MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity . * HY-145816A JPS016 TFA HDAC PROTACs Cancer JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-145815 JPS014 HDAC PROTACs Cancer JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-145816 JPS016 HDAC PROTACs Cancer JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-145818 JPS035 HDAC PROTACs Cancer JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-145819 JPS036 HDAC PROTACs Cancer JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-116818 Crebinostat HDAC Neurological Disease Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhances the expression of the cAMP response element-binding protein (CREB) target gene Egr1. Crebinostat increases the density of synapsin-1 punctae along dendrites in cultured neurons. Crebinostat can modulate chromatin-mediated neuroplasticity and exhibits enhanced memory in mice . * HY-10990 Abexinostat Maximum Cited Publications 6 Publications Verification CRA 024781; PCI-24781 HDAC Cancer Abexinostat (CRA 024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM . * HY-156096 HDAC3-IN-2 HDAC Histone Methyltransferase Caspase Apoptosis DNA/RNA Synthesis Cancer HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC50: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC50 of 0.55 μM against 4T1 and an IC50 of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels . * HY-145815A JPS014 TFA PROTACs HDAC Apoptosis Cancer JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 TFA degrades class I histone deacetylase (HDAC). JPS014 TFA is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells . * HY-117688 WJ35435 HDAC Topoisomerase Apoptosis Cancer WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that cause DNA damage associated with a low DNA repair capability, and induce cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer . * HY-117583 cis-BG47 HDAC Histone Methyltransferase Neurological Disease cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research . * HY-156094 JMJD3/HDAC-IN-1 HDAC Histone Demethylase Apoptosis Cancer JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion . * HY-126147 J22352 HDAC Cancer J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1 . * HY-144315 CYD19 Snail/hdac-IN-1 HDAC Cancer CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis . * HY-149718 Antitumor agent-123 JAK HDAC Cancer Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models . * HY-145406 IHCH-3064 Adenosine Receptor HDAC Inflammation/Immunology Cancer IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent. * HY-106409 Tefinostat 1 Publications Verification CHR-2845 HDAC Apoptosis Cancer Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias . * HY-153392 TYA-018 Oxidative Phosphorylation HDAC Cardiovascular Disease TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation . * HY-131961 Triciferol VD/VDR HDAC Cancer Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities . Art. -Nr. Produktname * HY-L024 Histone Modification Research Compound Library 669 compounds A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 669 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening. * HY-L005 Epigenetics Compound Library 1,325 compounds Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases. MCE provide a unique collection of 1,325 epigenetics-related compounds that can be used in the research of the related diseases. Art. -Nr. Produktname Type * HY-D2280 Estrogen receptor β/HDAC probe 1 Fluorescent Dyes/Probes Estrogen receptor β/HDAC probe 1 (compound P1) is a near-infrared fluorescent probe that dual-targets the estrogen receptor (Estrogen Receptor/ERR) β/histone deacetylase HDAC . Art. -Nr. Produktname Target Research Area * HY-144292 HDAC-IN-30 HDAC Cancer HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC50=13.4 nM),HDAC2 (IC50=28.0 nM), HDAC3 (IC50=9.18 nM), HDAC6 (IC50=42.7 nM), HDAC8 (IC50=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy . Online-Anfrage Your information is safe with us. * Required Fields. Salutation Dr. Prof. Mr. Ms. Mrs. Miss. 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