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Menu Search * Home * News * Health Tech * Biopharma * Devices & Diagnostics * Consumer / Employer * Contributors * MedCity Influencers * MedCitizens * Events * Jobs * Research * Newsletters * About Us * Advertising * Contact us * Send Tips * Advertising * About * Twitter * Facebook * RSS * Subscribe via email X Close Signup Modal MEDCITY >> INBOX Get the latest industry news first when you subscribe to our daily newsletter. We will never sell or share your information without your consent. See our privacy policy. * Send Tips * Advertising * About * Twitter * Facebook * RSS * Subscribe via email MEDCITY NEWS OSMIND SCORES $40M INVESTMENT TO AID IN MENTAL HEALTH RESEARCH AND TREATMENT PFIZER BUYS ITS WAY INTO MIGRAINE WITH $11.6B BIOHAVEN PHARMA ACQUISITION A NEW KIND OF CMO: WHY YOUR COMPANY NEEDS A CHIEF MEDICAL OFFICER TELADOC HEALTH CEO HIGHLIGHTS EVOLUTION OF TELEMEDICINE BUILDING AND MOBILIZING YOUR COMMUNITY: ADDRESSING CHALLENGES IN ENGAGING PATIENTS AND CAREGIVERS VIRTUAL PHYSICAL THERAPY: A NEW HORIZON IN AMBULATORY ARTHROPLASTY RECOVERY AIMING TO TREAT PARKINSON’S BY REPLACING NEURONS, ASPEN NEUROSCIENCE NABS $147M INVEST PITCH PERFECT WINNER: MYBIOMETRY AIMS TO PREVENT ASTHMA ATTACKS LONG BEFORE THEY HAPPEN GENERAL CATALYST VC: THIS TYPE OF COLLABORATION WITH INTERMOUNTAIN IS WHY WE WERE PUT ON EARTH RECLAIM YOUR PRIVACY BY BRINGING STI TESTING INTO THE HOME HOW CELL & GENE THERAPY STARTUPS CAN WARM UP TO INVESTORS IN THIS “BIOTECH NUCLEAR WINTER” THE NEW PARADIGM IN DRUG DEVELOPMENT: WHY PLATFORM TECHNOLOGY IS THE SOLUTION PATIENTS AND PAYERS NEED HOW IS AI MOVING THE NEEDLE IN THE PHARMACEUTICAL INDUSTRY? OVERHAULING PRIOR AUTHORIZATION: HOW TO ACHIEVE BETTER OUTCOMES AT A LOWER COST INVEST PITCH PERFECT WINNER: VINCERE HEALTH OFFERS UNDERSERVED PATIENTS A HOLISTIC SOLUTION TO QUIT SMOKING * News * Health Tech * BioPharma * Devices & Diagnostics * Consumer / Employer * Contributors * MedCity Influencers * MedCitizens * Events * INVEST * INVEST PharmaTech * INVEST Digital Health * INVEST Population Health * Jobs * Research * Newsletters Be Sure to Share Your Insights on Our Brief MedCity Audience Survey for a Chance to Win a $250 AMEX Gift Card BioPharma AIMING TO TREAT PARKINSON’S BY REPLACING NEURONS, ASPEN NEUROSCIENCE NABS $147M ASPEN NEUROSCIENCES IS DEVELOPING A CELL THERAPY THAT USES A PATIENT’S OWN STEM CELLS TO DEVELOP A PERSONALIZED TREATMENT FOR PARKINSON’S DISEASE. THE APPROACH IS SLIGHTLY DIFFERENT THAN THAT OF BAYER, WHOSE EXPERIMENTAL PARKINSON’S CELL THERAPY IS MADE FROM STEM CELLS SOURCED FROM HEALTHY DONORS. By Frank Vinluan Post a comment / May 9, 2022 at 3:15 PM 1Shares Parkinson’s disease patients lack sufficient amounts of a neurotransmitter that plays a key role in the brain’s ability to control movement and motor coordination. While drugs are available to address this deficiency, their effectiveness wanes over time. Aspen Neurosciences aims to treat Parkinson’s with a cell therapy. The biotech now has $147.5 million in new funding as it prepares for a first test in humans that could show not only how its technology works, but also whether it offers an edge over a Bayer cell therapy already in the clinic. Promoted IMPORTANCE OF PATIENT CAPITAL IN LIFE SCIENCES TSX Venture Exchange has a strong history of helping early stage health and life sciences companies raise patient capital for research and development purposes. Daniel Lubienietzky, Toronto Stock Exchange The Series B round of financing announced Monday was co-led by GV, LYFE Capital, and Revelation Partners. The key brain chemical lacking in Parkinson’s patients is dopamine, which comes from dopamine-producing neurons. According to Aspen, about half of these neurons are lost before a patient’s Parkinson’s is diagnosed. The San Diego-based biotech aims to use cell therapy to replace these neurons to restore the release of dopamine and reconstruct neural networks. Aspen makes its cell therapy, called ANPD001, from induced pluripotent stem cells (iPSCs), which have the potential to become almost any type of human cell. The biotech induces these cells to become dopamine-producing neurons. Just before those cells mature, they are transplanted into the patient. Aspen’s approach is a personalized one. The stem cells come from a skin biopsy of the patient. Prior to transplantation of the autologous cell therapy back into the patient, Aspen uses artificial intelligence to evaluate the potential effectiveness of the cells. The company claims its process reduces the time and cost of manufacturing a personalized cell therapy. Aspen also claims another advantage: avoidance of immune system suppressing drugs. Because the therapy is derived from a patient’s own cells, no immune-suppressing drugs are needed to prevent the immune system from rejecting the cell therapy. Promoted HOW MEDTECH CAN BETTER INTEGRATE WITH HEALTHCARE WORKFLOWS THROUGH DIGITAL SOLUTIONS Healthcare industry is transitioning to value-based care models. That’s why the medical device industry's ability to continue the development of life-changing innovations will rely on demonstrating how new technology fits under this value-based paradigm. To build future-ready solutions, it’s important to focus on choosing the right tools and technology partners. The Innovaccer Health Cloud is well-positioned to do just that! Innovaccer's Rishav Krishna & Smriti Khera Bayer is taking a similar approach to treating Parkinson’s. Like Aspen, the pharmaceutical giant is developing a cell therapy that would be implanted into the patient to restore dopamine production. However, Bayer’s cell therapy is allogeneic—the iPSCs come from healthy donors. This off-the-shelf approach is intended to offer its own advantages. Personalized cell therapies, such as CAR T-therapies for cancer, require an expensive, multi-step manufacturing process that takes a long time. But an off-the-shelf approach could result in therapies that are readily available from a manufacturing process that is more scalable. The experimental Bayer Parkinson’s cell therapy, DA01, comes from BlueRock Therapeutics, a biotech joint venture that the pharmaceutical giant had formed with Versant Ventures in 2016. In 2019, Bayer fully acquired BlueRock for $240 million up front and another $360 million tied to the achievement of milestones. Bayer advanced the BlueRock Parkinson’s cell therapy into human testing last summer, a Phase 1 clinical trial enrolling about a dozen patients. Those patients will take medicines to partially suppress their immune system for one year in order to prevent the body from rejecting the transplanted cells. Study participants will then be monitored for two years to assess tolerability to the treatment and the survival of the transplanted cells. Christian Rommel, head of research and development at Bayer’s pharmaceuticals division, told MedCity News in an interview during the J.P. Morgan Health Care Conference in January that preliminary clinical data from the study could come within the next year. According to Aspen, its lab and preclinical studies have demonstrated that its approach can produce dopamine-releasing neurons. The company is preparing to submit an investigational new drug application to the FDA. If the agency accepts the filing, the company could proceed to patient screening and a planned Phase 1/2a clinical trial. Damien McDevitt, Aspen’s president and CEO, said in a prepared statement that the Series B financing will also support development of other therapies in the company’s pipeline, including autologous gene-corrected cells and programs that explore the treatment of other neurological diseases. Since its founding in 2018, Aspen says it has raised more than $220 million. Other disclosed participants in the latest financing include new investors Newton Investment Management, EDBI, LifeForce Capital, Medical Excellence Capital Partners, Mirae Asset Capital, NS Investment. Earlier investors OrbiMed, Arch Venture Partners, Frazier Life Sciences, Section32 and Alexandria Venture Investments also participated in the Series B round. Image: koto_feja, Getty Images 1Shares TOPICS Aspen Neuroscience, Bayer, cell therapy, Clinical Trials, deals, Investing, Parkinson's Disease, San Diego, Startups HEAR THE LATEST INDUSTRY NEWS FIRST. SIGN UP FOR OUR DAILY NEWSLETTER. We will never sell or share your information without your consent. See our privacy policy. Promoted BETTER PRIMARY CARE ISN’T ONLY GOOD FOR HEALTH—IT’S GOOD FOR BUSINESS The rising cost of employer-sponsored healthcare makes it difficult for American businesses to compete globally. That doesn’t have to be the reality. Learn how one company changed its trajectory. Tom Gentile, CEO of Spirit AeroSystems & Richard Gephardt, Co-founder of SolidaritUS Health GOT NEWS? SEND US A TIP Promoted THE RISE OF VIRTUAL-FIRST CARE: BRIDGING THE GAP BETWEEN ONLINE AND OFFLINE PATIENT EXPERIENCES In a webinar sponsored by Wheel, health tech executives will explore how telehealth is increasingly becoming the first point of interaction between patients and providers and the potential for hybrid care models to improve the patient experience, health outcomes, and deliver cost savings. Wheel and MedCity News MEDCITY >> INBOX Get the latest industry news first when you subscribe to our newsletter. We will never sell or share your information without your consent. See our privacy policy. Promoted IMPORTANCE OF PATIENT CAPITAL IN LIFE SCIENCES TSX Venture Exchange has a strong history of helping early stage health and life sciences companies raise patient capital for research and development purposes. Daniel Lubienietzky, Toronto Stock Exchange Promoted HOW MEDTECH CAN BETTER INTEGRATE WITH HEALTHCARE WORKFLOWS THROUGH DIGITAL SOLUTIONS Healthcare industry is transitioning to value-based care models. That’s why the medical device industry's ability to continue the development of life-changing innovations will rely on demonstrating how new technology fits under this value-based paradigm. To build future-ready solutions, it’s important to focus on choosing the right tools and technology partners. The Innovaccer Health Cloud is well-positioned to do just that! Innovaccer's Rishav Krishna & Smriti Khera × HEAR THE LATEST INDUSTRY NEWS FIRST. SIGN UP FOR OUR DAILY NEWSLETTER. No thanks We will never sell or share your information without your consent. See our privacy policy. Advertise About Newsletter Our Sites * * * * * * * © 2022 Breaking Media, Inc. All rights reserved. Registration or use of this site constitutes acceptance of our Terms of Service and Privacy Policy. 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