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TRADITIONAL MEDICINE RESEARCH





Traditional Medicine Research   >>   2022, Vol. 7  >>   Issue (3):
No.19     DOI:10.53388/TMR20220330274

TRADITIONAL CHINESE MEDICINE: AN IMPORTANT BROAD-SPECTRUM ANTI-CORONAVIRUS
TREATMENT STRATEGY ON COVID-19 BACKGROUND?


Run-Dong Chai1#, Ya-Dong Fan1#, Qi-Yao Li1#, Huan-Tian Cui2, Hai-Zhao Liu1, Ying
Wang1, Bo-Yang Gong1, Lu Han1, Shuai Zhang1, Yu-Hong Bian1* () , Jun Kang3* () ,
Yu Wang1* ()
1 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2 School of life Sciences, Shandong University, Qingdao 266071, China.
3 School of life Sciences, Tianjin University, Tianjin 300072, China.


CITE THIS ARTICLE:

Chai RD, Fan YD, Li QY, et al. Traditional Chinese medicine: an important
broad-spectrum anti-coronavirus treatment strategy on COVID-19 background?.
Tradit Med Res. 2022;7(3):19. doi:10.53388/TMR20220330274

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 * Abstract
 * Medical history of objective
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 * Supplementary Material

Coronaviruses exist widely in nature, can cause cross-species transmission, and
pose serious threats to human and animal health. Over the past 20 years,
coronaviruses have led to three major epidemics that have caused global panic,
including severe acute respiratory syndrome, Middle East respiratory syndrome,
and coronavirus disease-19. At present, coronavirus disease-19 not only spreads
rapidly, but also mutates easily to escape host immune response, becoming more
pathogenic. At present, there are no effective specific therapeutic drugs or
vaccines. Drugs targeting severe acute respiratory syndrome coronavirus 2 and
the host cell defense system that have been developed based on the structure and
replication cycle of coronaviruses have a certain broad-spectrum antiviral
effect; however, their efficacy still needs to be demonstrated in further
clinical trials. Traditional Chinese medicine has an indispensable role in the
ongoing response to coronavirus disease-19. Anti-virus treatment with
traditional Chinese medicine has advantages such as broad-spectrum application,
low toxicity and side effects, low susceptibility to drug resistance, and
overall comprehensive regulation. Therefore, researches on effective components
and mechanisms of action of the anti-viral effects of traditional Chinese
medicine have increasingly gained attention. The present paper examines
coronaviruses, specifically summarizing the genomes, replication mechanisms, and
mutant strains. Afterward, the therapeutic effects and mechanisms of action of
modern broad-spectrum anti-coronavirus drugs and traditional Chinese medicine
are summarized. By considering the virus and the targets in the host
comprehensively, in addition to the beneficial multi-target and multi-path
antiviral effects of traditional Chinese medicines, this paper could guide the
development of treatment strategies for broad-spectrum anti-coronavirus
traditional Chinese medicines, and could facilitate the modernization and
globalization of traditional Chinese medicine.

Key words: COVID-19; SARS-CoV-2; traditional Chinese medicine; broad-spectrum
antivirals
DOI URL: https://doi.org/10.53388/TMR20220330274
Original DOI URL:


MEDICAL HISTORY OF OBJECTIVE



Coronavirus disease-19 spreads rapidly and mutates easily to escape immune
response. However, there are no effective specific therapeutic drugs or
vaccines. Broad-spectrum antivirals not only can act on multiple viruses or
multiple genotypes of the same virus, but also have significant advantages with
regard to time and cost of preparing new drugs or caccines. Tradtional Chinese
medicine has thousands of years of experience in anti-epidemic, and has an
indispensable role in the ongoing response to coronavirus disease-19. Nowadays,
there is paucity to summarize the specific and broad-spectrum antiviral
compounds in tradtional Chinese medicine.



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