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Submission: On January 12 via api from US — Scanned from DE
Effective URL: https://www.biophysics.nyc/
Submission: On January 12 via api from US — Scanned from DE
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* Contact Us * Chemistry Department * Brooklyn College Home People Research - Heme Proteins Research - Zinc Proteins New York Local Section of the American Chemical Society The American Chemical Society GIBNEY RESEARCH LABORATORY METALLOPROTEIN DESIGN LABORATORY WELCOME Our research focuses on the role of metal ions in biological systems, bioinorganic chemistry. Our current research is centered on the role of zinc in controlling gene expression in human cancer and in the role of heme proteins in heart disease. We utilize the tools of de novo protein design to construct simplified metalloproteins from first principles to test fundamental hypothesis about natural metalloproteins. In the case of zinc finger transcription factors, we have developed a method to parse apart the Gibbs free energy of metal-ion binding from the free energy cost of protein folding. In the case of heme proteins, we have delineated the relationships between the electrochemistry of a heme protein, and the affinity of the protein scaffold for ferric and ferrous heme, as well as the difference in global folding free energy between the ferric and ferrous heme protein. Professor Brian R. Gibney Biological and Inorganic Chemistry Email BROOKLYN COLLEGE Department of Chemistry 2900 Bedford Avenue, Brooklyn, NY 11210 718.951.5600 © 2014.