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/ ovesencraft6's Library/ Notes/ The 8-Minute Rule for Cytisine: Another Option
for Smoking Cessation - The Rho Chi


THE 8-MINUTE RULE FOR CYTISINE: ANOTHER OPTION FOR SMOKING CESSATION - THE RHO
CHI

The 8-Minute Rule for Cytisine: Another Option for Smoking Cessation - The Rho
Chi

from web site

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Sara Zarate and Gauri Pandey, graduate trainees from the laboratory of Rahul
Srinivasan, assistant teacher in the Department of Neuroscience & Experimental
Therapeutics, are co-first authors of the research. Their findings are published
in the Journal of Neurochemistry. There are approximately smoking cessation
coping with Parkinson's disease, a neurodegenerative condition that leads to a
range of signs that can consist of problem walking, tremblings, shaking and
others unassociated to movement.


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Currently, there is no treatment for Parkinson's and no treatment that can stop
or prevent the loss of these dopamine nerve cells that are needed for the body
to move. About a decade earlier, Srinivasan ended up being thinking about trying
to understand why smokers and individuals who take in tobacco chronically are at
a lower danger for developing Parkinson's illness.



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"But people truly don't comprehend why that is, due to the fact that tobacco and
smoke include many various chemicals. One of the chemicals clearly is nicotine,
and that describes the addicting homes of tobacco and cigarette smoke. So, I
started to study the potential function of nicotine in this protective result
versus Parkinson's disease." Given the reality that it is extremely difficult to
perform human and animal trials using nicotine due to severe side-effects,
Srinivasan decided to test cytisine as an alternative to nicotine.


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"What cytisine does is it binds to target receptors but does not activate them
as effectively as nicotine," Srinivasan stated. "It keeps the receptors
'inhabited' and 'chaperones' them to the surface area of the nerve cell. Because
cytisine is a natural compound, is readily available rather easily and is pretty
low-cost, I decided to test this principle of chaperoning in an animal design of
the disease to see if it works." During experiments, the team artificially
caused Parkinson's illness in animal models.


Then, the researchers performed a series of behavioral experiments in order to
see if there was any sort of protective effect on the animal models that were
given cytisine. Their findings showed that there was a protective effect both in
terms of reducing the Parkinsonian habits and likewise in terms of lowering the
number of dopamine nerve cells lost.




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