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WELCOME TO THE TRANSLATIONAL RESEARCH PROGRAM (TRP)

The Translational Research Program (TRP) is committed to reducing cancer
incidence and mortality and improving survival and quality of life for cancer
patients. TRP uses advances in basic sciences to develop new approaches for the
prevention, diagnosis, and treatment of cancer by fostering interdisciplinary
investigations and coordinating the resources of NCI with those of academia,
industry, and nonprofit organizations and foundations.

These objectives are accomplished by:

 * Supporting the Specialized Programs of Research Excellence (SPOREs) to
   translate novel scientific discoveries into clinical testing, including
   early-phase clinical trials
 * Encouraging a multidirectional approach to translational research
 * Promoting research in high incidence and rare cancers in adults and children
 * Facilitating the cross-fertilization of ideas, leveraging resources, and
   ensuring access of resources to projects and investigators to bring
   discoveries from the laboratory to the clinic in the most efficient manner
 * Supporting additional grant mechanisms for translational research

TRP is the home of the SPOREs — the Specialized Programs of Research Excellence
- a cornerstone of NCI's efforts to promote collaborative, interdisciplinary
translational cancer research. SPORE grants involve both basic and
clinical/applied scientists working together and support projects that will
result in new and diverse approaches to the prevention, early detection,
diagnosis, and treatment of human cancers.

Each SPORE is focused on a specific organ site, a group of highly related
cancers, or a common pathway or theme that ties together the cancers under
study. SPOREs are designed to enable the rapid and efficient movement of basic
scientific findings into clinical settings, as well as to determine the
biological basis for observations made in individuals with cancer or in
populations at risk for cancer. SPOREs are required to reach a human endpoint
within the 5-year funding period. Currently, 21 organ sites, systems, and
pathway-specific themes are represented in the SPORE portfolio, including:
brain, breast, cancer health disparities, cervical, endometrial, epigenetics,
gastrointestinal, head and neck, hyperactive RAS, liver, kidney, leukemia, lung,
lymphoma, myeloma, , ovarian, pancreatic, prostate, radiation sensitivity,
sarcoma, and skin.

The objective for all SPOREs is to reduce cancer incidence and mortality and to
improve survival and quality of life for cancer patients. SPOREs encourage the
advice of patient advocates in SPORE activities. Prospective applicants are
encouraged to contact TRP Program Officials for advice prior to submission. The
current Program Announcement for submitting applications can be found here.

TRP currently uses the P50, U54, and P20 funding mechanisms for the SPORE
program. In addition, TRP staff currently oversee a relatively smaller number of
R21, R01, and R50 translational research grants. The breakdown of 2023 grants
across organ sites and thematic SPOREs can be found here.

TRP also manages grants that are part of special initiatives when those grants
are translational and are connected to the themes of currently funded SPOREs. An
example is the R50 Research Specialist Career Awards where the applicant is
integral to the work of a funded SPORE.

TRP is also involved in the following DCTD Activities:

 * Small Cell Lung Cancer Consortium (SCLC-C)
 * Pancreatic Stromal Reprogramming Consortium (PSRC)
 * The Integrated Canine Data Commons
 * Longitudinal Studies in Dogs with Cancer as a Comparative Oncology Model


FUTURE DIRECTIONS

Following are descriptions of TRP initiatives planned for future years:

 * Encourage research that will enable precision medicine approaches, such as
   genomic and proteomic-based diagnostic technologies, that will allow cancer
   patients with specific molecular alterations to receive the most effective
   treatments
 * Increase translational cancer research areas that are underrepresented in the
   NCI portfolio: pancreatic cancer, endometrial cancer, pediatric cancers, and
   cancers that display health disparities
 * Advance studies on the dynamic relationship between tumors and
   cells/mediators in the microenvironment to make a difference in the diagnosis
   and treatment of cancer, particularly in the area of immunotherapy
 * Advance the goals of translational research by facilitating collaborations
   between SPOREs and other NCI-funded mechanisms such that discoveries can move
   quickly and seamlessly along pathways from the laboratory to Phase 1 and
   Phase 2 trials and beyond, with strong correlative study and biomarker
   support.


NCI CENTER TO REDUCE CANCER HEALTH DISPARITIES (CRCHD)

In partnership with NCI Center to Reduce Cancer Health Disparities (CRCHD), the
TRP supports feasibility and planning activities (P20) to develop translational
research programs focused on cancer health disparities research with the
expectation that the research programs will become competitive for a full
Specialized Programs of Research Excellence (SPORE) awards.


TRP PRIORITIES

Current priorities include translational research in:

 * Cancer health disparities 
 * Endometrial cancer 
 * Pancreatic cancer 
 * Pediatric cancers 


SPORES AND P20S BY STATE

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SPORES BY ORGAN LOCATION




QUICK LINKS

SPORE Funding Opportunities
SPORE Pre-Application Materials
Staff Directory
The NCI Experimental Therapeutics Program (NExT)

SCLC Consortium
Glioblastoma Therapeutics Network (GTN)
Pancreatic Ductal Adenocarcinoma Stromal Reprogramming Consortium (PSRC)
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