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MOM SWITCHES HER TEEN SON FROM 5-HTP TO TRYPTOPHAN. IN 3 DAYS HE HAS LESS
ANXIETY, FEARS AND RUMINATING THOUGHTS, LAUGHS MORE AND SLEEPS BETTER.

February 16, 2024 By Trudy Scott 33 Comments

> My son has autism and OCD. I took him off fluvoxamine in May and used cbd and
> some other things and he was doing fine up until this past winter. He began
> having irrational fears and ruminating thoughts/fears that would not stop! I
> started 5-HTP, theanine, B12, probiotics with him for the last month and did
> not see any improvement. I was ready to go back to the medication when I came
> across your blog and information.
> 
> I assumed 5-HTP would be better for OCD, but after reading your comments you
> mentioned that you just switch to tryptophan if the 5-HTP is not working. I
> had tryptophan at home already. That night I emptied half a capsule into a
> little stevia flavored water and had him hold it in his mouth for a minute.
> 
> He was a different kid after that!!!! This is just the 3rd day but even his
> teachers are telling me he is doing really well and is less anxious at school.
> I am so thankful! I am now giving him 500mg in the morning and early evening.
> 
> I bought some inositol and plan to try adding that in the afternoons to see if
> that will help as well. I believe that he has PANDAS. He is a hand washer, and
> spits a lot, and has lots of other quirks that I would love to see decrease.
> 
> I have hope again! I am buying your book so that I can get a good plan going
> for him. If you have any other suggestions for him please let me know!!

This wonderful feedback was posted in the comments of one of the tryptophan
blogs. I’m so thrilled for this mom and young man (he’s almost 20). I thanked
her for sharing all this on the blog and offered to share additional generic
feedback via a new blog post. I also asked for additional feedback on exactly
how the tryptophan helped (more on that below).

Read on to learn how tryptophan helped with his ruminating thoughts, fears,
crying and improved his sleep. And my insights about the ideal timing of
tryptophan, finding the optimal dose and why it may work when 5-HTP doesn’t. I
also share some insights about inositol and  OCD (obsessive compulsive
disorder).


LOW SEROTONIN SYMPTOMS AND THE QUESTIONS I HAD ABOUT HIS SYMPTOMS

I do hope he continues to see these benefits. Seeing such amazing results in 3
days is always what we’re looking for and it’s not unexpected to get such
profound results so quickly!

I had some additional questions so I could share some general feedback as to how
I work in situations like this. I wanted to know his age and if the switch to
tryptophan helped any of his OCD symptoms and if yes how many notches
improvement?

And which of the classic low serotonin symptoms the tryptophan helped and by how
much: anxiety? irrational fears? and ruminating thoughts/fears? anything else?
(all the low serotonin symptoms here)

Knowing this helps me know if I’m on track with a client i.e. the tryptophan is
helping with low serotonin symptoms. And it also helps me decide we should
consider increasing the dose and possibly adjust the number of times to use
tryptophan. I share more about this below.


TRYPTOPHAN HELPS REDUCE HIS RUMINATING THOUGHTS, FEAR AND ANXIETY. AND HE’S
LAUGHING MORE AND SLEEPS BETTER

She shared some specific examples as to how much the tryptophan helps reduce his
ruminating thoughts, fear and anxiety. And he’s laughing more and it helps him
sleep:

> He would often call me or text me throughout the day with questions about his
> health, and he would come to me 10-15 times in the afternoons/evenings, for
> about 3 weeks or so, and ask me the same questions about a rare disease that
> he believed he had.
> 
> He would cry and shake with fear and anxiety at some point and I would need to
> reassure him over and over again that he did not have this disease, and that
> it was literally impossible for him to have it.
> 
> After starting the tryptophan supplements 2x500mg morning/early evening he did
> not come to me at all and seemed content the 1st day.
> 
> Yesterday, he didn’t get the 2nd tryptophan until 5pm so he did come to me
> with 1 question/concern. I reassured him and he seemed fine especially after
> his supplement. Then 1 more question later that night but he accepted my
> reassurance both times and let it go.
> 
> So that was a big difference compared to the last 4 weeks. He was also
> laughing at some cartoon he was watching which I had not seen him do for a
> month either. Anxiety is less. He is sleeping better too. So far he still
> seems to believe the irrational things.

Tryptophan is clearly helping so many of his symptoms but we have more
opportunities for further gains with tryptophan.


TRYPTOPHAN FOR LOW SEROTONIN: DOSING AND TIMING

As I share in my book and other blog posts, typically 500 mg tryptophan twice a
day is a good starting dose, used away from protein mid-afternoon and evening.
It’s used like this because serotonin starts to decline in the afternoon. We
increase based on individual needs to find the ideal dose. We may also add
tryptophan or 5-HTP earlier in the day.

In a situation like this, if we were working together, I’d consider the
following:

 * Adding a mid-afternoon dose of tryptophan
 * A switch to just afternoon and evening dosing (unless the morning dose was
   used for a specific reason i.e. morning symptoms)
 * Adding a second dose of tryptophan each time (he is using Nature Stacks
   Serotonin Brain Food and I’d recommend Lidtke 500 mg tryptophan for the
   second dose each time because it contains only tryptophan)

With changes we do one thing at a time and track symptom improvements carefully.


TRYPTOPHAN VS 5-HTP?

I commend her for figuring out the switch from 5-HTP to tryptophan.

It’s a well known fact that some folks just do better on one vs the other and if
5-HTP isn’t working I’ll have clients switch to tryptophan and vice versa. I
typically start with tryptophan because it seems to be better tolerated. The
biggest issue that I see with 5-HTP is that it’s often not tolerated if you have
high cortisol. It can also cause nightmares for some folks.


PRECAUTION ABOUT SEROTONIN SYNDROME WITH TRYPTOPHAN/5-HTP

There are precautions when using certain amino acids and I always review them
with all my clients. If they have been prescribed an SSRI, I have them discuss
the use of tryptophan/5-HTP with their prescribing doctor so they can be
monitored for serotonin syndrome. With careful monitoring and doctor approval I
feel comfortable having my clients use tryptophan/5-HTP 6 hours away from their
one and only SSRI.

If they are using more than one SSRI and/or a combination of psychiatric
medications, the use of tryptophan/5-HTP is not advised.

None of the above applied in this situation but it’s important to be aware of.


INOSITOL AND OCD: WHEN TO CONSIDER ADDING IT?

OCD or even mildly obsessive behaviors or thoughts can be a sign of low
serotonin. I will do a trial of tryptophan as above and for some folks it’s
often enough. Sometimes tryptophan at least helps to some degree and when it’s
not enough, adding inositol (a B vitamin) takes it to the next level.

For many folks 500 -1000 mg capsules are typically recommended but this is a
really low dose for OCD. The powdered form is really effective because you can
increase as needed. You can actually go as high as 18g. I start low, with 1-2g
in kids and adults, and keep going up by 2g a week until the obsessive symptoms
disappear. More on inositol and OCD here.


GABA, DOPAMINE AND ENDORPHIN SUPPORT TOO

She mentions that her son “seems to be low serotonin, low GABA (1st 1/2 of the
list), low endorphins and low catecholamines” so other amino acids are likely to
be of benefit too.

As always we used the neurotransmitter symptoms questionnaire and do trials of
each amino acid: GABA for low GABA symptoms, DPA for low endorphins and tyrosine
for low dopamine. These trials of each one are done one at a time with careful
tracking to find the ideal dose before layering in the next amino acid.


USING THE AMINO ACIDS SO IT’S EASY TO REDUCE SUGAR AND GO GLUTEN-FREE

I also asked what dietary changes he has already made and she responded: “We are
in the  process of reducing sugar and going back to gluten-free as much as
possible but this will be hardest to stick to. Have done a keto-like and
gluten-free-casein-free diet on and off since he was 4 years old.”

This is a great start and using the amino acids help reduce cravings and make it
easy to reduce sugar and go gluten-free.

There is a sugar cravings aspect to all the neurotransmitter imbalances. The
type of craving can be found on the above symptoms questionnaire. It’s not
uncommon to need support in more than one area:

 * Low serotonin – tryptophan or 5-HTP for afternoon/evening cravings
 * Low endorphins – DPA for comfort/reward eating
 * Low catecholamines – tyrosine for low energy sugar cravings
 * Low GABA – GABA for stress eating

You can read more about this here: The individual amino acids glutamine, GABA,
tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar
cravings, often within 5 minutes

I’m glad she is getting a copy of my book The Antianxiety Food Solution. It has
all the foundational dietary information, sections on cravings and a chapter on
the amino acids.

It also has a chapter on pyroluria, which is very common in autism and something
I help most of my clients address. Here is the pyroluria questionnaire.


TRYPTOPHAN AND INOSITOL PRODUCT OPTIONS



Products I recommend include Lidtke 500 mg Tryptophan and Designs for Health
Inositol Powder.  You can purchase these from my online store (Fullscript – only
available to US customers – use this link to set up an account).



If you’re not in the US, Doctor’s Best L-Tryptophan 500mg and Now Inositol
Powder are products I recommend on iherb (use this link to save 5%).


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING TRYPTOPHAN AND OTHER AMINO ACIDS
AS SUPPLEMENTS

We use the symptoms questionnaire to figure out if low serotonin or other
neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control (this is
covered in an entire chapter too), sugar cravings, anxiety and mood issues. The
importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Have you had success with tryptophan for anxiety, fears, crying and ruminations?
And has it also helped with sleep, how happy you feel and reduced cravings? Has
it also helped with OCD?

Did you first trial 5-HTP and then found tryptophan worked better or vice versa?

If yes, what dose and when do you use it?

What about using inositol to further reduce OCD? And what dose helped?

If you’re a practitioner do you use tryptophan and/or inositol with
clients/patients with these low serotonin symptoms?

And please let me know if it’s helpful that I’m now including product
recommendations and where to get them?

Feel free to share and ask your questions below.

Filed Under: Anxiety and panic, Children/Teens, Cravings, OCD, Tryptophan Tagged
With: 5-HTP, amino acids, anxiety, anxious, autism, crying, fears, GABA
Quickstart; Balancing Neurotransmitters: the Fundamentals program for
practitioners, inositol, laughs, neurotransmitters, obsessive compulsive
disorder, OCD, ruminating thoughts, ruminations, sleeps, teen, tryptophan


REACTIVE HYPOGLYCEMIA IN BINGE EATING DISORDER, FOOD ADDICTION AND INTENSE SUGAR
CRAVINGS, AND HOW GLUTAMINE STOPS THE CRAVINGS

February 9, 2024 By Trudy Scott 4 Comments

A number of years ago a woman came to see me looking for help for her anxiety,
insomnia and out of control sugar cravings which she described as an “almost
demonic urge  to eat sugar and all things sweet.”

Before working with me she had been trying to control her low blood sugar levels
(or hypoglycemia) by eating the right foods at the right times i.e. healthy fats
and quality protein especially at breakfast. But this wasn’t enough to eliminate
her intense sweet cravings. She would make and eat sweet treats all day long,
using “healthier” sweeteners like monk fruit and maple syrup.

I had her complete the brain chemistry symptoms questionnaire and she scored
high on all the low blood sugar symptoms as well as low GABA and low serotonin.
We focused on low blood sugar first and the solution for her cravings was using
500 mg of glutamine opened onto her tongue.

Initially she was sure this would NOT work – how would she possibly be able to
use glutamine in the midst of experiencing reactive hypoglycemia or low blood
sugar?

I had the same conversation  that  I have with all my clients who would
obviously rather eat something sweet than open a glutamine capsule onto  their
tongue: “If you have an intense craving for something sweet, tell yourself that 
you’re  going to  indulge, but also humor your nutritionist and take the
glutamine anyway. You may be surprised to find your urge completely disappears.”

She did that and it worked time and time again, ending her demonic urge to eat
something sweet every time and very quickly. And it helped her with all her low
blood sugar symptoms.

This blog addresses the role of low blood sugar or reactive hypoglycemia in
intense sugar cravings, binge eating disorder and food addiction, and how
glutamine helps.


RESEARCH: REACTIVE HYPOGLYCEMIA IN BINGE EATING DISORDER AND FOOD ADDICTION

The 2023 paper, Reactive hypoglycemia in binge eating disorder, food addiction,
and the comorbid phenotype: unravelling the metabolic drive to disordered eating
behaviours, highlights the fact that “impaired metabolic response” such as
fasting blood glucose fluctuations are a factor in binge eating and food
addiction, driving out of control and “repetitive consumption of highly
processed food.”

The researchers “investigated hypoglycemia events during a 5-hour-long oral
glucose tolerance test” in 200 participants and “the association between the
severity of eating psychopathology and the variability in hypoglycemia events
was explored.”

The authors conclude as follows:

People with binge eating disorder/BED or food addiction/FA are prone to
experiencing reactive hypoglycemia; food addiction severity may predict early
and symptomatic hypoglycemia events. This can further reinforce disordered
eating behaviours by promoting addictive responses, both biologically and
behaviourally.

You can read the study here.

It’s worth noting that the participants did not have diabetes. I mention this
because most of the reactive hypoglycemia research looks at diabetic patients.
Reactive hypoglycemia in the non-diabetic population is considered controversial
even amongst functional medicine and/or integrative practitioners. This paper
stands out for this reason.

It’s also recently published which makes me excited. This research is confirming
what we see clinically.

This research is very much in line with the demonic urge my client described,
and directly tied to her low blood sugar and blood sugar swings. My client did
not do a 5 hour oral glucose tolerance test. Instead we used the low blood sugar
symptoms questionnaire (see below) and a trial of glutamine.

My client was also not diagnosed with binge eating disorder or food addiction
but didn’t have to be for us to recognize the issue and have her benefit from
nutritional support in the way of glutamine and learning to eat for blood sugar
stability.

Unfortunately the authors do not discuss glutamine as a solution in this
particular paper or in any other research on human participants who are
non-diabetic. There are a few animal diabetes studies, with this 2013 study
reporting that “glutamine was more effective in promoting glycemia recovery if
compared with glucose, lactate, glycerol, or alanine.”  The authors call for
further investigations which I look forward to reading.


LOW BLOOD SUGAR SYMPTOMS AND A GLUTAMINE TRIAL

As a reminder here are the signs of low blood sugar:

Sugar cravings, binge eating and addiction symptoms:

 * Crave sugar, starch or alcohol any time during the day
 * Very intense cravings for sweets/sugar
 * Binge eating and/or food addiction (updated with this based on this research)

There are also anxiety, mood, sleep and energy symptoms when you have low blood
sugar:

 * Nervous, anxious, panic attacks
 * Irritable, shaky, headachey – especially if you go too long between meals
 * Lightheaded if meals are missed
 * Agitated, easily upset
 * Eating relieves fatigue
 * Waking in the night or early hours with a jolt of anxiety/shakiness (I
   blogged about this here)

As I mention in the waking with a jolt/low blood sugar blog the good news is
it’s relatively easy to figure out if low blood sugar is causing your symptoms.
First I have clients rate their symptoms on the low blood sugar questionnaire
and do a trial of glutamine. Next is figuring out the dosing and timing of
glutamine, looking at a current food log and making dietary changes as needed.

Glutamine is always best opened on to the tongue but it must be used this way
for stopping the intense sugar cravings quickly – as in immediately. It’s also
used away from meals like all the amino acids.

If you notice improvements it’s very likely that reactive hypoglycemia or low
blood sugar is a factor.


GLUTAMINE FOR LOW BLOOD SUGAR CRAVINGS: DOSING AND TIMING

As I share in my book and other blog posts, typically 500 mg glutamine is a good
starting dose for intense cravings for sugary foods. We may increase based on
individual needs and you may find you do need to use 500 mg -1000 mg two to
three times a day when the intense desire for something sweet strikes – as blood
sugar dips. Using a glutamine powder is a great way to use it especially if you
find you do need more than 500 mg each time.

As I mentioned above when you use glutamine powder directly on the tongue
(rather than mixed in water), the benefits are seen almost immediately and even
if you don’t believe it could possibly work – like my client – your desire for
sugar disappears.


GABA AND SEROTONIN SUPPORT TOO

My client also needed GABA and serotonin support for her anxiety and sleep
issues. Again, we used the low GABA and low serotonin symptoms questionnaire and
did trials of GABA and tryptophan for her which helped further.


SUGAR CRAVINGS AND BINGE EATING WITH OTHER NEUROTRANSMITTER IMBALANCES TOO

Keep in mind that there is a sugar cravings aspect to all the neurotransmitter
imbalances. The type of craving can be found on the above symptoms
questionnaire. It’s not uncommon to need support more than one area:

 * Low blood sugar /hypoglycemia – glutamine for intense cravings at any time of
   the day
 * Low serotonin – tryptophan or 5-HTP for afternoon/evening cravings
 * Low endorphins – DPA for comfort/reward eating
 * Low catecholamines – tyrosine for low energy sugar cravings
 * Low GABA – GABA for stress eating

You can read more about this here: The individual amino acids glutamine, GABA,
tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar
cravings, often within 5 minutes 


GLUTAMINE PRODUCT OPTIONS – CAPSULE VS POWDER



Products I recommend include Pure Encapsulations 500 mg l-glutamine (capsules
opened on to your tongue) and Designs for Health l-glutamine powder as you find
you need higher amounts.  You can purchase these from my online store
(Fullscript – only available to US customers – use this link to set up an
account).



If you’re not in the US, Now l-glutamine 500 mg and Doctor’s best l-glutamine
powder are products I recommend on iherb (use this link to save 5%).


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING GLUTAMINE AND OTHER AMINO ACIDS
AS SUPPLEMENTS

We use the symptoms questionnaire to figure out if low blood sugar and/or low
serotonin and/or low GABA and other neurotransmitter imbalances may be an issue
for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control (this is
covered in an entire chapter too), sugar cravings, anxiety and mood issues. The
importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Have you had success with glutamine for blood sugar stability and binge eating,
food addiction and intense cravings for sugar and carbs?

Have you also found it helps with sleep, leaky gut and anxiety during the day?

If yes, how much helps you? And how often do you use it? And what sugary foods
have you been able to stop eating?

If you’re a practitioner do you use glutamine and with clients/patients with
these low blood sugar cravings? Do you recognize reactive hypoglycemia as a very
real issue in non-diabetics?

And please let me know if it’s helpful that I’m now including product
recommendations and where to get them?

Feel free to share and ask your questions below.

Filed Under: Addiction, Anxiety and panic, Cravings, Glutamine, Hypoglycemia
Tagged With: addiction, anxiety, binge, binge eating, carb craving, dosage, GABA
Quickstart; Balancing Neurotransmitters: the Fundamentals program for
practitioners, glutamine, Hypoglycemia, insomnia, low blood sugar,
neurotransmitters, reactive hypoglycemia, sugar craving, Timing


WAKING WITH A JOLT, FEELING SHAKY AND ANXIOUS: LOW BLOOD SUGAR/HYPOGLYCEMIA,
GLUTAMINE AND EATING FOR BLOOD SUGAR STABILITY

February 2, 2024 By Trudy Scott 11 Comments

Low blood sugar is one of a number of causes of waking in the night or early
hours, often with a jolt and feelings of anxiety or feeling like you’re having a
panic attack. As shared in a recent blog post, cortisol that is high at night
can cause very similar symptoms.

Because of a low blood sugar question on the high cortisol blog, today I’m
explaining the very different solutions to each root cause: glutamine and eating
for blood sugar stability when you have low blood sugar versus Seriphos when you
have high cortisol.

Katherine shares that she has low cortisol and suspects hypoglycemia or low
blood sugar, and is hesitant about using Seriphos:

> My last 4 point cortisol test showed mine is low throughout the day. But I’m
> having episodes where I’m waking up in the mornings feeling a jolt (every time
> I wake up from sleeping) and sometimes also shaky and anxious.
> 
> A functional pharmacist suggested my blood sugar may be dropping during the
> night and hypoglycemia could cause an adrenaline surge.
> 
> I don’t know. I’m nervous to try something [such as Seriphos] to lower
> cortisol when it seems mine is already too low.

I agree with her functional pharmacist that hypoglycemia is likely a factor as
it often is with adrenal dysfunction and low cortisol. And I am glad Katherine
is being cautious about using Seriphos.

I shared that Seriphos is not the solution in this instance because she doesn’t
have high cortisol based on her adrenal saliva test (4 collections). Instead,
she has low cortisol throughout the day and using Seriphos would lower her
cortisol even further. What many folks don’t realize is that high cortisol and
low cortisol can lead to similar symptoms of anxiety, shakiness and waking in
the night and early hours.

The good news is it’s relatively easy to figure out if low blood sugar is
causing your symptoms. First I have clients rate their symptoms on the low blood
sugar questionnaire and do a trial of glutamine. Next is figuring out the dosing
and timing of glutamine, looking at a current food log and making dietary
changes as needed.

If Katherine notices improvements – typically seen within a week – it’s very
likely that hypoglycemia is a factor.

Finally, if additional support is needed for her anxiety I’d consider looking at
low GABA and low serotonin symptoms and doing a trial of GABA and/or tryptophan.

Longer term solutions include all the dietary changes mentioned in my book –
gluten-free, no sugar, no caffeine or alcohol, using nutritional support for the
adrenals and addressing toxins, infections, trauma etc.


LOW BLOOD SUGAR SYMPTOMS

First I have clients rate their symptoms on the low blood sugar
questionnaire and do a trial of glutamine if they have low blood sugar symptoms.

Here are the low blood sugar symptoms which are rated on a scale of 1 to 10,
with 10 being most severe:

 * Crave sugar, starch or alcohol any time during the day
 * Irritable, shaky, headachey – especially if too long between meals
 * Intense cravings for sweets
 * Lightheaded if meals are missed
 * Eating relieves fatigue
 * Agitated, easily upset, nervous
 * Waking in the night or early hours with a jolt of anxiety/shakiness

If the ratings indicate the possibility of low blood sugar i.e. any cluster of
the above symptoms, we do a trial of the amino acid glutamine on the tongue and
record before and after ratings of a few symptoms.

Glutamine is a key amino acid for blood sugar stability and helps quickly while
the adrenals heal and the dietary changes are figured out.


GLUTAMINE FOR LOW BLOOD SUGAR: DOSING AND TIMING

Typically 500 mg glutamine is a good starting dose. I see many folks start too
high, like 5000 mg / 5 g and up multiple times a day, and it’s not necessary.
However, we increase based on individual needs and you may find you do need to
use 500 mg -1000 mg two to three times a day. Using a glutamine powder is a
great way to use it especially if you find you do need more than 500 mg each
time.

When you use glutamine powder directly on the tongue (rather than mixed in
water), the benefits are seen almost immediately.

For someone like Katherine, using glutamine throughout the day may set her up
for night time or early morning low blood sugar. She may also find she needs to
use some glutamine just before bed too.


GABA AND/OR SEROTONIN SUPPORT TOO?

Depending on the causes of her anxiety and shakiness, in addition to glutamine,
Katherine may need to consider GABA and/or tryptophan too. We use the low GABA
and low serotonin symptoms questionnaire and do trials of GABA and/or
tryptophan/5-HTP.

All three amino acids can be used before bed and during the night if needed but
trials are best done one at a time.


GLUTAMINE FOR LOW BLOOD SUGAR, HEALING THE GUT, TO REDUCE SUGAR CRAVINGS AND FOR
BETTER SLEEP

In addition to helping with blood sugar stability and sleep issues, glutamine
also helps to heal the gut and helps reduce sugar cravings. Laura shared how
it’s been helping her with all of this on another blog:

> I am currently struggling with gastritis (inflammation of the stomach lining)
> as well as a lifetime of low blood sugar and irritability. I started glutamine
> a few days ago (15 grams a day) and I am amazed at how it has calmed my gut as
> well as calmed the sugar cravings. I am also sleeping better!

I did share that 15 g is considered a high starting dose of glutamine. She may
well get similar benefits with much less.


GLUTAMINE FOR EARLY MORNING LOW BLOOD SUGAR AND HEADACHES

As you can see in this case, Cat finds 500 mg glutamine just once a day works
well for her unique needs:

> I found a powder that I mix approximately 500 mg of with water. It works
> within about 15 minutes and keeps me going for about 2 – 3 hours — long enough
> to reach a reasonable time for lunch.
> 
> I’m thrilled to have this option as anytime that I travel, low blood sugar
> becomes a huge issue as I suffer from ketotic hypoglycemia and end up with
> massive headaches and vomiting for 6-8 hours.

You can read more about Cat’s success here – Glutamine for hypoglycemia/low
blood sugar: “500mg mixed in water works in 15 minutes and keeps me going for 2
– 3 hours”.


DIETARY CHANGES FOR BLOOD SUGAR CONTROL AND ADRENAL SUPPORT

All my clients keep a food log and we look at what they are eating on a typical
day and when. It’s key to eat in a certain way in order to control blood sugar:.
breakfast on waking, healthy snacks 3 to 4  x day and some folks do well with a
snack before bed. These meals and snacks should include quality animal protein
and healthy fats. This is all outlined in detail in the diet and low blood sugar
chapters in my book “The Antianxiety Food Solution”.

A protein smoothie in the morning is a good option too and especially helpful if
you have the social anxiety condition pyroluria, where morning nausea and a low
appetite is common initially. This blog highlights a research paper about
breakfast smoothies helping to reduce anxiety and hypoglycemia symptoms.

Nutritional support for adrenal function includes a good B vitamin complex,
extra vitamin B5/pantothenic acid, vitamin C and adaptogenic herbs such as
rhodiola and ashwagandha.


GLUTAMINE PRODUCT OPTIONS – CAPSULE VS POWDER



Products I recommend include Pure Encapsulations 500 mg l-glutamine (capsules
opened on to your tongue) and Designs for Health l-glutamine powder as you find
you need higher amounts.  You can purchase these from my online store
(Fullscript – only available to US customers – use this link to set up an
account).



If you’re not in the US, Now l-glutamine 500 mg and Doctor’s best l-glutamine
powder are products I recommend on iherb (use this link to save 5%).


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING AMINO ACIDS AS SUPPLEMENTS

We use the symptoms questionnaire to figure out if low blood sugar and/or low
serotonin and/or low GABA and other neurotransmitter imbalances may be an issue
for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control (this is
covered in an entire chapter too), sugar cravings, anxiety and mood issues. The
importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Have you had success with glutamine for blood sugar stability and waking with a
jolt of anxiety/panic at night or in the early hours?

Have you used it for blood sugar stability, reduced cravings, leaky gut and
anxiety during the day?

If yes, how much helps you? And how often do you use it?

Have dietary changes and adrenal support helped too?

If you’re a practitioner do you use glutamine and dietary approaches with
clients/patients with low blood sugar?

And please let me know if it’s helpful that I’m now including product
recommendations and where to get them?

Feel free to share and ask your questions below.

Filed Under: Adrenals, Anxiety and panic, Glutamine, Insomnia Tagged With:
anxiety, cortisol, dosage, GABA Quickstart; Balancing Neurotransmitters: the
Fundamentals program for practitioners, glutamine, Hypoglycemia, insomnia, jolt,
low blood sugar, panic, salivary testing, shakiness, shaky, Timing, waking


SERIPHOS TO LOWER HIGH CORTISOL: HELP PREVENT AN ADRENALINE-TYPE SURGE AND
WAKING WITH ANXIETY AND PANIC. YOUR QUESTIONS ANSWERED

January 26, 2024 By Trudy Scott 11 Comments

When you have high night-time cortisol it can cause you to wake in the middle of
the night with anxiety and/or feeling like you’re having a panic attack. If your
cortisol is really high in the early morning (outside of the normal range), you
can also wake with a jolt and feelings of anxiety and panic. Seriphos, a
phosphorylated serine product, can help to lower your high cortisol and
eventually prevent these symptoms.

Today I’m addressing your questions about how to use Seriphos to lower high
cortisol and help prevent an adrenaline-type surge – like dosing/timing at night
and in the early morning, how long you can take it for, cortisol salivary
testing, interactions, brands and another option to Seriphos.

Soma shared her symptoms on Facebook when I said I’d be taking questions:

> Can feel the adrenaline rush “crash” over me. I responded so so to beta
> blockers but still having fitful sleep and occasional “shocks” into
> wakefulness in the night as if tragedy struck … fight or flight upon waking.
> Tremendous night sweats. Generally hyper vigilant as a person.

This is her question: “What dosage and when to take (how soon before bed) is
recommended?”

Addressing dosage and timing is a good place to start (and a common question)
but I asked her if she has done a 4-5x cortisol salivary collection to confirm
that her night time cortisol is high. She has not done this simple and very
effective adrenal test and I highly recommend it before using Seriphos. The
reason is that low cortisol can often have similar symptoms to high cortisol and
using Seriphos is going to make things worse.


WHAT DOSAGE AND WHEN TO TAKE SERIPHOS (HOW SOON BEFORE BED) IS RECOMMENDED?

Assuming Soma has done the adrenal saliva test and knows her middle of the night
cortisol (5th saliva collection) is high, using 1-3 capsules a few hours before
the high cortisol seems to be most effective. For example, for 2-4 am waking
this typically means taking Seriphos right before bed. In some instances, taking
1 on waking in the night can help too (for a maximum of 3).

If her late evening 10 pm (4th saliva collection) is high too, the dose can be
split. For example, taking 1 Seriphos at 7- 8 pm (a few hours before the high
cortisol at 10 pm) and 1-2 right before bed for the 2 -4 am high cortisol.

The bottle states to use 1 capsule with water 15 minutes before a meal. I’m
really not sure why they state this.


HOW TO USE SERIPHOS FOR HIGH MORNING CORTISOL AND ADRENALINE SURGE ON WAKING?

Syd asks this question about high morning cortisol (as confirmed by saliva
adrenal testing):

> Opinion about using it for confirmed high MORNING cortisol? (Yup, I know
> cortisol is supposed to be highest in the morning, but this is off the charts,
> literally, high.)
> 
> “Adrenaline surge” or “catecholamine surge” is exactly how I’ve explained it
> to people!! No cognitive worrying, just that surge.

Because Seriphos works best taken a few hours in advance of high cortisol, I
typically have clients use Lactium in this situation. It’s a hydrolyzed casein
product that also lowers high cortisol. If casein is an issue then Relora is
another option. I’ve blogged about both – Lactium here and Relora here.

One other option is to experiment with Seriphos – using it in the morning and
also trying it at bedtime.


SHOULD I TAKE TWO SERIPHOS? I WAKE HALFWAY THROUGH THE NIGHT

Anne asks this question:

> I only take one capsule? Should I take two? I wake halfway through the night,
> usually due to a full bladder. I fall back to sleep easily if I use a CBD
> gummy. Tested high for cortisol throughout the day on a DUTCH complete test,
> which measures at least 4 times.

Anne has done a DUTCH test which includes 4 adrenal saliva collections but
doesn’t know if her cortisol is high in the middle of the night.  As mentioned
above, 1-3 capsules of Seriphos is ideal so I have clients start with 1 and
increase to 2 and then 3. Since her cortisol is high throughout the day she may
do better using Seriphos in the day and continuing with CBD at night when she
wakes.

She may also want to consider low GABA and/or low serotonin as factors causing
her to not sleep through the night. This applies to anyone using Seriphos to
lower high cortisol. More on amino acids below.

If she does have bladder issues addressing this is key too.


FOR HOW LONG CAN SERIPHOS BE TAKEN?

It is recommended to take a one-month break after 3 months of Seriphos use.
Ideally, once some or all the root causes of high cortisol are addressed (like
gluten, stress, parasites, infections, trauma etc), you should be able to stop
anyway.  Or take a break, retest cortisol and then continue.


DOES SERIPHOS HAVE ANY INTERACTIONS? AND IS THERE ANY COHORT WHO SHOULD NOT USE
IT?

Someone asked about using Seriphos with a beta blocker and someone else asked
about using it with a SSRI. I’m not aware of any medication interactions but
it’s best to always discuss with the prescribing physician.


WHAT BRANDS MAKE SERIPHOS AND WHERE CAN I FIND IT?



There is only one product and it’s called Interplexis Seriphos. You can purchase
this from my online store (Fullscript – only available to US customers – use
this link to set up an account) and you can also find it on iherb (use this link
to save 5%).



Since I mentioned Lactium above, Biotics Research De-Stress contains 150mg
hydrolyzed casein or lactium. You can find this in my online Fullscript too –
use this link to set up an account.  For non-US customers, Life Extension
Bioactive Milk Peptides also contains 150mg hydrolyzed casein or lactium (you’ll
see casein decapeptide and lactium on the label.)  You can find this on iherb
(use this link to save 5%).


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING AMINO ACIDS AS SUPPLEMENTS

We use the symptoms questionnaire to figure out if low serotonin or low GABA and
other neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control, sugar
cravings, anxiety and mood issues. The importance of quality animal protein is
also covered.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Have you had success with Seriphos (or Lactium or Relora) to lower high cortisol
and help with anxiety, panic and/or adrenaline-type surges?

Have you used Seriphos in combination with amino acids and dietary changes?

If you’re a practitioner do you use Seriphos with clients/patients?

Feel free to share and ask your questions below.

Filed Under: Adrenals, Anxiety and panic, Insomnia Tagged With: adrenaline-type
surge, anxiety, cortisol, de-stress, dosage, fight or flight, high cortisol,
interactions; GABA Quickstart; Balancing Neurotransmitters: the Fundamentals
program for practitioners, jolt, lactium, panic, phosphorylated serine, safe,
salivary testing, seriphos, shocks, Timing, waking


HOW TO USE BRIGHT LIGHT THERAPY FOR INCREASED ANXIETY, INCREASED PANIC AND SAD
DURING THE COLD DARK WINTER MONTHS

January 19, 2024 By Trudy Scott 2 Comments

There is a seasonality to anxiety and panic disorder just as there are seasonal
variations in mood for certain susceptible individuals:

> Following a clinical observation of increased anxiety symptoms and mood
> changes during winter in panic disorder patients, the Seasonal Pattern
> Assessment Questionnaire (SPAQ) was completed by 133 patients. Global
> Seasonality Scores (GSS), and the prevalence of Seasonal Affective Disorder
> (SAD), were significantly higher than reported in general population studies.
> 
> Seasonal changes were also found in anxiety and panic attacks.
> 
> These findings suggest the possibility of a common aetiology [etiology or
> cause] for panic disorder and SAD, that seasonality may be a far more general
> phenomenon in psychopathology, and that light therapy may be a useful
> treatment for some panic disorder patients.

The above abstract is from this paper: Seasonality in panic disorder

If you’re new to bright light therapy or are currently using it with success and
would like to learn more, I’d like to point you to this excellent review paper,
Bright Light as a Personalized Precision Treatment of Mood Disorders. The
authors of the above paper cover some of the basics like how to use bright light
for SAD (seasonal affective disorder) or the winter blues, and for how long,
possible adverse effects and who should not use bright light therapy (this last
aspect is theoretical).

This information about bright light and mood disorders can be applied to anxiety
and panic attacks, in addition to SAD.

As you’ll read below there are also often benefits for non seasonal depression,
bipolar disorder, fatigue, sleep issues, emotional eating and other conditions
too.  And bright light therapy can be used in conjunction with the amino acids
tryptophan or 5-HTP, and is often used with psychiatric medications too.


HOW TO USE BRIGHT LIGHT FOR SAD AND WINTER ANXIETY/PANIC AND FOR HOW LONG?

You sit in front of the light box or full spectrum lamp – on a table or your
desk – with open eyes.  Using a standing lamp as a source of light is another
option.

The authors of the Bright Light paper share the following approach for SAD
(seasonal affective disorder or the winter blues), all of which is applicable
for increased anxiety and panic attacks in winter too):

 * Start with a “duration of 30 minutes, using a light intensity of 10,000 lux.”
   (more on lux comparisons below)
 * “Early morning administration offers greater chances for remission” (although
   there is documented research and clinical results that for some folks later
   in the day works well too).
 * “Measured at eye level, a therapeutic distance of 60–80 cm from the light box
   can be seen as standard requirements (some other devices recommend a distance
   of 30 cm, so we advise to follow the device recommendations that take into
   account light parameters and distance).” Most of the lights/devices I
   recommend state a distance of 30 cm so it’s best to follow the manufacturer’s
   guidelines.
 * “Lower intensities also appear to be effective, but need longer exposure
   durations: 2,500 Lux for 2 hours per day or 5,000 Lux for 1 hour a day.” This
   means sitting further away may allow you to sit in front of the lamp/device
   for longer duration and get the same benefits.
 * “Significant effects appear only at 2–3 weeks of treatment.” Based on my
   clinical results, I have clients start to feel some improvements right away
   with the correct distance and a good lamp.
 * “Treatment is usually continued until the time of usual spontaneous remission
   in the spring or summer” (and is ideally started as fall/autumn starts to
   approach rather than in the middle of winter).

I’m also adding this missing and yet important fact from another paper: “The
light box is angled ~30° from the line of gaze. The user does not stare directly
into the light.”

They also discuss guidelines for year round use of bright light therapy for
non-seasonal unipolar depression, another term for major depressive disorder.
And midday or morning use for bipolar depression (when on mood stabilizers). I
share more about this in my blog: Midday bright light therapy for bipolar
depression. I refer you to the study for this information so it can be discussed
with your doctor.


BRIGHT LIGHT THERAPY FOR INSOMNIA AND DECREASED ALERTNESS/FATIGUE

The Bright Light paper also mentions how light therapy “may also be useful to
improve sleep quality” … and … “abnormalities in circadian rhythms such as sleep
phase delay syndrome, that are frequently associated in mood disorders.”

The authors also mention how light therapy can also help “decreased alertness”,
presumably as a result of poor sleep.

Clinically, I see these benefits for clients in similar ways that tryptophan or
5-HTP help with sleep issues. This is related to the serotonin boosting
mechanism of bright light therapy. Keep in mind anxiety and panic are symptoms
of low serotonin.


WHAT ARE SOME POSSIBLE ADVERSE EFFECTS OF BRIGHT LIGHT THERAPY?

The authors state that bright light therapy “is well-tolerated by patients;
adverse effects such as headache, eyestrain, nausea and agitation, are usually
transient and mild.” Clinically, I have seldom seen clients experience headache,
eyestrain and nausea.

However, I have seen agitation and other low serotonin symptoms get worse – like
feeling more sad or more worried or more angry or more irritated or more sleep
issues (or all of the above). Too much bright light therapy can ramp up low
serotonin symptoms in a similar way that too much tryptophan or 5-HTP can. In
other words, it can be overdone and more is not necessarily better. You have to
find a balance and figure out what works best for your needs.

I also have clients who are prescribed antidepressants discuss light therapy
with their prescribing doctor as I suspect there is the possibility of serotonin
syndrome. I don’t see any reports of this in the research and a number of
reports of bright light therapy being used successfully in conjunction with
antidepressants.


WHO SHOULD NOT USE BRIGHT LIGHT THERAPY?

The authors share these contraindications: “ophthalmic disorders (cataract,
macular degeneration, glaucoma, retinitis pigmentosa) and disorders affecting
the retina (retinopathy, diabetes, herpes, etc.).” They recommend getting an eye
examination if you are in doubt.

Other papers state that the above is theoretical and there are no documented
cases of eye damage from bright light therapy. But if you suspect you may be at
high risk, get the approval from your ophthalmologist and ongoing monitoring
too.


RECOMMENDED LIGHTS, LAMPS AND PANELS: ALWAYS 10,000 LUX

This blog post, Winter blues or SAD: light therapy has been updated (as of Jan
2024) with new links for recommended lights/lamps/panels, all 10,000 lux. You
can also read feedback from folks who use and find the benefits of full spectrum
light or bright light therapy. For example, Chrstine shared this:

> My office is the darkest room in the house and I have one sitting on my desk,
> especially helpful in the winter. This is the second Verilux Happy Light I
> have used and I really like it. Living in Nevada where there is sunshine over
> 330 days of the year I am so accustomed to light and brightness that if I am
> in a dark room or space for too long it really affects me. This has been a
> great product for me and I can recommend it.

If you’re curious about lux, it is a unit of illumination and this paper, Light
Therapy in Mood Disorders: A Brief History with Physiological Insights, includes
this very useful lux comparison image:

The above is shared under the Creative Commons Attribution License and can be
found here .


THE COMBINATION OF USING BRIGHT LIGHT THERAPY WITH AMINO ACIDS SUCH AS
TRYPTOPHAN AND 5-HTP

I often recommend the use of light therapy in conjunction with amino acids such
as tryptophan and 5-HTP. This offers additional serotonin support and helps ease
worry-type anxiety, panic attacks, low mood, insomnia, cravings and more. I
discuss this combination approach in the winter blues blog.

When someone is already using amino acids with some success, we may just add
light therapy and keep amino acid dosing the same or we may use higher doses of
amino acids like tryptophan, 5-HTP and GABA during the winter months. We may
also use both depending on the person’s unique needs.

I had one client who did really well with tryptophan: his anxiety decreased
dramatically but then ramped up before winter. Increasing tryptophan was too
much for him so we kept the original tryptophan dose and he started bright light
therapy. This worked very well for him until the end of spring when he was able
to stop the light therapy.

I also share links to increased OCD (obsessive compulsive disorder), intrusive
thoughts, PMDD (premenstrual dysphoric disorder), PMS (premenstrual syndrome),
binge eating/emotional eating and drinking/alcoholism in the winter months – and
the role of light therapy and amino acids.


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING TRYPTOPHAN OR OTHER AMINO ACIDS
AS SUPPLEMENTS

We use the symptoms questionnaire to figure out if low serotonin or other
neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control, sugar
cravings, anxiety and mood issues. The importance of quality animal protein is
also covered.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Do you experience increased anxiety, panic attacks and/or the winter blues in
the winter months? Have you had success with bright light therapy?

If yes, which full spectrum lamp have you found to be the most useful? What time
of the day do you use it, how often do you use it and for what duration?

Have you used a combination of amino acids and light therapy, and adjusted up
your amino acids during the colder and darker winter months?

If you’re a practitioner do you recommend light therapy to your
clients/patients?

Feel free to share and ask your questions below.

Filed Under: Amino Acids, Anxiety and panic, Depression, Emotional Eating Tagged
With: 000 lux, 10, 5-HTP, anxiety, Bipolar, Bright light therapy, depression,
emotional eating amino acids, fatigue, GABA Quickstart; Balancing
Neurotransmitters: the Fundamentals program for practitioners, how to use, light
therapy, mood, panic, SAD, seasonal affective disorder, seasonality, sleep,
tryptophan, winter, winter blues


D-PHENYLALANINE (DPA) FOR EASING BOTH PHYSICAL PAIN (TOOTH PAIN) AND EMOTIONAL
PAIN OVER THE HOLIDAYS

January 5, 2024 By Trudy Scott 6 Comments

Today I share how the amino acid D-phenylalanine (DPA), used as a supplement
multiple times a day, and opened on to my tongue, eased both the physical tooth
pain I experienced for 14 days and the emotional pain I was feeling over the
holidays.

In this blog I share more about DPA and endorphins when it comes to pain – both
physical and emotional. I also share two DPA products I recommend, product label
confusion and more about how DPA differs from DLPA (DL-phenylalanine). I am
often asked this question and even long time users of DLPA are sometimes
surprised to learn how different DPA is. As always, I like to share some
research and other related blogs on the topic. Here is my recent and very
positive personal experience with DPA, a firm favorite of mine:

> I’m just back from the dentist – my crown was re-cemented and I’m a happy
> camper now. It popped off just before Christmas and I had to wait until now!
> There was a tiny cavity beneath the crown which is why I was having daily
> pain.
> 
> Thank goodness I always have DPA (the amino acid d-phenylananine) on hand. I
> gravitate to it for pain relief – sports injuries like muscle sprains, the
> rare headache and this time for tooth/jaw pain.
> 
> I opened a DPA onto my tongue as soon as I could feel the dull ache start and
> the pain relief lasted a few hours. It works by boosting endorphins to provide
> pain relief – kind of like acupuncture.  I call it “powdered acupuncture”.
> 
> Some days I used 3-4 and one day I needed 6. Taking one before bed was
> wonderful.
> 
> I also got bonus benefits for emotional well-being over the holidays. It’s the
> first Christmas without my darling mom and I really needed the endorphin boost
> to help with the emotional pain.

The DPA product I used was Doctor’s best (details below) and I opened up the 500
mg capsule onto my tongue each time I needed pain relief.

The number of capsules I needed seemed to vary by how much chewing I was doing
(for example, I had more pain after a steak meal vs smoked salmon) and what I
was eating or drinking (for example, I had more pain after drinking something
cold). I simply used a DPA capsule when the dull pain started, making sure it
was away from protein (not always but most of the time).


ONE OF THE DPA PRODUCTS I RECOMMEND: DOCTOR’S BEST D-PHENYLALANINE

There are not many d-phenylalanine/DPA products available but of those I have
two that I recommend: Doctor’s Best D-Phenylalanine and Lidtke Endorphigen. Both
contain 500 mg DPA but the labels can be confusing at first – at least until
you’re familiar with them.

Also, this amino acid, DPA, is not to be confused with docosapentaenoic acid
(also abbreviated as DPA), an omega-3 fatty acid similar to eicosapentaenoic
acid (EPA).



Here is the Doctor’s Best D-Phenylalanine description:

Doctor’s Best D-phenylalanine is a non-protein amino acid that acts as an
inhibiting agent to enzymes that degrade enkephalins, naturally occurring
peptides in the body that metabolize endorphins. Endorphins are
neurotransmitters that play a key role in the function of the nervous system and
are associated with feelings of pleasure. By limiting production of enzymes that
break down endorphins, the supplement can help support a healthy mood and normal
functioning of the nervous system.

 * Helps support healthy mood
 * Helps support endorphin metabolism
 * Help support neurotransmitter function

This is the actual product that I used over the past 2 weeks and have used it on
and off as needed for a few years. It was one of the nutrients that helped when
I sprained my ankle when visiting my brother in Las Vegas. More here

As you can see there is no mention of pain on the label or product description.
I share more on the pain/endorphin connection below.

You can purchase this online from their website or from iherb. If you use my
iherb link you’ll save 5%. This is a good option if you’re not in the USA and
already use iherb for one-stop shopping of quality products.


THE OTHER DPA PRODUCT I RECOMMEND: LIDTKE ENDORPHIGEN

The other product I recommend is Lidtke Endorphigen which also contains 500 mg
DPA and a small amount of vitamin B6 and riboflavin (vitamin B2). As you can
see, this product does mention pain but not the emotional support/mood benefits
on the front label.



Here is the Lidtke Endorphigen description

Ease Minor Pain & Feel Good with Healthy Endorphin Level Maintenance

Endorphins are nature’s way to relieve common minor pain and promote a cheerful
mood. Research shows that endorphins are released in response to pain and
stress, bringing relief. The second wind and runner’s high during and after a
vigorous run are results of endorphins. Acting as an analgesic and sedative,
endorphins diminish our perception of pain…. But there is more.

Recovery centers report that endorphins promote recovery from a wide variety of
unhealthy cravings.


LOW ENDORPHIN SYMPTOMS AND TYPICAL DOSING OF DPA

I use the symptoms questionnaire to help clients identify if they have low
endorphin symptoms (you can see that here).

Typical dosing is 500 mg to 1000 mg DPA 3-4 x day between meals/away from
protein. I do find having clients open the capsule onto their tongue to be more
effective for quick pain relief – with results as quickly as 5-10 minutes.


DPA VS DLPA: THEY ARE QUITE DIFFERENT BUT HAVE SOME OVERLAPS

I am often asked if DPA and DLPA are the same – they are quite different but
have some overlaps as outlined in this blog post on the topic: What is the
difference between DPA and DLPA (amino acids) and which one do I use for
weepiness, heart-ache, pain and energy?

The precautions are also not the same so I always review contraindications with
all my clients and encourage you to do the same.


DPA FOR MS PAIN, WEEPINESS, EMOTIONAL PAIN AND MORE

Here are a few blog posts illustrating the use of DPA in multiple sclerosis,
weepiness, physical pain, emotional pain and resilience, cravings/emotional
eating and even helping to wean off prescription pain medication:

 * Multiple sclerosis: low endorphin research and the amino acid DPA
   (d-phenylalanine) for pain, depression, comfort and trauma support “The
   endogenous opioid system is …well known to play a role in the development of
   chronic pain and negative affect [i.e. depression], both of which are common
   comorbidities in MS.”
 * DPA for weepiness, pain and comfort and reward eating
 * The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and
   tyrosine are powerful for eliminating sugar cravings, often within 5 minutes
 * When using the amino acid DPA (d-phenylalanine) I have more resilience and
   more buffer in the caregiving work I do, and just the oops’s of life As I
   mentioned above, using DPA over these holidays also gave me more resilience
   and the endorphin boost I needed help with the emotional pain of losing my
   mom.
 * Wean off prescription pain medication, improve sleep and reduce emotional
   eating with DPA (an endorphin-boosting amino acid)

Be sure to use the search feature on the blog to find additional applications of
DPA.


DPA RESEARCH ON PAIN AND DEPRESSION

The use of DPA is not new as you can read in this paper from 1982 –
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents:
implications for some important therapeutic application

A number of compounds have been shown to inhibit the degradation of enkephalins.
As expected, these compounds produce naloxone reversible analgesia and
potentiate the analgesia produced by enkephalins and by acupuncture.

One of these, D-phenylalanine, is also anti-inflammatory.

D-phenylalanine has proven to be beneficial in many human patients with chronic,
intractable pain. It is proposed the enkephalinase inhibitors may be effective
in a number of human “endorphin deficiency diseases” such as depression,
schizophrenia, convulsive disorders and arthritis.


ADDITIONAL RESOURCES WHEN YOU ARE NEW TO USING DPA AND THE OTHER AMINO ACIDS AS
SUPPLEMENTS

We use the symptoms questionnaire to figure out if low endorphins or other
neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my
book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm
Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend
getting it and reading it before jumping in and using amino acids on your own so
you are knowledgeable. And be sure to share it with the practitioner/health team
you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout
the book in the sections on gut health, gluten, blood sugar control, sugar
cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this
blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists
the amino acids that I use with my individual clients and those in my group
programs. You can find them all – including the Lidtke Endorphigen 500 mg that I
mentioned above.

Also mentioned above is Doctor’s Best D-Phenylalanine which can be purchased on
iherb.

If, after reading this blog and my book, you don’t feel comfortable figuring
things out on your own (i.e. doing the symptoms questionnaire and respective
amino acids trials), a good place to get help is the GABA QuickStart Program (if
you have low GABA symptoms too). This is a paid online/virtual group program
where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the
Fundamentals program. This is also a paid online/virtual program with an
opportunity to interact with me and other practitioners who are also using the
amino acids.

Have you had success using DPA for your pain issues – what kind of pain has it
helped and how much has helped you?

Has DPA also helped with emotional pain and weepiness? And cravings/emotional
eating?

If you’re a practitioner do you have success using DPA with your
clients/patients?

Feel free to share and ask your questions below.

Filed Under: Depression, DPA/DLPA, Emotional Eating, Endorphins, Pain Tagged
With: Acupuncture, amino acids, cavity, crown, d-phenylalanine, dentist,
depression, dl-phenylalanine, DLPA, Doctor’s Best D-Phenylalanine, DPA, dull
ache, emotional pain, emotional well-being, endorphins, GABA Quickstart;
Balancing Neurotransmitters: the Fundamentals program for practitioners,
headache, Lidtke Endorphigen, muscle sprains, physical pain, tooth pain,
weepiness

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