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Text Content

Learn how AbbVie could help you save on SKYRIZI.
Call 1.866.SKYRIZI or click tap to learn more ▸

Skip to Main content
* Important Safety Information
* Full Prescribing Information & Patient Information
* Full Prescribing Information (English)
* Medication Guide

* Healthcare Professionals Site

* SKYRIZI
* Select Condition
* Moderate to Severe Plaque Psoriasis
* Active Psoriatic Arthritis
* Moderate to Severe Crohn's Disease

* Starting SKYRIZI
* About Skyrizi Complete
* Ways to Save
* Your Nurse Ambassador
* Injection Support
* Resources to Stay on Track

* MANAGING YOUR TREATMENT
* Preparing for Treatment
* Understanding Insurance
* Living With Your Condition
* Share Your Story

* Sign In or Register

SKYRIZI INJECTION SUPPORT

1 INJECTION, 4 TIMES A YEAR AFTER 2 STARTER DOSES

SKYRIZI has 2 options designed around your needs for injecting: the SKYRIZI Pen
and the single-dose prefilled syringe. Talk to your doctor about the options
available to you.

Remember, your Skyrizi Complete Nurse Ambassador* is ready to answer your
questions about how to inject properly. And help coach you through the process.

Have a question right now? Call your Nurse Ambassador at 1.866.SKYRIZI
(1.866.759.7494).

IN THIS SECTION:

* About Skyrizi Complete
* Ways to Save
* Your Nurse Ambassador
* Injection Support
* Resources to Stay on Track

Need help reviewing insurance
coverage options?

This comparison chart can help ▸

SUPPORT FOR ADULTS WITH MODERATE TO SEVERE CROHN'S DISEASE

SKYRIZI infusion support
SKYRIZI On-Body Injector support

SKYRIZI Pen
Prefilled Syringe

INJECTING WITH THE SKYRIZI PEN

The SKYRIZI Pen helps you take your SKYRIZI with just one injection per
treatment. Click the circles below to explore the Pen's features.

Hold down button to automatically inject medicine–it clicks when starting and
stopping

Locking mechanism prevents you from starting injection accidentally

Large window gives clear view of medicine

Wide grip with rubber-lined sides make it easy to hold

Hold down button to automatically inject medicine–it clicks when starting and
stopping

Locking mechanism prevents you from starting injection accidentally

Large window gives clear view of medicine

Wide grip with rubber-lined sides make it easy to hold

WATCH, STEP-BY-STEP, HOW TO INJECT WITH THE SKYRIZI PEN:

1. Now Playing
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2. Now Playing
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5. Now Playing
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5:45
6.

SKYRIZI150_PEN_FULL_H264-2
In this video, Michael, an experienced SKYRIZI patient, gives step-by-step
instructions on using the SKYRIZI Pen, including how to prepare for the
injection, how to inject, and the proper way to dispose of the used SKYRIZI Pen.

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SKYRIZI150_PEN_FULL_H264-2

In this video, Michael, an experienced SKYRIZI patient, gives step-by-step
instructions on using the SKYRIZI Pen, including how to prepare for the
injection, how to inject, and the proper way to dispose of the used SKYRIZI Pen.

Transcript

WATCH THE FULL VIDEO. THEN CHOOSE A SPECIFIC STEP FROM THE MENU ABOVE TO WATCH
ANY OF SECTIONS AGAIN.

View Transcript

Quick Links CHAPTER 1:

A GUIDE TO INJECTING SKYRIZI

CHAPTER 2:

INJECTION PREP

CHAPTER 3:

HOW TO INJECT STEP-BY-STEP

CHAPTER 4:

HELPFUL TIPS FOR SELF-INJECTING

CHAPTER 1: A GUIDE TO INJECTING SKYRIZI

Hi, I’m Michael. And I’m here to show you how to inject using a SKYRIZI Pen.
I’ve been doing this for a while now, and I feel like I have a good handle on
it.

My doctor showed me how to inject when I first started, and I called Lauren (my
Nurse Ambassador) and she helped me the first few times I did it at home by
myself.

CHAPTER 2: INJECTION PREP

Now, I get my SKYRIZI by mail and I keep it in the fridge until I’m ready to
inject. Ah, there it is. There we go. So, very important. I’ll leave it out at
room temperature and out of direct sunlight for 30 to 90 minutes before
injecting.

Now that I’ve washed and dried my hands, I’m good to go. So, I take out
everything I need: Ah, I got my SKYRIZI Pen. I’ve got the Instructions for Use
for reference. I’ve also got an alcohol swab, a cotton ball, and my sharps
container. So, I do my injections here because there’s just plenty of light and
a lot of good space.

CHAPTER 3: HOW TO INJECT STEP-BY-STEP

I like to think about the injection process like this…Pick. Pull. Place. Push.
And press. So first...

I’ll pick my injection site. I’m gonna go with my left thigh. But you can also
inject into your stomach or your other thigh. If you choose your stomach, make
sure that you inject at least two inches away from your belly button.

Grab your alcohol swab and clean your skin in a circular motion like this. And
let it dry.

Now, I hold the Pen with the dark gray cap pointing up. I pull the cap straight
off and throw it away.

Now I check the liquid through the inspection window. It should look clear to
slightly yellow and may contain tiny white or clear particles. It’s normal to
see one or more bubbles in the liquid.

So, I hold my Pen with my fingers on the gray grips. See? And I turn the Pen so
that the white needle sleeve points toward my injection site and I can see the
green activator button. I also make sure that I can clearly see the inspection
window while I’m injecting.

I gently squeeze my skin at my injection site and make a raised area and hold it
firmly. Then I place the white needle sleeve straight against the raised area,
at a 90-degree angle, and push the Pen down against my skin. Throughout the
process, I keep pinching the raised area and keep steady pressure against it.

Now I can see the green activator button and inspection window. The Pen only
activates if the white needle sleeve is pressed firmly down against me before
pressing the green activator button. A loud click means the start of the
injection. There it goes.

And hold it like that for 15 seconds. Now, I’ll keep pushing the Pen down
against my skin until I hear a second click or the yellow indicator has filled
the inspection window–either one signals the injection is complete.And there it
goes. I check to make sure that the yellow indicator is fully down to be sure
the injection is complete. Only then do I slowly pull the pen straight out from
my skin.

You might notice one last click. And look at this. You see how the white needle
sleeve covers the needle tip?

And that’s it. Now, I press a cotton ball where I injected. You could also use a
gauze pad.

And I drop my used Pen in one of these Sharps Disposal Containers.

There. Safe and sound, and also out of reach. Another injection complete.

CHAPTER 4: HELPFUL TIPS FOR SELF-INJECTING

To recap, I prepare myself and my space. Pick an injection site. Pull the cap
off the Pen. Place the Pen on the injection site. Push the Pen firmly down
against my skin. Press the button to inject. And keep steady pressure on the
injection site for the full 15 seconds.

Then safely discard the used Pen. That’s the whole injection process.

When I started injecting at home, it didn’t take me long to get it down. Lauren,
my Nurse Ambassador, she suggested I create a routine. Inject at the same time
and place.

I also like to treat myself after each injection. And maybe I’ll cycle or listen
to a new album.

And this Skyrizi Complete App helps me stay on track, and I don’t know what I’d
do without it.

I used it to log my first starter dose, so I knew when to take my second starter
dose four weeks later.

And you can set reminders for future doses, too, since after two starter doses,
SKYRIZI is only 1 injection, 4 times a year.

And when I get those reminders, I know to contact my specialty pharmacy to get
my next injection on time.

And don’t forget about the Skyrizi Complete Sharps Disposal and mail-back
service. I signed up online, so once my Sharps Container gets full, I request a
new one. Which is sent to me with a box to send my full one back. It’s so
convenient, and it doesn’t cost me anything.

And I’m lucky that my family’s always around if I need help. I’ve got Skyrizi
Complete, too. Like Lauren, who has answers to my questions and a pretty awesome
app.

You’ve got this.

--------------------------------------------------------------------------------

Looking for specific injection information?

PREPARING FOR YOUR SKYRIZI INJECTION

Special Warming Instructions:
First, take your SKYRIZI Pen out 30 to 90 minutes before injecting and leave the
carton at room temperature, out of direct sunlight.

Once you wash and dry your hands and settle into a place where you feel relaxed,
make sure you have everything laid out on a clean, flat surface.

You’ll need:
An alcohol swab, a cotton ball or gauze pad, your sharps container, which
ensures your pen is disposed of safely, and of course, your SKYRIZI Pen.

A few things to look out for:

* DO NOT remove the Pen from the carton while allowing SKYRIZI to reach room
temperature
* DO NOT warm SKYRIZI in any other way (for example, DO NOT warm it in a
microwave or hot water)
* DO NOT use the Pen if liquid has been frozen, even if it has been thawed

TAKING YOUR SKYRIZI

TAKING YOUR SKYRIZI INJECTION IN 4 STEPS

A simple way to remember how to inject is with “4 P’s”:

1. Pick the injection site
2. Pull the cap off
3. Place Pen on site
4. Press the button

1. PICK THE INJECTION SITE

Choose where you’re most comfortable with your injection:

* In the front of either thigh or in your stomach, at least 2 inches from your
belly button

Once you wash and dry your hands:

* Settle into a relaxed place
* Wipe the injection site in a circular motion with the alcohol swab
* Let it dry

A few things to look out for:

* DO NOT touch or blow on the injection site after it is cleaned.
* Allow the skin to dry before injecting
* DO NOT inject through clothes
* DO NOT inject into skin that is sore, bruised, red, hard, scarred, has
stretch marks, or areas with psoriasis

2. PULL THE CAP OFF

* Hold the Pen with the dark gray cap pointing up
* Pull the dark gray cap straight off
* Throw the dark gray cap away

Check the liquid through the inspection window

* It is normal to see one or more bubbles in the liquid
* The liquid should look clear to yellow and may contain tiny white or clear
particles
* DO NOT use if the liquid is cloudy or contains flakes or large particles

3. PLACE PEN ON SITE

* Hold the Pen with your fingers on the gray hand grips
* Turn the Pen so that the white needle sleeve points toward the injection site
and you can see the green activator button
* Gently squeeze the skin at your injection site to make a raised area and hold
it firmly
* Place the white needle sleeve straight (90° angle) against the raised
injection site

4. PRESS THE BUTTON

* Hold the Pen so that you can see the green activator button and inspection
window
* Push and keep pressing the Pen down against the pinched skin

The Pen will activate only if the white needle sleeve is pressed down.

* Press the green activator button and hold the Pen for 15 seconds

A loud “click” means the start of the injection.

* Keep pressing the Pen down against the injection site

The injection is complete when:

* the Pen has made a second “click”

* the yellow indicator has filled the inspection window

This takes up to 15 seconds.

When the injection is complete

* Slowly pull the Pen straight out from the skin

After completing the injection

* Place a cotton ball or gauze pad on the skin at the injection site

The white needle sleeve will cover the needle tip and make another “click.”

A few things to know:

* DO NOT rub the injection site
* Slight bleeding at the injection site is normal

DISPOSING OF YOUR PEN

Dispose of your Pen in a sharps disposal container.

Need a sharps container?
Skyrizi Complete can deliver one right to your door at no cost to you. Sign up
or log in to access your Skyrizi Complete resources and order your container
today.

Remember—do not throw your Pens away in the household trash. When your sharps
disposal container is almost full, you will need to follow your community
guidelines for the right way to dispose of it. There may be state or local laws
about how you should throw away used needles and syringes.

For more information about safe sharps disposal, and for specific information
about sharps disposal in the state that you live in, go to the FDA’s website at:
www.fda.gov/safesharpsdisposal

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

Download here:

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

Don’t have the App? Download here.

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

IMPORTANT INJECTION INFORMATION

* 1 full dose is 1 injection
* Store SKYRIZI in the refrigerator at 36° to 46°F (2° to 8°C)
* Keep SKYRIZI in the original carton to protect from light until you are ready
to use
* Before injecting, take the SKYRIZI carton out of the refrigerator. Leave the
carton at room temperature and out of direct sunlight for 30 to 90 minutes
* The liquid in the inspection window should look clear to yellow and may
contain tiny white or clear particles
* DO NOT shake SKYRIZI
* DO NOT remove the dark gray cap until right before injection
* SKYRIZI is not made with natural rubber latex

Do not use your SKYRIZI Pen if:

* Liquid is cloudy or contains flakes or large particles
* Expiration date (EXP) has passed
* Liquid has been frozen, even if it has been thawed
* It has been dropped or damaged
* Carton perforations are broken. Return product to pharmacy

4 QUICK TIPS FOR INJECTING

This guide can help give you a refresher on helpful tips for injecting.
You can print it out or save it for your next injection.
Check it out here

INJECTING WITH THE SKYRIZI SINGLE-DOSE PREFILLED SYRINGE

The single-dose prefilled syringe takes one injection per treatment. Click the
circles below to explore the syringe’s features.

Self-guided plunger lets you activate and control the injection

You control the duration of your injection

Finger grips to help hold the syringe while injecting

Guard comes over the needle to let you know injection is finished

Finger grips to help hold the syringe while injecting

You control the duration of your injection

Self-guided plunger lets you activate and control the injection

Does your prescribed treatment call for injecting with 2 syringes, 4 times a
year?

Check the box your SKYRIZI arrived in to see if it says "75mg". If it does,
learn how to inject here

--------------------------------------------------------------------------------

If your box says "150mg", the injection information for the single-dose syringe
is below.

WATCH, STEP-BY-STEP, HOW TO INJECT SKYRIZI WITH A SYRINGE:

US-SKZ-220107 SComplete 1x50mg Injection Training Video (Syringe) Update
Website_SYRINGE_MIXMASTER_ONLINE_UNDER60MB

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US-SKZ-220107 SCOMPLETE 1X50MG INJECTION TRAINING VIDEO (SYRINGE) UPDATE
WEBSITE_SYRINGE_MIXMASTER_ONLINE_UNDER60MB

Transcript
View Transcript

Quick Links CHAPTER 1:

A GUIDE TO INJECTING SKYRIZI

CHAPTER 2:

INJECTION PREP

CHAPTER 3:

HOW TO INJECT STEP-BY-STEP

CHAPTER 4:

HELPFUL TIPS FOR SELF-INJECTING

CHAPTER 1: A GUIDE TO INJECTING SKYRIZI

Hey there! I’m Maya and I’m here to walk you through how to inject yourself with
SKYRIZI. Now, if it’s your first time, don’t worry! And if it’s not your first
time, I hope you pick up some new tips while you’re here.

Now, I’ve done this a few times by myself, but my doctor originally walked me
through how to inject, and I called Bryan, who’s my Nurse Ambassador, when I
first started injecting on my own at home.

CHAPTER 2: INJECTION PREP

All right, let’s get started. So, when my SKYRIZI comes in the mail, it goes
straight in the fridge. Now, before I inject, I let it sit out for 15 to 30
minutes, out of direct sunlight, to get to room temperature. And while I wait, I
try to relax.

Okay, that should be enough time. So, once my hands are clean, I like to put out
everything that I’ll need. So, I have my SKYRIZI syringe. I have an alcohol
swab, which I got from my local pharmacy. I also have the Instructions for Use,
just in case. I like to grab a cotton ball (I had some right in my medicine
cabinet) and then a sharps container. Now, I like this spot because there’s a
lot of space and I don’t have to leave my couch.

CHAPTER 3: HOW TO INJECT STEP-BY-STEP

So, it helps me to break down the injection process into 4 simple steps: the 4
P’s. And you can see them here on the package. We have: pick, prepare, pinch,
push. Okay?

So, first I pick my injection site. So, I’ll go with my left thigh. But, you can
also pick your right thigh or your lower stomach.

But, if you choose your stomach, make sure to inject at least 2 inches away from
your belly button.

So, you want to grab your alcohol swab to clean your skin in a circular motion,
like this, and let it dry.

Now, I hold my syringe with the needle facing down, and I check the liquid
inside to make sure that everything looks okay. So, it should be clear to
slightly yellow, which it is. See that? There’s a few bubbles in there, but
that’s normal. So, looks like we’re good to go!

All right, so I hold my syringe in one hand, and I take the needle cover off
with the other hand, okay? Like this, and then you want to throw it away. You
see? You may see a drop of liquid at the end of the needle, which is normal,
okay?.

So, I’ve got my syringe in one hand, and with the other hand, I’m gently
pinching the area of my cleaned skin to hold firmly.

Now I’ll inject the needle into my skin at about a 45-degree angle using a
quick, short movement–like this. Now, holding the angle steady, I slowly push
the plunger in all the way until all of the liquid is injected, and the syringe
is empty. There we go.

Now, I pull the needle out of my skin while keeping the syringe at the same
angle, like this. I release the plunger to allow the syringe to move up... until
the entire needle is covered up by the needle guard. See how that works? The
needle guard won’t come back down unless all the liquid has been injected.

All right, so now, I press my cotton ball where I just injected, and that’s it!

I drop my used syringe in one of these handy sharps disposal containers
and—voila—safe and sound.

Now I’ll just put it back out of reach. Just like that, another injection
complete.

CHAPTER 4: HELPFUL TIPS FOR SELF-INJECTING

So, to recap, I prepare myself and my space. I pick an injection site, prepare
the syringe, pinch the skin, push the plunger in.

And safely discard the syringe. That’s the whole injection process!

Now, it seemed tricky at first, but I got it down soon enough. And Bryan, my
Nurse Ambassador, he recommended I create a routine–injecting at the same time,
same place–that sort of thing. I also do something nice for myself after
each injection–maybe I’ll paint as a reward.

Oh, and this Skyrizi Complete App has helped me so much.

I mean, I used it to log my first starter dose so I knew when to take my second
starter dose 4 weeks later. You can set reminders for future doses, too.

Since, after 2 starter doses, SKYRIZI is only 1 injection 4 times a year.

And when I get those reminders, I know to contact my specialty pharmacy to get
my next injection on time.

Oh, and I can’t forget about the Skyrizi Complete sharps disposal and mail-back
service.

Once my sharps container gets full, I request a new one that’s sent to me with a
box to mail this one back. I signed up for the service online, and it doesn’t
cost me anything!

I’m lucky to have people around to support me. I’ve got Skyrizi Complete on my
team, too. Like Bryan, who’s such a good listener, and this App!

There’s always someone to reach out to if you need help. You’ve got this.

LOOKING FOR SPECIFIC INJECTION INFORMATION?

PREPARING FOR YOUR SKYRIZI INJECTION

First, bring your syringe to room temperature by removing the carton from the
refrigerator 15 to 30 minutes before you inject. Keep the carton out of direct
sunlight.

Wash and dry your hands. Then, place your single-dose prefilled syringe and
alcohol swab on a clean, flat surface.

You’ll also need:

* A cotton ball or gauze pad
* A sharps disposal container, which is a safe way to dispose of your syringe

A few things to look out for:

* DO NOT remove the syringe from the carton while allowing SKYRIZI to reach
room temperature
* DO NOT warm SKYRIZI in any other way (for example, DO NOT warm it in a
microwave or in hot water)

TAKING YOUR SKYRIZI

TAKING YOUR SKYRIZI INJECTION IN 4 STEPS

A simple way to remember how to inject is with “4 P’s”:

1. Pick the injection site
2. Prepare the syringe
3. Pinch the skin
4. Push the plunger in

1. PICK THE INJECTION SITE

Choose where you’re most comfortable with your injection:

* In the front of either thigh or in your stomach, at least 2 inches from your
belly button

Once you wash and dry your hands:

* Settle into a relaxed place
* Wipe the injection site in a circular motion with an alcohol swab before
injecting

Do not touch or blow on the injection site after it is cleaned.

* Allow the skin to dry before injecting

A few things to look out for:

* DO NOT inject through your clothes
* DO NOT inject into skin that’s bruised, red, sore, scarred, hard, has stretch
marks, or is affected by psoriasis
* DO NOT use SKYRIZI if the expiration date has passed
* DO NOT use SKYRIZI if liquid has been frozen, even if it has been thawed

2. PREPARE THE SYRINGE

* Hold the syringe with the covered needle facing down
* The liquid in the syringe should look clear to slightly yellow and may
contain tiny white or clear particles. It is normal to see 1 or 2 bubbles
* Hold the syringe in 1 hand and gently pull the needle cover straight off with
the other. Then throw it away

It’s normal to see a drop of fluid on the needle point

A few things to look out for:

* DO NOT use the prefilled syringe if the liquid is cloudy or has large
particles or flakes
* DO NOT hold or pull the plunger when removing the needle cover

Remember not to touch the needle with your fingers or let the needle touch
anything.

3. PINCH THE SKIN

* Hold the body of the syringe in 1 hand, between the thumb and index finger
* With the other hand, gently pinch the area of cleaned skin and hold it
* Insert the needle at a 45-degree angle with a quick, short movement. Hold the
angle steady

Something to look out for:

* DO NOT touch the needle with your fingers or let the needle touch anything

4. PUSH THE PLUNGER IN

* Slowly push the plunger all the way down until all of the liquid is injected
and the syringe is empty
* Gently pull the needle out of the skin while keeping the syringe at the same
angle
* Release the plunger and allow the syringe to move up until the entire needle
is covered by the needle guard

The syringe needle guard will not activate unless all the liquid has been
injected.

* Press a cotton ball or gauze pad over your injection site for 10 seconds

Something to look out for:

* DO NOT rub the injection site.
* It’s normal to have some bleeding

DISPOSING OF YOUR SYRINGE

Dispose of your syringe in a sharps disposal container.

Need a sharps container?
Skyrizi Complete can deliver one right to your door at no cost to you. Sign up
or log in to access your Skyrizi Complete resources and order your container
today.

A few things to look out for:

Remember not to throw your syringe away in the household trash. When your sharps
disposal container is almost full, you will need to follow your community
guidelines for the right way to dispose of it. There may be state or local laws
about how you should throw away used needles and syringes.

For more information about safe sharps disposal, and for specific information
about sharps disposal in the state that you live in, go to the FDA’s website at:
www.fda.gov/safesharpsdisposal

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

Download here:

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

Don’t have the App? Download here.

Want to prepare for your next injection? You can set reminders and log
injections on the Skyrizi Complete App.

IMPORTANT INJECTION INFORMATION

* One full dose is only 1 injection
* You can store SKYRIZI in the refrigerator at 36°F to 46°F. Keep SKYRIZI in
the original carton to protect it from light until it’s time to use it
* Before injecting, leave the carton at room temperature and out of direct
sunlight for 15 to 30 minutes to warm
* Keep your syringe in the carton while allowing SKYRIZI to reach room
temperature—don’t try to warm your injection in hot water, in the microwave,
or in any other way
* Don’t remove the needle cover before you’re ready to give yourself your
injection

Do not use your injection if:

* The liquid has been frozen, even if it was thawed
* The liquid is cloudy or contains flakes or large particles
* The expiration date (EXP) has passed
* The syringe has been dropped or damaged
* The syringe seal tray is broken or missing; return the product to the
pharmacy

4 QUICK TIPS FOR INJECTING

This guide can help give you a refresher on helpful tips for injecting.
You can print it out or save it for your next injection.
Check it out here

YOUR NURSE AMBASSADOR IS HERE TO HELP

Whether you’re just getting the hang of injecting or could use some refresher
training, your Skyrizi Complete Nurse Ambassador is here to help. At no cost to
you, they offer step-by-step injection training and can help you access what
you’ll need to get started and stay on track with your prescribed treatment
plan.

NEED HELP NOW?

Call your dedicated Nurse Ambassador at 1.866.SKYRIZI (1.866.759.7494).

DON’T HAVE A NURSE AMBASSADOR?

By signing up for Skyrizi Complete, you’ll be connected with your dedicated
Skyrizi Complete Nurse Ambassador, who will get to know you and listen to your
unique needs.

Enroll now

*Nurse Ambassadors are provided by AbbVie and do not work under the direction of
your health care professional (HCP) or give medical advice. They are trained to
direct patients to their HCP for treatment-related advice, including further
referrals.

YOUR SKYRIZI TREATMENT

When you’re first prescribed SKYRIZI, you’ll go to your doctor’s office to
receive your 2 starter doses. After that, you can continue to get your injection
at your doctor’s office. Or, once you’re trained, you can inject SKYRIZI at
home. Talk to your doctor about which option is right for you.

--------------------------------------------------------------------------------

Mark your injection in the Skyrizi Complete App or your calendar ahead of time
to remember when to take SKYRIZI.

Download here:

Mark your injection in the Skyrizi Complete App or your calendar ahead of time
to remember when to take SKYRIZI.

Don’t have the App? Download here.

Mark your injection in the Skyrizi Complete App or your calendar ahead of time
to remember when to take SKYRIZI.

Don’t have the App? Download here.

YOU HAVE RESOURCES TO HELP WITH INJECTING

YOUR SKYRIZI COMPLETE APP

Log injections and set reminders to help build a routine and stay on track with
your prescribed SKYRIZI treatment plan.

SHARPS CONTAINER AND MAIL-BACK DISPOSAL KIT

You can safely dispose of your used Pens or syringes with containers shipped to
and from your doorstep.

SKYRIZI INSULATED TRAVEL CASE

Transport your medicine whenever you need to, at a refrigerated temperature, for
up to 8 hours.

Check out your resources

YOUR SKYRIZI COMPLETE NURSE AMBASSADOR CAN HELP YOU LEARN HOW TO INJECT AT HOME,
WHETHER YOU’RE NEW TO INJECTING OR JUST NEED A REFRESHER.

Need help now?
Call 1.866.SKYRIZI (1.866.759.7494)

Have a new insurance plan? Make sure your SKYRIZI is covered.

Check this helpful checklist

YOU MAY ALSO BE INTERESTED IN:

Ways to Save
Your Nurse Ambassador
Resources to Stay on Track

USES

SKYRIZI is a prescription medicine used to treat adults with:

* moderate to severe plaque psoriasis who may benefit from taking injections or
pills (systemic therapy) or treatment using ultraviolet or UV light
(phototherapy).
* active psoriatic arthritis (PsA).
* moderate to severe Crohn's disease.

IMPORTANT SAFETY INFORMATION

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT SKYRIZI®
(RISANKIZUMAB-RZAA)?

SKYRIZI IS A PRESCRIPTION MEDICINE THAT MAY CAUSE SERIOUS SIDE EFFECTS,
INCLUDING:

SERIOUS ALLERGIC REACTIONS:

* Stop using SKYRIZI and get emergency medical help right away if you get any
of the following symptoms of a serious allergic reaction:
* - fainting, dizziness, feeling lightheaded
(low blood pressure)
* - swelling of your face, eyelids, lips, mouth,
tongue, or throat
* - trouble breathing or throat tightness
* - chest tightness
* - skin rash, hives
* - itching

INFECTIONS:

SKYRIZI may lower the ability of your immune system to fight infections and may
increase your risk of infections. Your healthcare provider should check you for
infections and tuberculosis (TB) before starting treatment with SKYRIZI and may
treat you for TB before you begin treatment with SKYRIZI if you have a history
of TB or have active TB. Your healthcare provider should watch you closely for
signs and symptoms of TB during and after treatment with SKYRIZI.

* Tell your healthcare provider right away if you have an infection or have
symptoms of an infection, including:
* - fever, sweats, or chills
* - cough
* - shortness of breath
* - blood in your mucus (phlegm)
* - muscle aches
* - warm, red, or painful skin
or sores on your body different from your psoriasis
* - weight loss
* - diarrhea or stomach pain
* - burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a
complete list of ingredients.

BEFORE USING SKYRIZI, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL OF YOUR MEDICAL
CONDITIONS, INCLUDING IF YOU:

* have any of the conditions or symptoms listed in the section "What is the
most important information I should know about SKYRIZI?"
* have an infection that does not go away or that keeps coming back.
* have TB or have been in close contact with someone with TB.
* have recently received or are scheduled to receive an immunization (vaccine).
Medicines that interact with the immune system may increase your risk of
getting an infection after receiving live vaccines. You should avoid
receiving live vaccines right before, during, or right after treatment with
SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before
receiving a vaccine.
* are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm
your unborn baby.
* are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes
into your breast milk.
* become pregnant while taking SKYRIZI. You are encouraged to enroll in the
Pregnancy Registry, which is used to collect information about the health of
you and your baby. Talk with your healthcare provider or call 1-877-302-2161
to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important
information I should know about SKYRIZI?"

Liver problems in Crohn's disease: A person with Crohn's disease who received
SKYRIZI through a vein in the arm developed changes in liver blood tests with a
rash that led to hospitalization. Your healthcare provider will do blood tests
to check your liver before, during, and up to 12 weeks of treatment and may stop
treatment with SKYRIZI if you develop liver problems. Tell your healthcare
provider right away if you notice any of the following symptoms: unexplained
rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of
appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease
include: upper respiratory infections, headache, joint pain, stomach (abdominal)
pain, injection site reactions, low red blood cells (anemia), fever, back pain,
and urinary tract infection.

The most common side effects of SKYRIZI in people treated for plaque psoriasis
and psoriatic arthritis include: upper respiratory infections, headache, feeling
tired, injection site reactions, and fungal skin infections.

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 150 mg/mL prefilled syringe and pen, a 600 mg/10 mL
vial for intravenous infusion, and a 180 mg/1.2 mL or 360 mg/2.4 mL single-dose
prefilled cartridge with on-body injector.

USES

SKYRIZI is a prescription medicine used to treat adults with:

US-SKZ-220579

Please see the Full Prescribing Information, including the Medication Guide, for
SKYRIZI.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help.
Visit AbbVie.com/myAbbVieAssist to learn more.

Legal Notices/Privacy Policy. Copyright 2023, AbbVie Inc., North Chicago,
Illinois, U.S.A. If you have any questions about AbbVie’s SKYRIZI.com website
that have not been answered, click here. This website and the information
contained herein is intended for use by US residents only, is provided for
informational purposes only and is not intended to replace a discussion with a
healthcare provider. All decisions regarding patient care must be made with a
healthcare provider and consider the unique characteristics of each patient.

Skyrizi CD Complete Savings Card Terms & Conditions

Eligibility: Available to patients with commercial insurance coverage for
SKYRIZI® (risankizumab-rzaa) who meet eligibility criteria. This co-pay
assistance program is not available to patients receiving prescription
reimbursement under any federal, state, or government-funded insurance programs
(for example, Medicare [including Part D], Medicare Advantage, Medigap,
Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where
prohibited by law. Offer subject to change or termination without notice.
Restrictions, including monthly maximums, may apply. This is not health
insurance. For full Terms and Conditions, visit SKYRIZISavingsCard.com or call
1.866.SKYRIZI for additional information. For full Terms and Conditions for
SKYRIZI Crohn’s Disease patients, visit SKYRIZICDSavingsCard.com or call
1.866.SKYRIZI for additional information. To learn about AbbVie’s privacy
practices and your privacy choices, visit https://privacy.abbvie

SKYRIZI (RISANKIZUMAB-RZAA)

* Moderate to Severe Plaque Psoriasis
* Active Psoriatic Arthritis
* Moderate to Severe Crohn’s Disease
* About Skyrizi Complete

IMPORTANT SAFETY INFORMATION FOR PATIENTS

* Important Safety Information
* Medication Guide
* Full Prescribing Information

INFORMATION FROM ABBVIE

* Healthcare Professionals Site
* Accessibility Statement
* Contact Us
* Terms of Use
* Privacy Notice
* Cookies Settings
* Your Privacy Choices

US-SKZ-230158

Leaving AbbVie Web Site

You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site
that is not under the control of AbbVie. AbbVie is not responsible for the
contents of any such site or any further links from such site. AbbVie is
providing these links to you only as a convenience and the inclusion of any link
does not imply the endorsement of the linked site by AbbVie. You should also be
aware that the linked site may be governed by its own set of terms and
conditions and privacy policy for which AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

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US-RISN-190090

LEAVING ABBVIE WEB SITE

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are leaving the SKYRIZI site and connecting to a site that is not under the
control of AbbVie. AbbVie is not responsible for the contents of any such site
or any further links from such site. AbbVie is providing these links to you only
as a convenience and the inclusion of any link does not imply the endorsement of
the linked site by AbbVie. You should also be aware that the linked site may be
governed by its own set of terms and conditions and privacy policy for which
AbbVie has no responsibility.

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-SKZ-220373

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

You are about to enter a site that is for US healthcare professionals only. By
continuing, you certify that you are a healthcare professional and that you wish
to proceed to the healthcare professionals section of this site. Products or
treatments described on this site are available in the US but may not be
available in all other countries.

Iam a licensed healthcare professional and wish to proceed to the healthcare
professionals section of this site.

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI.com or AbbVie.

Do you wish to leave this site?

Yes
No

US-SKZ-220373

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

Important Updates to the Medication Guide for
SKYRIZI® (risankizumab-rzaa) injection, for subcutaneous use

On January 21, 2022, the SKYRIZI (risankizumab-rzaa) Prescribing Information and
Medication Guide were updated to include new information about serious allergic
reactions.

The following describes the recent changes to the SKYRIZI Medication Guide.
Please refer to the full Prescribing Information and Medication Guide for
additional safety information.

The following serious side effects were added to the section “What is the most
important information I should know about SKYRIZI?”

SKYRIZI may cause serious side effects, including:

Serious allergic reactions. Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

* fainting, dizziness, feeling lightheaded (low blood pressure)
* swelling of your face, eyelids, lips, mouth, tongue, or throat
* trouble breathing or throat tightness
* chest tightness
* skin rash, hives
* itching

Who should not use SKYRIZI?

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the end of the Medication Guide for a complete list
of ingredients in SKYRIZI here.

This is not a complete list of all the changes made to the Prescribing
Information and Medication Guide for SKYRIZI. Please refer to the full
Prescribing Information and Medication Guide for additional safety information.

INDICATIONS1

SKYRIZI is a prescription medicine used to treat adults:

• with moderate to severe plaque psoriasis who may benefit from taking
injections or pills (systemic therapy) or treatment using ultraviolet or UV
light (phototherapy).

• with active psoriatic arthritis (PsA).

Important Safety Information1

What is the most important information I should know about SKYRIZI®
(risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions:

• Stop using SKYRIZI and get emergency medical help right away if you get any of
the following symptoms of a serious allergic reaction:

− fainting, dizziness, feeling lightheaded (low blood pressure)

− swelling of your face, eyelids, lips, mouth, tongue, or throat

− trouble breathing or throat tightness

− chest tightness

− skin rash, hives

− itching

Infections:

• Tell your healthcare provider right away if you have an infection or have
symptoms of an infection, including:

− fever, sweats, or chills

− cough

− shortness of breath

− blood in your mucus (phlegm)

− muscle aches

− warm, red, or painful skin or sores on your body different from your psoriasis

− weight loss

− diarrhea or stomach pain

− burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI.

Before using SKYRIZI, tell your healthcare provider about all of your medical
conditions, including if you:

• have any of the conditions or symptoms listed in the section “What is the most
important information I should know about SKYRIZI?”

• have an infection that does not go away or that keeps coming back.

• have TB or have been in close contact with someone with TB.

• have recently received or are scheduled to receive an immunization (vaccine).
Medications that interact with the immune system may increase your risk of
getting an infection after receiving live vaccines. You should avoid receiving
live vaccines right before, during, or right after treatment with SKYRIZI. Tell
your healthcare provider that you are taking SKYRIZI before receiving a vaccine.

• are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm
your unborn baby.

• are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes
into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See “What is the most important
information I should know about SKYRIZI?”

The most common side effects of SKYRIZI include upper respiratory infections,
feeling tired, fungal skin infections, headache, and injection site reactions.

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 150 mg/mL prefilled syringe and pen.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to
help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see accompanying full Prescribing Information or visit
www.rxabbvie.com/pdf/skyrizi_pi.pdf.

US-SKZ-220001

Leaving AbbVie Web Site

Conversely, the presence of this link does not imply the linked site's
endorsement of SKYRIZI or AbbVie.

Do you wish to leave this site?

Yes
No

US-RISN-190090

USES

SKYRIZI is a prescription medicine used to
treat adults:

* with moderate to severe plaque psoriasis who may benefit from taking
injections or pills (systemic therapy) or treatment using ultraviolet or UV
light (phototherapy).

* with active psoriatic arthritis (PsA).

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

• fainting, dizziness, feeling lightheaded (low blood pressure) • swelling of
face, eyelids, lips, mouth, tongue, or throat • trouble breathing or throat
tightness • chest tightness • skin rash, hives • itching

Infections: SKYRIZI may lower the ability of your immune system to fight
infections and may increase

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

Infections: SKYRIZI may lower the ability of your

USES

SKYRIZI is a prescription medicine used to
treat adults:

* with moderate to severe plaque psoriasis who may benefit from taking
injections or pills (systemic therapy) or treatment using ultraviolet or UV
light (phototherapy).

* with active psoriatic arthritis (PsA).

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

Infections: SKYRIZI may lower the ability of your immune system to fight
infections and may increase

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects,
including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help
right away if you get any of the following symptoms of a serious allergic
reaction:

Infections: SKYRIZI may lower the ability of your

USES

SKYRIZI is a prescription medicine used to treat adults with:

IMPORTANT SAFETY INFORMATION

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT SKYRIZI®
(RISANKIZUMAB-RZAA)?

SKYRIZI IS A PRESCRIPTION MEDICINE THAT MAY CAUSE SERIOUS SIDE EFFECTS,
INCLUDING:

SERIOUS ALLERGIC REACTIONS:

INFECTIONS:

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the
ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a
complete list of ingredients.

BEFORE USING SKYRIZI, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL OF YOUR MEDICAL
CONDITIONS, INCLUDING IF YOU:

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important
information I should know about SKYRIZI?"

These are not all the possible side effects of SKYRIZI. Call your doctor for
medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

USES

SKYRIZI is a prescription medicine used to treat adults with:

US-SKZ-220579

AbbVie may use and disclose online usage data about you collected automatically
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